Published in Proc Natl Acad Sci U S A on June 23, 2006
Concerted loading of Mcm2-7 double hexamers around DNA during DNA replication origin licensing. Cell (2009) 5.56
Cell cycle regulation of DNA replication. Annu Rev Genet (2007) 3.80
A double-hexameric MCM2-7 complex is loaded onto origin DNA during licensing of eukaryotic DNA replication. Proc Natl Acad Sci U S A (2009) 3.68
Excess MCM proteins protect human cells from replicative stress by licensing backup origins of replication. Proc Natl Acad Sci U S A (2008) 3.29
The structural basis for MCM2-7 helicase activation by GINS and Cdc45. Nat Struct Mol Biol (2011) 2.93
How do Cdc7 and cyclin-dependent kinases trigger the initiation of chromosome replication in eukaryotic cells? Genes Dev (2010) 2.88
Replication licensing and cancer--a fatal entanglement? Nat Rev Cancer (2008) 2.86
Selective bypass of a lagging strand roadblock by the eukaryotic replicative DNA helicase. Cell (2011) 2.54
The Dbf4-Cdc7 kinase promotes S phase by alleviating an inhibitory activity in Mcm4. Nature (2010) 2.50
The Mcm complex: unwinding the mechanism of a replicative helicase. Microbiol Mol Biol Rev (2009) 2.29
Establishing the program of origin firing during S phase in fission Yeast. Cell (2009) 2.20
DNA replication in the archaea. Microbiol Mol Biol Rev (2006) 2.17
A key role for Ctf4 in coupling the MCM2-7 helicase to DNA polymerase alpha within the eukaryotic replisome. EMBO J (2009) 2.17
Regulated eukaryotic DNA replication origin firing with purified proteins. Nature (2015) 2.07
Diminished dosage of 22q11 genes disrupts neurogenesis and cortical development in a mouse model of 22q11 deletion/DiGeorge syndrome. Proc Natl Acad Sci U S A (2009) 2.04
Strand-specific analysis shows protein binding at replication forks and PCNA unloading from lagging strands when forks stall. Mol Cell (2014) 1.90
Assembly of the Cdc45-Mcm2-7-GINS complex in human cells requires the Ctf4/And-1, RecQL4, and Mcm10 proteins. Proc Natl Acad Sci U S A (2009) 1.88
CDK-dependent complex formation between replication proteins Dpb11, Sld2, Pol (epsilon}, and GINS in budding yeast. Genes Dev (2010) 1.86
Stalled fork rescue via dormant replication origins in unchallenged S phase promotes proper chromosome segregation and tumor suppression. Mol Cell (2011) 1.77
Incorporation into the prereplicative complex activates the Mcm2-7 helicase for Cdc7-Dbf4 phosphorylation. Genes Dev (2009) 1.76
A Major Role of DNA Polymerase δ in Replication of Both the Leading and Lagging DNA Strands. Mol Cell (2015) 1.75
Uncoupling of sister replisomes during eukaryotic DNA replication. Mol Cell (2010) 1.73
Break-induced replication requires all essential DNA replication factors except those specific for pre-RC assembly. Genes Dev (2010) 1.71
Mrc1 and Tof1 regulate DNA replication forks in different ways during normal S phase. Mol Biol Cell (2007) 1.70
Cdc48 and a ubiquitin ligase drive disassembly of the CMG helicase at the end of DNA replication. Science (2014) 1.69
Cryo-EM structure of a helicase loading intermediate containing ORC-Cdc6-Cdt1-MCM2-7 bound to DNA. Nat Struct Mol Biol (2013) 1.66
Mechanism of asymmetric polymerase assembly at the eukaryotic replication fork. Nat Struct Mol Biol (2014) 1.59
MCM2-7 form double hexamers at licensed origins in Xenopus egg extract. J Biol Chem (2011) 1.55
Regulating DNA replication in eukarya. Cold Spring Harb Perspect Biol (2013) 1.52
Reduced expression of GINS complex members induces hallmarks of pre-malignancy in primary untransformed human cells. Cell Cycle (2009) 1.49
GINS motion reveals replication fork progression is remarkably uniform throughout the yeast genome. Mol Syst Biol (2010) 1.45
Human Mcm10 regulates the catalytic subunit of DNA polymerase-alpha and prevents DNA damage during replication. Mol Biol Cell (2007) 1.44
Properties of the human Cdc45/Mcm2-7/GINS helicase complex and its action with DNA polymerase epsilon in rolling circle DNA synthesis. Proc Natl Acad Sci U S A (2012) 1.44
