Published in EMBO J on May 01, 1993
Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress. Proc Natl Acad Sci U S A (1996) 5.53
Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-kappa B. Proc Natl Acad Sci U S A (1996) 4.11
Crosstalk of reactive oxygen species and NF-κB signaling. Cell Res (2010) 3.71
Oxidative burst: an early plant response to pathogen infection. Biochem J (1997) 3.37
Cross-coupling of the NF-kappa B p65 and Fos/Jun transcription factors produces potentiated biological function. EMBO J (1993) 3.28
AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1. Proc Natl Acad Sci U S A (1997) 3.21
Cellular stress responses: cell survival and cell death. Int J Cell Biol (2010) 2.74
An iron-sulfur center essential for transcriptional activation by the redox-sensing SoxR protein. EMBO J (1994) 2.66
Hypoxia-responsive transcription factors. Pflugers Arch (2005) 2.64
Distinct effects of thioredoxin and antioxidants on the activation of transcription factors NF-kappa B and AP-1. Proc Natl Acad Sci U S A (1994) 2.62
The redox and DNA-repair activities of Ref-1 are encoded by nonoverlapping domains. Proc Natl Acad Sci U S A (1994) 2.55
The cellular response to oxidative stress: influences of mitogen-activated protein kinase signalling pathways on cell survival. Biochem J (1998) 2.50
Activation of protein kinase C by tyrosine phosphorylation in response to H2O2. Proc Natl Acad Sci U S A (1997) 2.42
Oxidative stress and antioxidant defense. World Allergy Organ J (2012) 2.35
A novel signal transduction pathway from the endoplasmic reticulum to the nucleus is mediated by transcription factor NF-kappa B. EMBO J (1995) 2.31
Peptide methionine sulfoxide reductase contributes to the maintenance of adhesins in three major pathogens. Proc Natl Acad Sci U S A (1996) 2.05
Thiol-based redox switches in eukaryotic proteins. Antioxid Redox Signal (2009) 1.97
Inhibition of NF-kappaB DNA binding by nitric oxide. Nucleic Acids Res (1996) 1.94
Role of cysteine residues in regulation of p53 function. Mol Cell Biol (1995) 1.91
Transposon tagging of tobacco mosaic virus resistance gene N: its possible role in the TMV-N-mediated signal transduction pathway. Proc Natl Acad Sci U S A (1995) 1.89
rac1 regulates a cytokine-stimulated, redox-dependent pathway necessary for NF-kappaB activation. Mol Cell Biol (1996) 1.86
Oxidative stress by tumor-derived macrophages suppresses the expression of CD3 zeta chain of T-cell receptor complex and antigen-specific T-cell responses. Proc Natl Acad Sci U S A (1996) 1.79
Transcription factor NF-kappaB is activated in primary neurons by amyloid beta peptides and in neurons surrounding early plaques from patients with Alzheimer disease. Proc Natl Acad Sci U S A (1997) 1.77
Bcl-2 down-regulates the activity of transcription factor NF-kappaB induced upon apoptosis. J Cell Biol (1996) 1.71
Elevated glutathione biosynthetic capacity in the chloroplasts of transgenic tobacco plants paradoxically causes increased oxidative stress Plant Cell (1999) 1.70
Expression of influenza virus hemagglutinin activates transcription factor NF-kappa B. J Virol (1995) 1.63
Induction of the mammalian stress response gene GADD153 by oxidative stress: role of AP-1 element. Biochem J (1996) 1.62
Activation of transcription factor NF-kappaB by the adenovirus E3/19K protein requires its ER retention. J Cell Biol (1996) 1.62
Rapid responses to oxidative stress mediated by iron regulatory protein. EMBO J (1995) 1.56
Environmental toxicity, redox signaling and lung inflammation: the role of glutathione. Mol Aspects Med (2008) 1.56
Attachment of the ubiquitin-related protein Urm1p to the antioxidant protein Ahp1p. Eukaryot Cell (2003) 1.52
Overexpression of thioredoxin in transgenic mice attenuates focal ischemic brain damage. Proc Natl Acad Sci U S A (1999) 1.50
Inhibition of endothelial cell activation by adenovirus-mediated expression of I kappa B alpha, an inhibitor of the transcription factor NF-kappa B. J Exp Med (1996) 1.49
