Published in Mol Cell Biol on December 01, 1999
Isolation of the Cdc45/Mcm2-7/GINS (CMG) complex, a candidate for the eukaryotic DNA replication fork helicase. Proc Natl Acad Sci U S A (2006) 5.66
Eukaryotic MCM proteins: beyond replication initiation. Microbiol Mol Biol Rev (2004) 4.19
A double-hexamer archaeal minichromosome maintenance protein is an ATP-dependent DNA helicase. Proc Natl Acad Sci U S A (2000) 3.35
A requirement for MCM7 and Cdc45 in chromosome unwinding during eukaryotic DNA replication. EMBO J (2004) 3.02
Cell cycle- and cell growth-regulated proteolysis of mammalian CDC6 is dependent on APC-CDH1. Genes Dev (2000) 2.58
DNA synthesis at individual replication forks requires the essential initiation factor Cdc45p. EMBO J (2000) 2.51
On helicases and other motor proteins. Curr Opin Struct Biol (2008) 2.43
The Mcm complex: unwinding the mechanism of a replicative helicase. Microbiol Mol Biol Rev (2009) 2.29
Processive DNA helicase activity of the minichromosome maintenance proteins 4, 6, and 7 complex requires forked DNA structures. Proc Natl Acad Sci U S A (2001) 2.14
Mcm10 and the MCM2-7 complex interact to initiate DNA synthesis and to release replication factors from origins. Genes Dev (2000) 2.04
A rotary pumping model for helicase function of MCM proteins at a distance from replication forks. EMBO Rep (2003) 1.86
Interaction between human MCM7 and Rad17 proteins is required for replication checkpoint signaling. EMBO J (2004) 1.75
Crystal structure of a near-full-length archaeal MCM: functional insights for an AAA+ hexameric helicase. Proc Natl Acad Sci U S A (2008) 1.66
Subunit organization of Mcm2-7 and the unequal role of active sites in ATP hydrolysis and viability. Mol Cell Biol (2008) 1.61
Mammalian nuclei become licensed for DNA replication during late telophase. J Cell Sci (2002) 1.51
An episomal mammalian replicon: sequence-independent binding of the origin recognition complex. EMBO J (2003) 1.45
The Mre11 complex mediates the S-phase checkpoint through an interaction with replication protein A. Mol Cell Biol (2007) 1.38
De novo replication of the influenza virus RNA genome is regulated by DNA replicative helicase, MCM. EMBO J (2007) 1.38
Drosophila minichromosome maintenance 6 is required for chorion gene amplification and genomic replication. Mol Biol Cell (2002) 1.31
Thymine-rich single-stranded DNA activates Mcm4/6/7 helicase on Y-fork and bubble-like substrates. EMBO J (2003) 1.25
Insights into DNA replication from the third domain of life. Proc Natl Acad Sci U S A (2000) 1.23
MCM3AP, a novel acetyltransferase that acetylates replication protein MCM3. EMBO Rep (2001) 1.23
Schizosaccharomyces pombe pfh1+ encodes an essential 5' to 3' DNA helicase that is a member of the PIF1 subfamily of DNA helicases. Mol Biol Cell (2002) 1.23
Identification of two residues in MCM5 critical for the assembly of MCM complexes and Stat1-mediated transcription activation in response to IFN-gamma. Proc Natl Acad Sci U S A (2001) 1.22
Cdc45 limits replicon usage from a low density of preRCs in mammalian cells. PLoS One (2011) 1.19
Human Mcm proteins at a replication origin during the G1 to S phase transition. Nucleic Acids Res (2002) 1.19
The ATR-mediated S phase checkpoint prevents rereplication in mammalian cells when licensing control is disrupted. J Cell Biol (2007) 1.17
Biochemical analysis of components of the pre-replication complex of Archaeoglobus fulgidus. Nucleic Acids Res (2003) 1.16
Phosphorylation of MCM4 at sites inactivating DNA helicase activity of the MCM4-MCM6-MCM7 complex during Epstein-Barr virus productive replication. J Virol (2006) 1.13
Differential requirements for MCM proteins in DNA replication in Drosophila S2 cells. PLoS One (2007) 1.13
In vitro nuclear interactome of the HIV-1 Tat protein. Retrovirology (2009) 1.13