DNA polymerase epsilon: a polymerase of unusual size (and complexity). Prog Nucleic Acid Res Mol Biol (2008) 1.44
Quality control in the initiation of eukaryotic DNA replication. Philos Trans R Soc Lond B Biol Sci (2011) 1.40
DNA binding polarity, dimerization, and ATPase ring remodeling in the CMG helicase of the eukaryotic replisome. Elife (2014) 1.40
Cdt1 revisited: complex and tight regulation during the cell cycle and consequences of deregulation in mammalian cells. Cell Div (2006) 1.38
Mcm10 associates with the loaded DNA helicase at replication origins and defines a novel step in its activation. EMBO J (2012) 1.37
Crystal structure of the GINS complex and functional insights into its role in DNA replication. Proc Natl Acad Sci U S A (2007) 1.36
RAD51- and MRE11-dependent reassembly of uncoupled CMG helicase complex at collapsed replication forks. Nat Struct Mol Biol (2011) 1.36
Partial MCM4 deficiency in patients with growth retardation, adrenal insufficiency, and natural killer cell deficiency. J Clin Invest (2012) 1.35
The human GINS complex associates with Cdc45 and MCM and is essential for DNA replication. Nucleic Acids Res (2009) 1.35
Cdc7-Drf1 kinase links chromosome cohesion to the initiation of DNA replication in Xenopus egg extracts. Genes Dev (2008) 1.34
Nuclear accumulation of the papillomavirus E1 helicase blocks S-phase progression and triggers an ATM-dependent DNA damage response. J Virol (2011) 1.33
Genome-wide analysis of the core DNA replication machinery in the higher plants Arabidopsis and rice. Plant Physiol (2007) 1.32
Helicase activation and establishment of replication forks at chromosomal origins of replication. Cold Spring Harb Perspect Biol (2013) 1.32
Whither the replisome: emerging perspectives on the dynamic nature of the DNA replication machinery. Cell Cycle (2009) 1.28
Mechanisms for initiating cellular DNA replication. Annu Rev Biochem (2013) 1.28
The Saccharomyces cerevisiae Mcm6/2 and Mcm5/3 ATPase active sites contribute to the function of the putative Mcm2-7 'gate'. Nucleic Acids Res (2010) 1.28
Cdc45-MCM-GINS, a new power player for DNA replication. Cell Div (2006) 1.27
L3MBTL1 polycomb protein, a candidate tumor suppressor in del(20q12) myeloid disorders, is essential for genome stability. Proc Natl Acad Sci U S A (2010) 1.27
SCF(Dia2) regulates DNA replication forks during S-phase in budding yeast. EMBO J (2009) 1.25
SV40 DNA replication: from the A gene to a nanomachine. Virology (2008) 1.25
Crystal structure of the human GINS complex. Genes Dev (2007) 1.25
Rif1 controls DNA replication by directing Protein Phosphatase 1 to reverse Cdc7-mediated phosphorylation of the MCM complex. Genes Dev (2014) 1.25
Sister acts: coordinating DNA replication and cohesion establishment. Genes Dev (2010) 1.24
Regulation of the initiation step of DNA replication by cyclin-dependent kinases. Chromosoma (2010) 1.24
CDC-48/p97 coordinates CDT-1 degradation with GINS chromatin dissociation to ensure faithful DNA replication. Mol Cell (2011) 1.24
A global profile of replicative polymerase usage. Nat Struct Mol Biol (2015) 1.23
ATP-dependent conformational dynamics underlie the functional asymmetry of the replicative helicase from a minimalist eukaryote. Proc Natl Acad Sci U S A (2012) 1.21
Studies on human DNA polymerase epsilon and GINS complex and their role in DNA replication. J Biol Chem (2011) 1.21
Dbf4-Cdc7 phosphorylation of Mcm2 is required for cell growth. J Biol Chem (2009) 1.20
Incremental genetic perturbations to MCM2-7 expression and subcellular distribution reveal exquisite sensitivity of mice to DNA replication stress. PLoS Genet (2010) 1.20
A novel DNA nuclease is stimulated by association with the GINS complex. Nucleic Acids Res (2011) 1.19
Domain architecture and biochemical characterization of vertebrate Mcm10. J Biol Chem (2007) 1.19
CMG helicase and DNA polymerase ε form a functional 15-subunit holoenzyme for eukaryotic leading-strand DNA replication. Proc Natl Acad Sci U S A (2014) 1.18
The role of CDK in the initiation step of DNA replication in eukaryotes. Cell Div (2007) 1.18
