Published in Cell on June 01, 1983
Long noncoding RNAs with enhancer-like function in human cells. Cell (2010) 13.00
Characterization of enhancer elements in the long terminal repeat of Moloney murine sarcoma virus. J Virol (1984) 7.80
Multiple sequence motifs are involved in SV40 enhancer function. EMBO J (1986) 7.76
Elevated levels of mRNA can account for the trans-activation of human immunodeficiency virus. Proc Natl Acad Sci U S A (1986) 6.57
Mechanisms of gene regulation in the general control of amino acid biosynthesis in Saccharomyces cerevisiae. Microbiol Rev (1988) 6.13
The structure of the mouse glutathione peroxidase gene: the selenocysteine in the active site is encoded by the 'termination' codon, TGA. EMBO J (1986) 5.94
Nucleotide sequence of an mRNA transcribed in latent growth-transforming virus infection indicates that it may encode a membrane protein. J Virol (1984) 5.87
Replication and supercoiling of simian virus 40 DNA in cell extracts from human cells. Mol Cell Biol (1985) 5.83
Intragenic cis-acting art gene-responsive sequences of the human immunodeficiency virus. Proc Natl Acad Sci U S A (1988) 5.47
Interferon-induced transcription of a gene encoding a 15-kDa protein depends on an upstream enhancer element. Proc Natl Acad Sci U S A (1987) 4.61
Upstream regions of the human cardiac actin gene that modulate its transcription in muscle cells: presence of an evolutionarily conserved repeated motif. Mol Cell Biol (1986) 4.59
cis and trans activation of globin gene transcription in transient assays. Proc Natl Acad Sci U S A (1983) 4.41
Stimulation of in vitro transcription from the SV40 early promoter by the enhancer involves a specific trans-acting factor. EMBO J (1984) 4.28
A synthetic HIS4 regulatory element confers general amino acid control on the cytochrome c gene (CYC1) of yeast. Proc Natl Acad Sci U S A (1985) 4.13
A human hepatitis B viral enhancer element. EMBO J (1985) 3.94
Polyomavirus enhancer contains multiple redundant sequence elements that activate both DNA replication and gene expression. Mol Cell Biol (1985) 3.91
Nucleotide sequence of human endogenous retrovirus genome related to the mouse mammary tumor virus genome. J Virol (1986) 3.52
Structure of the human interleukin 2 gene. Proc Natl Acad Sci U S A (1983) 3.45
Negative and positive regulation in trans of gene expression from adeno-associated virus vectors in mammalian cells by a viral rep gene product. Mol Cell Biol (1986) 3.34
cis-Acting RNA packaging locus in the 115-nucleotide direct repeat of Rous sarcoma virus. J Virol (1983) 3.34
Characterization of two genes required for the position-effect control of yeast mating-type genes. EMBO J (1984) 3.30
Human HSP70 promoter contains at least two distinct regulatory domains. Proc Natl Acad Sci U S A (1986) 3.27
Transcriptional trans-activation by the human papillomavirus type 16 E2 gene product. J Virol (1987) 3.24
Identification of AML-1 and the (8;21) translocation protein (AML-1/ETO) as sequence-specific DNA-binding proteins: the runt homology domain is required for DNA binding and protein-protein interactions. Mol Cell Biol (1993) 3.17
An enhancer-like element in the adenovirus E2 promoter contains sequences essential for uninduced and E1A-induced transcription. Proc Natl Acad Sci U S A (1985) 3.15
Functional analysis of regulatory elements in a plant embryo-specific gene. Proc Natl Acad Sci U S A (1986) 3.14
Adenovirus 2 early region 1A stimulates expression of both viral and cellular genes. EMBO J (1984) 3.03
Tripartite upstream promoter element essential for expression of Saccharomyces cerevisiae ribosomal protein genes. Mol Cell Biol (1986) 3.00
Transcriptional "silencer" element in rat repetitive sequences associated with the rat insulin 1 gene locus. Proc Natl Acad Sci U S A (1986) 2.95
