Molecular cloning of the human hepatitis C virus genome from Japanese patients with non-A, non-B hepatitis.

PubWeight™: 9.98‹?› | Rank: Top 0.1%

🔗 View Article (PMC 55204)

Published in Proc Natl Acad Sci U S A on December 01, 1990

Authors

N Kato1, M Hijikata, Y Ootsuyama, M Nakagawa, S Ohkoshi, T Sugimura, K Shimotohno

Author Affiliations

1: Virology Division, National Cancer Center Research Institute, Tokyo, Japan.

Articles citing this

(truncated to the top 100)

Internal ribosome entry site within hepatitis C virus RNA. J Virol (1992) 9.14

Expression and identification of hepatitis C virus polyprotein cleavage products. J Virol (1993) 8.47

Gene mapping of the putative structural region of the hepatitis C virus genome by in vitro processing analysis. Proc Natl Acad Sci U S A (1991) 7.15

Characterization of the hepatitis C virus-encoded serine proteinase: determination of proteinase-dependent polyprotein cleavage sites. J Virol (1993) 6.36

Identification and properties of the RNA-dependent RNA polymerase of hepatitis C virus. EMBO J (1996) 5.47

Two distinct proteinase activities required for the processing of a putative nonstructural precursor protein of hepatitis C virus. J Virol (1993) 5.41

Hepatitis C virus-encoded enzymatic activities and conserved RNA elements in the 3' nontranslated region are essential for virus replication in vivo. J Virol (2000) 5.26

Translation of human hepatitis C virus RNA in cultured cells is mediated by an internal ribosome-binding mechanism. J Virol (1993) 5.08

NS3 is a serine protease required for processing of hepatitis C virus polyprotein. J Virol (1993) 4.60

Identification of a highly conserved sequence element at the 3' terminus of hepatitis C virus genome RNA. J Virol (1996) 4.59

Nonstructural protein 3 of the hepatitis C virus encodes a serine-type proteinase required for cleavage at the NS3/4 and NS4/5 junctions. J Virol (1993) 4.57

Control of PKR protein kinase by hepatitis C virus nonstructural 5A protein: molecular mechanisms of kinase regulation. Mol Cell Biol (1998) 4.52

Evidence for immune selection of hepatitis C virus (HCV) putative envelope glycoprotein variants: potential role in chronic HCV infections. Proc Natl Acad Sci U S A (1992) 4.47

Expanded classification of hepatitis C virus into 7 genotypes and 67 subtypes: updated criteria and genotype assignment web resource. Hepatology (2014) 4.15

Efficient generation of recombinant adenoviruses using adenovirus DNA-terminal protein complex and a cosmid bearing the full-length virus genome. Proc Natl Acad Sci U S A (1996) 3.85

Sequence analysis of the 5' noncoding region of hepatitis C virus. Proc Natl Acad Sci U S A (1992) 3.72

Clinical significance of hepatitis C virus genotypes. Clin Microbiol Rev (2000) 3.70

Proteolytic processing and membrane association of putative nonstructural proteins of hepatitis C virus. Proc Natl Acad Sci U S A (1993) 3.68

Processing in the hepatitis C virus E2-NS2 region: identification of p7 and two distinct E2-specific products with different C termini. J Virol (1994) 3.61

Both NS3 and NS4A are required for proteolytic processing of hepatitis C virus nonstructural proteins. J Virol (1994) 3.51

Phosphorylation of hepatitis C virus-encoded nonstructural protein NS5A. J Virol (1995) 3.41

Structure of the 3' terminus of the hepatitis C virus genome. J Virol (1996) 3.40

At least 12 genotypes of hepatitis C virus predicted by sequence analysis of the putative E1 gene of isolates collected worldwide. Proc Natl Acad Sci U S A (1993) 3.37

Kinetic and structural analyses of hepatitis C virus polyprotein processing. J Virol (1994) 3.35

Detection of hepatitis C virus RNA by a combined reverse transcription-polymerase chain reaction assay. J Clin Microbiol (1993) 3.34