Enigmatic roles of Mcm10 in DNA replication. Trends Biochem Sci (2013) 1.17
Ancient diversification of eukaryotic MCM DNA replication proteins. BMC Evol Biol (2009) 1.17
The minichromosome maintenance replicative helicase. Cold Spring Harb Perspect Biol (2013) 1.16
A conserved MCM single-stranded DNA binding element is essential for replication initiation. Elife (2014) 1.15
Mcm10 plays an essential role in origin DNA unwinding after loading of the CMG components. EMBO J (2012) 1.15
The architecture of a eukaryotic replisome. Nat Struct Mol Biol (2015) 1.15
Structural basis for DNA binding by replication initiator Mcm10. Structure (2008) 1.14
Prereplicative complexes assembled in vitro support origin-dependent and independent DNA replication. EMBO J (2014) 1.14
Regulation of DNA replication during development. Development (2012) 1.13
Differential requirements for MCM proteins in DNA replication in Drosophila S2 cells. PLoS One (2007) 1.13
The human GINS complex binds to and specifically stimulates human DNA polymerase alpha-primase. EMBO Rep (2006) 1.12
Insights into the MCM functional mechanism: lessons learned from the archaeal MCM complex. Crit Rev Biochem Mol Biol (2010) 1.12
Minichromosome maintenance helicase paralog MCM9 is dispensible for DNA replication but functions in germ-line stem cells and tumor suppression. Proc Natl Acad Sci U S A (2011) 1.12
Prevention of DNA re-replication in eukaryotic cells. J Mol Cell Biol (2011) 1.12
Reconstitution of a eukaryotic replisome reveals suppression mechanisms that define leading/lagging strand operation. Elife (2015) 1.12
The dynamics of replication licensing in live Caenorhabditis elegans embryos. J Cell Biol (2012) 1.11
Chromosome Duplication in Saccharomyces cerevisiae. Genetics (2016) 1.11
Multiple functions for Mcm2-7 ATPase motifs during replication initiation. Mol Cell (2014) 1.09
Origin plasticity during budding yeast DNA replication in vitro. EMBO J (2014) 1.08
Structure of the eukaryotic replicative CMG helicase suggests a pumpjack motion for translocation. Nat Struct Mol Biol (2016) 1.08
Molecular architecture of the human GINS complex. EMBO Rep (2007) 1.07
The DNA unwinding element binding protein DUE-B interacts with Cdc45 in preinitiation complex formation. Mol Cell Biol (2010) 1.07
A structural framework for replication origin opening by AAA+ initiation factors. Curr Opin Struct Biol (2012) 1.06
Phosphorylation of Mcm2 by Cdc7 promotes pre-replication complex assembly during cell-cycle re-entry. Mol Cell (2009) 1.06
The human intra-S checkpoint response to UVC-induced DNA damage. Carcinogenesis (2009) 1.05
Epigenetic inheritance: histone bookmarks across generations. Trends Cell Biol (2014) 1.05
The direct binding of Mrc1, a checkpoint mediator, to Mcm6, a replication helicase, is essential for the replication checkpoint against methyl methanesulfonate-induced stress. Mol Cell Biol (2009) 1.04
The mechanism of DNA replication termination in vertebrates. Nature (2015) 1.04
Cryo-EM structures of the eukaryotic replicative helicase bound to a translocation substrate. Nat Commun (2016) 1.04
Switch on the engine: how the eukaryotic replicative helicase MCM2-7 becomes activated. Chromosoma (2014) 1.03
In the absence of ATPase activity, pre-RC formation is blocked prior to MCM2-7 hexamer dimerization. Nucleic Acids Res (2013) 1.03
Cryo-electron microscopy reveals a novel DNA-binding site on the MCM helicase. EMBO J (2008) 1.03
Structural and functional insights into the DNA replication factor Cdc45 reveal an evolutionary relationship to the DHH family of phosphoesterases. J Biol Chem (2011) 1.03
S-phase checkpoint proteins Tof1 and Mrc1 form a stable replication-pausing complex. Nature (2003) 6.43
GINS maintains association of Cdc45 with MCM in replisome progression complexes at eukaryotic DNA replication forks. Nat Cell Biol (2006) 6.36
Uninterrupted MCM2-7 function required for DNA replication fork progression. Science (2000) 6.27
