Published in Mutat Res on July 30, 1999
Detection and quantification of mitochondrial DNA deletions in individual cells by real-time PCR. Nucleic Acids Res (2002) 2.88
Removal of oxidative DNA damage via FEN1-dependent long-patch base excision repair in human cell mitochondria. Mol Cell Biol (2008) 1.95
Site-specific somatic mitochondrial DNA point mutations in patients with thymidine phosphorylase deficiency. J Clin Invest (2003) 1.60
Mitochondrial DNA deletion mutations are concomitant with ragged red regions of individual, aged muscle fibers: analysis by laser-capture microdissection. Nucleic Acids Res (2001) 1.48
Mitochondrial DNA repair in aging and disease. Mech Ageing Dev (2008) 1.43
DNA damage links mitochondrial dysfunction to atherosclerosis and the metabolic syndrome. Circ Res (2010) 1.36
Mitochondrial dysfunction due to oxidative mitochondrial DNA damage is reduced through cooperative actions of diverse proteins. Mol Cell Biol (2002) 1.35
Cisplatin induced mitochondrial DNA damage in dorsal root ganglion neurons. Neurobiol Dis (2010) 1.29
Effects of alcohol and oxidative stress on liver pathology: the role of the mitochondrion. Alcohol Clin Exp Res (2002) 1.23
Increased postischemic brain injury in mice deficient in uracil-DNA glycosylase. J Clin Invest (2004) 1.22
Dual localization of human DNA topoisomerase IIIalpha to mitochondria and nucleus. Proc Natl Acad Sci U S A (2002) 1.19
The DNA polymerase gamma Y955C disease variant associated with PEO and parkinsonism mediates the incorporation and translesion synthesis opposite 7,8-dihydro-8-oxo-2'-deoxyguanosine. Hum Mol Genet (2007) 1.19
Mitochondrial DNA damage and a hypoxic response are induced by CoCl(2) in rat neuronal PC12 cells. Nucleic Acids Res (2000) 1.17
POS5 gene of Saccharomyces cerevisiae encodes a mitochondrial NADH kinase required for stability of mitochondrial DNA. Eukaryot Cell (2003) 1.14
CoQ(10) deficiencies and MNGIE: two treatable mitochondrial disorders. Biochim Biophys Acta (2012) 1.10
Mitochondrial genome maintenance in health and disease. DNA Repair (Amst) (2014) 1.08
Evidence for a role of FEN1 in maintaining mitochondrial DNA integrity. DNA Repair (Amst) (2009) 1.04
A role for MHR1, a gene required for mitochondrial genetic recombination, in the repair of damage spontaneously introduced in yeast mtDNA. Nucleic Acids Res (2000) 1.02
Mitochondrial dynamics and autophagy aid in removal of persistent mitochondrial DNA damage in Caenorhabditis elegans. Nucleic Acids Res (2012) 1.02
QPCR: a tool for analysis of mitochondrial and nuclear DNA damage in ecotoxicology. Ecotoxicology (2010) 1.01
Pathobiology of cancer chemotherapy-induced peripheral neuropathy (CIPN). Front Pharmacol (2013) 0.99
A persistent mitochondrial deletion reduces fitness and sperm performance in heteroplasmic populations of C. elegans. BMC Genet (2007) 0.97
Base excision repair, aging and health span. Mech Ageing Dev (2008) 0.97
Aging and HIV/AIDS: pathogenetic role of therapeutic side effects. Lab Invest (2013) 0.95
Quantitative PCR-based measurement of nuclear and mitochondrial DNA damage and repair in mammalian cells. Methods Mol Biol (2014) 0.95
Endothelial mitochondria--less respiration, more integration. Pflugers Arch (2012) 0.94
Leukocyte mitochondrial DNA alteration in systemic lupus erythematosus and its relevance to the susceptibility to lupus nephritis. Int J Mol Sci (2012) 0.93
The impact of age-related dysregulation of the angiotensin system on mitochondrial redox balance. Front Physiol (2014) 0.89
Iminohydantoin lesion induced in DNA by peracids and other epoxidizing oxidants. J Am Chem Soc (2009) 0.88