Whole adult organism transcriptional profiling of acute metal exposures in male zebrafish. BMC Pharmacol Toxicol (2014) 1.13
Insights into the MCM functional mechanism: lessons learned from the archaeal MCM complex. Crit Rev Biochem Mol Biol (2010) 1.12
Minichromosome Maintenance Protein 7 is a potential therapeutic target in human cancer and a novel prognostic marker of non-small cell lung cancer. Mol Cancer (2011) 1.05
Licensing for DNA replication requires a strict sequential assembly of Cdc6 and Cdt1 onto chromatin in Xenopus egg extracts. Nucleic Acids Res (2005) 1.03
A new member of the MCM protein family encoded by the human MCM8 gene, located contrapodal to GCD10 at chromosome band 20p12.3-13. Nucleic Acids Res (2003) 1.02
Mcm subunits can assemble into two different active unwinding complexes. J Biol Chem (2008) 1.02
Regulation of DNA replication machinery by Mrc1 in fission yeast. Genetics (2006) 1.01
Phosphorylation of simian virus 40 T antigen on Thr 124 selectively promotes double-hexamer formation on subfragments of the viral core origin. J Virol (2000) 0.98
MCM7 interacts with androgen receptor. Am J Pathol (2008) 0.96
Evolution of DNA replication protein complexes in eukaryotes and Archaea. PLoS One (2010) 0.96
Structure and mutagenesis studies of the C-terminal region of licensing factor Cdt1 enable the identification of key residues for binding to replicative helicase Mcm proteins. J Biol Chem (2010) 0.96
Different phenotypes in vivo are associated with ATPase motif mutations in Schizosaccharomyces pombe minichromosome maintenance proteins. Genetics (2002) 0.96
Cdt1 forms a complex with the minichromosome maintenance protein (MCM) and activates its helicase activity. J Biol Chem (2008) 0.95
DNA binding and helicase actions of mouse MCM4/6/7 helicase. Nucleic Acids Res (2005) 0.95
Nascent transcription of MCM2-7 is important for nuclear localization of the minichromosome maintenance complex in G1. Mol Biol Cell (2007) 0.92
Oncogenic activity of MCM7 transforming cluster. World J Clin Oncol (2011) 0.90
Inhibition of prostate cancer growth and metastasis using small interference RNA specific for minichromosome complex maintenance component 7. Cancer Gene Ther (2010) 0.88
C. elegans MCM-4 is a general DNA replication and checkpoint component with an epidermis-specific requirement for growth and viability. Dev Biol (2010) 0.88
Functional conservation of beta-hairpin DNA binding domains in the Mcm protein of Methanobacterium thermoautotrophicum and the Mcm5 protein of Saccharomyces cerevisiae. Genetics (2008) 0.87
Structure of the Cdt1 C-terminal domain: conservation of the winged helix fold in replication licensing factors. Protein Sci (2009) 0.87
Functional cooperation between FACT and MCM is coordinated with cell cycle and differential complex formation. J Biomed Sci (2010) 0.86
The fertilization-induced DNA replication factor MCM6 of maize shuttles between cytoplasm and nucleus, and is essential for plant growth and development. Plant Physiol (2006) 0.85
Molecular cloning of a cDNA encoding mouse DNA helicase B, which has homology to Escherichia coli RecD protein, and identification of a mutation in the DNA helicase B from tsFT848 temperature-sensitive DNA replication mutant cells. Nucleic Acids Res (2001) 0.85
Molecular mechanism of activation of human Cdc7 kinase: bipartite interaction with Dbf4/activator of S phase kinase (ASK) activation subunit stimulates ATP binding and substrate recognition. J Biol Chem (2011) 0.85
Requirement for p38 mitogen-activated protein kinase activity in neointima formation after vascular injury. Circulation (2008) 0.85
ATP binding and hydrolysis by Mcm2 regulate DNA binding by Mcm complexes. J Mol Biol (2009) 0.85
MCM Paradox: Abundance of Eukaryotic Replicative Helicases and Genomic Integrity. Mol Biol Int (2014) 0.85