Genomic structure of the human prototype strain H of hepatitis C virus: comparison with American and Japanese isolates. Proc Natl Acad Sci U S A (1991) 3.34

An RNA pseudoknot is an essential structural element of the internal ribosome entry site located within the hepatitis C virus 5' noncoding region. RNA (1995) 3.30

Biosynthesis and biochemical properties of the hepatitis C virus core protein. J Virol (1994) 3.19

Comparison of full-length sequences of interferon-sensitive and resistant hepatitis C virus 1b. Sensitivity to interferon is conferred by amino acid substitutions in the NS5A region. J Clin Invest (1995) 3.19

Sequence analysis of the core gene of 14 hepatitis C virus genotypes. Proc Natl Acad Sci U S A (1994) 2.83

New hepatitis C virus (HCV) genotyping system that allows for identification of HCV genotypes 1a, 1b, 2a, 2b, 3a, 3b, 4, 5a, and 6a. J Clin Microbiol (1997) 2.78

Cross-reactivity between hepatitis C virus and Influenza A virus determinant-specific cytotoxic T cells. J Virol (2001) 2.77

Hepatitis C virus-encoded nonstructural protein NS4A has versatile functions in viral protein processing. J Virol (1995) 2.76

Humoral immune response to hypervariable region 1 of the putative envelope glycoprotein (gp70) of hepatitis C virus. J Virol (1993) 2.74

Hepatitis C virus structural proteins assemble into viruslike particles in insect cells. J Virol (1998) 2.71

De novo initiation of RNA synthesis by the RNA-dependent RNA polymerase (NS5B) of hepatitis C virus. J Virol (2000) 2.65

Hepatitis C virus NS3 serine proteinase: trans-cleavage requirements and processing kinetics. J Virol (1994) 2.64

Translational control of viral gene expression in eukaryotes. Microbiol Mol Biol Rev (2000) 2.63

Interaction of polypyrimidine tract-binding protein with the 5' noncoding region of the hepatitis C virus RNA genome and its functional requirement in internal initiation of translation. J Virol (1995) 2.57

Hepatitis C virus (HCV)-specific cytotoxic T lymphocytes recognize epitopes in the core and envelope proteins of HCV. J Virol (1993) 2.57

At least five related, but distinct, hepatitis C viral genotypes exist. Proc Natl Acad Sci U S A (1992) 2.56

Clinical significance of intrahepatic hepatitis C virus levels in patients with chronic HCV infection. Gut (1998) 2.45

Two hepatitis C virus glycoprotein E2 products with different C termini. J Virol (1994) 2.38

Mapping of serotype-specific, immunodominant epitopes in the NS-4 region of hepatitis C virus (HCV): use of type-specific peptides to serologically differentiate infections with HCV types 1, 2, and 3. J Clin Microbiol (1993) 2.36

A conserved helical element is essential for internal initiation of translation of hepatitis C virus RNA. J Virol (1994) 2.35

The helicase activity associated with hepatitis C virus nonstructural protein 3 (NS3). J Virol (1996) 2.30

Importance of primer selection for the detection of hepatitis C virus RNA with the polymerase chain reaction assay. Proc Natl Acad Sci U S A (1992) 2.30

Determination of the secondary structure of and cellular protein binding to the 3'-untranslated region of the hepatitis C virus RNA genome. J Virol (1997) 2.28

Hepatitis C virus persistence after spontaneous or treatment-induced resolution of hepatitis C. J Virol (2004) 2.27

Diagnosis of hepatitis C virus (HCV) infection using an immunodominant chimeric polyprotein to capture circulating antibodies: reevaluation of the role of HCV in liver disease. Proc Natl Acad Sci U S A (1992) 2.18

Suppression of hepatitis B virus expression and replication by hepatitis C virus core protein in HuH-7 cells. J Virol (1993) 2.16

Heterogeneous nuclear ribonucleoprotein L interacts with the 3' border of the internal ribosomal entry site of hepatitis C virus. J Virol (1998) 2.00