Pyrrolidine dithiocarbamate attenuates the development of acute and chronic inflammation. Br J Pharmacol (2002) 1.47
IL-2 gene expression and NF-kappa B activation through CD28 requires reactive oxygen production by 5-lipoxygenase. EMBO J (1995) 1.47
Activation-induced apoptosis in human macrophages: developmental regulation of a novel cell death pathway by macrophage colony-stimulating factor and interferon gamma. J Exp Med (1995) 1.42
Involvement of the transcription factor NF-kappaB in tubular morphogenesis of human microvascular endothelial cells by oxidative stress. Mol Cell Biol (1996) 1.42
Antagonistic effects of different members of the fibroblast and platelet-derived growth factor families on adipose conversion and NADPH-dependent H2O2 generation in 3T3 L1-cells. Biochem J (1995) 1.42
Role of hydrogen peroxide in hypoxia-induced erythropoietin production. Biochem J (1994) 1.36
Transcriptional induction of the mouse metallothionein-I gene in hydrogen peroxide-treated Hepa cells involves a composite major late transcription factor/antioxidant response element and metal response promoter elements. Nucleic Acids Res (1994) 1.35
Are diverse signalling pathways integrated in the regulation of arabidopsis antioxidant defence gene expression in response to excess excitation energy? Philos Trans R Soc Lond B Biol Sci (2000) 1.35
Dengue virus replication in human hepatoma cells activates NF-kappaB which in turn induces apoptotic cell death. J Virol (1997) 1.29
Ectopic expression of hepatitis C virus core protein differentially regulates nuclear transcription factors. J Virol (1998) 1.29
Oxidative stress and transcriptional regulation in Alzheimer disease. Alzheimer Dis Assoc Disord (2007) 1.29
Inhibition of I kappa B-alpha phosphorylation and degradation and subsequent NF-kappa B activation by glutathione peroxidase overexpression. J Cell Biol (1996) 1.26
Suppression of Ras-induced apoptosis by the Rac GTPase. Mol Cell Biol (1999) 1.26
Human isolates of dengue type 1 virus induce apoptosis in mouse neuroblastoma cells. J Virol (1996) 1.26
Thioredoxin: a redox-regulating cellular cofactor for glucocorticoid hormone action. Cross talk between endocrine control of stress response and cellular antioxidant defense system. J Clin Invest (1996) 1.23
Evidence for five divergent thioredoxin h sequences in Arabidopsis thaliana. Proc Natl Acad Sci U S A (1995) 1.22
Asbestos causes translocation of p65 protein and increases NF-kappa B DNA binding activity in rat lung epithelial and pleural mesothelial cells. Am J Pathol (1997) 1.20
Regulation of p53 by metal ions and by antioxidants: dithiocarbamate down-regulates p53 DNA-binding activity by increasing the intracellular level of copper. Mol Cell Biol (1997) 1.19
Identification of stress-responsive genes in Caenorhabditis elegans using RT-PCR differential display. Nucleic Acids Res (1998) 1.19
Role of NF-kappaB and AP-1 on Helicobater pylori-induced IL-8 expression in AGS cells. Dig Dis Sci (2003) 1.18
The Arabidopsis thaliana apurinic endonuclease Arp reduces human transcription factors Fos and Jun. Proc Natl Acad Sci U S A (1994) 1.17
Oxidized low density lipoprotein inhibits lipopolysaccharide-induced binding of nuclear factor-kappaB to DNA and the subsequent expression of tumor necrosis factor-alpha and interleukin-1beta in macrophages. J Clin Invest (1996) 1.16
Redox modification of cell signaling in the cardiovascular system. J Mol Cell Cardiol (2011) 1.15
Dual regulation of heat-shock transcription factor (HSF) activation and DNA-binding activity by H2O2: role of thioredoxin. Biochem J (1996) 1.15
Reactive oxygen intermediates induce monocyte chemotactic protein-1 in vascular endothelium after brief ischemia. Am J Pathol (2001) 1.11
Thiols decrease human interleukin (IL) 4 production and IL-4-induced immunoglobulin synthesis. J Exp Med (1995) 1.09
An 'environment to nucleus' signaling system operates in B lymphocytes: redox status modulates BSAP/Pax-5 activation through Ref-1 nuclear translocation. Nucleic Acids Res (2000) 1.09