Mutational analysis of an archaeal minichromosome maintenance protein exterior hairpin reveals critical residues for helicase activity and DNA binding. BMC Mol Biol (2010) 0.83
Promoter of a salinity and cold stress-induced MCM6 DNA helicase from pea. Plant Signal Behav (2011) 0.82
Interaction of MCM7 and RACK1 for activation of MCM7 and cell growth. Am J Pathol (2013) 0.81
The mini-chromosome maintenance (Mcm) complexes interact with DNA polymerase α-primase and stimulate its ability to synthesize RNA primers. PLoS One (2013) 0.79
The effects of oligomerization on Saccharomyces cerevisiae Mcm4/6/7 function. BMC Biochem (2010) 0.78
Geminin inhibits a late step in the formation of human pre-replicative complexes. J Biol Chem (2014) 0.77
A superfamily 3 DNA helicase encoded by plasmid pSSVi from the hyperthermophilic archaeon Sulfolobus solfataricus unwinds DNA as a higher-order oligomer and interacts with host primase. J Bacteriol (2010) 0.77
Arabidopsis thaliana MCM3 single subunit of MCM2-7 complex functions as 3' to 5' DNA helicase. Protoplasma (2015) 0.76
Identification of genes with altered expression in male and female Schlager hypertensive mice. BMC Med Genet (2014) 0.75
iTRAQ-based Proteomic Analysis of Porcine Kidney Epithelial PK15 cells Infected with Pseudorabies virus. Sci Rep (2017) 0.75
The DNA replication licensing factor miniature chromosome maintenance 7 is essential for RNA splicing of epidermal growth factor receptor, c-Met, and platelet-derived growth factor receptor. J Biol Chem (2014) 0.75
Components and dynamics of DNA replication complexes in S. cerevisiae: redistribution of MCM proteins and Cdc45p during S phase. Cell (1997) 8.23
Mechanisms of helicase-catalyzed DNA unwinding. Annu Rev Biochem (1996) 5.81
Cdc6p-dependent loading of Mcm proteins onto pre-replicative chromatin in budding yeast. Proc Natl Acad Sci U S A (1997) 5.51
Loading of an Mcm protein onto DNA replication origins is regulated by Cdc6p and CDKs. Cell (1997) 5.15
A DNA helicase activity is associated with an MCM4, -6, and -7 protein complex. J Biol Chem (1997) 4.97
A group of interacting yeast DNA replication genes. Genes Dev (1991) 4.45
Purification of an MCM-containing complex as a component of the DNA replication licensing system. Nature (1995) 4.00
Initiation of DNA replication in eukaryotic cells. Annu Rev Cell Dev Biol (1997) 3.81
The phosphorylated form of the enhancer-binding protein NTRC has an ATPase activity that is essential for activation of transcription. Cell (1991) 3.70
A common set of conserved motifs in a vast variety of putative nucleic acid-dependent ATPases including MCM proteins involved in the initiation of eukaryotic DNA replication. Nucleic Acids Res (1993) 3.54
Identification of the yeast MCM3-related protein as a component of Xenopus DNA replication licensing factor. Cell (1995) 3.47
MCM3 complex required for cell cycle regulation of DNA replication in vertebrate cells. Nature (1995) 3.33
Mcm2 is a target of regulation by Cdc7-Dbf4 during the initiation of DNA synthesis. Genes Dev (1997) 3.05
mcm5/cdc46-bob1 bypasses the requirement for the S phase activator Cdc7p. Proc Natl Acad Sci U S A (1997) 3.01
Mcm2 and Mcm3, two proteins important for ARS activity, are related in structure and function. Genes Dev (1991) 2.92
Genetic and biochemical characterization of mutations in the ATPase and helicase regions of the Upf1 protein. Mol Cell Biol (1996) 2.78
Fission yeast minichromosome loss mutants mis cause lethal aneuploidy and replication abnormality. Mol Biol Cell (1994) 2.77
MCM proteins: evolution, properties, and role in DNA replication. Biochim Biophys Acta (1998) 2.73
Replication focus-forming activity 1 and the Werner syndrome gene product. Nat Genet (1998) 2.47
The role of MCM/P1 proteins in the licensing of DNA replication. Trends Biochem Sci (1996) 2.44
