Published in Infect Immun on September 01, 1999
Defensins and innate host defence of the gastrointestinal tract. Gut (1999) 1.41
Defensin expression by the cornea: multiple signalling pathways mediate IL-1beta stimulation of hBD-2 expression by human corneal epithelial cells. Invest Ophthalmol Vis Sci (2003) 1.39
Capsular antigen fraction 1 and Pla modulate the susceptibility of Yersinia pestis to pulmonary antimicrobial peptides such as cathelicidin. Infect Immun (2008) 1.04
Defensins and other antimicrobial peptides at the ocular surface. Ocul Surf (2004) 1.00
CCR6 regulation of the actin cytoskeleton orchestrates human beta defensin-2- and CCL20-mediated restitution of colonic epithelial cells. J Biol Chem (2009) 0.98
Identification of rat lung--prominent genes by a parallel DNA microarray hybridization. BMC Genomics (2006) 0.86
Bifidobacterium bifidum in a rat model of necrotizing enterocolitis: antimicrobial peptide and protein responses. Pediatr Res (2012) 0.84
Identification, cloning and functional characterization of novel beta-defensins in the rat (Rattus norvegicus). Reprod Biol Endocrinol (2006) 0.84
Do β-defensins and other antimicrobial peptides play a role in neuroimmune function and neurodegeneration? ScientificWorldJournal (2012) 0.83
Increased expression of beta-defensin-2 and -3 during the development of autoimmune sialoadenitis in MRL/lpr mice. Med Mol Morphol (2007) 0.78
In vivo beta-defensin gene expression in rat gingival epithelium in response to Actinobacillus actinomycetemcomitans infection. J Periodontal Res (2006) 0.76
β-defensin 2 ameliorates lung injury caused by Pseudomonas infection and regulates proinflammatory and anti-inflammatory cytokines in rat. Int J Mol Sci (2014) 0.75
ATP serves an anti-inflammatory role by enhancing β-defensin-2 response in acute pneumonia of rat. Biomed Rep (2017) 0.75
A peptide antibiotic from human skin. Nature (1997) 7.64
Cystic fibrosis airway epithelia fail to kill bacteria because of abnormal airway surface fluid. Cell (1996) 6.84
Human beta-defensin-1 is a salt-sensitive antibiotic in lung that is inactivated in cystic fibrosis. Cell (1997) 5.99
Tracheal antimicrobial peptide, a cysteine-rich peptide from mammalian tracheal mucosa: peptide isolation and cloning of a cDNA. Proc Natl Acad Sci U S A (1991) 3.98
Production of beta-defensins by human airway epithelia. Proc Natl Acad Sci U S A (1998) 3.85
An improved method for isolating type II cells in high yield and purity. Am Rev Respir Dis (1986) 3.80
hBD-1: a novel beta-defensin from human plasma. FEBS Lett (1995) 3.79
Human beta-defensin-1: an antimicrobial peptide of urogenital tissues. J Clin Invest (1998) 3.78
Epithelial antibiotics induced at sites of inflammation. Science (1995) 3.61
Human beta-defensin 2 is a salt-sensitive peptide antibiotic expressed in human lung. J Clin Invest (1998) 3.51
The forkhead transcription factor gene FKHL7 is responsible for glaucoma phenotypes which map to 6p25. Nat Genet (1998) 3.24
Killing of gram-negative bacteria by lactoferrin and lysozyme. J Clin Invest (1991) 2.54
Defensins. Pharmacol Ther (1995) 2.52
Antibacterial activity of antileukoprotease. Infect Immun (1996) 2.48
Cloning, organization, and expression of the bioluminescence genes of Xenorhabdus luminescens. J Bacteriol (1990) 2.38
Airway epithelial cells are the site of expression of a mammalian antimicrobial peptide gene. Proc Natl Acad Sci U S A (1993) 2.22
Human airway epithelia express a beta-defensin. Am J Respir Cell Mol Biol (1997) 2.07
Structure and mapping of the human beta-defensin HBD-2 gene and its expression at sites of inflammation. Gene (1998) 1.99
