Published in EMBO J on September 15, 1999
Transcriptional control by the TGF-beta/Smad signaling system. EMBO J (2000) 8.49
SIP1/ZEB2 induces EMT by repressing genes of different epithelial cell-cell junctions. Nucleic Acids Res (2005) 3.41
Regulation of Smad signaling through a differential recruitment of coactivators and corepressors by ZEB proteins. EMBO J (2003) 2.67
miR-200b mediates post-transcriptional repression of ZFHX1B. RNA (2007) 2.67
The emerging role of miR-200 family of microRNAs in epithelial-mesenchymal transition and cancer metastasis. RNA Biol (2009) 2.56
Mutator-like elements in Arabidopsis thaliana. Structure, diversity and evolution. Genetics (2000) 2.52
Adherens junction: molecular architecture and regulation. Cold Spring Harb Perspect Biol (2009) 2.45
Signaling mechanisms of the epithelial-mesenchymal transition. Sci Signal (2014) 2.42
Opposing functions of ZEB proteins in the regulation of the TGFbeta/BMP signaling pathway. EMBO J (2003) 2.20
Snail and SIP1 increase cancer invasion by upregulating MMP family in hepatocellular carcinoma cells. Br J Cancer (2004) 2.03
Integrated analysis of yeast regulatory sequences for biologically linked clusters of genes. Funct Integr Genomics (2003) 1.98
Mice lacking ZFHX1B, the gene that codes for Smad-interacting protein-1, reveal a role for multiple neural crest cell defects in the etiology of Hirschsprung disease-mental retardation syndrome. Am J Hum Genet (2003) 1.88
Regulation of miR-200 family microRNAs and ZEB transcription factors in ovarian cancer: evidence supporting a mesothelial-to-epithelial transition. Gynecol Oncol (2009) 1.84
Mowat-Wilson syndrome. J Med Genet (2003) 1.75
Direct repression of cyclin D1 by SIP1 attenuates cell cycle progression in cells undergoing an epithelial mesenchymal transition. Mol Biol Cell (2007) 1.71
Redox sensor CtBP mediates hypoxia-induced tumor cell migration. Proc Natl Acad Sci U S A (2006) 1.67
Sip1 regulates sequential fate decisions by feedback signaling from postmitotic neurons to progenitors. Nat Neurosci (2009) 1.54
Mowat-Wilson syndrome. Orphanet J Rare Dis (2007) 1.37
The transcription factor ZEB1 (deltaEF1) represses Plakophilin 3 during human cancer progression. FEBS Lett (2007) 1.36
ZEB1 regulates the latent-lytic switch in infection by Epstein-Barr virus. PLoS Pathog (2007) 1.33
Regulation of collagen type I in vascular smooth muscle cells by competition between Nkx2.5 and deltaEF1/ZEB1. Mol Cell Biol (2004) 1.32
Expanding roles of ZEB factors in tumorigenesis and tumor progression. Am J Cancer Res (2011) 1.26
The miR-200 and miR-221/222 microRNA families: opposing effects on epithelial identity. J Mammary Gland Biol Neoplasia (2012) 1.25
Dual-mode modulation of Smad signaling by Smad-interacting protein Sip1 is required for myelination in the central nervous system. Neuron (2012) 1.18
Large-scale deletions and SMADIP1 truncating mutations in syndromic Hirschsprung disease with involvement of midline structures. Am J Hum Genet (2001) 1.11
Nonsense and frameshift mutations in ZFHX1B, encoding Smad-interacting protein 1, cause a complex developmental disorder with a great variety of clinical features. Am J Hum Genet (2001) 1.11
MiR-132 suppresses the migration and invasion of lung cancer cells via targeting the EMT regulator ZEB2. PLoS One (2014) 1.09
ZEB-1, a repressor of the semaphorin 3F tumor suppressor gene in lung cancer cells. Neoplasia (2009) 1.09
Cellular microRNAs 200b and 429 regulate the Epstein-Barr virus switch between latency and lytic replication. J Virol (2010) 1.09
Transcriptional repressor ZEB2 promotes terminal differentiation of CD8+ effector and memory T cell populations during infection. J Exp Med (2015) 1.07
Evolutionary functional analysis and molecular regulation of the ZEB transcription factors. Cell Mol Life Sci (2012) 1.06
Protein expression of ZEB2 in renal cell carcinoma and its prognostic significance in patient survival. PLoS One (2013) 1.04
BRCA1-associated epigenetic regulation of p73 mediates an effector pathway for chemosensitivity in ovarian carcinoma. Cancer Res (2010) 1.01
