Published in J Biol Chem on October 10, 1997
Base excision repair of oxidative DNA damage and association with cancer and aging. Carcinogenesis (2008) 2.42
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Electrophile and oxidant damage of mitochondrial DNA leading to rapid evolution of homoplasmic mutations. Proc Natl Acad Sci U S A (2003) 1.66
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Mismatch repair activity in mammalian mitochondria. Nucleic Acids Res (2003) 1.24
The complete sequence of the zebrafish (Danio rerio) mitochondrial genome and evolutionary patterns in vertebrate mitochondrial DNA. Genome Res (2001) 1.23
The single-strand DNA binding activity of human PC4 prevents mutagenesis and killing by oxidative DNA damage. Mol Cell Biol (2004) 1.19
Mitochondrial DNA damage and a hypoxic response are induced by CoCl(2) in rat neuronal PC12 cells. Nucleic Acids Res (2000) 1.17
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Altered 8-oxoguanine glycosylase in mild cognitive impairment and late-stage Alzheimer's disease brain. Free Radic Biol Med (2008) 1.10
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Evidence of reactive oxygen species-mediated damage to mitochondrial DNA in children with typical autism. Mol Autism (2013) 0.95
Mitochondrial base excision repair assays. Methods (2010) 0.95
2-Hydroxy-dATP is incorporated opposite G by Escherichia coli DNA polymerase III resulting in high mutagenicity. Nucleic Acids Res (2000) 0.93
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Saccharomyces cerevisiae polymerase zeta functions in mitochondria. Genetics (2006) 0.91
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Real-time PCR analysis of a 3895 bp mitochondrial DNA deletion in nonmelanoma skin cancer and its use as a quantitative marker for sunlight exposure in human skin. Br J Cancer (2006) 0.87
Inflammatory colonic carcinogenesis: a review on pathogenesis and immunosurveillance mechanisms in ulcerative colitis. World J Gastroenterol (2014) 0.86
Benfotiamine reduces genomic damage in peripheral lymphocytes of hemodialysis patients. Naunyn Schmiedebergs Arch Pharmacol (2008) 0.86
Maternal blood mitochondrial DNA copy number and placental abruption risk: results from a preliminary study. Int J Mol Epidemiol Genet (2013) 0.86
Chlamydomonas reinhardtii: a convenient model system for the study of DNA repair in photoautotrophic eukaryotes. Curr Genet (2007) 0.86
Absence of pathogenic mitochondrial DNA mutations in mouse brain tumors. BMC Cancer (2005) 0.85
DNA damage and its processing. relation to human disease. J Inherit Metab Dis (2002) 0.84
Error-prone processing of apurinic/apyrimidinic (AP) sites by PolX underlies a novel mechanism that promotes adaptive mutagenesis in Bacillus subtilis. J Bacteriol (2014) 0.84
The mismatch repair system modulates curcumin sensitivity through induction of DNA strand breaks and activation of G2-M checkpoint. Mol Cancer Ther (2010) 0.83
Translesion DNA synthesis in the context of cancer research. Cancer Cell Int (2011) 0.82
Evidence that msh1p plays multiple roles in mitochondrial base excision repair. Genetics (2009) 0.82
A case-control study of maternal blood mitochondrial DNA copy number and preeclampsia risk. Int J Mol Epidemiol Genet (2012) 0.81
Genome-wide profiling of 8-oxoguanine reveals its association with spatial positioning in nucleus. DNA Res (2014) 0.80
Life span extensions associated with upregulation of gene expression of antioxidant enzymes in Caenorhabditis elegans; studies of mutation in the age-1, PI3 kinase homologue and short-term exposure to hyperoxia. J Am Aging Assoc (2002) 0.80
Mitochondrial control region alterations and breast cancer risk: a study in South Indian population. PLoS One (2014) 0.79
Burn serum causes a CD14-dependent mitochondrial damage in primary cardiomyocytes. Am J Physiol Heart Circ Physiol (2010) 0.79