Proteasome inhibitors up-regulate haem oxygenase-1 gene expression: requirement of p38 MAPK (mitogen-activated protein kinase) activation but not of NF-kappaB (nuclear factor kappaB) inhibition. Biochem J (2004) 1.08
Antioxidant-induced changes of the AP-1 transcription complex are paralleled by a selective suppression of human papillomavirus transcription. J Virol (1997) 1.06
Role of oxidative stress in stem, cancer, and cancer stem cells. Cancers (Basel) (2010) 1.06
Functional modulation of estrogen receptor by redox state with reference to thioredoxin as a mediator. Nucleic Acids Res (1997) 1.05
Activation of iron regulatory protein-1 by oxidative stress in vitro. Proc Natl Acad Sci U S A (1998) 1.05
NADPH oxidase limits lipopolysaccharide-induced lung inflammation and injury in mice through reduction-oxidation regulation of NF-κB activity. J Immunol (2013) 1.04
Impaired pulmonary NF-kappaB activation in response to lipopolysaccharide in NADPH oxidase-deficient mice. Infect Immun (2001) 1.02
Hydrogen peroxide decreases endothelial nitric oxide synthase promoter activity through the inhibition of AP-1 activity. Am J Physiol Lung Cell Mol Physiol (2008) 1.02
The organization of the human GSTP1-1 gene promoter and its response to retinoic acid and cellular redox status. Biochem J (1996) 1.02
NF-kappaB is involved in the regulation of CD154 (CD40 ligand) expression in primary human T cells. Clin Exp Immunol (2001) 1.01
The cytoprotective effect of N-acetyl-L-cysteine against ROS-induced cytotoxicity is independent of its ability to enhance glutathione synthesis. Toxicol Sci (2010) 1.01
Strong and prolonged induction of c-jun and c-fos proto-oncogenes by photodynamic therapy. Br J Cancer (1996) 1.00
Dynamic compression counteracts IL-1beta induced inducible nitric oxide synthase and cyclo-oxygenase-2 expression in chondrocyte/agarose constructs. Arthritis Res Ther (2008) 0.98
Influence of hypoxia in inflammatory synovitis. Ann Rheum Dis (1998) 0.98
Regulation of c-jun expression during hypoxic and low-glucose stress. Mol Cell Biol (1994) 0.96
Sustained oxidative stress inhibits NF-kappaB activation partially via inactivating the proteasome. Free Radic Biol Med (2008) 0.96
Arterial oxygen partial pressures reduce the insulin-dependent induction of the perivenously located glucokinase in rat hepatocyte cultures: mimicry of arterial oxygen pressures by H2O2. Biochem J (1997) 0.95
A novel promoter sequence is involved in the oxidative stress-induced expression of the adult T-cell leukemia-derived factor (ADF)/human thioredoxin (Trx) gene. Nucleic Acids Res (1996) 0.94
Activation of the NF-kappaB transcription factor in a T-lymphocytic cell line by hypochlorous acid. Biochem J (1997) 0.92
Inhibition of lipid peroxidation, NF-kappaB activation and IL-8 production by rebamipide in Helicobacter pylori-stimulated gastric epithelial cells. Dig Dis Sci (2000) 0.92
Novel functions of the alpha-ketoglutarate dehydrogenase complex may mediate diverse oxidant-induced changes in mitochondrial enzymes associated with Alzheimer's disease. Biochim Biophys Acta (2007) 0.92
Anti-human immunodeficiency virus 1 (HIV-1) activities of 3-deazaadenosine analogs: increased potency against 3'-azido-3'-deoxythymidine-resistant HIV-1 strains. Proc Natl Acad Sci U S A (1995) 0.91
Antiviral effects of pyrrolidine dithiocarbamate on human rhinoviruses. J Virol (2002) 0.91
Inhibition of the differentiation of human myeloid cell lines by redox changes induced through glutathione depletion. Biochem J (1994) 0.89
Activation of early signaling transcription factor, NF-kappaB following low-level manganese exposure. Toxicol Lett (2002) 0.89
Functional activation of the egr-1 (early growth response-1) gene by hydrogen peroxide. Biochem J (1996) 0.89
Protective effect of thioredoxin upon NO-mediated cell injury in THP1 monocytic human cells. Biochem J (2000) 0.89
Mitochondria and reactive oxygen species: physiology and pathophysiology. Int J Mol Sci (2013) 0.89
Arsenic trioxide inhibits hepatitis C virus RNA replication through modulation of the glutathione redox system and oxidative stress. J Virol (2008) 0.89