The adenovirus-2 early EIIa transcription unit possesses two overlapping promoters with different sequence requirements for EIa-dependent stimulation. EMBO J (1985) 2.89
How damaged is the biologically active subpopulation of transfected DNA? Mol Cell Biol (1984) 2.88
Adenovirus 5 E2 transcription unit: an E1A-inducible promoter with an essential element that functions independently of position or orientation. Mol Cell Biol (1984) 2.88
trans Activation of the simian virus 40 late transcription unit by T-antigen. Mol Cell Biol (1985) 2.85
Effects of the position of the simian virus 40 enhancer on expression of multiple transcription units in a single plasmid. Mol Cell Biol (1986) 2.73
Cell type-specific transcriptional enhancement in vitro requires the presence of trans-acting factors. EMBO J (1985) 2.70
Cyclic AMP regulation of the human glycoprotein hormone alpha-subunit gene is mediated by an 18-base-pair element. Proc Natl Acad Sci U S A (1987) 2.68
A 13 bp palindrome is a functional estrogen responsive element and interacts specifically with estrogen receptor. Nucleic Acids Res (1988) 2.67
Efficient expression of the Saccharomyces cerevisiae PGK gene depends on an upstream activation sequence but does not require TATA sequences. Mol Cell Biol (1986) 2.63
Requirement for the 3' flanking region of the bovine growth hormone gene for accurate polyadenylylation. Proc Natl Acad Sci U S A (1984) 2.58
The immunoglobulin heavy-chain B-lymphocyte enhancer efficiently stimulates transcription in non-lymphoid cells. EMBO J (1986) 2.56
Different 3' end points of deletions causing delta beta-thalassemia and hereditary persistence of fetal hemoglobin: implications for the control of gamma-globin gene expression in man. Proc Natl Acad Sci U S A (1983) 2.56
Expression of immunoglobulin heavy chain at a high level in the absence of a proposed immunoglobulin enhancer element in cis. Proc Natl Acad Sci U S A (1984) 2.55
Hormonal response region in the mouse mammary tumor virus long terminal repeat can be dissociated from the proviral promoter and has enhancer properties. Proc Natl Acad Sci U S A (1985) 2.47
Stimulation of in vitro transcription from heterologous promoters by the simian virus 40 enhancer. Proc Natl Acad Sci U S A (1984) 2.44
Genomic structure of the cottontail rabbit (Shope) papillomavirus. Proc Natl Acad Sci U S A (1985) 2.40
Analysis of the tissue-specific enhancer at the 3' end of the chicken adult beta-globin gene. Proc Natl Acad Sci U S A (1987) 2.30
Multiple enhancer domains in the 3' terminus of the Prague strain of Rous sarcoma virus. Nucleic Acids Res (1984) 2.28
Differential protein binding in lymphocytes to a sequence in the enhancer of the mouse retrovirus SL3-3. Mol Cell Biol (1988) 2.27
Molecular cloning and long terminal repeat sequences of human endogenous retrovirus genes related to types A and B retrovirus genes. J Virol (1986) 2.25
Characterization of the trans-activation-responsive element of the parvovirus H-1 P38 promoter. J Virol (1987) 2.25
Binding of a nuclear factor to a consensus sequence in the 5' flanking region of zein genes from maize. EMBO J (1987) 2.20
The lysozyme enhancer: cell-specific activation of the chicken lysozyme gene by a far-upstream DNA element. EMBO J (1986) 2.19
Suppression in Drosophila: su(Hw) and su(f) gene products interact with a region of gypsy (mdg4) regulating its transcriptional activity. EMBO J (1989) 2.16
Functional analysis of the transcription control region located within the avian retroviral long terminal repeat. Mol Cell Biol (1985) 2.12
An enhancer element lies 3' to the human A gamma globin gene. EMBO J (1987) 2.11
Identification of the SL3-3 virus enhancer core as a T-lymphoma cell-specific element. J Virol (1989) 2.07
The DAL7 promoter consists of multiple elements that cooperatively mediate regulation of the gene's expression. Mol Cell Biol (1989) 2.07
Identification of a cell-specific transcriptional enhancer in the first intron of the mouse alpha 2 (type I) collagen gene. Proc Natl Acad Sci U S A (1987) 2.07