Mitochondrial DNA mutations in human tumor cells. Oncol Lett (2012) 0.78
Mitochondrial DNA mutations in differentiated thyroid cancer with respect to the age factor. World J Surg (2007) 0.78
The mitochondrial C16069T polymorphism, not mitochondrial D310 (D-loop) mononucleotide sequence variations, is associated with bladder cancer. Cancer Cell Int (2013) 0.78
Activities of DNA base excision repair enzymes in liver and brain correlate with body mass, but not lifespan. Age (Dordr) (2011) 0.78
Sepsis-induced Cardiac Mitochondrial Damage and Potential Therapeutic Interventions in the Elderly. Aging Dis (2014) 0.78
Complex IV subunit 1 defect predicts postoperative survival in hepatocellular carcinoma. Oncol Lett (2014) 0.78
Oxidative photoreceptor cell damage in autoimmune uveitis. J Ophthalmic Inflamm Infect (2010) 0.77
Mitochondrial dysfunction and oxidative stress in patients with chronic kidney disease. Physiol Rep (2016) 0.77
The hOGG1 Ser326Cys gene polymorphism and the risk of coronary ectasia in the Chinese population. Int J Mol Sci (2014) 0.77
Do we age because we have mitochondria? Protoplasma (2013) 0.77
Mutational hotspots in the mitochondrial D-loop region of cancerous and precancerous colorectal lesions in Egyptian patients. DNA Cell Biol (2011) 0.77
Mitochondrial polymorphism A10398G and Haplogroup I are associated with Fuchs' endothelial corneal dystrophy. Invest Ophthalmol Vis Sci (2014) 0.77
Non-randomized mtDNA damage after ionizing radiation via charge transport. Sci Rep (2012) 0.77
Placental mitochondrial DNA content and placental abruption: a pilot study. BMC Res Notes (2015) 0.77
Mitochondrial stress controls the radiosensitivity of the oxygen effect: Implications for radiotherapy. Oncotarget (2016) 0.77
Life span extensions associated with upregulation of gene expression of antioxidant enzymes in Caenorhabdms elegans; studies of mutation in the AGE-1, PI3 kinase homologue and short-term exposure to hyperoxia. J Am Aging Assoc (2001) 0.76
Insights into dynamic mitotic chromatin organization through the NIMA kinase suppressor SonC, a chromatin-associated protein involved in the DNA damage response. Genetics (2013) 0.76
Relationship between hOGG1 Ser326Cys gene polymorphism and coronary artery lesions in patients with diabetes mellitus. Int J Clin Exp Med (2015) 0.76
Base excision repair activities differ in human lung cancer cells and corresponding normal controls. Anticancer Res (2010) 0.75
Value of the 8-oxodG/dG ratio in chronic liver inflammation of patients with hepatocellular carcinoma. Redox Biol (2016) 0.75
Mutations in the Mitochondrial ND1 Gene Are Associated with Postoperative Prognosis of Localized Renal Cell Carcinoma. Int J Mol Sci (2016) 0.75
Ogg1-Dependent DNA Repair Regulates NLRP3 Inflammasome and Prevents Atherosclerosis. Circ Res (2016) 0.75
Mitochondrial poly(ADP-ribose) polymerase: The Wizard of Oz at work. Free Radic Biol Med (2016) 0.75
Circulating mitochondrial DNA content associated with the risk of liver cirrhosis: a nested case-control study. Dig Dis Sci (2015) 0.75
Potential role of oxidative stress-induced apoptosis in mediating chromosomal rearrangements in nasopharyngeal carcinoma. Cell Biosci (2016) 0.75
Association between Salivary Mitochondrial DNA Copy Number and Chronic Fatigue according to Combined Symptoms in Korean Adults. Korean J Fam Med (2017) 0.75
DNA repair in an active gene: removal of pyrimidine dimers from the DHFR gene of CHO cells is much more efficient than in the genome overall. Cell (1985) 7.62
The Bloom's and Werner's syndrome proteins are DNA structure-specific helicases. Nucleic Acids Res (2001) 4.47
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Replication protein A physically interacts with the Bloom's syndrome protein and stimulates its helicase activity. J Biol Chem (2000) 3.17