Regulation of the expression and activity of the antiangiogenic homeobox gene GAX/MEOX2 by ZEB2 and microRNA-221. Mol Cell Biol (2010) 1.00
Characterization of the promoters of Epsilon glutathione transferases in the mosquito Anopheles gambiae and their response to oxidative stress. Biochem J (2005) 0.97
Reprogramming of replicative senescence in hepatocellular carcinoma-derived cells. Proc Natl Acad Sci U S A (2006) 0.94
Loss of Sip1 leads to migration defects and retention of ectodermal markers during lens development. Mech Dev (2013) 0.93
Zebrafish sip1a and sip1b are essential for normal axial and neural patterning. Dev Dyn (2008) 0.91
Overexpression of ZEB2 in peritumoral liver tissue correlates with favorable survival after curative resection of hepatocellular carcinoma. PLoS One (2012) 0.91
Neuropilin-2 Is upregulated in lung cancer cells during TGF-β1-induced epithelial-mesenchymal transition. Cancer Res (2013) 0.90
Knockdown of human TCF4 affects multiple signaling pathways involved in cell survival, epithelial to mesenchymal transition and neuronal differentiation. PLoS One (2013) 0.90
Ubiquitin ligase Cbl-b represses IGF-I-induced epithelial mesenchymal transition via ZEB2 and microRNA-200c regulation in gastric cancer cells. Mol Cancer (2014) 0.90
The transcription factor Zeb2 regulates development of conventional and plasmacytoid DCs by repressing Id2. J Exp Med (2016) 0.88
ZEB1 limits adenoviral infectability by transcriptionally repressing the coxsackie virus and adenovirus receptor. Mol Cancer (2011) 0.88
Functional conservation of zinc-finger homeodomain gene zfh1/SIP1 in Drosophila heart development. Dev Genes Evol (2006) 0.88
Regulation of metastasis in colorectal adenocarcinoma: a collision between development and tumor biology. Surgery (2008) 0.87
ZEB1 in Pancreatic Cancer. Cancers (Basel) (2010) 0.86
Shutoff of BZLF1 gene expression is necessary for immortalization of primary B cells by Epstein-Barr virus. J Virol (2012) 0.86
Functional impact of ZEB1 mutations associated with posterior polymorphous and Fuchs' endothelial corneal dystrophies. Invest Ophthalmol Vis Sci (2014) 0.85
GLUT3 is induced during epithelial-mesenchymal transition and promotes tumor cell proliferation in non-small cell lung cancer. Cancer Metab (2014) 0.85
The ZFHX1A gene is differentially autoregulated by its isoforms. Biochem Biophys Res Commun (2007) 0.85
ZENON, a novel POZ Kruppel-like DNA binding protein associated with differentiation and/or survival of late postmitotic neurons. Mol Cell Biol (2005) 0.84
Discoidin domain receptor 1 is a novel transcriptional target of ZEB1 in breast epithelial cells undergoing H-Ras-induced epithelial to mesenchymal transition. Int J Cancer (2014) 0.83
miR-200b regulates cell migration via Zeb family during mouse palate development. Histochem Cell Biol (2012) 0.83
δEF1 associates with DNMT1 and maintains DNA methylation of the E-cadherin promoter in breast cancer cells. Cancer Med (2014) 0.83
Characterization of a weakly expressed KIR2DL1 variant reveals a novel upstream promoter that controls KIR expression. Genes Immun (2014) 0.83
Transcription regulation of E-cadherin by zinc finger E-box binding homeobox proteins in solid tumors. Biomed Res Int (2014) 0.83
MiR-206 suppresses epithelial mesenchymal transition by targeting TGF-β signaling in estrogen receptor positive breast cancer cells. Oncotarget (2016) 0.81
delta-EF1 is a negative regulator of Ihh in the developing growth plate. J Cell Biol (2009) 0.80
Churchill and Sip1a repress fibroblast growth factor signaling during zebrafish somitogenesis. Dev Dyn (2010) 0.79
Insulin-like growth factor-I induces epithelial to mesenchymal transition via GSK-3β and ZEB2 in the BGC-823 gastric cancer cell line. Oncol Lett (2014) 0.79
Zinc finger E-box-binding homeobox 1: its clinical significance and functional role in human thyroid cancer. Onco Targets Ther (2016) 0.78
Aptamers and their potential to selectively target aspects of EGF, Wnt/β-catenin and TGFβ-smad family signaling. Int J Mol Sci (2013) 0.78
Four amino acids within a tandem QxVx repeat in a predicted extended α-helix of the Smad-binding domain of Sip1 are necessary for binding to activated Smad proteins. PLoS One (2013) 0.78