Transposable element sequences involved in the enhancement of yeast gene expression. Proc Natl Acad Sci U S A (1985) 2.05
Avian retroviral long terminal repeats bind CCAAT/enhancer-binding protein. Mol Cell Biol (1989) 2.03
Tissue-specific expression of the human growth hormone gene is conferred in part by the binding of a specific trans-acting factor. EMBO J (1987) 2.02
Upstream promoter element of the human metallothionein-IIA gene can act like an enhancer element. Proc Natl Acad Sci U S A (1985) 1.97
Functional analysis of the murine IgH enhancer: evidence for negative control of cell-type specificity. Nucleic Acids Res (1986) 1.94
Nucleotide sequence characterization of Ty 1-17, a class II transposon from yeast. Nucleic Acids Res (1985) 1.94
DNA sequences outside the receptor-binding sites differently modulate the responsiveness of the mouse mammary tumour virus promoter to various steroid hormones. EMBO J (1988) 1.93
Transformation of Neurospora crassa with the cloned am (glutamate dehydrogenase) gene. Mol Cell Biol (1984) 1.92
Cloning and sequencing of a c-myc oncogene in a Burkitt's lymphoma cell line that is translocated to a germ line alpha switch region. Mol Cell Biol (1985) 1.90
Negative regulation of the major histocompatibility class I gene in undifferentiated embryonal carcinoma cells. Proc Natl Acad Sci U S A (1986) 1.90
Interaction of a nuclear factor with the polyomavirus enhancer region. Proc Natl Acad Sci U S A (1986) 1.89
cis-acting regulatory elements within gag genes of avian retroviruses. Mol Cell Biol (1987) 1.88
Long terminal repeat sequences impart hematopoietic transformation properties to the myeloproliferative sarcoma virus. Proc Natl Acad Sci U S A (1985) 1.88
Structure of the highly repeated, long interspersed DNA family (LINE or L1Rn) of the rat. Mol Cell Biol (1986) 1.85
Binding in vitro of multiple cellular proteins to immunoglobulin heavy-chain enhancer DNA. Mol Cell Biol (1986) 1.83
Identification and characterization of two functional domains within the murine heavy-chain enhancer. Mol Cell Biol (1988) 1.81
Murine leukemia virus long terminal repeat sequences can enhance gene activity in a cell-type-specific manner. Mol Cell Biol (1985) 1.81
Adenovirus VA RNAI mediates a translational stimulation which is not restricted to the viral mRNAs. EMBO J (1985) 1.80
Synthetic lac operator mediates repression through lac repressor when introduced upstream and downstream from lac promoter. EMBO J (1986) 1.80
Short repeated elements in the upstream regulatory region of the SUC2 gene of Saccharomyces cerevisiae. Mol Cell Biol (1986) 1.80
The first exon of the c-myc proto-oncogene contains a novel positive control element. EMBO J (1986) 1.80
Bidirectional promoter elements of simian virus 40 are required for efficient replication of the viral DNA. Mol Cell Biol (1986) 1.79
Deletion of the IgH enhancer does not reduce immunoglobulin heavy chain production of a hybridoma IgD class switch variant. EMBO J (1984) 1.78
Glucocorticoids enhance stability of human growth hormone mRNA. Mol Cell Biol (1987) 1.77
Mechanisms of nucleolar dominance in animals and plants. J Cell Biol (1985) 1.74
A conserved CATTCCT motif is required for skeletal muscle-specific activity of the cardiac troponin T gene promoter. Proc Natl Acad Sci U S A (1988) 1.74
Multiple positive and negative 5' regulatory elements control the cell-type-specific expression of the embryonic skeletal myosin heavy-chain gene. Mol Cell Biol (1987) 1.73
Transformation of Neurospora crassa with recombinant plasmids containing the cloned glutamate dehydrogenase (am) gene: evidence for autonomous replication of the transforming plasmid. Mol Cell Biol (1984) 1.73
Nucleotide sequence and genomic organization of Aleutian mink disease parvovirus (ADV): sequence comparisons between a nonpathogenic and a pathogenic strain of ADV. J Virol (1988) 1.70