Inhibition of the promotion of hepatocarcinogenesis by 2,2',4,4',5,5'-hexachlorobiphenyl (PCB-153) by the deletion of the p50 subunit of NF-kappa B in mice. Toxicol Appl Pharmacol (2008) 0.89
Caffeic acid phenethyl ester modulates Helicobacter pylori-induced nuclear factor-kappa B and activator protein-1 expression in gastric epithelial cells. Br J Pharmacol (2005) 0.89
MicroRNA-30b-mediated regulation of catalase expression in human ARPE-19 cells. PLoS One (2012) 0.89
Parasite-mediated nuclear factor kappaB regulation in lymphoproliferation caused by Theileria parva infection. Proc Natl Acad Sci U S A (1997) 0.89
Gamma-oryzanol rich fraction regulates the expression of antioxidant and oxidative stress related genes in stressed rat's liver. Nutr Metab (Lond) (2010) 0.89
Redox regulation of genome stability by effects on gene expression, epigenetic pathways and DNA damage/repair. Redox Biol (2015) 0.88
Antioxidant: a new role for RU-486 and related compounds. J Clin Invest (1994) 0.88
Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem (1987) 281.19
A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. Anal Biochem (1983) 206.01
A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology (1973) 127.36
Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res (1983) 124.30
I kappa B: a specific inhibitor of the NF-kappa B transcription factor. Science (1988) 16.40
Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1. EMBO J (1991) 11.86
Thioredoxin. Annu Rev Biochem (1985) 9.82
The inducible transcription activator NF-kappa B: regulation by distinct protein subunits. Biochim Biophys Acta (1991) 7.70
Redox regulation of fos and jun DNA-binding activity in vitro. Science (1990) 7.09
Characterization of SAP-1, a protein recruited by serum response factor to the c-fos serum response element. Cell (1992) 7.07
Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity. Cell (1991) 6.89
Prooxidant states and tumor promotion. Science (1985) 6.26
The antioxidant responsive element. Activation by oxidative stress and identification of the DNA consensus sequence required for functional activity. J Biol Chem (1991) 6.16
Phosphorylation of transcription factor p62TCF by MAP kinase stimulates ternary complex formation at c-fos promoter. Nature (1992) 5.69
Dithiocarbamates as potent inhibitors of nuclear factor kappa B activation in intact cells. J Exp Med (1992) 5.32
Redox activation of Fos-Jun DNA binding activity is mediated by a DNA repair enzyme. EMBO J (1992) 5.23
The ability of a ternary complex to form over the serum response element correlates with serum inducibility of the human c-fos promoter. Cell (1989) 5.11
Intracellular thiols regulate activation of nuclear factor kappa B and transcription of human immunodeficiency virus. Proc Natl Acad Sci U S A (1990) 4.61
Nuclear factor kappa B: an oxidative stress-responsive transcription factor of eukaryotic cells (a review). Free Radic Res Commun (1992) 4.45
Selection of optimal kappa B/Rel DNA-binding motifs: interaction of both subunits of NF-kappa B with DNA is required for transcriptional activation. Mol Cell Biol (1992) 4.36
Occupation of the c-fos serum response element in vivo by a multi-protein complex is unaltered by growth factor induction. Nature (1989) 4.26
The mammalian ultraviolet response is triggered by activation of Src tyrosine kinases. Cell (1992) 4.04
Ets-related protein Elk-1 is homologous to the c-fos regulatory factor p62TCF. Nature (1992) 3.88
UV-induced DNA damage is an intermediate step in UV-induced expression of human immunodeficiency virus type 1, collagenase, c-fos, and metallothionein. Mol Cell Biol (1989) 3.83
NF-kappa B and related proteins: Rel/dorsal homologies meet ankyrin-like repeats. Trends Biochem Sci (1992) 3.81
Rapid and preferential activation of the c-jun gene during the mammalian UV response. Mol Cell Biol (1991) 3.70
Regulation of bacterial oxidative stress genes. Annu Rev Genet (1991) 3.36
