Published in Curr Biol on September 09, 1999
Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012. Cell Death Differ (2011) 9.44
Identification of RIP1 kinase as a specific cellular target of necrostatins. Nat Chem Biol (2008) 9.24
Molecular mechanisms of necroptosis: an ordered cellular explosion. Nat Rev Mol Cell Biol (2010) 9.06
The role of autophagy in mammalian development: cell makeover rather than cell death. Dev Cell (2008) 4.25
BNIP3 and genetic control of necrosis-like cell death through the mitochondrial permeability transition pore. Mol Cell Biol (2000) 3.77
An alternative, nonapoptotic form of programmed cell death. Proc Natl Acad Sci U S A (2000) 3.13
Hypersensitivity to contact inhibition provides a clue to cancer resistance of naked mole-rat. Proc Natl Acad Sci U S A (2009) 2.84
Cathepsin B acts as a dominant execution protease in tumor cell apoptosis induced by tumor necrosis factor. J Cell Biol (2001) 2.68
Essential versus accessory aspects of cell death: recommendations of the NCCD 2015. Cell Death Differ (2014) 2.66
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is required for induction of autophagy during lumen formation in vitro. Proc Natl Acad Sci U S A (2004) 2.56
Sequential activation of poly(ADP-ribose) polymerase 1, calpains, and Bax is essential in apoptosis-inducing factor-mediated programmed necrosis. Mol Cell Biol (2007) 2.22
Alternative cell death mechanisms in development and beyond. Genes Dev (2010) 2.14
Preservation of mitochondrial structure and function after Bid- or Bax-mediated cytochrome c release. J Cell Biol (2000) 1.91
Caspase-independent cell death: leaving the set without the final cut. Oncogene (2008) 1.74
Mechanisms by which Bak and Bax permeabilise mitochondria during apoptosis. J Cell Sci (2009) 1.70
Necrotic death pathway in Fas receptor signaling. J Cell Biol (2000) 1.68
Cell death mechanisms and modulation in traumatic brain injury. Neurotherapeutics (2010) 1.54
Autophagy inhibition radiosensitizes in vitro, yet reduces radioresponses in vivo due to deficient immunogenic signalling. Cell Death Differ (2013) 1.49
Autophagy upregulation by inhibitors of caspase-3 and mTOR enhances radiotherapy in a mouse model of lung cancer. Autophagy (2008) 1.49
"Where, O death, is thy sting?" A brief review of apoptosis biology. Mol Neurobiol (2010) 1.47
Phagocytosis of necrotic cells by macrophages is phosphatidylserine dependent and does not induce inflammatory cytokine production. Mol Biol Cell (2003) 1.47
Mutations of the mitochondrial holocytochrome c-type synthase in X-linked dominant microphthalmia with linear skin defects syndrome. Am J Hum Genet (2006) 1.32
Die another way--non-apoptotic mechanisms of cell death. J Cell Sci (2014) 1.27
Cell death in health and disease. J Cell Mol Med (2007) 1.27
Genetic control of programmed cell death during animal development. Annu Rev Genet (2009) 1.24
Caspase-independent mitochondrial cell death results from loss of respiration, not cytotoxic protein release. Mol Biol Cell (2009) 1.23
Mitochondrial regulation of cell death. Cold Spring Harb Perspect Biol (2013) 1.19
The variability of autophagy and cell death susceptibility: Unanswered questions. Autophagy (2013) 1.15
Change of the death pathway in senescent human fibroblasts in response to DNA damage is caused by an inability to stabilize p53. Mol Cell Biol (2001) 1.10
Apoptosis. Mol Pathol (2000) 1.10
More than one way to go. Proc Natl Acad Sci U S A (2001) 1.04
Broad targeting of resistance to apoptosis in cancer. Semin Cancer Biol (2015) 1.03
Receptor interacting protein kinase-mediated necrosis contributes to cone and rod photoreceptor degeneration in the retina lacking interphotoreceptor retinoid-binding protein. J Neurosci (2013) 1.02
Protein synthesis persists during necrotic cell death. J Cell Biol (2005) 1.00
The AF4-mimetic peptide, PFWT, induces necrotic cell death in MV4-11 leukemia cells. Leuk Res (2007) 1.00
NF-kappaB protects from the lysosomal pathway of cell death. EMBO J (2003) 1.00
DNA-damage response network at the crossroads of cell-cycle checkpoints, cellular senescence and apoptosis. J Zhejiang Univ Sci B (2007) 0.99
Persephone/Spätzle pathogen sensors mediate the activation of Toll receptor signaling in response to endogenous danger signals in apoptosis-deficient Drosophila. J Biol Chem (2014) 0.96