DNA damage response in peripheral nervous system: coping with cancer therapy-induced DNA lesions. DNA Repair (Amst) (2013) 0.88
Alteration of energy substrates and ROS production in diabetic cardiomyopathy. Mediators Inflamm (2013) 0.88
p53 as guardian of the mitochondrial genome. FEBS Lett (2016) 0.87
Mitochondrial DNA adducts in the lung and liver of F344 rats chronically treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and (S)-4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol. Chem Res Toxicol (2009) 0.87
Concern Oxidative stress-mediated mitochondrial dysfunction contributes to angiotensin II-induced nonalcoholic fatty liver disease in transgenic Ren2 rats. Am J Pathol (2009) 0.86
Mitochondrial DNA variants in the pathogenesis of type 2 diabetes - relevance of asian population studies. Rev Diabet Stud (2009) 0.86
Replication of murine mitochondrial DNA following irradiation. Adv Exp Med Biol (2009) 0.86
A haplotype variation affecting the mitochondrial transportation of hMYH protein could be a risk factor for colorectal cancer in Chinese. BMC Cancer (2008) 0.84
Erythropoietin overrides the triggering effect of DNA platination products in a mouse model of cisplatin-induced neuropathy. BMC Neurosci (2009) 0.83
Higher mitochondrial DNA copy number is associated with lower prevalence of microalbuminuria. Exp Mol Med (2009) 0.82
Mitochondrial DNA deletions in Alzheimer's brains: a review. Alzheimers Dement (2013) 0.78
Mitochondrial DNA exhibits resistance to induced point and deletion mutations. Nucleic Acids Res (2016) 0.76
Neuronal injury from cardiac arrest: aging years in minutes. Age (Dordr) (2014) 0.75
Cisplatin induces mitochondrial deficits in Drosophila larval segmental nerve. Neurobiol Dis (2016) 0.75
Cisplatin Toxicity in Dorsal Root Ganglion Neurons Is Relieved by Meclizine via Diminution of Mitochondrial Compromise and Improved Clearance of DNA Damage. Mol Neurobiol (2016) 0.75
DNA repair in an active gene: removal of pyrimidine dimers from the DHFR gene of CHO cells is much more efficient than in the genome overall. Cell (1985) 7.62
The Bloom's and Werner's syndrome proteins are DNA structure-specific helicases. Nucleic Acids Res (2001) 4.47
Preferential DNA repair of an active gene in human cells. Proc Natl Acad Sci U S A (1986) 3.42
Replication protein A physically interacts with the Bloom's syndrome protein and stimulates its helicase activity. J Biol Chem (2000) 3.17
Werner's syndrome protein (WRN) migrates Holliday junctions and co-localizes with RPA upon replication arrest. EMBO Rep (2000) 2.88
Functional and physical interaction between WRN helicase and human replication protein A. J Biol Chem (1999) 2.77
Survival of UV-irradiated mammalian cells correlates with efficient DNA repair in an essential gene. Proc Natl Acad Sci U S A (1986) 2.29
Ku complex interacts with and stimulates the Werner protein. Genes Dev (2000) 2.21
Werner syndrome protein interacts with human flap endonuclease 1 and stimulates its cleavage activity. EMBO J (2001) 2.21
Differential DNA repair in transcriptionally active and inactive proto-oncogenes: c-abl and c-mos. Cell (1986) 2.13
Repair of 8-oxodeoxyguanosine lesions in mitochondrial dna depends on the oxoguanine dna glycosylase (OGG1) gene and 8-oxoguanine accumulates in the mitochondrial dna of OGG1-defective mice. Cancer Res (2001) 2.04
Repair of oxidative damage to nuclear and mitochondrial DNA in mammalian cells. J Biol Chem (1997) 2.02
Increased hypermutation at G and C nucleotides in immunoglobulin variable genes from mice deficient in the MSH2 mismatch repair protein. J Exp Med (1998) 2.00
Repair of mitochondrial DNA after various types of DNA damage in Chinese hamster ovary cells. Carcinogenesis (1992) 1.92