Thioredoxin regulates the DNA binding activity of NF-kappa B by reduction of a disulphide bond involving cysteine 62. Nucleic Acids Res (1992) 3.22
Modulation of transcription factor NF-kappa B binding activity by oxidation-reduction in vitro. Proc Natl Acad Sci U S A (1991) 3.07
Bacterial defenses against oxidative stress. Trends Genet (1990) 2.89
The PAR1 (YAP1/SNQ3) gene of Saccharomyces cerevisiae, a c-jun homologue, is involved in oxygen metabolism. Curr Genet (1992) 2.80
A role for oxygen radicals as second messengers. Trends Cell Biol (1991) 2.72
ATL-derived factor (ADF), an IL-2 receptor/Tac inducer homologous to thioredoxin; possible involvement of dithiol-reduction in the IL-2 receptor induction. EMBO J (1989) 2.62
Regulation of human NAD(P)H:quinone oxidoreductase gene. Role of AP1 binding site contained within human antioxidant response element. J Biol Chem (1992) 2.46
Activation of the c-fos gene by UV and phorbol ester: different signal transduction pathways converge to the same enhancer element. Oncogene (1988) 2.43
The inhibitory ankyrin and activator Rel proteins. Curr Opin Genet Dev (1992) 2.39
Identification of a transcriptional enhancer element upstream from the proto-oncogene fos. Science (1985) 2.39
Measurement of endothelial cell free radical generation: evidence for a central mechanism of free radical injury in postischemic tissues. Proc Natl Acad Sci U S A (1988) 2.34
The insulinomimetic agents H2O2 and vanadate stimulate protein tyrosine phosphorylation in intact cells. J Biol Chem (1990) 2.03
Redox regulation of a protein tyrosine kinase in the endoplasmic reticulum. Cell (1991) 1.79
Transcriptional activation of early-response genes by hydrogen peroxide in a mouse osteoblastic cell line. Eur J Biochem (1991) 1.77
Turning on the respiratory burst. Trends Biochem Sci (1990) 1.75
In vitro DNA binding activity of Fos/Jun and BZLF1 but not C/EBP is affected by redox changes. Oncogene (1991) 1.63
Inhibition of HIV-1 replication and NF-kappa B activity by cysteine and cysteine derivatives. AIDS (1991) 1.57
Redox status of cells influences constitutive or induced NF-kappa B translocation and HIV long terminal repeat activity in human T and monocytic cell lines. J Immunol (1992) 1.48
Diseases associated with HTLV-I: virus, IL-2 receptor dysregulation and redox regulation. Immunol Today (1992) 1.47
Determining the effect of inducible protein phosphorylation on the DNA-binding activity of transcription factors. Anal Biochem (1992) 1.40
Mechanism of c-fos induction by active oxygen. Cancer Res (1992) 1.34
Plasmid vectors with multiple cloning sites and cat-reporter gene for promoter cloning and analysis in animal cells. Gene (1988) 1.19
Hormone- and tumor promoter-induced activation or membrane association of protein kinase C in intact cells. Methods Enzymol (1987) 1.17
Signal transduction and gene control. Curr Opin Cell Biol (1991) 1.16
Regulation of AP-1/DNA complex formation in vitro. Oncogene (1991) 1.13
A new method for constructing linker scanning mutants. Nucleic Acids Res (1987) 1.10
Involvement of reactive oxygen intermediates in the induction of c-jun gene transcription by ionizing radiation. Biochemistry (1992) 1.00
Alpha-lipoic acid is a potent inhibitor of NF-kappa B activation in human T cells. Biochem Biophys Res Commun (1992) 0.98
Antioxidant capacity of diethyldithiocarbamate in a metal independent lipid peroxidative process. Free Radic Biol Med (1989) 0.92
Antioxidant effect of diethyldithiocarbamate on microsomal lipid peroxidation assessed by low-level chemiluminescence and alkane production. FEBS Lett (1983) 0.90
Interleukin-1 induces protein tyrosine phosphorylation in T cells. Eur J Immunol (1992) 0.89
Leukotriene B4 stimulates c-fos and c-jun gene transcription and AP-1 binding activity in human monocytes. Biochem J (1992) 0.88
Identification of jun-B as third member in human antioxidant response element-nuclear proteins complex. Biochem Biophys Res Commun (1992) 0.86
Transcriptional regulation of cytokine expression by diethyldithiocarbamate in human HL-60 promyelocytic leukemia cells. Biochem Pharmacol (1992) 0.82