The human beta-defensin-1 and alpha-defensins are encoded by adjacent genes: two peptide families with differing disulfide topology share a common ancestry. Genomics (1997) 1.86
Mouse beta-defensin 1 is a salt-sensitive antimicrobial peptide present in epithelia of the lung and urogenital tract. Infect Immun (1998) 1.59
The dependence of lysozyme activity on pH and ionic strength. Biochim Biophys Acta (1969) 1.51
Fundamental principles of in situ hybridization. J Histochem Cytochem (1993) 1.49
Enteric beta-defensin: molecular cloning and characterization of a gene with inducible intestinal epithelial cell expression associated with Cryptosporidium parvum infection. Infect Immun (1998) 1.48
beta-Defensins: endogenous antibiotics of the innate host defense response. Clin Immunol Immunopathol (1998) 1.42
Lung epithelial Na channel subunits are differentially regulated during development and by steroids. Am J Physiol (1995) 1.21
The mouse genome encodes a single homolog of the antimicrobial peptide human beta-defensin 1. FEBS Lett (1997) 1.21
Mouse beta defensin-1 is a functional homolog of human beta defensin-1. Mamm Genome (1998) 1.15
Human beta-defensin-1: A urinary peptide present in variant molecular forms and its putative functional implication. Eur J Med Res (1998) 1.13
Localization and genomic organization of sheep antimicrobial peptide genes. Gene (1998) 1.13
Human surfactant protein B: structure, function, regulation, and genetic disease. Physiol Rev (1995) 1.08
Mapping of the gene encoding human beta-defensin-2 (DEFB2) to chromosome region 8p22-p23.1. Genomics (1997) 1.05
Antimicrobial peptide expression is developmentally regulated in the ovine gastrointestinal tract. J Nutr (1998) 1.02
Molecular cloning and tissue expression of porcine beta-defensin-1. FEBS Lett (1998) 1.01
Human enteric defensin genes: chromosomal map position and a model for possible evolutionary relationships. Genomics (1996) 1.00
Sphingomyelin metabolism is developmentally regulated in rat lung. Am J Respir Cell Mol Biol (1997) 0.90
The susceptibility to lysozyme of beta-lactamase-producing and non-producing derivatives of Staphylococcus aureus strain 1030. J Med Microbiol (1987) 0.86
Somatic cell mapping of beta-defensin genes to cattle syntenic group U25 and fluorescence in situ localization to chromosome 27. Mamm Genome (1995) 0.85
Developmental regulation of epithelial sodium channel subunit mRNA expression in rat colon and lung. Am J Physiol (1998) 0.83
Intracellular distribution of lysozyme in rat alveolar type II epithelial cells. Exp Lung Res (1995) 0.78
The sequence of the human genome. Science (2001) 101.55
Highly pathogenic H5N1 influenza virus infection in migratory birds. Science (2005) 9.64
Identification of a gene that causes primary open angle glaucoma. Science (1997) 8.14
A PPxY motif within the VP40 protein of Ebola virus interacts physically and functionally with a ubiquitin ligase: implications for filovirus budding. Proc Natl Acad Sci U S A (2000) 5.30
Large scale isolation of functionally active components of the human complement system. J Biol Chem (1981) 5.26
Parameter relations for the Shinnar-Le Roux selective excitation pulse design algorithm [NMR imaging]. IEEE Trans Med Imaging (1991) 4.97
NOD2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal alpha-defensin expression. Gut (2004) 4.39
Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: implications for cancer and neuronal damage. Proc Natl Acad Sci U S A (1997) 4.38
Structure of an E6AP-UbcH7 complex: insights into ubiquitination by the E2-E3 enzyme cascade. Science (1999) 4.21