Cell type-specific negative regulatory element in the control region of the rat alpha-fetoprotein gene. Proc Natl Acad Sci U S A (1986) 1.70
Interaction of distinct nuclear proteins with sequences controlling the expression of polyomavirus early genes. Mol Cell Biol (1986) 1.69
Structural organization of the P25 gene of Bombyx mori and comparative analysis of its 5' flanking DNA with that of the fibroin gene. Nucleic Acids Res (1985) 1.68
Transcriptional activity of avian retroviral long terminal repeats directly correlates with enhancer activity. J Virol (1985) 1.67
Control of adenovirus late promoter expression in two human cell lines. Mol Cell Biol (1985) 1.66
Identification and sequence analysis of the 5' end of the major chicken vitellogenin gene. Nucleic Acids Res (1984) 1.64
Efficient transcription of a protein-coding gene from the RNA polymerase I promoter in transfected cells. Proc Natl Acad Sci U S A (1985) 1.63
Transcriptional control of the mouse alpha 2(I) collagen gene: functional deletion analysis of the promoter and evidence for cell-specific expression. Mol Cell Biol (1986) 1.60
Retroviral mutants efficiently expressed in embryonal carcinoma cells. Proc Natl Acad Sci U S A (1986) 1.60
Multiple point mutations affecting the simian virus 40 enhancer. Science (1983) 13.69
Simian virus 40 tandem repeated sequences as an element of the early promoter. Proc Natl Acad Sci U S A (1981) 13.67
Host-specific activation of transcription by tandem repeats from simian virus 40 and Moloney murine sarcoma virus. Proc Natl Acad Sci U S A (1982) 12.30
Pax7 is required for the specification of myogenic satellite cells. Cell (2000) 9.88
Characterization of enhancer elements in the long terminal repeat of Moloney murine sarcoma virus. J Virol (1984) 7.80
Specific interaction between enhancer-containing molecules and cellular components. Cell (1984) 6.96
Participation of p53 cellular tumour antigen in transformation of normal embryonic cells. Nature (1985) 6.86
The genome of human papovavirus BKV. Cell (1979) 6.36
Development of peripheral lymphoid organs and natural killer cells depends on the helix-loop-helix inhibitor Id2. Nature (1999) 6.23
Activation of SV40 genome by 72-base pair tandem repeats of Moloney sarcoma virus. Nature (1982) 6.02
Temporal control of gene expression in transgenic mice by a tetracycline-responsive promoter. Proc Natl Acad Sci U S A (1994) 5.71
New type of POU domain in germ line-specific protein Oct-4. Nature (1990) 5.65
Pax-6, a murine paired box gene, is expressed in the developing CNS. Development (1991) 5.49
A map of simian virus 40 transcription sites expressed in productively infected cells. J Mol Biol (1973) 5.02
Trans-activation of the human immunodeficiency virus long terminal repeat sequence by DNA viruses. Proc Natl Acad Sci U S A (1986) 4.89
Cre-mediated gene deletion in the mammary gland. Nucleic Acids Res (1997) 4.89
Posttranscriptional selection of simian virus 40-specific RNA. J Virol (1975) 4.87
BKV splice sequences based on analysis of preferred donor and acceptor sites. Nucleic Acids Res (1979) 4.86
Bovine papilloma virus deoxyribonucleic acid: a novel eucaryotic cloning vector. Mol Cell Biol (1981) 4.75
The Pax4 gene is essential for differentiation of insulin-producing beta cells in the mammalian pancreas. Nature (1997) 4.69
Pax6 is required for the multipotent state of retinal progenitor cells. Cell (2001) 4.65
Novel mechanism for RNA maturation: the leader sequences of simian virus 40 mRNA are not transcribed adjacent to the coding sequences. Proc Natl Acad Sci U S A (1977) 4.64
Pax6 is required for differentiation of glucagon-producing alpha-cells in mouse pancreas. Nature (1997) 4.58
Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development. Cell (1998) 4.53
