Published in Proc Natl Acad Sci U S A on August 21, 2007
Discovering small molecules that promote cardiomyocyte generation by modulating Wnt signaling. Chem Biol (2011) 1.52
Ndrg4 is required for normal myocyte proliferation during early cardiac development in zebrafish. Dev Biol (2008) 1.35
Fishing for the genetic basis of cardiovascular disease. Dis Model Mech (2009) 1.16
Zebrafish models in cardiac development and congenital heart birth defects. Differentiation (2012) 1.07
Fli+ etsrp+ hemato-vascular progenitor cells proliferate at the lateral plate mesoderm during vasculogenesis in zebrafish. PLoS One (2011) 0.81
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Gridlock signalling pathway fashions the first embryonic artery. Nature (2001) 3.30
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Gata5 is required for the development of the heart and endoderm in zebrafish. Genes Dev (1999) 2.95
gridlock, an HLH gene required for assembly of the aorta in zebrafish. Science (2000) 2.90
High-throughput assay for small molecules that modulate zebrafish embryonic heart rate. Nat Chem Biol (2005) 2.64
Chemical suppression of a genetic mutation in a zebrafish model of aortic coarctation. Nat Biotechnol (2004) 2.57
Morphogenesis of the right ventricle requires myocardial expression of Gata4. J Clin Invest (2005) 2.50
Genetic dissection of cardiac growth control pathways. Annu Rev Physiol (2000) 2.41
A threshold of GATA4 and GATA6 expression is required for cardiovascular development. Proc Natl Acad Sci U S A (2006) 2.32
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A decade of discoveries in cardiac biology. Nat Med (2004) 2.22
Hey genes: a novel subfamily of hairy- and Enhancer of split related genes specifically expressed during mouse embryogenesis. Mech Dev (1999) 2.13
GATA4 is a dosage-sensitive regulator of cardiac morphogenesis. Dev Biol (2004) 2.13
Members of the HRT family of basic helix-loop-helix proteins act as transcriptional repressors downstream of Notch signaling. Proc Natl Acad Sci U S A (2000) 2.05
Ventricular septal defect and cardiomyopathy in mice lacking the transcription factor CHF1/Hey2. Proc Natl Acad Sci U S A (2002) 2.04
Reptin and pontin antagonistically regulate heart growth in zebrafish embryos. Cell (2002) 2.03
Cardiomyopathy in zebrafish due to mutation in an alternatively spliced exon of titin. Nat Genet (2002) 1.99
Tetralogy of fallot and other congenital heart defects in Hey2 mutant mice. Curr Biol (2002) 1.85
Mouse gridlock: no aortic coarctation or deficiency, but fatal cardiac defects in Hey2 -/- mice. Curr Biol (2002) 1.70
Developmental patterning of the cardiac atrioventricular canal by Notch and Hairy-related transcription factors. Development (2006) 1.67
The roles of GATA-4, -5 and -6 in vertebrate heart development. Semin Cell Dev Biol (2004) 1.53
Methods for reverse genetic screening in zebrafish by resequencing and TILLING. Methods (2006) 1.53
Cardiovascular basic helix loop helix factor 1, a novel transcriptional repressor expressed preferentially in the developing and adult cardiovascular system. J Biol Chem (2000) 1.49
Hey basic helix-loop-helix transcription factors are repressors of GATA4 and GATA6 and restrict expression of the GATA target gene ANF in fetal hearts. Mol Cell Biol (2005) 1.46
Essential roles of the bHLH transcription factor Hrt2 in repression of atrial gene expression and maintenance of postnatal cardiac function. Proc Natl Acad Sci U S A (2007) 1.42
Identification and expression of a novel family of bHLH cDNAs related to Drosophila hairy and enhancer of split. Biochem Biophys Res Commun (1999) 1.38
Hesr1 and Hesr2 regulate atrioventricular boundary formation in the developing heart through the repression of Tbx2. Development (2007) 1.33