Multidimensional Proteomics Reveals a Role of UHRF2 in the Regulation of Epithelial-Mesenchymal Transition (EMT). Mol Cell Proteomics (2016) 0.77
Bipartite recognition of DNA by TCF/Pangolin is remarkably flexible and contributes to transcriptional responsiveness and tissue specificity of wingless signaling. PLoS Genet (2014) 0.77
Effect of 5/6 nephrectomized rat serum on epithelial-to-mesenchymal transition in vitro. Ren Fail (2011) 0.77
Easy passage: germline transgenesis in frogs. Proc Natl Acad Sci U S A (1999) 0.76
SIP1 is a downstream effector of GADD45G in senescence induction and growth inhibition of liver tumor cells. Oncotarget (2015) 0.75
Role of Linkers between Zinc Fingers in Spacing Recognition by Plant TFIIIA-Type Zinc-Finger Proteins. J Amino Acids (2011) 0.75
ZEB2 inhibits HBV transcription and replication by targeting its core promoter. Oncotarget (2016) 0.75
Critical involvement of ZEB2 in collagen fibrillogenesis: the molecular similarity between Mowat-Wilson syndrome and Ehlers-Danlos syndrome. Sci Rep (2017) 0.75
Carcinoma-associated fucosylated antigens are markers of the epithelial state and can contribute to cell adhesion through CLEC17A (Prolectin). Oncotarget (2016) 0.75
Sip1 regulates the generation of the inner nuclear layer retinal cell lineages in mammals. Development (2016) 0.75
Investigating the Molecular Basis of PPCD3: Characterization of ZEB1 Regulation of COL4A3 Expression. Invest Ophthalmol Vis Sci (2016) 0.75
Zeb2 Regulates Cell Fate at the Exit from Epiblast State in Mouse Embryonic Stem Cells. Stem Cells (2016) 0.75
Transcriptomic Profiling of Posterior Polymorphous Corneal Dystrophy. Invest Ophthalmol Vis Sci (2017) 0.75
All-atom empirical potential for molecular modeling and dynamics studies of proteins. J Phys Chem B (1998) 54.00
Analysis of any point mutation in DNA. The amplification refractory mutation system (ARMS). Nucleic Acids Res (1989) 15.35
Complete structure of the hemagglutinin gene from the human influenza A/Victoria/3/75 (H3N2) strain as determined from cloned DNA. Cell (1980) 14.28
The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion. Mol Cell (2001) 10.02
A novel, rapid method for the isolation of terminal sequences from yeast artificial chromosome (YAC) clones. Nucleic Acids Res (1990) 8.52
Methylmercury poisoning in Iraq. Science (1973) 6.84
In vitro mutagenesis of a full-length cDNA clone of Semliki Forest virus: the small 6,000-molecular-weight membrane protein modulates virus release. J Virol (1991) 6.02
Overview of the National Infant Mortality Surveillance (NIMS) project--design, methods, results. Public Health Rep (1987) 5.66
Silberblick/Wnt11 mediates convergent extension movements during zebrafish gastrulation. Nature (2000) 5.52
Antigenic drift between the haemagglutinin of the Hong Kong influenza strains A/Aichi/2/68 and A/Victoria/3/75. Nature (1980) 5.25
Autotrophic picoplankton in the tropical ocean. Science (1983) 4.80
Aortic homograft valve replacement. A long-term follow-up of an initial series of 101 patients. Circulation (1969) 4.10
Xwnt11 is a target of Xenopus Brachyury: regulation of gastrulation movements via Dishevelled, but not through the canonical Wnt pathway. Development (2000) 4.06
SOX10 mutations in patients with Waardenburg-Hirschsprung disease. Nat Genet (1998) 3.82
In utero antiepileptic drug exposure: fetal death and malformations. Neurology (2006) 3.64
Direct evidence for SIR2 modulation of chromatin structure in yeast rDNA. EMBO J (1997) 3.54
SIP1, a novel zinc finger/homeodomain repressor, interacts with Smad proteins and binds to 5'-CACCT sequences in candidate target genes. J Biol Chem (1999) 3.35
Graded changes in dose of a Xenopus activin A homologue elicit stepwise transitions in embryonic cell fate. Nature (1990) 3.27
The pathology of human aortic valve homografts. Thorax (1967) 3.01
Lung cancer mortality and smoking habits: Mexican-American women. Am J Public Health (1982) 2.85
Plasma lipids and risk of developing renal dysfunction: the atherosclerosis risk in communities study. Kidney Int (2000) 2.85
Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency. Proc Natl Acad Sci U S A (1999) 2.82
Models of respiratory rhythm generation in the pre-Bötzinger complex. I. Bursting pacemaker neurons. J Neurophysiol (1999) 2.76
A 3.5 genome equivalent multi access YAC library: construction, characterisation, screening and storage. Nucleic Acids Res (1990) 2.51
Neuronal pacemaker for breathing visualized in vitro. Nature (1999) 2.49
Osteogenic protein-1 binds to activin type II receptors and induces certain activin-like effects. J Cell Biol (1995) 2.36
Smad5 knockout mice die at mid-gestation due to multiple embryonic and extraembryonic defects. Development (1999) 2.35
Responses of embryonic Xenopus cells to activin and FGF are separated by multiple dose thresholds and correspond to distinct axes of the mesoderm. Cell (1992) 2.34
Thermodynamic stability of water molecules in the bacteriorhodopsin proton channel: a molecular dynamics free energy perturbation study. Biophys J (1996) 2.30
Influenza virus messenger RNAs are incomplete transcripts of the genome RNAs. Nucleic Acids Res (1977) 2.26
Models of respiratory rhythm generation in the pre-Bötzinger complex. II. Populations Of coupled pacemaker neurons. J Neurophysiol (1999) 2.23
Urinary tract in schoolgirls with covert bacteriuria. Arch Dis Child (1975) 2.21
Plasma-zinc in health and disease. Lancet (1970) 2.20
Bone morphogenetic protein 4: a ventralizing factor in early Xenopus development. Development (1992) 2.19
Identification of a potent Xenopus mesoderm-inducing factor as a homologue of activin A. Nature (1990) 2.17
Nodal-related signals induce axial mesoderm and dorsalize mesoderm during gastrulation. Development (1995) 2.16
The imprinted antisense RNA at the Igf2r locus overlaps but does not imprint Mas1. Nat Genet (2000) 2.16
Cellular mechanisms underlying modulation of breathing pattern in mammals. Ann N Y Acad Sci (1989) 2.16
The role of dynamics in enzyme activity. Annu Rev Biophys Biomol Struct (2002) 2.14
Role of excitatory amino acids in the generation and transmission of respiratory drive in neonatal rat. J Physiol (1991) 2.14
Inhibition of Xbra transcription activation causes defects in mesodermal patterning and reveals autoregulation of Xbra in dorsal mesoderm. Development (1996) 2.13
Distinct spatial and temporal expression patterns of two type I receptors for bone morphogenetic proteins during mouse embryogenesis. Endocrinology (1995) 2.12
Analgesic use and chronic renal disease. N Engl J Med (1989) 2.12
Operational criteria for the determination of suicide. J Forensic Sci (1988) 2.09
Generation and transmission of respiratory oscillations in medullary slices: role of excitatory amino acids. J Neurophysiol (1993) 2.07
The diagnosis and management of urinary incontinence in the female. J Obstet Gynaecol Br Commonw (1972) 2.02
Regional differences in birth weight-specific infant mortality, United States, 1980. Public Health Rep (1987) 1.99
Mortality, morbidity and complications following transurethral resection of the prostate for benign prostatic hypertrophy. J Urol (1992) 1.97
Complete structure of A/duck/Ukraine/63 influenza hemagglutinin gene: animal virus as progenitor of human H3 Hong Kong 1968 influenza hemagglutinin. Cell (1981) 1.96
Alcohol consumption among Mexican American and Anglo women: results of a survey along the U.S.--Mexico border. J Stud Alcohol (1984) 1.94
Causes of maternal mortality in the United States. Obstet Gynecol (1985) 1.91
The amino-terminal sequence of human fibroblast interferon as deduced from reverse transcripts obtained using synthetic oligonucleotide primers. Nucleic Acids Res (1980) 1.89
Demographic trends of tubal sterilization in the United States 1970-75. Am J Public Health (1980) 1.88
Mesoderm induction in Xenopus caused by activation of MAP kinase. Nature (1995) 1.86
Overexpression of activin A in the skin of transgenic mice reveals new activities of activin in epidermal morphogenesis, dermal fibrosis and wound repair. EMBO J (1999) 1.84
Sodium and potassium intake and balance in adults consuming self-selected diets. Am J Clin Nutr (1984) 1.82