Antiapoptotic and oncogenic potentials of hepatitis C virus are linked to interferon resistance by viral repression of the PKR protein kinase. J Virol (1999) 1.96

The native form and maturation process of hepatitis C virus core protein. J Virol (1998) 1.91

Conservation of the conformation and positive charges of hepatitis C virus E2 envelope glycoprotein hypervariable region 1 points to a role in cell attachment. J Virol (2001) 1.90

Hepatitis C virus nonstructural protein NS3 transforms NIH 3T3 cells. J Virol (1995) 1.87

5' and 3' untranslated regions of pestivirus genome: primary and secondary structure analyses. Nucleic Acids Res (1993) 1.86

Hepatitis C virus core protein interacts with the cytoplasmic tail of lymphotoxin-beta receptor. J Virol (1997) 1.84

Classification of hepatitis C viruses based on phylogenetic analysis of the envelope 1 and nonstructural 5B regions and identification of five additional subtypes. Proc Natl Acad Sci U S A (1994) 1.82

Correlation between the infectivity of hepatitis C virus in vivo and its infectivity in vitro. Proc Natl Acad Sci U S A (1993) 1.78

An amino-terminal domain of the hepatitis C virus NS3 protease is essential for interaction with NS4A. J Virol (1995) 1.78

Mutational analysis of the hepatitis C virus RNA helicase. J Virol (1997) 1.77

Hyperphosphorylation of the hepatitis C virus NS5A protein requires an active NS3 protease, NS4A, NS4B, and NS5A encoded on the same polyprotein. J Virol (1999) 1.75

Transfection of a differentiated human hepatoma cell line (Huh7) with in vitro-transcribed hepatitis C virus (HCV) RNA and establishment of a long-term culture persistently infected with HCV. J Virol (1995) 1.70

An epitope in hepatitis C virus core region recognized by cytotoxic T cells in mice and humans. J Virol (1994) 1.68

Expression of processed envelope protein of hepatitis C virus in mammalian and insect cells. J Virol (1992) 1.68

Interaction of hepatitis C virus core protein with viral sense RNA and suppression of its translation. J Virol (1999) 1.63

Hepatitis C virus core protein interacts with cellular putative RNA helicase. J Virol (1999) 1.63

Regulated processing of hepatitis C virus core protein is linked to subcellular localization. J Virol (1997) 1.63

Nonstructural protein precursor NS4A/B from hepatitis C virus alters function and ultrastructure of host secretory apparatus. J Virol (2003) 1.62

Specific interaction of polypyrimidine tract-binding protein with the extreme 3'-terminal structure of the hepatitis C virus genome, the 3'X. J Virol (1997) 1.61

The NS2 protein of hepatitis C virus is a transmembrane polypeptide. J Virol (1995) 1.61

Self-assembly of nucleocapsid-like particles from recombinant hepatitis C virus core protein. J Virol (2001) 1.59

Interferon resistance of hepatitis C virus genotype 1b: relationship to nonstructural 5A gene quasispecies mutations. J Virol (1998) 1.59

Participation of rab5, an early endosome protein, in hepatitis C virus RNA replication machinery. J Virol (2007) 1.58

Molecular model of the specificity pocket of the hepatitis C virus protease: implications for substrate recognition. Proc Natl Acad Sci U S A (1994) 1.57

Genetic drift in hypervariable region 1 of the viral genome in persistent hepatitis C virus infection. J Virol (1994) 1.57

Detection of intrahepatic replication of hepatitis C virus RNA by in situ hybridization and comparison with histopathology. Proc Natl Acad Sci U S A (1992) 1.56

Multiple enzymatic activities associated with recombinant NS3 protein of hepatitis C virus. J Virol (1998) 1.54

Cell fusion activity of hepatitis C virus envelope proteins. J Virol (2000) 1.50

Hepatitis C virus-encoded NS2-3 protease: cleavage-site mutagenesis and requirements for bimolecular cleavage. J Virol (1995) 1.49