Hairy-related transcription factors inhibit GATA-dependent cardiac gene expression through a signal-responsive mechanism. J Biol Chem (2004) 1.24
Targeted disruption of hesr2 results in atrioventricular valve anomalies that lead to heart dysfunction. Circ Res (2004) 1.16
Hand2 regulates epithelial formation during myocardial diferentiation. Curr Biol (2005) 1.12
Zebrafish genetics and formation of embryonic vasculature. Curr Top Dev Biol (2005) 0.96
Characterization of hey bHLH genes in teleost fish. Dev Genes Evol (2003) 0.95
Zebrafish apoptosis assays for drug discovery. Methods Cell Biol (2004) 0.87
Serum response factor regulates a muscle-specific microRNA that targets Hand2 during cardiogenesis. Nature (2005) 17.17
Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors. Cell (2010) 15.58
Dysregulation of cardiogenesis, cardiac conduction, and cell cycle in mice lacking miRNA-1-2. Cell (2007) 12.72
miR-145 and miR-143 regulate smooth muscle cell fate and plasticity. Nature (2009) 10.26
In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes. Nature (2012) 7.80
miR-126 regulates angiogenic signaling and vascular integrity. Dev Cell (2008) 6.59
GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5. Nature (2003) 6.40
Mutations in NOTCH1 cause aortic valve disease. Nature (2005) 6.27
A dynamic pathway for calcium-independent activation of CaMKII by methionine oxidation. Cell (2008) 6.16
Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair. Nature (2004) 4.97
A developmental view of microRNA function. Trends Biochem Sci (2007) 4.75
MicroRNA regulation of cell lineages in mouse and human embryonic stem cells. Cell Stem Cell (2008) 4.70
Dynamic and coordinated epigenetic regulation of developmental transitions in the cardiac lineage. Cell (2012) 4.22
Cardiac fibroblasts regulate myocardial proliferation through beta1 integrin signaling. Dev Cell (2009) 4.21
MicroRNA1 influences cardiac differentiation in Drosophila and regulates Notch signaling. Proc Natl Acad Sci U S A (2005) 3.78
The Hand1 and Hand2 transcription factors regulate expansion of the embryonic cardiac ventricles in a gene dosage-dependent manner. Development (2004) 2.61
Chemical suppression of a genetic mutation in a zebrafish model of aortic coarctation. Nat Biotechnol (2004) 2.57
MicroRNAs as regulators of differentiation and cell fate decisions. Cell Stem Cell (2010) 2.57
Canonical Wnt signaling is a positive regulator of mammalian cardiac progenitors. Proc Natl Acad Sci U S A (2007) 2.56
The antiproliferative action of progesterone in uterine epithelium is mediated by Hand2. Science (2011) 2.46
MicroRNA regulation of cardiovascular development. Circ Res (2009) 2.42
Bop encodes a muscle-restricted protein containing MYND and SET domains and is essential for cardiac differentiation and morphogenesis. Nat Genet (2002) 2.27
miR-24 inhibits apoptosis and represses Bim in mouse cardiomyocytes. J Exp Med (2011) 2.24
The homeodomain transcription factor Irx5 establishes the mouse cardiac ventricular repolarization gradient. Cell (2005) 2.19
Direct reprogramming of human fibroblasts toward a cardiomyocyte-like state. Stem Cell Reports (2013) 2.05
Tbx1 is regulated by tissue-specific forkhead proteins through a common Sonic hedgehog-responsive enhancer. Genes Dev (2003) 2.01
Cardiomyopathy in zebrafish due to mutation in an alternatively spliced exon of titin. Nat Genet (2002) 1.99
Calmodulin kinase II is required for fight or flight sinoatrial node physiology. Proc Natl Acad Sci U S A (2009) 1.95
Genetics of human cardiovascular disease. Cell (2012) 1.90
Thymosin beta4 mediated PKC activation is essential to initiate the embryonic coronary developmental program and epicardial progenitor cell activation in adult mice in vivo. J Mol Cell Cardiol (2009) 1.88
Death, cardiac dysfunction, and arrhythmias are increased by calmodulin kinase II in calcineurin cardiomyopathy. Circulation (2006) 1.85