Enzymatic and DNA binding properties of purified WRN protein: high affinity binding to single-stranded DNA but not to DNA damage induced by 4NQO. Nucleic Acids Res (1999) 1.90
Altered spectra of hypermutation in antibodies from mice deficient for the DNA mismatch repair protein PMS2. Proc Natl Acad Sci U S A (1998) 1.86
Reduced RNA polymerase II transcription in intact and permeabilized Cockayne syndrome group B cells. Proc Natl Acad Sci U S A (1997) 1.74
FEN1 stimulation of DNA polymerase beta mediates an excision step in mammalian long patch base excision repair. J Biol Chem (2000) 1.66
Role of DNA polymerase beta in the excision step of long patch mammalian base excision repair. J Biol Chem (1999) 1.65
Interaction of human AP endonuclease 1 with flap endonuclease 1 and proliferating cell nuclear antigen involved in long-patch base excision repair. Biochemistry (2001) 1.56
DNA damage and repair in telomeres: relation to aging. Proc Natl Acad Sci U S A (1995) 1.56
Repair pathways for processing of 8-oxoguanine in DNA by mammalian cell extracts. J Biol Chem (1998) 1.52
Characterization of a DNA repair domain containing the dihydrofolate reductase gene in Chinese hamster ovary cells. J Biol Chem (1986) 1.51
ERCC1 and ERCC2 expression in malignant tissues from ovarian cancer patients. J Natl Cancer Inst (1992) 1.46
Deficient DNA repair capacity, a predisposing factor in breast cancer. Br J Cancer (1996) 1.46
DNA repair, mitochondria, and neurodegeneration. Neuroscience (2006) 1.41
Increased gene-specific repair of cisplatin interstrand cross-links in cisplatin-resistant human ovarian cancer cell lines. Mol Cell Biol (1992) 1.39
The Cockayne Syndrome group B gene product is involved in general genome base excision repair of 8-hydroxyguanine in DNA. J Biol Chem (2001) 1.37
Human DNA polymerase beta initiates DNA synthesis during long-patch repair of reduced AP sites in DNA. EMBO J (2001) 1.37
An oxidative damage-specific endonuclease from rat liver mitochondria. J Biol Chem (1997) 1.36
Repair of alkali-labile sites within the mitochondrial DNA of RINr 38 cells after exposure to the nitrosourea streptozotocin. J Biol Chem (1991) 1.32
Coordinate action of the helicase and 3' to 5' exonuclease of Werner syndrome protein. J Biol Chem (2001) 1.32
Gene-specific formation and repair of cisplatin intrastrand adducts and interstrand cross-links in Chinese hamster ovary cells. J Biol Chem (1991) 1.32
Persistent DNA damage inhibits S-phase and G2 progression, and results in apoptosis. Mol Biol Cell (1997) 1.31
Third complementarity-determining region of mutated VH immunoglobulin genes contains shorter V, D, J, P, and N components than non-mutated genes. Immunology (2001) 1.30
Repair of 8-oxoguanine in DNA is deficient in Cockayne syndrome group B cells. Nucleic Acids Res (1999) 1.30
The Werner syndrome protein is involved in RNA polymerase II transcription. Mol Biol Cell (1999) 1.29
Kinetics of excision of purine lesions from DNA by Escherichia coli Fpg protein. Nucleic Acids Res (1997) 1.28
Age-associated change in mitochondrial DNA damage. Free Radic Res (1998) 1.28
Potent inhibition of werner and bloom helicases by DNA minor groove binding drugs. Nucleic Acids Res (2000) 1.26
Unwinding of a DNA triple helix by the Werner and Bloom syndrome helicases. J Biol Chem (2000) 1.25
A new xeroderma pigmentosum group C poly(AT) insertion/deletion polymorphism. Carcinogenesis (2000) 1.21
Age-associated increase in 8-oxo-deoxyguanosine glycosylase/AP lyase activity in rat mitochondria. Nucleic Acids Res (1999) 1.21
Inhibition of the Bloom's and Werner's syndrome helicases by G-quadruplex interacting ligands. Biochemistry (2001) 1.20