Hepatitis C virus hijacks P-body and stress granule components around lipid droplets. J Virol (2011) 1.47

A cellular RNA-binding protein enhances internal ribosomal entry site-dependent translation through an interaction downstream of the hepatitis C virus polyprotein initiation codon. Mol Cell Biol (2004) 1.46

Analysis of N-terminal processing of hepatitis C virus nonstructural protein 2. J Virol (1994) 1.45

The N-terminal region of hepatitis C virus-encoded NS5A is important for NS4A-dependent phosphorylation. J Virol (1997) 1.45

Intramembrane proteolysis and endoplasmic reticulum retention of hepatitis C virus core protein. J Virol (2004) 1.40

Hepatitis C: progress and problems. Clin Microbiol Rev (1994) 1.37

Modulation of retinoid signaling by a cytoplasmic viral protein via sequestration of Sp110b, a potent transcriptional corepressor of retinoic acid receptor, from the nucleus. Mol Cell Biol (2003) 1.37

Serodiagnosis of hepatitis C virus (HCV) infection with an HCV core protein molecularly expressed by a recombinant baculovirus. Proc Natl Acad Sci U S A (1991) 1.36

Induced oxidative stress and activated expression of manganese superoxide dismutase during hepatitis C virus replication: role of JNK, p38 MAPK and AP-1. Biochem J (2004) 1.36

LKM-1 autoantibodies recognize a short linear sequence in P450IID6, a cytochrome P-450 monooxygenase. J Clin Invest (1991) 1.34

A long-range RNA-RNA interaction between the 5' and 3' ends of the HCV genome. RNA (2009) 1.34

Prospective characterization of full-length hepatitis C virus NS5A quasispecies during induction and combination antiviral therapy. J Virol (2000) 1.32

Activity of purified hepatitis C virus protease NS3 on peptide substrates. J Virol (1996) 1.32

Interleukin-1 inhibits hepatitis C virus subgenomic RNA replication by activation of extracellular regulated kinase pathway. J Virol (2003) 1.31

Substrate determinants for cleavage in cis and in trans by the hepatitis C virus NS3 proteinase. J Virol (1995) 1.31

Identification of the sequence on NS4A required for enhanced cleavage of the NS5A/5B site by hepatitis C virus NS3 protease. J Virol (1996) 1.31

Group specific sequences and conserved secondary structures at the 3' end of HCV genome and its implication for viral replication. Nucleic Acids Res (1992) 1.31

Sequence analysis of the 5' untranslated region in isolates of at least four genotypes of hepatitis C virus in The Netherlands. J Clin Microbiol (1994) 1.30

Inhibition of hepatitis C virus-like particle binding to target cells by antiviral antibodies in acute and chronic hepatitis C. J Virol (2004) 1.29

Articles cited by this

Screening lambdagt recombinant clones by hybridization to single plaques in situ. Science (1977) 83.82

A simple and very efficient method for generating cDNA libraries. Gene (1983) 55.36

Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome. Science (1989) 37.89

An assay for circulating antibodies to a major etiologic virus of human non-A, non-B hepatitis. Science (1989) 18.79

Identification of four conserved motifs among the RNA-dependent polymerase encoding elements. EMBO J (1989) 10.84

Hepatitis C virus shares amino acid sequence similarity with pestiviruses and flaviviruses as well as members of two plant virus supergroups. Proc Natl Acad Sci U S A (1990) 8.92

Nucleotide sequence of yellow fever virus: implications for flavivirus gene expression and evolution. Science (1985) 8.54

Complete nucleotide sequence of the attenuated poliovirus Sabin 1 strain genome. Proc Natl Acad Sci U S A (1982) 6.09

Molecular cloning and nucleotide sequence of the pestivirus bovine viral diarrhea virus. Virology (1988) 5.92

The 5'-terminal sequence of the hepatitis C virus genome. Jpn J Exp Med (1990) 5.46

Molecular cloning and nucleotide sequence of the genome of hog cholera virus. Virology (1989) 5.29