A DNA helicase activity is associated with an MCM4, -6, and -7 protein complex. J Biol Chem (1997) 4.97
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Eukaryotic MCM proteins: beyond replication initiation. Microbiol Mol Biol Rev (2004) 4.19
Localization of MCM2-7, Cdc45, and GINS to the site of DNA unwinding during eukaryotic DNA replication. Mol Cell (2006) 3.77
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GINS, a novel multiprotein complex required for chromosomal DNA replication in budding yeast. Genes Dev (2003) 3.53
Assembly of a complex containing Cdc45p, replication protein A, and Mcm2p at replication origins controlled by S-phase cyclin-dependent kinases and Cdc7p-Dbf4p kinase. Mol Cell Biol (2000) 3.52
Self-assembling protein microarrays. Science (2004) 3.37
A double-hexamer archaeal minichromosome maintenance protein is an ATP-dependent DNA helicase. Proc Natl Acad Sci U S A (2000) 3.35
Mcm2 is a target of regulation by Cdc7-Dbf4 during the initiation of DNA synthesis. Genes Dev (1997) 3.05
A requirement for MCM7 and Cdc45 in chromosome unwinding during eukaryotic DNA replication. EMBO J (2004) 3.02
mcm5/cdc46-bob1 bypasses the requirement for the S phase activator Cdc7p. Proc Natl Acad Sci U S A (1997) 3.01
Differential assembly of Cdc45p and DNA polymerases at early and late origins of DNA replication. Proc Natl Acad Sci U S A (1999) 2.96
The single minichromosome maintenance protein of Methanobacterium thermoautotrophicum DeltaH contains DNA helicase activity. Proc Natl Acad Sci U S A (1999) 2.93
A novel ring-like complex of Xenopus proteins essential for the initiation of DNA replication. Genes Dev (2003) 2.75
Identification of a Drosophila Myb-E2F2/RBF transcriptional repressor complex. Genes Dev (2004) 2.73
Sld3, which interacts with Cdc45 (Sld4), functions for chromosomal DNA replication in Saccharomyces cerevisiae. EMBO J (2001) 2.70
Xenopus Cdc45-dependent loading of DNA polymerase alpha onto chromatin under the control of S-phase Cdk. EMBO J (1998) 2.66
Pumps, paradoxes and ploughshares: mechanism of the MCM2-7 DNA helicase. Trends Biochem Sci (2005) 2.53
Mcm2, but not RPA, is a component of the mammalian early G1-phase prereplication complex. J Cell Biol (1999) 2.43
Biochemical analysis of the intrinsic Mcm4-Mcm6-mcm7 DNA helicase activity. Mol Cell Biol (1999) 2.42
The intrinsic DNA helicase activity of Methanobacterium thermoautotrophicum delta H minichromosome maintenance protein. J Biol Chem (2000) 2.29
CDC45, a novel yeast gene that functions with the origin recognition complex and Mcm proteins in initiation of DNA replication. Mol Cell Biol (1997) 2.17
The nuclear envelope prevents reinitiation of replication by regulating the binding of MCM3 to chromatin in Xenopus egg extracts. Curr Biol (1995) 2.16
Mcm4,6,7 uses a "pump in ring" mechanism to unwind DNA by steric exclusion and actively translocate along a duplex. J Biol Chem (2003) 2.15
Central role for cdc45 in establishing an initiation complex of DNA replication in Xenopus egg extracts. Genes Cells (2000) 2.12
Xenopus cdc7 function is dependent on licensing but not on XORC, XCdc6, or CDK activity and is required for XCdc45 loading. Genes Dev (2000) 2.10
Isolation and characterization of various complexes of the minichromosome maintenance proteins of Schizosaccharomyces pombe. J Biol Chem (2000) 2.04
Cdc45p assembles into a complex with Cdc46p/Mcm5p, is required for minichromosome maintenance, and is essential for chromosomal DNA replication. Proc Natl Acad Sci U S A (1996) 1.94
A globular complex formation by Nda1 and the other five members of the MCM protein family in fission yeast. Genes Cells (1997) 1.84
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Drosophila MCM10 interacts with members of the prereplication complex and is required for proper chromosome condensation. Mol Biol Cell (2003) 1.60
CDK- and Cdc45-dependent priming of the MCM complex on chromatin during S-phase in Xenopus egg extracts: possible activation of MCM helicase by association with Cdc45. Genes Cells (2003) 1.57