microRNA-138 modulates cardiac patterning during embryonic development. Proc Natl Acad Sci U S A (2008) 1.80
Tbx1 regulates fibroblast growth factors in the anterior heart field through a reinforcing autoregulatory loop involving forkhead transcription factors. Development (2004) 1.75
Oxidation of CaMKII determines the cardiotoxic effects of aldosterone. Nat Med (2011) 1.74
A regulatory pathway involving Notch1/beta-catenin/Isl1 determines cardiac progenitor cell fate. Nat Cell Biol (2009) 1.73
Spectrum of heart disease associated with murine and human GATA4 mutation. J Mol Cell Cardiol (2007) 1.71
Stromal cell-derived factor-1alpha is cardioprotective after myocardial infarction. Circulation (2008) 1.68
Developmental patterning of the cardiac atrioventricular canal by Notch and Hairy-related transcription factors. Development (2006) 1.67
Notch post-translationally regulates β-catenin protein in stem and progenitor cells. Nat Cell Biol (2011) 1.66
A resource for the conditional ablation of microRNAs in the mouse. Cell Rep (2012) 1.66
Chromosomal haplotypes by genetic phasing of human families. Am J Hum Genet (2011) 1.58
MicroRNAs: opening a new vein in angiogenesis research. Sci Signal (2009) 1.58
Ca2+/calmodulin-dependent kinase II triggers cell membrane injury by inducing complement factor B gene expression in the mouse heart. J Clin Invest (2009) 1.56
MicroRNA-10 regulates the angiogenic behavior of zebrafish and human endothelial cells by promoting vascular endothelial growth factor signaling. Circ Res (2012) 1.56
Pbx1/Pbx2 requirement for distal limb patterning is mediated by the hierarchical control of Hox gene spatial distribution and Shh expression. Development (2006) 1.56
Diabetes increases mortality after myocardial infarction by oxidizing CaMKII. J Clin Invest (2013) 1.53
Discovering small molecules that promote cardiomyocyte generation by modulating Wnt signaling. Chem Biol (2011) 1.52
Green fluorescent protein expression in germ-line transmitted transgenic zebrafish under a stratified epithelial promoter from keratin8. Dev Dyn (2002) 1.50
Cooperative and antagonistic interactions between Sall4 and Tbx5 pattern the mouse limb and heart. Nat Genet (2005) 1.47
Ephrin-B2 reverse signaling is required for axon pathfinding and cardiac valve formation but not early vascular development. Dev Biol (2004) 1.47
Subepicardial endothelial cells invade the embryonic ventricle wall to form coronary arteries. Cell Res (2013) 1.46
Elevation of receptor tyrosine kinase EphA2 mediates resistance to trastuzumab therapy. Cancer Res (2009) 1.44
Essential roles of the bHLH transcription factor Hrt2 in repression of atrial gene expression and maintenance of postnatal cardiac function. Proc Natl Acad Sci U S A (2007) 1.42
Serum response factor orchestrates nascent sarcomerogenesis and silences the biomineralization gene program in the heart. Proc Natl Acad Sci U S A (2008) 1.39
Alternative induced pluripotent stem cell characterization criteria for in vitro applications. Cell Stem Cell (2009) 1.36
Derivation conditions impact X-inactivation status in female human induced pluripotent stem cells. Cell Stem Cell (2012) 1.35
Ndrg4 is required for normal myocyte proliferation during early cardiac development in zebrafish. Dev Biol (2008) 1.35
Notch1 represses osteogenic pathways in aortic valve cells. J Mol Cell Cardiol (2009) 1.32
Reprogramming of mouse fibroblasts into cardiomyocyte-like cells in vitro. Nat Protoc (2013) 1.31
A Slit/miR-218/Robo regulatory loop is required during heart tube formation in zebrafish. Development (2011) 1.31
Interaction of Gata4 and Gata6 with Tbx5 is critical for normal cardiac development. Dev Biol (2008) 1.29
Limited gene expression variation in human embryonic stem cell and induced pluripotent stem cell-derived endothelial cells. Stem Cells (2013) 1.29