A cytochrome c mutant with high electron transfer and antioxidant activities but devoid of apoptogenic effect. Biochem J (2002) 0.95
Apoptotic and nonapoptotic caspase functions in animal development. Cold Spring Harb Perspect Biol (2012) 0.94
A calpain-like protease inhibits autophagic cell death. Autophagy (2007) 0.92
Conserved metabolic energy production pathways govern Eiger/TNF-induced nonapoptotic cell death. Proc Natl Acad Sci U S A (2011) 0.92
Necrosis-like death can engage multiple pro-apoptotic Bcl-2 protein family members. Apoptosis (2012) 0.90
Expression of Fas, FasL, caspase-8 and other factors of the extrinsic apoptotic pathway during the onset of interdigital tissue elimination. Histochem Cell Biol (2016) 0.90
GAPDH binds to active Akt, leading to Bcl-xL increase and escape from caspase-independent cell death. Cell Death Differ (2013) 0.88
Dictyostelium cell death: early emergence and demise of highly polarized paddle cells. J Cell Biol (2003) 0.87
Different types of cell death induced by enterotoxins. Toxins (Basel) (2010) 0.82
Digital development and morphogenesis. J Anat (2003) 0.81
Incudomalleal joint formation: the roles of apoptosis, migration and downregulation. BMC Dev Biol (2007) 0.79
Apoptosis during embryonic tissue remodeling is accompanied by cell senescence. Aging (Albany NY) (2015) 0.78
Interrogating the relevance of mitochondrial apoptosis for vertebrate development and postnatal tissue homeostasis. Genes Dev (2016) 0.77
Activation of innate antiviral immune response via double-stranded RNA-dependent RLR receptor-mediated necroptosis. Sci Rep (2016) 0.77
Disruptive environmental chemicals and cellular mechanisms that confer resistance to cell death. Carcinogenesis (2015) 0.77
Transcriptional control of non-apoptotic developmental cell death in C. elegans. Cell Death Differ (2016) 0.76
Cell death in the pathogenesis of systemic lupus erythematosus and lupus nephritis. Clin Immunol (2016) 0.76
Anti-tumour activity of phosphoinositide-3-kinase antagonist AEZS 126 in models of triple-negative breast cancer. J Cancer Res Clin Oncol (2013) 0.75
Casp8p41: The Protean Mediator of Death in CD4 T-cells that Replicate HIV. J Cell Death (2016) 0.75
DNA damage precedes apoptosis during the regression of the interdigital tissue in vertebrate embryos. Sci Rep (2016) 0.75
Creation of nano eye-drops and effective drug delivery to the interior of the eye. Sci Rep (2017) 0.75
The Fas death factor. Science (1995) 13.81
Multiple point mutations affecting the simian virus 40 enhancer. Science (1983) 13.69
Simian virus 40 tandem repeated sequences as an element of the early promoter. Proc Natl Acad Sci U S A (1981) 13.67
Host-specific activation of transcription by tandem repeats from simian virus 40 and Moloney murine sarcoma virus. Proc Natl Acad Sci U S A (1982) 12.30
Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009. Cell Death Differ (2008) 10.45
Enhancer elements. Cell (1983) 10.41
Pax7 is required for the specification of myogenic satellite cells. Cell (2000) 9.88
Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family. Cell (1993) 9.06
T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines. J Exp Med (1996) 8.59
Characterization of enhancer elements in the long terminal repeat of Moloney murine sarcoma virus. J Virol (1984) 7.80
Fas and perforin pathways as major mechanisms of T cell-mediated cytotoxicity. Science (1994) 7.34
Specific interaction between enhancer-containing molecules and cellular components. Cell (1984) 6.96
Participation of p53 cellular tumour antigen in transformation of normal embryonic cells. Nature (1985) 6.86
Development of peripheral lymphoid organs and natural killer cells depends on the helix-loop-helix inhibitor Id2. Nature (1999) 6.23
Activation of SV40 genome by 72-base pair tandem repeats of Moloney sarcoma virus. Nature (1982) 6.02
Temporal control of gene expression in transgenic mice by a tetracycline-responsive promoter. Proc Natl Acad Sci U S A (1994) 5.71
New type of POU domain in germ line-specific protein Oct-4. Nature (1990) 5.65
Pax-6, a murine paired box gene, is expressed in the developing CNS. Development (1991) 5.49
A new member of the immunoglobulin superfamily--CTLA-4. Nature (1987) 5.10
Early steps of lymphocyte activation bypassed by synergy between calcium ionophores and phorbol ester. Nature (1985) 5.06
Cre-mediated gene deletion in the mammary gland. Nucleic Acids Res (1997) 4.89