Paneth cells of the human small intestine express an antimicrobial peptide gene. J Biol Chem (1992) 4.04
Tracheal antimicrobial peptide, a cysteine-rich peptide from mammalian tracheal mucosa: peptide isolation and cloning of a cDNA. Proc Natl Acad Sci U S A (1991) 3.98
Production of beta-defensins by human airway epithelia. Proc Natl Acad Sci U S A (1998) 3.85
Human beta-defensin-1: an antimicrobial peptide of urogenital tissues. J Clin Invest (1998) 3.78
Structures of the native and swollen forms of cowpea chlorotic mottle virus determined by X-ray crystallography and cryo-electron microscopy. Structure (1995) 3.76
Role of miR-143 targeting KRAS in colorectal tumorigenesis. Oncogene (2009) 3.64
Multiplex PCR for detection of genes for Staphylococcus aureus enterotoxins, exfoliative toxins, toxic shock syndrome toxin 1, and methicillin resistance. J Clin Microbiol (2000) 3.59
A collection of tri- and tetranucleotide repeat markers used to generate high quality, high resolution human genome-wide linkage maps. Hum Mol Genet (1995) 3.44
Human circadian rhythms. Physiol Rev (1966) 3.44
Identification of a natural soluble form of the vascular endothelial growth factor receptor, FLT-1, and its heterodimerization with KDR. Biochem Biophys Res Commun (1996) 3.33
A single EFEMP1 mutation associated with both Malattia Leventinese and Doyne honeycomb retinal dystrophy. Nat Genet (1999) 3.32
Role of poly(ADP-ribose) polymerase (PARP) cleavage in apoptosis. Caspase 3-resistant PARP mutant increases rates of apoptosis in transfected cells. J Biol Chem (1999) 3.17
The multifaceted Paneth cell. Cell Mol Life Sci (2002) 3.11
Tritium labeling of proteins to high specific radioactivity by reduction methylation. J Biol Chem (1980) 3.04
Evidence for presence of an internal thiolester bond in third component of human complement. Proc Natl Acad Sci U S A (1980) 3.00
Factors affecting reliability and reproducibility of amplification-based DNA fingerprinting of representative bacterial pathogens. J Clin Microbiol (1997) 2.87
Defensin-6 mRNA in human Paneth cells: implications for antimicrobial peptides in host defense of the human bowel. FEBS Lett (1993) 2.82
AKT1/PKBalpha kinase is frequently elevated in human cancers and its constitutive activation is required for oncogenic transformation in NIH3T3 cells. Am J Pathol (2001) 2.81
Identification of verotoxin type 2 variant B subunit genes in Escherichia coli by the polymerase chain reaction and restriction fragment length polymorphism analysis. J Clin Microbiol (1991) 2.78
Laguna Negra virus associated with HPS in western Paraguay and Bolivia. Virology (1997) 2.78
Rhabdoviruses and the cellular ubiquitin-proteasome system: a budding interaction. J Virol (2001) 2.66
The health effects of swimming in ocean water contaminated by storm drain runoff. Epidemiology (1999) 2.58
Frequent activation of AKT2 and induction of apoptosis by inhibition of phosphoinositide-3-OH kinase/Akt pathway in human ovarian cancer. Oncogene (2000) 2.55
Synergistic and additive killing by antimicrobial factors found in human airway surface liquid. Am J Physiol Lung Cell Mol Physiol (2000) 2.55
Identification of a Bardet-Biedl syndrome locus on chromosome 3 and evaluation of an efficient approach to homozygosity mapping. Hum Mol Genet (1994) 2.52
A clinical and immunologic evaluation of women with silicone breast implants and symptoms of rheumatic disease. Ann Intern Med (1993) 2.50
Use of a DNA pooling strategy to identify a human obesity syndrome locus on chromosome 15. Hum Mol Genet (1995) 2.50
