Published in Pediatr Cardiol on January 31, 2009
Inhibition of notch1-dependent cardiomyogenesis leads to a dilated myopathy in the neonatal heart. Circ Res (2010) 1.06
Jagged1 (JAG1) mutations in patients with tetralogy of Fallot or pulmonic stenosis. Hum Mutat (2010) 1.05
Atrioventricular valve development: new perspectives on an old theme. Differentiation (2012) 0.98
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Application of gene network analysis techniques identifies AXIN1/PDIA2 and endoglin haplotypes associated with bicuspid aortic valve. PLoS One (2010) 0.96
Endocardial to myocardial notch-wnt-bmp axis regulates early heart valve development. PLoS One (2013) 0.85
Role of Notch signaling in the mammalian heart. Braz J Med Biol Res (2013) 0.85
The intracellular domains of Notch1 and Notch2 are functionally equivalent during development and carcinogenesis. Development (2015) 0.83
Ultra high-resolution gene centric genomic structural analysis of a non-syndromic congenital heart defect, Tetralogy of Fallot. PLoS One (2014) 0.82
Comparative and evolutionary analysis of the HES/HEY gene family reveal exon/intron loss and teleost specific duplication events. PLoS One (2012) 0.80
Timely inhibition of Notch signaling by DAPT promotes cardiac differentiation of murine pluripotent stem cells. PLoS One (2014) 0.79
NOTCH1 regulates matrix gla protein and calcification gene networks in human valve endothelium. J Mol Cell Cardiol (2015) 0.79
NOTCH1 missense alleles associated with left ventricular outflow tract defects exhibit impaired receptor processing and defective EMT. Biochim Biophys Acta (2010) 0.79
Insight into pathologic abnormalities in congenital semilunar valve disease based on advances in understanding normal valve microstructure and extracellular matrix. Cardiovasc Pathol (2011) 0.79
MicroRNA-375 overexpression influences P19 cell proliferation, apoptosis and differentiation through the Notch signaling pathway. Int J Mol Med (2015) 0.77
Enhancement of early cardiac differentiation of dedifferentiated fat cells by dimethyloxalylglycine via notch signaling pathway. Am J Transl Res (2016) 0.75
Notch signaling: cell fate control and signal integration in development. Science (1999) 28.83
A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain. Nature (1999) 10.36
Echocardiographic and pathoanatomical characteristics of isolated left ventricular non-compaction: a step towards classification as a distinct cardiomyopathy. Heart (2001) 7.87
Notch signaling is essential for vascular morphogenesis in mice. Genes Dev (2000) 6.88
Mutations in NOTCH1 cause aortic valve disease. Nature (2005) 6.27
A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1. Mol Cell (2000) 5.56
Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation. Genes Dev (2003) 4.89
The role of Notch in tumorigenesis: oncogene or tumour suppressor? Nat Rev Cancer (2003) 4.75
The Notch target genes Hey1 and Hey2 are required for embryonic vascular development. Genes Dev (2004) 4.41
Fringe is a glycosyltransferase that modifies Notch. Nature (2000) 4.09
Molecular interactions between the protein products of the neurogenic loci Notch and Delta, two EGF-homologous genes in Drosophila. Cell (1990) 4.07
Notch1 is essential for postimplantation development in mice. Genes Dev (1994) 4.06
The Notch1 receptor is cleaved constitutively by a furin-like convertase. Proc Natl Acad Sci U S A (1998) 3.99
Notch4/int-3, a mammary proto-oncogene, is an endothelial cell-specific mammalian Notch gene. Development (1996) 3.84
MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors. Nat Genet (2000) 3.82
NF-kappa B and related proteins: Rel/dorsal homologies meet ankyrin-like repeats. Trends Biochem Sci (1992) 3.81
NOTCH2 mutations cause Alagille syndrome, a heterogeneous disorder of the notch signaling pathway. Am J Hum Genet (2006) 3.55
Glycosyltransferase activity of Fringe modulates Notch-Delta interactions. Nature (2000) 3.51
Jagged: a mammalian ligand that activates Notch1. Cell (1995) 3.51
Physical interaction between a novel domain of the receptor Notch and the transcription factor RBP-J kappa/Su(H). Curr Biol (1995) 3.46
Disruption of the mouse RBP-J kappa gene results in early embryonic death. Development (1995) 3.30
Notch signaling in development and cancer. Endocr Rev (2007) 3.22
A mouse model of Alagille syndrome: Notch2 as a genetic modifier of Jag1 haploinsufficiency. Development (2002) 2.88
Left ventricular hypertrabeculation/noncompaction and association with additional cardiac abnormalities and neuromuscular disorders. Am J Cardiol (2002) 2.84
Notch signaling is essential for ventricular chamber development. Dev Cell (2007) 2.53
Modulation of cardiac growth and development by HOP, an unusual homeodomain protein. Cell (2002) 2.53