A family of octamer-specific proteins present during mouse embryogenesis: evidence for germline-specific expression of an Oct factor. EMBO J (1989) 4.47
Oct-4: a germline-specific transcription factor mapping to the mouse t-complex. EMBO J (1990) 4.42
Mapping the spliced and unspliced late lytic SV40 RNAs. Cell (1978) 4.25
The tat gene of human T-lymphotropic virus type 1 induces mesenchymal tumors in transgenic mice. Science (1987) 4.01
Regulation of early and late simian virus 40 transcription: overproduction of early viral RNA in the absence of a functional T-antigen. J Virol (1977) 3.96
Six3, a murine homologue of the sine oculis gene, demarcates the most anterior border of the developing neural plate and is expressed during eye development. Development (1995) 3.90
Splicing as a requirement for biogenesis of functional 16S mRNA of simian virus 40. Proc Natl Acad Sci U S A (1979) 3.89
Pax6 activity in the lens primordium is required for lens formation and for correct placement of a single retina in the eye. Genes Dev (2000) 3.85
Pax-3, a novel murine DNA binding protein expressed during early neurogenesis. EMBO J (1991) 3.85
Stimulation of simian virus 40 late gene expression by simian virus 40 tumor antigen. Proc Natl Acad Sci U S A (1984) 3.80
Identification of the SV40 agnogene product: a DNA binding protein. Nature (1981) 3.80
p53 transformation-related protein: detection by monoclonal antibody in mouse and human cells. Proc Natl Acad Sci U S A (1981) 3.72
Homeotic transformations of murine vertebrae and concomitant alteration of Hox codes induced by retinoic acid. Cell (1991) 3.71
Patterns of Simian Virus 40 DNA transcription after acute infection of permissive and nonpermissive cells. Proc Natl Acad Sci U S A (1972) 3.65
Waardenburg's syndrome patients have mutations in the human homologue of the Pax-3 paired box gene. Nature (1992) 3.63
Pax-2 controls multiple steps of urogenital development. Development (1995) 3.42
BK viral enhancer element and a human cellular homolog. Science (1983) 3.36
lac repressor can regulate expression from a hybrid SV40 early promoter containing a lac operator in animal cells. Cell (1987) 3.33
A multigene family encoding several "finger" structures is present and differentially active in mammalian genomes. Cell (1987) 3.09
Identification of p40x-responsive regulatory sequences within the human T-cell leukemia virus type I long terminal repeat. J Virol (1987) 3.03
Prox1 function is crucial for mouse lens-fibre elongation. Nat Genet (1999) 3.01
Transcriptional "silencer" element in rat repetitive sequences associated with the rat insulin 1 gene locus. Proc Natl Acad Sci U S A (1986) 2.95
Production of chimaeric mice containing embryonic stem (ES) cells carrying a homoeobox Hox 1.1 allele mutated by homologous recombination. Nature (1989) 2.94
Identification of a precursor in the biosynthesis of the p21 transforming protein of harvey murine sarcoma virus. J Virol (1982) 2.89
trans Activation of the simian virus 40 late transcription unit by T-antigen. Mol Cell Biol (1985) 2.85
Processing and expression of early SV40 mRNA: a role for RNA conformation in splicing. Cell (1979) 2.80
Pax6 controls radial glia differentiation in the cerebral cortex. Neuron (1998) 2.78
Expression of simian virus 40-rat preproinsulin recombinants in monkey kidney cells: use of preproinsulin RNA processing signals. Proc Natl Acad Sci U S A (1981) 2.76
Follicular cells of the thyroid gland require Pax8 gene function. Nat Genet (1998) 2.75
Post-transcriptional control of myc and p53 expression during differentiation of the embryonal carcinoma cell line F9. Nature (1985) 2.75
Pax2, a new murine paired-box-containing gene and its expression in the developing excretory system. Development (1990) 2.72
Murine developmental control genes. Science (1990) 2.71
Cell type-specific transcriptional enhancement in vitro requires the presence of trans-acting factors. EMBO J (1985) 2.70