Lipopolysaccharide induces Rac1-dependent reactive oxygen species formation and coordinates tumor necrosis factor-alpha secretion through IKK regulation of NF-kappa B. J Biol Chem (2001) 2.50
A mouse model for the delta F508 allele of cystic fibrosis. J Clin Invest (1995) 2.48
Case study of the effects of atmospheric aerosols and regional haze on agriculture: an opportunity to enhance crop yields in China through emission controls? Proc Natl Acad Sci U S A (1999) 2.44
Therapeutic doses of oral methylphenidate significantly increase extracellular dopamine in the human brain. J Neurosci (2001) 2.41
Locating genes associated with root morphology and drought avoidance in rice via linkage to molecular markers. Theor Appl Genet (1995) 2.39
The cDNA sequence for the protein-tyrosine kinase substrate p36 (calpactin I heavy chain) reveals a multidomain protein with internal repeats. Cell (1986) 2.36
Higher direct medical costs associated with physical inactivity. Phys Sportsmed (2000) 2.30
Bactericidal activity of mammalian cathelicidin-derived peptides. Infect Immun (2000) 2.24
Airway epithelial cells are the site of expression of a mammalian antimicrobial peptide gene. Proc Natl Acad Sci U S A (1993) 2.22
In vivo sequence diversity of the protease of human immunodeficiency virus type 1: presence of protease inhibitor-resistant variants in untreated subjects. J Virol (1996) 2.22
Protein kinase CK2 in health and disease: CK2: a key player in cancer biology. Cell Mol Life Sci (2009) 2.21
Coordinate induction of two antibiotic genes in tracheal epithelial cells exposed to the inflammatory mediators lipopolysaccharide and tumor necrosis factor alpha. Infect Immun (1996) 2.20
An unusual hantavirus outbreak in southern Argentina: person-to-person transmission? Hantavirus Pulmonary Syndrome Study Group for Patagonia. Emerg Infect Dis (1997) 2.19
Production of beta-defensin antimicrobial peptides by the oral mucosa and salivary glands. Infect Immun (1999) 2.19
Inducible expression of an antibiotic peptide gene in lipopolysaccharide-challenged tracheal epithelial cells. Proc Natl Acad Sci U S A (1996) 2.18
Altered fluid transport across airway epithelium in cystic fibrosis. Science (1993) 2.09
In vivo distribution of the human immunodeficiency virus/simian immunodeficiency virus coreceptors: CXCR4, CCR3, and CCR5. J Virol (1998) 2.09
Discovery of new human beta-defensins using a genomics-based approach. Gene (2001) 2.08
Cloning, expression, and tissue distribution of a human amiloride-sensitive Na+ channel. Am J Physiol (1994) 2.07
Metabolism of gallic acid and syringic acid by Pseudomonas putida. J Biol Chem (1972) 2.04
Purification and properties of 4-hydroxy-4-methyl-2-oxoglutarate aldolase. J Biol Chem (1972) 2.04
Hantavirus pulmonary syndrome in Panama: identification of novel hantaviruses and their likely reservoirs. Virology (2000) 2.03
Polarity influences the efficiency of recombinant adenoassociated virus infection in differentiated airway epithelia. Hum Gene Ther (1998) 2.00
Structure and mapping of the human beta-defensin HBD-2 gene and its expression at sites of inflammation. Gene (1998) 1.99
Laboratory diagnostic techniques for patients with early Lyme disease associated with erythema migrans: a comparison of different techniques. Clin Infect Dis (2001) 1.94
Gene therapy progress and prospects: development of improved lentiviral and retroviral vectors--design, biosafety, and production. Gene Ther (2005) 1.93
Transformation-mediated ductility in CuZr-based bulk metallic glasses. Nat Mater (2010) 1.92
A tetrahedron-based inhomogeneous Monte Carlo optical simulator. Phys Med Biol (2010) 1.89