Werner's syndrome protein (WRN) migrates Holliday junctions and co-localizes with RPA upon replication arrest. EMBO Rep (2000) 2.88
Functional and physical interaction between WRN helicase and human replication protein A. J Biol Chem (1999) 2.77
Survival of UV-irradiated mammalian cells correlates with efficient DNA repair in an essential gene. Proc Natl Acad Sci U S A (1986) 2.29
Werner syndrome protein interacts with human flap endonuclease 1 and stimulates its cleavage activity. EMBO J (2001) 2.21
Ku complex interacts with and stimulates the Werner protein. Genes Dev (2000) 2.21
Differential DNA repair in transcriptionally active and inactive proto-oncogenes: c-abl and c-mos. Cell (1986) 2.13
Repair of 8-oxodeoxyguanosine lesions in mitochondrial dna depends on the oxoguanine dna glycosylase (OGG1) gene and 8-oxoguanine accumulates in the mitochondrial dna of OGG1-defective mice. Cancer Res (2001) 2.04
Increased hypermutation at G and C nucleotides in immunoglobulin variable genes from mice deficient in the MSH2 mismatch repair protein. J Exp Med (1998) 2.00
Repair of mitochondrial DNA after various types of DNA damage in Chinese hamster ovary cells. Carcinogenesis (1992) 1.92
Enzymatic and DNA binding properties of purified WRN protein: high affinity binding to single-stranded DNA but not to DNA damage induced by 4NQO. Nucleic Acids Res (1999) 1.90
Altered spectra of hypermutation in antibodies from mice deficient for the DNA mismatch repair protein PMS2. Proc Natl Acad Sci U S A (1998) 1.86
Reduced RNA polymerase II transcription in intact and permeabilized Cockayne syndrome group B cells. Proc Natl Acad Sci U S A (1997) 1.74
FEN1 stimulation of DNA polymerase beta mediates an excision step in mammalian long patch base excision repair. J Biol Chem (2000) 1.66
Role of DNA polymerase beta in the excision step of long patch mammalian base excision repair. J Biol Chem (1999) 1.65
Interaction of human AP endonuclease 1 with flap endonuclease 1 and proliferating cell nuclear antigen involved in long-patch base excision repair. Biochemistry (2001) 1.56
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Mitochondrial DNA repair pathways. Mutat Res (1999) 1.53
Repair pathways for processing of 8-oxoguanine in DNA by mammalian cell extracts. J Biol Chem (1998) 1.52
Characterization of a DNA repair domain containing the dihydrofolate reductase gene in Chinese hamster ovary cells. J Biol Chem (1986) 1.51
Deficient DNA repair capacity, a predisposing factor in breast cancer. Br J Cancer (1996) 1.46
ERCC1 and ERCC2 expression in malignant tissues from ovarian cancer patients. J Natl Cancer Inst (1992) 1.46
DNA repair, mitochondria, and neurodegeneration. Neuroscience (2006) 1.41
Increased gene-specific repair of cisplatin interstrand cross-links in cisplatin-resistant human ovarian cancer cell lines. Mol Cell Biol (1992) 1.39
The Cockayne Syndrome group B gene product is involved in general genome base excision repair of 8-hydroxyguanine in DNA. J Biol Chem (2001) 1.37
Human DNA polymerase beta initiates DNA synthesis during long-patch repair of reduced AP sites in DNA. EMBO J (2001) 1.37
An oxidative damage-specific endonuclease from rat liver mitochondria. J Biol Chem (1997) 1.36
Repair of alkali-labile sites within the mitochondrial DNA of RINr 38 cells after exposure to the nitrosourea streptozotocin. J Biol Chem (1991) 1.32
Gene-specific formation and repair of cisplatin intrastrand adducts and interstrand cross-links in Chinese hamster ovary cells. J Biol Chem (1991) 1.32
Coordinate action of the helicase and 3' to 5' exonuclease of Werner syndrome protein. J Biol Chem (2001) 1.32
Persistent DNA damage inhibits S-phase and G2 progression, and results in apoptosis. Mol Biol Cell (1997) 1.31