A cDNA fragment of hepatitis C virus isolated from an implicated donor of post-transfusion non-A, non-B hepatitis in Japan. Nucleic Acids Res (1989) 4.29

Nucleotide and complete amino acid sequences of Kunjin virus: definitive gene order and characteristics of the virus-specified proteins. J Gen Virol (1988) 4.09

Complete nucleotide sequence of the Japanese encephalitis virus genome RNA. Virology (1987) 3.96

The nucleotide sequence of dengue type 4 virus: analysis of genes coding for nonstructural proteins. Virology (1987) 3.51

Prevalence of antibodies to hepatitis C virus in Italian patients with hepatocellular carcinoma. Lancet (1989) 3.42

Prevalence of antibodies to hepatitis C virus in Spanish patients with hepatocellular carcinoma and hepatic cirrhosis. Lancet (1989) 2.94

Nucleotide sequence of core and envelope genes of the hepatitis C virus genome derived directly from human healthy carriers. Nucleic Acids Res (1990) 2.76

Primary structure of the West Nile flavivirus genome region coding for all nonstructural proteins. Virology (1986) 2.75

Non-A, non-B hepatitis. I. Recognition, epidemiology, and clinical features. Gastroenterology (1983) 2.56

Detection of mRNA for the tax1/rex1 gene of human T-cell leukemia virus type I in fresh peripheral blood mononuclear cells of adult T-cell leukemia patients and viral carriers by using the polymerase chain reaction. Proc Natl Acad Sci U S A (1989) 2.49

Hepatitis C viral cDNA clones isolated from a healthy carrier donor implicated in post-transfusion non-A, non-B hepatitis. Gene (1990) 2.12

A cDNA clone closely associated with non-A, non-B hepatitis. Nucleic Acids Res (1990) 1.76

Prevalence of antibody against non-A, non-B hepatitis virus in Japanese patients with hepatocellular carcinoma. Jpn J Cancer Res (1990) 1.43

Increasing incidence of hepatocellular carcinoma possibly associated with non-A, non-B hepatitis in Japan, disclosed by hepatitis B virus DNA analysis of surgically resected cases. Cancer Res (1988) 1.36

Detection of hepatitis C virus RNA in sera and liver tissues of non-A, non-B hepatitis patients using the polymerase chain reaction. Jpn J Cancer Res (1990) 1.35

Articles by these authors

Long-term consequences of Kawasaki disease. A 10- to 21-year follow-up study of 594 patients. Circulation (1996) 7.29

Gene mapping of the putative structural region of the hepatitis C virus genome by in vitro processing analysis. Proc Natl Acad Sci U S A (1991) 7.15

Comprehensive analysis of microRNA expression patterns in hepatocellular carcinoma and non-tumorous tissues. Oncogene (2006) 6.61

Sequence of retrovirus provirus resembles that of bacterial transposable elements. Nature (1980) 5.95

Two distinct proteinase activities required for the processing of a putative nonstructural precursor protein of hepatitis C virus. J Virol (1993) 5.41

Silencing of the E-cadherin invasion-suppressor gene by CpG methylation in human carcinomas. Proc Natl Acad Sci U S A (1995) 4.28

Complete nucleotide sequence of an infectious clone of human T-cell leukemia virus type II: an open reading frame for the protease gene. Proc Natl Acad Sci U S A (1985) 4.28

Amplification of c-erbB-2 oncogene in human adenocarcinomas in vivo. Lancet (1986) 3.93

Mitochondrial myopathies. Ann Neurol (1985) 3.81

Formation of infectious progeny virus after insertion of herpes simplex thymidine kinase gene into DNA of an avian retrovirus. Cell (1981) 3.80

Elucidation of the Erwinia uredovora carotenoid biosynthetic pathway by functional analysis of gene products expressed in Escherichia coli. J Bacteriol (1990) 3.78