The C-terminal alphaO helix of human Ogg1 is essential for 8-oxoguanine DNA glycosylase activity: the mitochondrial beta-Ogg1 lacks this domain and does not have glycosylase activity. Nucleic Acids Res (2004) 1.19
Base excision repair in nuclear and mitochondrial DNA. Prog Nucleic Acid Res Mol Biol (2001) 1.18
Preferential DNA repair of (6-4) photoproducts in the dihydrofolate reductase gene of Chinese hamster ovary cells. J Biol Chem (1989) 1.18
Selective blockage of the 3'-->5' exonuclease activity of WRN protein by certain oxidative modifications and bulky lesions in DNA. Nucleic Acids Res (2000) 1.17
Reduced RNA polymerase II transcription in extracts of cockayne syndrome and xeroderma pigmentosum/Cockayne syndrome cells. Nucleic Acids Res (1997) 1.15
Quantification of aminofluorene adduct formation and repair in defined DNA sequences in mammalian cells using the UVRABC nuclease. J Biol Chem (1989) 1.14
DNA base excision repair in human malaria parasites is predominantly by a long-patch pathway. Biochemistry (2000) 1.14
Localization of mitochondrial DNA base excision repair to an inner membrane-associated particulate fraction. Nucleic Acids Res (2005) 1.13
General method for quantifying base adducts in specific mammalian genes. Proc Natl Acad Sci U S A (1988) 1.13
Role of mitochondrial hOGG1 and aconitase in oxidant-induced lung epithelial cell apoptosis. Free Radic Biol Med (2009) 1.12
A UV-responsive G2 checkpoint in rodent cells. Mol Cell Biol (1995) 1.11
Niacin, poly(ADP-ribose) polymerase-1 and genomic stability. Mutat Res (2001) 1.09
The C-terminal domain of p21 inhibits nucleotide excision repair In vitro and In vivo. Mol Biol Cell (1999) 1.08
Genomic heterogeneity of nucleotide excision repair. Gene (2000) 1.08
p53 Modulates the exonuclease activity of Werner syndrome protein. J Biol Chem (2001) 1.07
Impact of DNA polymorphisms in key DNA base excision repair proteins on cancer risk. Hum Exp Toxicol (2012) 1.07
Single-nucleotide patch base excision repair of uracil in DNA by mitochondrial protein extracts. Nucleic Acids Res (1999) 1.06
Heterogeneity of nitrogen mustard-induced DNA damage and repair at the level of the gene in Chinese hamster ovary cells. J Biol Chem (1990) 1.06
Role of the ATPase domain of the Cockayne syndrome group B protein in UV induced apoptosis. Oncogene (2000) 1.06
No evidence of mitochondrial respiratory dysfunction in OGG1-null mice deficient in removal of 8-oxodeoxyguanine from mitochondrial DNA. Free Radic Biol Med (2005) 1.06
DNA repair in the metallothionein gene increases with transcriptional activation. Nucleic Acids Res (1987) 1.06
Gene- and strand-specific damage and repair in Chinese hamster ovary cells treated with 4-nitroquinoline 1-oxide. Cancer Res (1992) 1.05
A functional interaction of Ku with Werner exonuclease facilitates digestion of damaged DNA. Nucleic Acids Res (2001) 1.05
Mitochondrial endogenous oxidative damage has been overestimated. FASEB J (2000) 1.05
Repair of individual DNA strands in the hamster dihydrofolate reductase gene after treatment with ultraviolet light, alkylating agents, and cisplatin. J Biol Chem (1993) 1.04
Single nucleotide patch base excision repair is the major pathway for removal of thymine glycol from DNA in human cell extracts. J Biol Chem (2000) 1.03
Accelerated methylation of ribosomal RNA genes during the cellular senescence of Werner syndrome fibroblasts. FASEB J (2000) 1.02
DNA repair and aging in mouse liver: 8-oxodG glycosylase activity increase in mitochondrial but not in nuclear extracts. Free Radic Biol Med (2001) 1.02