Distinct cis-essential modules direct the time-space pattern of the Pax6 gene activity. Dev Biol (1999) 2.70
Octamer binding proteins confer transcriptional activity in early mouse embryogenesis. EMBO J (1989) 2.70
Characterization of cellular factors that interact with the human T-cell leukemia virus type I p40x-responsive 21-base-pair sequence. J Virol (1988) 2.67
A rapid enzymatic DNA sequencing technique: determination of sequence alterations in early simian virus 40 temperature sensitive and deletion mutants. Nucleic Acids Res (1980) 2.65
Pax: a murine multigene family of paired box-containing genes. Genomics (1991) 2.60
Phosphorylation of T-antigen and control T-antigen expression in cells transformed by wild-type and tsA mutants of simian virus 40. J Virol (1979) 2.59
Pax-3 is required for the development of limb muscles: a possible role for the migration of dermomyotomal muscle progenitor cells. Development (1994) 2.45
Homeobox genes and connective tissue patterning. Development (1995) 2.43
Pax8, a murine paired box gene expressed in the developing excretory system and thyroid gland. Development (1990) 2.42
Cortical upper layer neurons derive from the subventricular zone as indicated by Svet1 gene expression. Development (2001) 2.37
JC virus enhancer-promoter active in human brain cells. Science (1984) 2.36
Pax2 contributes to inner ear patterning and optic nerve trajectory. Development (1996) 2.33
Dysgenesis of cephalic neural crest derivatives in Pax7-/- mutant mice. Development (1996) 2.31
Multiple enhancer domains in the 3' terminus of the Prague strain of Rous sarcoma virus. Nucleic Acids Res (1984) 2.28
Origin of DNA replication in papovavirus chromatin is recognized by endogenous endonuclease. Proc Natl Acad Sci U S A (1978) 2.24
Reversal of oncogenesis by the expression of a major histocompatibility complex class I gene. Science (1985) 2.22
Prox 1, a prospero-related homeobox gene expressed during mouse development. Mech Dev (1993) 2.21
Deletion mutants of simian virus 40 defective in biosynthesis of late viral mRNA. Proc Natl Acad Sci U S A (1979) 2.19
Oct-6: a POU transcription factor expressed in embryonal stem cells and in the developing brain. EMBO J (1990) 2.19
Roles of Pax-genes in developing and adult brain as suggested by expression patterns. J Neurosci (1994) 2.19
A nexus between Oct-4 and E1A: implications for gene regulation in embryonic stem cells. Cell (1991) 2.18
Physical map of the BK virus genome. J Virol (1975) 2.18
Disruption of the murine homeobox gene Cdx1 affects axial skeletal identities by altering the mesodermal expression domains of Hox genes. Cell (1995) 2.15
The molecular basis of the undulated/Pax-1 mutation. Cell (1991) 2.14
Secretion of a transplantation-related antigen. Cell (1983) 2.12
The murine paired box gene, Pax7, is expressed specifically during the development of the nervous and muscular system. Mech Dev (1990) 2.12
Interdigital cell death can occur through a necrotic and caspase-independent pathway. Curr Biol (1999) 2.11
Pax 1, a member of a paired box homologous murine gene family, is expressed in segmented structures during development. Cell (1988) 2.05
An alpha-E-catenin gene trap mutation defines its function in preimplantation development. Proc Natl Acad Sci U S A (1997) 2.05
A transgenic mouse model for human neurofibromatosis. Science (1987) 2.05
Patterns of simian virus 40 deoxyribonucleic acid transcription. II. In transformed cells. J Virol (1973) 2.04
Structural analysis of murine genes containing homoeo box sequences and their expression in embryonal carcinoma cells. Nature (1985) 2.01
Spatially and temporally restricted expression of Pax2 during murine neurogenesis. Development (1990) 2.01
undulated, a mutation affecting the development of the mouse skeleton, has a point mutation in the paired box of Pax 1. Cell (1988) 2.01