Third complementarity-determining region of mutated VH immunoglobulin genes contains shorter V, D, J, P, and N components than non-mutated genes. Immunology (2001) 1.30
Repair of 8-oxoguanine in DNA is deficient in Cockayne syndrome group B cells. Nucleic Acids Res (1999) 1.30
The Werner syndrome protein is involved in RNA polymerase II transcription. Mol Biol Cell (1999) 1.29
Age-associated change in mitochondrial DNA damage. Free Radic Res (1998) 1.28
Kinetics of excision of purine lesions from DNA by Escherichia coli Fpg protein. Nucleic Acids Res (1997) 1.28
Potent inhibition of werner and bloom helicases by DNA minor groove binding drugs. Nucleic Acids Res (2000) 1.26
Unwinding of a DNA triple helix by the Werner and Bloom syndrome helicases. J Biol Chem (2000) 1.25
A new xeroderma pigmentosum group C poly(AT) insertion/deletion polymorphism. Carcinogenesis (2000) 1.21
Age-associated increase in 8-oxo-deoxyguanosine glycosylase/AP lyase activity in rat mitochondria. Nucleic Acids Res (1999) 1.21
Inhibition of the Bloom's and Werner's syndrome helicases by G-quadruplex interacting ligands. Biochemistry (2001) 1.20
The C-terminal alphaO helix of human Ogg1 is essential for 8-oxoguanine DNA glycosylase activity: the mitochondrial beta-Ogg1 lacks this domain and does not have glycosylase activity. Nucleic Acids Res (2004) 1.19
Base excision repair in nuclear and mitochondrial DNA. Prog Nucleic Acid Res Mol Biol (2001) 1.18
Preferential DNA repair of (6-4) photoproducts in the dihydrofolate reductase gene of Chinese hamster ovary cells. J Biol Chem (1989) 1.18
Selective blockage of the 3'-->5' exonuclease activity of WRN protein by certain oxidative modifications and bulky lesions in DNA. Nucleic Acids Res (2000) 1.17
Reduced RNA polymerase II transcription in extracts of cockayne syndrome and xeroderma pigmentosum/Cockayne syndrome cells. Nucleic Acids Res (1997) 1.15
Quantification of aminofluorene adduct formation and repair in defined DNA sequences in mammalian cells using the UVRABC nuclease. J Biol Chem (1989) 1.14
DNA base excision repair in human malaria parasites is predominantly by a long-patch pathway. Biochemistry (2000) 1.14
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Localization of mitochondrial DNA base excision repair to an inner membrane-associated particulate fraction. Nucleic Acids Res (2005) 1.13
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A UV-responsive G2 checkpoint in rodent cells. Mol Cell Biol (1995) 1.11
Genomic heterogeneity of nucleotide excision repair. Gene (2000) 1.08
The C-terminal domain of p21 inhibits nucleotide excision repair In vitro and In vivo. Mol Biol Cell (1999) 1.08
p53 Modulates the exonuclease activity of Werner syndrome protein. J Biol Chem (2001) 1.07
Impact of DNA polymorphisms in key DNA base excision repair proteins on cancer risk. Hum Exp Toxicol (2012) 1.07
Single-nucleotide patch base excision repair of uracil in DNA by mitochondrial protein extracts. Nucleic Acids Res (1999) 1.06
Heterogeneity of nitrogen mustard-induced DNA damage and repair at the level of the gene in Chinese hamster ovary cells. J Biol Chem (1990) 1.06
No evidence of mitochondrial respiratory dysfunction in OGG1-null mice deficient in removal of 8-oxodeoxyguanine from mitochondrial DNA. Free Radic Biol Med (2005) 1.06
DNA repair in the metallothionein gene increases with transcriptional activation. Nucleic Acids Res (1987) 1.06
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A functional interaction of Ku with Werner exonuclease facilitates digestion of damaged DNA. Nucleic Acids Res (2001) 1.05
Mitochondrial endogenous oxidative damage has been overestimated. FASEB J (2000) 1.05
Repair of individual DNA strands in the hamster dihydrofolate reductase gene after treatment with ultraviolet light, alkylating agents, and cisplatin. J Biol Chem (1993) 1.04