Selective peptide antagonist of the class E calcium channel from the venom of the tarantula Hysterocrates gigas. Biochemistry (1998) 1.89
In vivo measures of cochlear length and insertion depth of nucleus cochlear implant electrode arrays. Ann Otol Rhinol Laryngol Suppl (1998) 1.87
A force-plate actometer for quantitating rodent behaviors: illustrative data on locomotion, rotation, spatial patterning, stereotypies, and tremor. J Neurosci Methods (2001) 1.86
Helicobacter pylori seropositivity and subsite-specific gastric cancer risks in Linxian, China. J Natl Cancer Inst (2001) 1.84
Differential expression of apoptotic protease-activating factor-1 and caspase-3 genes and susceptibility to apoptosis during brain development and after traumatic brain injury. J Neurosci (2001) 1.83
Human enteric defensins. Gene structure and developmental expression. J Biol Chem (1996) 1.82
Requirements for the solubilization of immune aggregates by complement: assembly of a factor B-dependent C3-convertase on the immune complexes. J Exp Med (1977) 1.79
Developement of circadian rhythms in infancy. Chronobiologia (1976) 1.78
NMDA antagonist neurotoxicity: mechanism and prevention. Science (1991) 1.75
Longitudinal studies of Sin Nombre virus in deer mouse-dominated ecosystems of Montana. Am J Trop Med Hyg (2001) 1.72
Amino-terminal sequence of p36 and associated p10: identification of the site of tyrosine phosphorylation and homology with S-100. Proc Natl Acad Sci U S A (1985) 1.72
Hyperpnoea in man produced by sudden release of occluded blood. J Physiol (1944) 1.72
Microinjection and growth of bacteria in the cytosol of mammalian host cells. Proc Natl Acad Sci U S A (2001) 1.71
Mechanical properties and microstructures of glass-ionomer cements. Dent Mater (2000) 1.70
Effects of shape-discrimination training on the selectivity of inferotemporal cells in adult monkeys. J Neurophysiol (1998) 1.70
Normal sweat chloride values do not exclude the diagnosis of cystic fibrosis. Am J Respir Crit Care Med (1995) 1.70
Comparison of molecular methods for typing Vibrio parahaemolyticus. J Clin Microbiol (1999) 1.70
Search for the Ebola virus reservoir in Kikwit, Democratic Republic of the Congo: reflections on a vertebrate collection. J Infect Dis (1999) 1.70
Transcriptional regulation of beta-defensin gene expression in tracheal epithelial cells. Infect Immun (2000) 1.69
The toxoplasma micronemal protein MIC4 is an adhesin composed of six conserved apple domains. J Biol Chem (2000) 1.68
Genetics of xanthan production in Xanthomonas campestris: the xanA and xanB genes are involved in UDP-glucose and GDP-mannose biosynthesis. J Bacteriol (1992) 1.68
X-ray CT metal artifact reduction using wavelets: an application for imaging total hip prostheses. IEEE Trans Med Imaging (2000) 1.68
Molecular cloning of the cDNA encoding the Epstein-Barr virus/C3d receptor (complement receptor type 2) of human B lymphocytes. Proc Natl Acad Sci U S A (1987) 1.68
An outbreak of hantavirus pulmonary syndrome in western Paraguay. Am J Trop Med Hyg (1997) 1.68
Non-secretion of mutant proteins of the glaucoma gene myocilin in cultured trabecular meshwork cells and in aqueous humor. Hum Mol Genet (2001) 1.67
Third component of human complement: appearance of a sulfhydryl group following chemical or enzymatic inactivation. Biochemistry (1980) 1.67
Rsp5 ubiquitin-protein ligase mediates DNA damage-induced degradation of the large subunit of RNA polymerase II in Saccharomyces cerevisiae. Mol Cell Biol (1999) 1.66
Natural history of Sin Nombre virus in western Colorado. Emerg Infect Dis (1999) 1.65