Mammalian karyopherin alpha 1 beta and alpha 2 beta heterodimers: alpha 1 or alpha 2 subunit binds nuclear localization signal and beta subunit interacts with peptide repeat-containing nucleoporins. Proc Natl Acad Sci U S A (1995) 3.73

Detection of elevated levels of α-synuclein oligomers in CSF from patients with Parkinson disease. Neurology (2010) 3.70

Proteolytic processing and membrane association of putative nonstructural proteins of hepatitis C virus. Proc Natl Acad Sci U S A (1993) 3.68

Requirement of multiple copies of a 21-nucleotide sequence in the U3 regions of human T-cell leukemia virus type I and type II long terminal repeats for trans-acting activation of transcription. Proc Natl Acad Sci U S A (1986) 3.60

Evidence for in vitro replication of hepatitis C virus genome in a human T-cell line. Proc Natl Acad Sci U S A (1992) 3.55

Phosphorylation of hepatitis C virus-encoded nonstructural protein NS5A. J Virol (1995) 3.41

Structure of the 3' terminus of the hepatitis C virus genome. J Virol (1996) 3.40

Identification of the putative transforming protein of the human T-cell leukemia viruses HTLV-I and HTLV-II. Science (1984) 3.39

Role of IQGAP1, a target of the small GTPases Cdc42 and Rac1, in regulation of E-cadherin- mediated cell-cell adhesion. Science (1998) 3.39

A simple and rapid method for generating a deletion by PCR. Nucleic Acids Res (1991) 3.20

Hypervariable regions in the putative glycoprotein of hepatitis C virus. Biochem Biophys Res Commun (1991) 3.09

Neutralizing antibodies against hepatitis C virus and the emergence of neutralization escape mutant viruses. J Virol (1994) 3.06

cDNA sequence of human transforming gene hst and identification of the coding sequence required for transforming activity. Proc Natl Acad Sci U S A (1987) 2.97

Production of two phosphoproteins from the NS5A region of the hepatitis C viral genome. Biochem Biophys Res Commun (1994) 2.89

Hepatitis C virus-encoded nonstructural protein NS4A has versatile functions in viral protein processing. J Virol (1995) 2.76

Humoral immune response to hypervariable region 1 of the putative envelope glycoprotein (gp70) of hepatitis C virus. J Virol (1993) 2.74

Structural analysis of cDNA for rat peroxisomal 3-ketoacyl-CoA thiolase. J Biol Chem (1987) 2.72

Amino-terminal presequence of the precursor of peroxisomal 3-ketoacyl-CoA thiolase is a cleavable signal peptide for peroxisomal targeting. Biochem Biophys Res Commun (1991) 2.71

Nucleotide sequence analysis of the long terminal repeat of human T-cell leukemia virus type II. Proc Natl Acad Sci U S A (1984) 2.67

C-myc transcript is induced in rat liver at a very early stage of regeneration or by cycloheximide treatment. Nature (1984) 2.63

A novel sequence found at the 3' terminus of hepatitis C virus genome. Biochem Biophys Res Commun (1995) 2.58

Molecular cloning of hepatitis C virus genome from a single Japanese carrier: sequence variation within the same individual and among infected individuals. Virus Res (1992) 2.56

miR-145 and miR-133a function as tumour suppressors and directly regulate FSCN1 expression in bladder cancer. Br J Cancer (2010) 2.51

Complete nucleotide sequence of cDNA and predicted amino acid sequence of rat acyl-CoA oxidase. J Biol Chem (1987) 2.51

Loss of heterozygosity on chromosomes 3, 13, and 17 in small-cell carcinoma and on chromosome 3 in adenocarcinoma of the lung. Proc Natl Acad Sci U S A (1987) 2.50

Detection of mRNA for the tax1/rex1 gene of human T-cell leukemia virus type I in fresh peripheral blood mononuclear cells of adult T-cell leukemia patients and viral carriers by using the polymerase chain reaction. Proc Natl Acad Sci U S A (1989) 2.49

Importance of 5'-terminal blocking structure to stabilize mRNA in eukaryotic protein synthesis. Proc Natl Acad Sci U S A (1977) 2.45