Bovine papilloma virus deoxyribonucleic acid: a novel eucaryotic cloning vector. Mol Cell Biol (1981) 4.75
The Pax4 gene is essential for differentiation of insulin-producing beta cells in the mammalian pancreas. Nature (1997) 4.69
Pax6 is required for the multipotent state of retinal progenitor cells. Cell (2001) 4.65
Pax6 is required for differentiation of glucagon-producing alpha-cells in mouse pancreas. Nature (1997) 4.58
Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development. Cell (1998) 4.53
Fas involvement in Ca(2+)-independent T cell-mediated cytotoxicity. J Exp Med (1993) 4.53
A family of octamer-specific proteins present during mouse embryogenesis: evidence for germline-specific expression of an Oct factor. EMBO J (1989) 4.47
Oct-4: a germline-specific transcription factor mapping to the mouse t-complex. EMBO J (1990) 4.42
Six3, a murine homologue of the sine oculis gene, demarcates the most anterior border of the developing neural plate and is expressed during eye development. Development (1995) 3.90
Splicing as a requirement for biogenesis of functional 16S mRNA of simian virus 40. Proc Natl Acad Sci U S A (1979) 3.89
Pax6 activity in the lens primordium is required for lens formation and for correct placement of a single retina in the eye. Genes Dev (2000) 3.85
Pax-3, a novel murine DNA binding protein expressed during early neurogenesis. EMBO J (1991) 3.85
CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus saimiri gene. J Immunol (1993) 3.74
Homeotic transformations of murine vertebrae and concomitant alteration of Hox codes induced by retinoic acid. Cell (1991) 3.71
Waardenburg's syndrome patients have mutations in the human homologue of the Pax-3 paired box gene. Nature (1992) 3.63
Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes. Cell Death Differ (2009) 3.44
Pax-2 controls multiple steps of urogenital development. Development (1995) 3.42
BK viral enhancer element and a human cellular homolog. Science (1983) 3.36
A multigene family encoding several "finger" structures is present and differentially active in mammalian genomes. Cell (1987) 3.09
Prox1 function is crucial for mouse lens-fibre elongation. Nat Genet (1999) 3.01
Cells mediating specific in vitro cytotoxicity. II. Probable autonomy of thymus-processed lymphocytes (T cells) for the killing of allogeneic target cells. J Exp Med (1972) 3.00
Apaf-1 is a transcriptional target for E2F and p53. Nat Cell Biol (2001) 2.96
Production of chimaeric mice containing embryonic stem (ES) cells carrying a homoeobox Hox 1.1 allele mutated by homologous recombination. Nature (1989) 2.94
CTLA-4 and CD28 activated lymphocyte molecules are closely related in both mouse and human as to sequence, message expression, gene structure, and chromosomal location. J Immunol (1991) 2.92
Classification of cell death: recommendations of the Nomenclature Committee on Cell Death. Cell Death Differ (2005) 2.91
Identification of a precursor in the biosynthesis of the p21 transforming protein of harvey murine sarcoma virus. J Virol (1982) 2.89
Processing and expression of early SV40 mRNA: a role for RNA conformation in splicing. Cell (1979) 2.80
Pax6 controls radial glia differentiation in the cerebral cortex. Neuron (1998) 2.78
Expression of simian virus 40-rat preproinsulin recombinants in monkey kidney cells: use of preproinsulin RNA processing signals. Proc Natl Acad Sci U S A (1981) 2.76
Follicular cells of the thyroid gland require Pax8 gene function. Nat Genet (1998) 2.75
Post-transcriptional control of myc and p53 expression during differentiation of the embryonal carcinoma cell line F9. Nature (1985) 2.75
Pax2, a new murine paired-box-containing gene and its expression in the developing excretory system. Development (1990) 2.72
Murine developmental control genes. Science (1990) 2.71
Cell type-specific transcriptional enhancement in vitro requires the presence of trans-acting factors. EMBO J (1985) 2.70
Distinct cis-essential modules direct the time-space pattern of the Pax6 gene activity. Dev Biol (1999) 2.70
Octamer binding proteins confer transcriptional activity in early mouse embryogenesis. EMBO J (1989) 2.70
Pax: a murine multigene family of paired box-containing genes. Genomics (1991) 2.60
Inhibition of murine T cell-mediated cytolysis and T cell proliferation by a rat monoclonal antibody immunoprecipitating two lymphoid cell surface polypeptides of 94 000 and 180 000 molecular weight. Eur J Immunol (1982) 2.47