Fission yeast cdc21+ belongs to a family of proteins involved in an early step of chromosome replication. Nucleic Acids Res (1992) 2.27
The RLF-M component of the replication licensing system forms complexes containing all six MCM/P1 polypeptides. EMBO J (1997) 2.27
CDC45, a novel yeast gene that functions with the origin recognition complex and Mcm proteins in initiation of DNA replication. Mol Cell Biol (1997) 2.17
Cell cycle-regulated nuclear import and export of Cdc47, a protein essential for initiation of DNA replication in budding yeast. Proc Natl Acad Sci U S A (1995) 2.13
The role of MCM proteins in the cell cycle control of genome duplication. Bioessays (1996) 2.09
The phenotype of the minichromosome maintenance mutant mcm3 is characteristic of mutants defective in DNA replication. Mol Cell Biol (1990) 2.08
Interactions of human nuclear proteins P1Mcm3 and P1Cdc46. Eur J Biochem (1995) 2.03
The MCM2-3-5 proteins: are they replication licensing factors? Trends Cell Biol (1994) 1.95
The prokaryotic enhancer binding protein NTRC has an ATPase activity which is phosphorylation and DNA dependent. EMBO J (1992) 1.94
Putting it all together: building a prereplicative complex. Cell (1997) 1.86
A globular complex formation by Nda1 and the other five members of the MCM protein family in fission yeast. Genes Cells (1997) 1.84
The ORC1 homolog orp1 in fission yeast plays a key role in regulating onset of S phase. Genes Dev (1996) 1.75
Biochemical function of mouse minichromosome maintenance 2 protein. J Biol Chem (1998) 1.74
Fission yeast cdc21, a member of the MCM protein family, is required for onset of S phase and is located in the nucleus throughout the cell cycle. EMBO J (1996) 1.70
Fission yeast genes nda1+ and nda4+, mutations of which lead to S-phase block, chromatin alteration and Ca2+ suppression, are members of the CDC46/MCM2 family. Mol Biol Cell (1993) 1.61
Binding of human minichromosome maintenance proteins with histone H3. J Biol Chem (1996) 1.45
Biochemical analysis of mutant T7 primase/helicase proteins defective in DNA binding, nucleotide hydrolysis, and the coupling of hydrolysis with DNA unwinding. J Biol Chem (1996) 1.44
A human homologue of the yeast replication protein Cdc21. Interactions with other Mcm proteins. Eur J Biochem (1995) 1.40
Reduced dosage of a single fission yeast MCM protein causes genetic instability and S phase delay. J Cell Sci (1999) 1.37
In vivo interaction of human MCM heterohexameric complexes with chromatin. Possible involvement of ATP. J Biol Chem (1997) 1.35
Molecular cloning of cDNA encoding mouse Cdc21 and CDC46 homologs and characterization of the products: physical interaction between P1(MCM3) and CDC46 proteins. Nucleic Acids Res (1995) 1.35
Cyclin-dependent kinase and initiation at eukaryotic origins: a replication switch? Curr Opin Cell Biol (1997) 1.33
Mouse MCM proteins: complex formation and transportation to the nucleus. Genes Cells (1996) 1.27
Multiple domains of fission yeast Cdc19p (MCM2) are required for its association with the core MCM complex. Mol Biol Cell (1998) 1.27
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Alteration by site-directed mutagenesis of the conserved lysine residue in the ATP-binding consensus sequence of the RecD subunit of the Escherichia coli RecBCD enzyme. J Biol Chem (1992) 1.14
Schizosaccharomyces pombe Mcm3p, an essential nuclear protein, associates tightly with Nda4p (Mcm5p). Nucleic Acids Res (1998) 1.11
Toroidal proteins: running rings around DNA. Curr Biol (1998) 1.11
High-molecular-mass complexes of human minichromosome-maintenance proteins in mitotic cells. Eur J Biochem (1997) 1.01
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Mutational analysis of Cdc19p, a Schizosaccharomyces pombe MCM protein. Genetics (1997) 0.99
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