Polymorphism and double hexamer structure in the archaeal minichromosome maintenance (MCM) helicase from Methanobacterium thermoautotrophicum. J Biol Chem (2005) 1.55
PSF1 is essential for early embryogenesis in mice. Mol Cell Biol (2005) 1.40
DNA unwinding is an Mcm complex-dependent and ATP hydrolysis-dependent process. J Biol Chem (2004) 1.34
Cdc7-Drf1 is a developmentally regulated protein kinase required for the initiation of vertebrate DNA replication. Genes Dev (2005) 1.32
Drosophila minichromosome maintenance 6 is required for chorion gene amplification and genomic replication. Mol Biol Cell (2002) 1.31
Thymine-rich single-stranded DNA activates Mcm4/6/7 helicase on Y-fork and bubble-like substrates. EMBO J (2003) 1.25
A novel intermediate in initiation complex assembly for fission yeast DNA replication. Mol Biol Cell (2004) 1.19
The human homolog of Saccharomyces cerevisiae CDC45. J Biol Chem (1998) 1.14
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Activation of the MCM2-7 helicase by association with Cdc45 and GINS proteins. Mol Cell (2010) 4.24
The structural basis for MCM2-7 helicase activation by GINS and Cdc45. Nat Struct Mol Biol (2011) 2.93
Identification of a Drosophila Myb-E2F2/RBF transcriptional repressor complex. Genes Dev (2004) 2.73
Role for a Drosophila Myb-containing protein complex in site-specific DNA replication. Nature (2002) 2.61
KDM4A lysine demethylase induces site-specific copy gain and rereplication of regions amplified in tumors. Cell (2013) 2.34
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Structure of the papillomavirus DNA-tethering complex E2:Brd4 and a peptide that ablates HPV chromosomal association. Mol Cell (2006) 2.11
Genomic profiling and expression studies reveal both positive and negative activities for the Drosophila Myb MuvB/dREAM complex in proliferating cells. Genes Dev (2007) 1.95
Zelda binding in the early Drosophila melanogaster embryo marks regions subsequently activated at the maternal-to-zygotic transition. PLoS Genet (2011) 1.95
The X-ray structure of the papillomavirus helicase in complex with its molecular matchmaker E2. Genes Dev (2004) 1.90
Stalled fork rescue via dormant replication origins in unchallenged S phase promotes proper chromosome segregation and tumor suppression. Mol Cell (2011) 1.77
Cancer. New epigenetic drivers of cancers. Science (2011) 1.73
DAXX envelops a histone H3.3-H4 dimer for H3.3-specific recognition. Nature (2012) 1.65
Dm-myb mutant lethality in Drosophila is dependent upon mip130: positive and negative regulation of DNA replication. Genes Dev (2004) 1.46
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Discovery of tMAC: a Drosophila testis-specific meiotic arrest complex paralogous to Myb-Muv B. Genes Dev (2007) 1.23
ATP-dependent conformational dynamics underlie the functional asymmetry of the replicative helicase from a minimalist eukaryote. Proc Natl Acad Sci U S A (2012) 1.21
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Specific detection of methionine 27 mutation in histone 3 variants (H3K27M) in fixed tissue from high-grade astrocytomas. Acta Neuropathol (2014) 1.15
Grainyhead and Zelda compete for binding to the promoters of the earliest-expressed Drosophila genes. Dev Biol (2010) 1.11
Characterization of simian virus 40 T-antigen double hexamers bound to a replication fork. The active form of the helicase. J Biol Chem (2002) 1.09
Adenovirus protein VII condenses DNA, represses transcription, and associates with transcriptional activator E1A. J Virol (2004) 0.98
Strategy for "detoxification" of a cancer-derived histone mutant based on mapping its interaction with the methyltransferase PRC2. J Am Chem Soc (2014) 0.98
CDK phosphorylation inhibits the DNA-binding and ATP-hydrolysis activities of the Drosophila origin recognition complex. J Biol Chem (2005) 0.97
Checkpoint kinase 2 (Chk2) inhibits the activity of the Cdc45/MCM2-7/GINS (CMG) replicative helicase complex. Proc Natl Acad Sci U S A (2012) 0.93
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