Inhibition of RNA polymerase II transcription in human cell extracts by cisplatin DNA damage. Biochemistry (1999) 1.02
The ATPase domain but not the acidic region of Cockayne syndrome group B gene product is essential for DNA repair. Mol Biol Cell (1999) 1.00
Role of the human ERCC-1 gene in gene-specific repair of cisplatin-induced DNA damage. Nucleic Acids Res (1994) 0.99
Gene-specific nuclear and mitochondrial repair of formamidopyrimidine DNA glycosylase-sensitive sites in Chinese hamster ovary cells. Mutat Res (1996) 0.99
Gene-specific DNA repair in xeroderma pigmentosum complementation groups A, C, D, and F. Relation to cellular survival and clinical features. J Biol Chem (1993) 0.99
Gene-specific DNA repair of UV-induced cyclobutane pyrimidine dimers in some cancer-prone and premature-aging human syndromes. Mutat Res (1994) 0.99
Demethylation enhances removal of pyrimidine dimers from the overall genome and from specific DNA sequences in Chinese hamster ovary cells. Mol Cell Biol (1989) 0.99
Mitochondrial and nuclear DNA base excision repair are affected differently by caloric restriction. FASEB J (2004) 0.98
Gene-specific and strand-specific DNA repair in the G1 and G2 phases of the cell cycle. Mol Cell Biol (1995) 0.98
DNA base excision repair activities and pathway function in mitochondrial and cellular lysates from cells lacking mitochondrial DNA. Nucleic Acids Res (2004) 0.97
DNA repair in the c-myc proto-oncogene locus: possible involvement in susceptibility or resistance to plasmacytoma induction in BALB/c mice. Mol Cell Biol (1991) 0.96
Oxidative damage-induced PCNA complex formation is efficient in xeroderma pigmentosum group A but reduced in Cockayne syndrome group B cells. Nucleic Acids Res (1999) 0.96
Homogenous repair of singlet oxygen-induced DNA damage in differentially transcribed regions and strands of human mitochondrial DNA. Nucleic Acids Res (1998) 0.96
Preferential binding of tumor suppressor p53 to positively or negatively supercoiled DNA involves the C-terminal domain. J Mol Biol (1999) 0.95
Telomere reduction and telomerase inactivation during neuronal cell differentiation. Biochem Biophys Res Commun (1996) 0.95
Relationship between DNA cross-links, cell cycle, and apoptosis in Burkitt's lymphoma cell lines differing in sensitivity to nitrogen mustard. Cancer Res (1991) 0.95
DNA repair at the level of the gene. Trends Biochem Sci (1988) 0.95
DNA interstrand cross-links induced by psoralen are not repaired in mammalian mitochondria. Cancer Res (1998) 0.94
Efficient PCNA complex formation is dependent upon both transcription coupled repair and genome overall repair. Mutat Res (1998) 0.94
Human diseases deficient in RecQ helicases. Biochimie (2003) 0.94
The human CSB (ERCC6) gene corrects the transcription-coupled repair defect in the CHO cell mutant UV61. Nucleic Acids Res (1996) 0.94
Mitochondrial toxin 3-nitropropionic acid induces cardiac and neurotoxicity differentially in mice. Am J Pathol (2001) 0.93
Impact of age on hypermutation of immunoglobulin variable genes in humans. J Clin Immunol (2001) 0.92
Enhanced repair of pyrimidine dimers in coding and non-coding genomic sequences in CHO cells expressing a prokaryotic DNA repair gene. Carcinogenesis (1987) 0.92
Deficient gene specific repair of cisplatin-induced lesions in Xeroderma pigmentosum and Fanconi's anemia cell lines. Carcinogenesis (1993) 0.91
DNA repair of pyrimidine dimers and 6-4 photoproducts in the ribosomal DNA. Nucleic Acids Res (1999) 0.91
DNA strand-specific repair of (+-)-3 alpha,4 beta-dihydroxy-1 alpha,2 alpha-epoxy-1,2,3,4-tetrahydrobenzo[c]phenanthrene adducts in the hamster dihydrofolate reductase gene. Proc Natl Acad Sci U S A (1992) 0.91