Hop is an unusual homeobox gene that modulates cardiac development. Cell (2002) 2.52
BMP10 is essential for maintaining cardiac growth during murine cardiogenesis. Development (2004) 2.50
Fringe modulates Notch-ligand interactions. Nature (1997) 2.44
Neuregulins promote survival and growth of cardiac myocytes. Persistence of ErbB2 and ErbB4 expression in neonatal and adult ventricular myocytes. J Biol Chem (1998) 2.42
Functional interaction between the mouse notch1 intracellular region and histone acetyltransferases PCAF and GCN5. J Biol Chem (2000) 2.38
Defects in development of the kidney, heart and eye vasculature in mice homozygous for a hypomorphic Notch2 mutation. Development (2001) 2.37
Genetic and cellular analyses of zebrafish atrioventricular cushion and valve development. Development (2005) 2.32
Notch2: a second mammalian Notch gene. Development (1992) 2.28
HRT1, HRT2, and HRT3: a new subclass of bHLH transcription factors marking specific cardiac, somitic, and pharyngeal arch segments. Dev Biol (1999) 2.27
Invasion of mesenchyme into three-dimensional collagen gels: a regional and temporal analysis of interaction in embryonic heart tissue. Dev Biol (1983) 2.25
Transient and restricted expression during mouse embryogenesis of Dll1, a murine gene closely related to Drosophila Delta. Development (1995) 2.20
Notch signalling and the control of cell fate choices in vertebrates. Semin Cell Dev Biol (1998) 2.17
Multiple functions of Notch signaling in self-renewing organs and cancer. FEBS Lett (2006) 2.14
Combined loss of Hey1 and HeyL causes congenital heart defects because of impaired epithelial to mesenchymal transition. Circ Res (2007) 2.05
Ventricular septal defect and cardiomyopathy in mice lacking the transcription factor CHF1/Hey2. Proc Natl Acad Sci U S A (2002) 2.04
Mouse Dll3: a novel divergent Delta gene which may complement the function of other Delta homologues during early pattern formation in the mouse embryo. Development (1997) 2.03
The novel Notch homologue mouse Notch 3 lacks specific epidermal growth factor-repeats and is expressed in proliferating neuroepithelium. Mech Dev (1994) 2.02
Notch1b and neuregulin are required for specification of central cardiac conduction tissue. Development (2006) 2.00
Expression pattern of Motch, a mouse homolog of Drosophila Notch, suggests an important role in early postimplantation mouse development. Development (1992) 1.99
Neuregulin-1 promotes formation of the murine cardiac conduction system. Proc Natl Acad Sci U S A (2002) 1.81
Transcriptional repression by suppressor of hairless involves the binding of a hairless-dCtBP complex in Drosophila. Curr Biol (2001) 1.78
Familial Tetralogy of Fallot caused by mutation in the jagged1 gene. Hum Mol Genet (2001) 1.75
Induction of cardiogenesis in embryonic stem cells via downregulation of Notch1 signaling. Circ Res (2006) 1.75
Developmental patterning of the cardiac atrioventricular canal by Notch and Hairy-related transcription factors. Development (2006) 1.67
Regulation of enzyme levels by proteolysis: the role of pest regions. Adv Enzyme Regul (1988) 1.56
Jagged2: a serrate-like gene expressed during rat embryogenesis. Dev Biol (1996) 1.43
Mouse hesr1 and hesr2 genes are redundantly required to mediate Notch signaling in the developing cardiovascular system. Dev Biol (2005) 1.42
Monitoring Notch1 activity in development: evidence for a feedback regulatory loop. Dev Dyn (2007) 1.33
Hesr1 and Hesr2 regulate atrioventricular boundary formation in the developing heart through the repression of Tbx2. Development (2007) 1.33
The expression of Jagged1 in the developing mammalian heart correlates with cardiovascular disease in Alagille syndrome. Hum Mol Genet (1999) 1.27
Synergistic roles of neuregulin-1 and insulin-like growth factor-I in activation of the phosphatidylinositol 3-kinase pathway and cardiac chamber morphogenesis. J Biol Chem (1999) 1.26
Activation of Notch1 signaling in cardiogenic mesoderm induces abnormal heart morphogenesis in mouse. Development (2006) 1.19
Targeted disruption of hesr2 results in atrioventricular valve anomalies that lead to heart dysfunction. Circ Res (2004) 1.16
Ventricular trabeculations in the chick embryo heart and their contribution to ventricular and muscular septal development. Circ Res (1985) 1.05
Cardiovascular and hematopoietic defects associated with Notch1 activation in embryonic Tie2-expressing populations. Circ Res (2008) 0.97
Hesr, a mediator of the Notch signaling, functions in heart and vessel development. Trends Cardiovasc Med (2005) 0.93
Notch regulates cell fate in the developing pronephros. Dev Biol (2000) 0.92
Normal stages of cardiac organogenesis in the mouse: II. Development of the internal relief of the heart. Am J Anat (1989) 0.92