Oxidized Ca(2+)/calmodulin-dependent protein kinase II triggers atrial fibrillation. Circulation (2013) 1.29
Elevated miR-499 levels blunt the cardiac stress response. PLoS One (2011) 1.28
Phosphorylation of angiomotin by Lats1/2 kinases inhibits F-actin binding, cell migration, and angiogenesis. J Biol Chem (2013) 1.27
Hairy-related transcription factors inhibit GATA-dependent cardiac gene expression through a signal-responsive mechanism. J Biol Chem (2004) 1.24
Zebrafish lacking Alzheimer presenilin enhancer 2 (Pen-2) demonstrate excessive p53-dependent apoptosis and neuronal loss. J Neurochem (2006) 1.23
Expression analyses of zebrafish transferrin, ifabp, and elastaseB mRNAs as differentiation markers for the three major endodermal organs: liver, intestine, and exocrine pancreas. Dev Dyn (2004) 1.22
Hypoxic repression of endothelial nitric-oxide synthase transcription is coupled with eviction of promoter histones. J Biol Chem (2009) 1.20
The paradoxical patent ductus arteriosus. J Clin Invest (2006) 1.18
microRNA-1 regulates sarcomere formation and suppresses smooth muscle gene expression in the mammalian heart. Elife (2013) 1.18
Endotoxin-induced cardiomyopathy and systemic inflammation in mice is prevented by aldose reductase inhibition. Circulation (2006) 1.17
Homozygous PLCB1 deletion associated with malignant migrating partial seizures in infancy. Epilepsia (2012) 1.17
Unraveling the genetic and developmental mysteries of 22q11 deletion syndrome. Trends Mol Med (2003) 1.16
I(f) and SR Ca(2+) release both contribute to pacemaker activity in canine sinoatrial node cells. J Mol Cell Cardiol (2010) 1.14
Voltage-gated sodium channels are required for heart development in zebrafish. Circ Res (2010) 1.14
Screening and biochemical analysis of GATA4 sequence variations identified in patients with congenital heart disease. Am J Med Genet A (2007) 1.13
Critical factors for cardiac reprogramming. Circ Res (2012) 1.12
Identification of GATA6 sequence variants in patients with congenital heart defects. Pediatr Res (2010) 1.10
Altered microRNAs in bicuspid aortic valve: a comparison between stenotic and insufficient valves. J Heart Valve Dis (2010) 1.10
Stem cell therapy for cardiac disease. Pediatr Res (2012) 1.10
ST-segment abnormalities and premature complexes are predictors of new-onset atrial fibrillation: the Niigata preventive medicine study. Am Heart J (2006) 1.09
A structural requirement for processing the cardiac K+ channel KCNQ1. J Biol Chem (2004) 1.08
Japanese encephalitis (JE). Part I: clinical profile of 1,282 adult acute cases of four epidemics. J Neurol (2011) 1.07
Hedgehog signaling induces arterial endothelial cell formation by repressing venous cell fate. Dev Biol (2010) 1.07
Wnt/beta-catenin signaling acts at multiple developmental stages to promote mammalian cardiogenesis. Cell Cycle (2008) 1.05
Reporter-based isolation of induced pluripotent stem cell- and embryonic stem cell-derived cardiac progenitors reveals limited gene expression variance. Circ Res (2010) 1.04
Recapitulation of fast skeletal muscle development in zebrafish by transgenic expression of GFP under the mylz2 promoter. Dev Dyn (2003) 1.03
Congenital heart disease-causing Gata4 mutation displays functional deficits in vivo. PLoS Genet (2012) 1.03
The chemokine receptor CXCR7 functions to regulate cardiac valve remodeling. Dev Dyn (2011) 1.03
Direct cardiac reprogramming: from developmental biology to cardiac regeneration. Circ Res (2013) 1.02
MicroRNAs in cardiac development. Pediatr Cardiol (2010) 1.01
Demonstration of site-directed recombination in transgenic zebrafish using the Cre/loxP system. Transgenic Res (2005) 1.01
Hrt and Hes negatively regulate Notch signaling through interactions with RBP-Jkappa. Biochem Biophys Res Commun (2006) 1.01