Single nucleotide patch base excision repair is the major pathway for removal of thymine glycol from DNA in human cell extracts. J Biol Chem (2000) 1.03
Accelerated methylation of ribosomal RNA genes during the cellular senescence of Werner syndrome fibroblasts. FASEB J (2000) 1.02
Inhibition of RNA polymerase II transcription in human cell extracts by cisplatin DNA damage. Biochemistry (1999) 1.02
DNA repair and aging in mouse liver: 8-oxodG glycosylase activity increase in mitochondrial but not in nuclear extracts. Free Radic Biol Med (2001) 1.02
The ATPase domain but not the acidic region of Cockayne syndrome group B gene product is essential for DNA repair. Mol Biol Cell (1999) 1.00
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Gene-specific DNA repair in xeroderma pigmentosum complementation groups A, C, D, and F. Relation to cellular survival and clinical features. J Biol Chem (1993) 0.99
Gene-specific nuclear and mitochondrial repair of formamidopyrimidine DNA glycosylase-sensitive sites in Chinese hamster ovary cells. Mutat Res (1996) 0.99
Gene-specific DNA repair of UV-induced cyclobutane pyrimidine dimers in some cancer-prone and premature-aging human syndromes. Mutat Res (1994) 0.99
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Mitochondrial and nuclear DNA base excision repair are affected differently by caloric restriction. FASEB J (2004) 0.98
DNA base excision repair activities and pathway function in mitochondrial and cellular lysates from cells lacking mitochondrial DNA. Nucleic Acids Res (2004) 0.97
DNA repair in the c-myc proto-oncogene locus: possible involvement in susceptibility or resistance to plasmacytoma induction in BALB/c mice. Mol Cell Biol (1991) 0.96
Oxidative damage-induced PCNA complex formation is efficient in xeroderma pigmentosum group A but reduced in Cockayne syndrome group B cells. Nucleic Acids Res (1999) 0.96
Homogenous repair of singlet oxygen-induced DNA damage in differentially transcribed regions and strands of human mitochondrial DNA. Nucleic Acids Res (1998) 0.96
Preferential binding of tumor suppressor p53 to positively or negatively supercoiled DNA involves the C-terminal domain. J Mol Biol (1999) 0.95
Telomere reduction and telomerase inactivation during neuronal cell differentiation. Biochem Biophys Res Commun (1996) 0.95
Relationship between DNA cross-links, cell cycle, and apoptosis in Burkitt's lymphoma cell lines differing in sensitivity to nitrogen mustard. Cancer Res (1991) 0.95
DNA repair at the level of the gene. Trends Biochem Sci (1988) 0.95
DNA interstrand cross-links induced by psoralen are not repaired in mammalian mitochondria. Cancer Res (1998) 0.94
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The human CSB (ERCC6) gene corrects the transcription-coupled repair defect in the CHO cell mutant UV61. Nucleic Acids Res (1996) 0.94
Efficient PCNA complex formation is dependent upon both transcription coupled repair and genome overall repair. Mutat Res (1998) 0.94
Mitochondrial toxin 3-nitropropionic acid induces cardiac and neurotoxicity differentially in mice. Am J Pathol (2001) 0.93
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Enhanced repair of pyrimidine dimers in coding and non-coding genomic sequences in CHO cells expressing a prokaryotic DNA repair gene. Carcinogenesis (1987) 0.92
Measurement of oxidatively induced base lesions in liver from Wistar rats of different ages. Free Radic Biol Med (1999) 0.91
Deficient gene specific repair of cisplatin-induced lesions in Xeroderma pigmentosum and Fanconi's anemia cell lines. Carcinogenesis (1993) 0.91
DNA strand-specific repair of (+-)-3 alpha,4 beta-dihydroxy-1 alpha,2 alpha-epoxy-1,2,3,4-tetrahydrobenzo[c]phenanthrene adducts in the hamster dihydrofolate reductase gene. Proc Natl Acad Sci U S A (1992) 0.91
DNA repair of pyrimidine dimers and 6-4 photoproducts in the ribosomal DNA. Nucleic Acids Res (1999) 0.91