Transcription factor activation and functional stimulation of human monocytes. Cell Biol Int Rep (1992) 0.80
Interleukin-1 induces c-fos and c-jun gene expression in T helper type II cells through different signal transmission pathways. Eur J Immunol (1992) 0.80
Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1. EMBO J (1991) 11.86
The DNA binding subunit of NF-kappa B is identical to factor KBF1 and homologous to the rel oncogene product. Cell (1990) 9.37
Rapid proteolysis of I kappa B-alpha is necessary for activation of transcription factor NF-kappa B. Nature (1993) 6.75
The p65 subunit is responsible for the strong transcription activating potential of NF-kappa B. EMBO J (1991) 6.08
Isolation of a rel-related human cDNA that potentially encodes the 65-kD subunit of NF-kappa B. Science (1991) 5.52
Dithiocarbamates as potent inhibitors of nuclear factor kappa B activation in intact cells. J Exp Med (1992) 5.32
Phosphorylation of human I kappa B-alpha on serines 32 and 36 controls I kappa B-alpha proteolysis and NF-kappa B activation in response to diverse stimuli. EMBO J (1995) 5.24
Nuclear factor kappa B: an oxidative stress-responsive transcription factor of eukaryotic cells (a review). Free Radic Res Commun (1992) 4.45
Purified human I kappa B can rapidly dissociate the complex of the NF-kappa B transcription factor with its cognate DNA. Cell (1990) 4.37
SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types. Cancer Res (1999) 4.23
A proteasome inhibitor prevents activation of NF-kappa B and stabilizes a newly phosphorylated form of I kappa B-alpha that is still bound to NF-kappa B. EMBO J (1994) 4.04
Nuclear factor kappaB is activated in macrophages and epithelial cells of inflamed intestinal mucosa. Gastroenterology (1998) 3.82
Intramolecular masking of the nuclear location signal and dimerization domain in the precursor for the p50 NF-kappa B subunit. Cell (1992) 3.73
Requirement of an ICE/CED-3 protease for Fas/APO-1-mediated apoptosis. Nature (1995) 3.59
The rel-associated pp40 protein prevents DNA binding of Rel and NF-kappa B: relationship with I kappa B beta and regulation by phosphorylation. Genes Dev (1991) 3.52
Nuclear uptake control of NF-kappa B by MAD-3, an I kappa B protein present in the nucleus. EMBO J (1993) 3.30
NF-kappa B contacts DNA by a heterodimer of the p50 and p65 subunit. EMBO J (1991) 3.28
IKAP is a scaffold protein of the IkappaB kinase complex. Nature (1998) 3.28
Tyrosine phosphorylation of I kappa B-alpha activates NF-kappa B without proteolytic degradation of I kappa B-alpha. Cell (1996) 3.00
The 65-kD subunit of NF-kappa B is a receptor for I kappa B and a modulator of DNA-binding specificity. Genes Dev (1990) 2.98
Activated transcription factor nuclear factor-kappa B is present in the atherosclerotic lesion. J Clin Invest (1996) 2.96
Nuclear import-export: in search of signals and mechanisms. Cell (1991) 2.82
DNA binding of purified transcription factor NF-kappa B. Affinity, specificity, Zn2+ dependence, and differential half-site recognition. J Biol Chem (1991) 2.80
Isolation of amplified DNA sequences from IMR-32 human neuroblastoma cells: facilitation by fluorescence-activated flow sorting of metaphase chromosomes. Proc Natl Acad Sci U S A (1983) 2.72
A role for oxygen radicals as second messengers. Trends Cell Biol (1991) 2.72
Chlorate--a potent inhibitor of protein sulfation in intact cells. Biochem Biophys Res Commun (1986) 2.57
The inducible transcription factor NF-kappa B: structure-function relationship of its protein subunits. Biochem J (1993) 2.49
Frequent high-level expression of the immunotherapeutic target Ep-CAM in colon, stomach, prostate and lung cancers. Br J Cancer (2006) 2.45
A novel signal transduction pathway from the endoplasmic reticulum to the nucleus is mediated by transcription factor NF-kappa B. EMBO J (1995) 2.31
Nuclear factor kappa B, a mediator of lipopolysaccharide effects. Immunobiology (1993) 2.28