The molecular cloning and characterisation of cDNA coding for the alpha subunit of the acetylcholine receptor. Nucleic Acids Res (1982) 1.80
Birth weight-specific causes of infant mortality, United States, 1980. Public Health Rep (1987) 1.78
Foreign transmembrane peptides replacing the internal signal sequence of transferrin receptor allow its translocation and membrane binding. Cell (1987) 1.76
Radiation, work experience, and cause specific mortality among workers at an energy research laboratory. Br J Ind Med (1985) 1.73
The epidemiology of rotavirus diarrhea in the United States: surveillance and estimates of disease burden. J Infect Dis (1996) 1.73
Birth weight-specific infant mortality, United States, 1960 and 1980. Public Health Rep (1987) 1.71
A randomized, controlled trial of routine early abdominal computed tomography in patients presenting with non-specific acute abdominal pain. Clin Radiol (2007) 1.70
Excitatory amino acid-mediated transmission of inspiratory drive to phrenic motoneurons. J Neurophysiol (1990) 1.68
Reduced basal ganglia volumes in Tourette's syndrome using three-dimensional reconstruction techniques from magnetic resonance images. Neurology (1993) 1.68
TTRAP, a novel protein that associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor-associated factors (TRAFs), and that inhibits nuclear factor-kappa B activation. J Biol Chem (2000) 1.67
The Xenopus Brachyury promoter is activated by FGF and low concentrations of activin and suppressed by high concentrations of activin and by paired-type homeodomain proteins. Genes Dev (1997) 1.66
Trends in the incidence of breastfeeding for Hispanics of Mexican origin and Anglos on the US-Mexico border. Am J Public Health (1982) 1.65
Alcohol use and interpersonal violence: alcohol detected in homicide victims. Am J Public Health (1986) 1.64
Far-field recorded frequency-following responses: evidence for the locus of brainstem sources. Electroencephalogr Clin Neurophysiol (1975) 1.64
Pre-Bötzinger complex in the cat. J Neurophysiol (1995) 1.63
[Oral rabies vaccination of foxes]. Zentralbl Veterinarmed B (1972) 1.62
Connective-tissue growth factor modulates WNT signalling and interacts with the WNT receptor complex. Development (2004) 1.60
Mesenchymal stem cells reside within the connective tissues of many organs. Dev Dyn (1995) 1.59
Determinants of T box protein specificity. Development (2001) 1.59
Liquid-like side-chain dynamics in myoglobin. J Mol Biol (1994) 1.57
Solvent dependence of dynamic transitions in protein solutions. Proc Natl Acad Sci U S A (2000) 1.57
Prevalence of malnutrition on admission to four hospitals in England. The Malnutrition Prevalence Group. Clin Nutr (2000) 1.56
Direct measurement of zinc in plasma by atomic absorption spectroscopy. Clin Chem (1979) 1.55
Dorsalization and neural induction: properties of the organizer in Xenopus laevis. J Embryol Exp Morphol (1983) 1.55
Cobb's collar--a forgotten entity. Br J Urol (1990) 1.54
Abdominal expiratory activity in the rat brainstem-spinal cord in situ: patterns, origins and implications for respiratory rhythm generation. J Physiol (2009) 1.53
The behavior of oxonol dyes in phospholipid dispersions. Biophys J (1979) 1.53
Differences in neonatal and postneonatal mortality by race, birth weight, and gestational age. Public Health Rep (1987) 1.49
Complete nucleotide sequence of the nucleoprotein gene from the human influenza strain A/PR/8/34 (HON1). Eur J Biochem (1981) 1.49
Variation in state-specific infant mortality risks. Public Health Rep (1987) 1.49
Effects of T'ai Chi training on function and quality of life indicators in older adults with osteoarthritis. J Am Geriatr Soc (2000) 1.49
Ectopic mesoderm formation in Xenopus embryos caused by widespread expression of a Brachyury homologue. Nature (1992) 1.49
Enzyme activity below the dynamical transition at 220 K. Biophys J (1998) 1.49
Legal abortion mortality in the United States. Epidemiologic surveillance, 1972-1974. JAMA (1977) 1.49
Modulation of furin-mediated proprotein processing activity by site-directed mutagenesis. J Biol Chem (1993) 1.48