Human Ig superfamily CTLA-4 gene: chromosomal localization and identity of protein sequence between murine and human CTLA-4 cytoplasmic domains. Eur J Immunol (1988) 2.45
Pax-3 is required for the development of limb muscles: a possible role for the migration of dermomyotomal muscle progenitor cells. Development (1994) 2.45
Homeobox genes and connective tissue patterning. Development (1995) 2.43
Pax8, a murine paired box gene expressed in the developing excretory system and thyroid gland. Development (1990) 2.42
Cortical upper layer neurons derive from the subventricular zone as indicated by Svet1 gene expression. Development (2001) 2.37
Pax2 contributes to inner ear patterning and optic nerve trajectory. Development (1996) 2.33
Dysgenesis of cephalic neural crest derivatives in Pax7-/- mutant mice. Development (1996) 2.31
Origin of DNA replication in papovavirus chromatin is recognized by endogenous endonuclease. Proc Natl Acad Sci U S A (1978) 2.24
Prox 1, a prospero-related homeobox gene expressed during mouse development. Mech Dev (1993) 2.21
Oct-6: a POU transcription factor expressed in embryonal stem cells and in the developing brain. EMBO J (1990) 2.19
Roles of Pax-genes in developing and adult brain as suggested by expression patterns. J Neurosci (1994) 2.19
A nexus between Oct-4 and E1A: implications for gene regulation in embryonic stem cells. Cell (1991) 2.18
Importance of newly generated neurons in the adult olfactory bulb for odor discrimination. Proc Natl Acad Sci U S A (2000) 2.18
Disruption of the murine homeobox gene Cdx1 affects axial skeletal identities by altering the mesodermal expression domains of Hox genes. Cell (1995) 2.15
The molecular basis of the undulated/Pax-1 mutation. Cell (1991) 2.14
The murine paired box gene, Pax7, is expressed specifically during the development of the nervous and muscular system. Mech Dev (1990) 2.12
Cells mediating specific in vitro cytotoxicity. I. Detection of receptor-bearing lymphocytes. J Exp Med (1971) 2.09
Pax 1, a member of a paired box homologous murine gene family, is expressed in segmented structures during development. Cell (1988) 2.05
An alpha-E-catenin gene trap mutation defines its function in preimplantation development. Proc Natl Acad Sci U S A (1997) 2.05
Structural analysis of murine genes containing homoeo box sequences and their expression in embryonal carcinoma cells. Nature (1985) 2.01
Spatially and temporally restricted expression of Pax2 during murine neurogenesis. Development (1990) 2.01
undulated, a mutation affecting the development of the mouse skeleton, has a point mutation in the paired box of Pax 1. Cell (1988) 2.01
Forebrain patterning defects in Small eye mutant mice. Development (1996) 1.95
A viral enhancer element specifically active in human haematopoietic cells. Nature (1985) 1.95
Magic enhancers? DNA (1984) 1.95
Efficient FLP recombination in mouse ES cells and oocytes. Genesis (2001) 1.94
The oncogenic potential of Pax genes. EMBO J (1993) 1.88
Caspase-2 is not required for thymocyte or neuronal apoptosis even though cleavage of caspase-2 is dependent on both Apaf-1 and caspase-9. Cell Death Differ (2002) 1.85
Mice lacking HSP90beta fail to develop a placental labyrinth. Development (2000) 1.83
Clustered homeo boxes are differentially expressed during murine development. Cell (1985) 1.80
Variations of cervical vertebrae after expression of a Hox-1.1 transgene in mice. Cell (1990) 1.79
Spatial specification of mammalian eye territories by reciprocal transcriptional repression of Pax2 and Pax6. Development (2000) 1.77
PAX8, a human paired box gene: isolation and expression in developing thyroid, kidney and Wilms' tumors. Development (1992) 1.77
Pax6 modulates the dorsoventral patterning of the mammalian telencephalon. J Neurosci (2000) 1.74
Pax6 lights-up the way for eye development. Curr Opin Cell Biol (2001) 1.74
Rescue of a splicing defective mutant by insertion of an heterologous intron. Nature (1980) 1.74
Programmed cell death in Dictyostelium. J Cell Sci (1994) 1.73
Pax genes and their roles in cell differentiation and development. Curr Opin Cell Biol (1996) 1.72
Interaction of distinct nuclear proteins with sequences controlling the expression of polyomavirus early genes. Mol Cell Biol (1986) 1.69