Recent advances towards understanding redox mechanisms in the activation of nuclear factor kappaB. Free Radic Biol Med (2000) 2.28
Selective activation of NF-kappa B by nerve growth factor through the neurotrophin receptor p75. Science (1996) 2.15
Clinical and molecular studies in full trisomy 22: further delineation of the phenotype and review of the literature. Am J Med Genet (1995) 2.15
Activation of the transcription factor nuclear factor-kappaB in human inflamed synovial tissue. Arthritis Rheum (1996) 2.07
The roles of hydrogen peroxide and superoxide as messengers in the activation of transcription factor NF-kappa B. Chem Biol (1995) 2.05
The ER-overload response: activation of NF-kappa B. Trends Biochem Sci (1997) 2.03
Constitutive NF-kappa B activity in neurons. Mol Cell Biol (1994) 1.96
The immunosuppressive fungal metabolite gliotoxin specifically inhibits transcription factor NF-kappaB. J Exp Med (1996) 1.87
Activate NF-kappa B or die? Curr Biol (1997) 1.85
Pyrrolidine dithiocarbamate inhibits NF-kappa B mobilization and TNF production in human monocytes. J Immunol (1993) 1.84
Molecular mechanisms in down-regulation of tumor necrosis factor expression. Proc Natl Acad Sci U S A (1990) 1.83
A novel complex between the p65 subunit of NF-kappa B and c-Rel binds to a DNA element involved in the phorbol ester induction of the human urokinase gene. EMBO J (1992) 1.81
Transcription factor NF-kappaB is activated in primary neurons by amyloid beta peptides and in neurons surrounding early plaques from patients with Alzheimer disease. Proc Natl Acad Sci U S A (1997) 1.77
Sex reversal by loss of the C-terminal transactivation domain of human SOX9. Nat Genet (1996) 1.76
Bcl-2 down-regulates the activity of transcription factor NF-kappaB induced upon apoptosis. J Cell Biol (1996) 1.71
Design, synthesis, and evaluations of substituted 3-[(3- or 4-carboxyethylpyrrol-2-yl)methylidenyl]indolin-2-ones as inhibitors of VEGF, FGF, and PDGF receptor tyrosine kinases. J Med Chem (1999) 1.70
NF-kappa B as inducible transcriptional activator of the granulocyte-macrophage colony-stimulating factor gene. Mol Cell Biol (1990) 1.69
The NF-kappa B transcription factor induces DNA bending which is modulated by its 65-kD subunit. Nucleic Acids Res (1990) 1.69
Isolation and functional characterization of TIF-IB, a factor that confers promoter specificity to mouse RNA polymerase I. Nucleic Acids Res (1990) 1.68
Proteins controlling the nuclear uptake of NF-kappa B, Rel and dorsal. Trends Cell Biol (1991) 1.68
Expression of influenza virus hemagglutinin activates transcription factor NF-kappa B. J Virol (1995) 1.63
Activation of transcription factor NF-kappaB by the adenovirus E3/19K protein requires its ER retention. J Cell Biol (1996) 1.62
Gene expression profiling of human stent-induced neointima by cDNA array analysis of microscopic specimens retrieved by helix cutter atherectomy: Detection of FK506-binding protein 12 upregulation. Circulation (2001) 1.61
The primary structure of human secretogranin II, a widespread tyrosine-sulfated secretory granule protein that exhibits low pH- and calcium-induced aggregation. J Biol Chem (1989) 1.60
Involvement of regulatory and catalytic subunits of phosphoinositide 3-kinase in NF-kappaB activation. Proc Natl Acad Sci U S A (1999) 1.58
Flk-1 as a target for tumor growth inhibition. Cancer Res (1996) 1.56
Interaction of the COOH-terminal transactivation domain of p65 NF-kappa B with TATA-binding protein, transcription factor IIB, and coactivators. J Biol Chem (1995) 1.53
The primary structure of bovine chromogranin A: a representative of a class of acidic secretory proteins common to a variety of peptidergic cells. EMBO J (1986) 1.52
Structural and functional analysis of the NF-kappa B p65 C terminus. An acidic and modular transactivation domain with the potential to adopt an alpha-helical conformation. J Biol Chem (1994) 1.50
Purified I kappa B-beta is inactivated upon dephosphorylation. J Biol Chem (1992) 1.50
The I kappa B kinase (IKK) complex is tripartite and contains IKK gamma but not IKAP as a regular component. J Biol Chem (2000) 1.49
Selective recognition of the activated form of transcription factor NF-kappa B by a monoclonal antibody. Biol Chem Hoppe Seyler (1995) 1.48
Severe combined immunodeficiency due to defective binding of the nuclear factor of activated T cells in T lymphocytes of two male siblings. Eur J Immunol (1996) 1.47
IL-2 gene expression and NF-kappa B activation through CD28 requires reactive oxygen production by 5-lipoxygenase. EMBO J (1995) 1.47
T cell leukemia-associated human Notch/translocation-associated Notch homologue has I kappa B-like activity and physically interacts with nuclear factor-kappa B proteins in T cells. J Exp Med (1996) 1.44
The role of the p50 and p65 subunits of NF-kappa B in the recognition of cognate sequences. New Biol (1991) 1.43
Hepatitis B virus transactivator MHBst: activation of NF-kappa B, selective inhibition by antioxidants and integral membrane localization. EMBO J (1992) 1.43
Brain synapses contain inducible forms of the transcription factor NF-kappa B. Mech Dev (1993) 1.40
Control of gene expression by proteolysis. Curr Opin Cell Biol (1996) 1.38
The proto-oncogene bcl-3 encodes an I kappa B protein. Genes Dev (1992) 1.38
Activation of NF-kappa B by ER stress requires both Ca2+ and reactive oxygen intermediates as messengers. FEBS Lett (1996) 1.36
Oxygen and the control of gene expression. Bioessays (1994) 1.36
Stimulation of ionotropic glutamate receptors activates transcription factor NF-kappa B in primary neurons. Proc Natl Acad Sci U S A (1995) 1.35
Tyrosine sulfation of yolk proteins 1, 2, and 3 in Drosophila melanogaster. J Biol Chem (1985) 1.29
KBF1 (p50 NF-kappa B homodimer) acts as a repressor of H-2Kb gene expression in metastatic tumor cells. J Exp Med (1993) 1.29
Transactivation domain 2 (TA2) of p65 NF-kappa B. Similarity to TA1 and phorbol ester-stimulated activity and phosphorylation in intact cells. J Biol Chem (1995) 1.28
Role of nuclear factor-kappa B in atherogenesis. Exp Physiol (1997) 1.26
Assessing oxygen radicals as mediators in activation of inducible eukaryotic transcription factor NF-kappa B. Methods Enzymol (1994) 1.25
Redox signalling by transcription factors NF-kappa B and AP-1 in lymphocytes. Biochem Pharmacol (1995) 1.25
Induction of oxidative stress by okadaic acid is required for activation of transcription factor NF-kappa B. J Biol Chem (1995) 1.21
Inhibition of N-glycosylation induces tyrosine sulphation of hybridoma immunoglobulin G. EMBO J (1984) 1.21
Regulation of the transcription factors NF-kappa B and AP-1 by redox changes. Chem Biol Interact (1994) 1.20
Antioxidants selectively suppress activation of NF-kappa B by human T-cell leukemia virus type I Tax protein. J Virol (1992) 1.18
T lymphocytes can be effectively recruited for ex vivo and in vivo lysis of AML blasts by a novel CD33/CD3-bispecific BiTE antibody construct. Leukemia (2012) 1.18
A secreted/shed product of Helicobacter pylori activates transcription factor nuclear factor-kappa B. J Immunol (1997) 1.17
Hydrogen peroxide as a potent activator of T lymphocyte functions. Eur J Immunol (1995) 1.14
Constitutive nuclear NF-kappa B in cells of the monocyte lineage. Biochem J (1994) 1.14
Study of gene regulation by NF-kappa B and AP-1 in response to reactive oxygen intermediates. Methods (1997) 1.13
Cellular and complement-dependent cytotoxicity of Ep-CAM-specific monoclonal antibody MT201 against breast cancer cell lines. Br J Cancer (2005) 1.12
Endoplasmicreticulum-induced signal transduction and gene expression. Trends Cell Biol (1997) 1.11
The genomic response of tumor cells to hypoxia and reoxygenation. Differential activation of transcription factors AP-1 and NF-kappa B. Eur J Biochem (1995) 1.09
Nuclear factor kB is activated by arachidonic acid but not by eicosapentaenoic acid. Biochem Biophys Res Commun (1996) 1.08
Distinct domains of the RelA NF-kappaB subunit are required for negative cross-talk and direct interaction with the glucocorticoid receptor. J Biol Chem (1997) 1.07