Loss of intervening sequences in genomic mouse alpha-globin DNA inserted in an infectious retrovirus vector. Nature (1982) 2.38

Two hepatitis C virus glycoprotein E2 products with different C termini. J Virol (1994) 2.38

E-cadherin gene mutations in human gastric carcinoma cell lines. Proc Natl Acad Sci U S A (1994) 2.35

Genomic sequence of hst, a transforming gene encoding a protein homologous to fibroblast growth factors and the int-2-encoded protein. Proc Natl Acad Sci U S A (1987) 2.34

Early pathological changes in the parkinsonian brain demonstrated by diffusion tensor MRI. J Neurol Neurosurg Psychiatry (2004) 2.32

Improvement in Castleman's disease by humanized anti-interleukin-6 receptor antibody therapy. Blood (2000) 2.31

Altered expression of the retinoblastoma (RB) gene in small-cell carcinoma of the lung. Oncogene (1988) 2.29

Tumor promoters block tyrosine-specific phosphorylation of the epidermal growth factor receptor. Proc Natl Acad Sci U S A (1984) 2.28

HRT1, HRT2, and HRT3: a new subclass of bHLH transcription factors marking specific cardiac, somitic, and pharyngeal arch segments. Dev Biol (1999) 2.27

The tumour-suppressive function of miR-1 and miR-133a targeting TAGLN2 in bladder cancer. Br J Cancer (2011) 2.25

Human ret proto-oncogene mapped to chromosome 10q11.2. Oncogene (1989) 2.17

Cardiac involvement in mitochondrial diseases. A study on 17 patients with documented mitochondrial DNA defects. Circulation (1995) 2.15

Reevaluation of the thyroidal radioactive iodine uptake test, with special reference to reversible primary hypothyroidism with elevated thyroid radioiodine uptake. J Clin Endocrinol Metab (1988) 2.15

Complete nucleotide sequence of cDNA and deduced amino acid sequence of rat liver catalase. Proc Natl Acad Sci U S A (1986) 2.15

Markedly increased amounts of messenger RNAs for vascular endothelial growth factor and placenta growth factor in renal cell carcinoma associated with angiogenesis. Cancer Res (1994) 2.13

Molecular cloning and nucleotide sequence of the cDNA for rat peroxisomal enoyl-CoA: hydratase-3-hydroxyacyl-CoA dehydrogenase bifunctional enzyme. J Biol Chem (1985) 2.12

Diastolic paradoxic jet flow in patients with hypertrophic cardiomyopathy: evidence of concealed apical asynergy with cavity obliteration. J Am Coll Cardiol (1992) 2.12

Nucleotide sequence of the 3' region of an infectious human T-cell leukemia virus type II genome. Proc Natl Acad Sci U S A (1984) 2.10

Ultrafast time domain demonstration of bulk magnetization precession at zero magnetic field ferromagnetic resonance induced by terahertz magnetic field. Opt Express (2010) 2.07

The concept of Tenju-gann, or "natural-end cancer". Cancer (1998) 2.07

Members of the HRT family of basic helix-loop-helix proteins act as transcriptional repressors downstream of Notch signaling. Proc Natl Acad Sci U S A (2000) 2.05

A new colon and mammary carcinogen in cooked food, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Carcinogenesis (1991) 2.04

WT1 as a new prognostic factor and a new marker for the detection of minimal residual disease in acute leukemia. Blood (1994) 2.03

Genetic alterations of the c-erbB-2 oncogene occur frequently in tubular adenocarcinoma of the stomach and are often accompanied by amplification of the v-erbA homologue. Oncogene (1988) 1.99

Detection of pX proteins in human T-cell leukemia virus (HTLV)-infected cells by using antibody against peptide deduced from sequences of X-IV DNA of HTLV-I and Xc DNA of HTLV-II proviruses. Gan (1984) 1.99

Transforming activity of human papillomavirus type 16 DNA sequence in a cervical cancer. Proc Natl Acad Sci U S A (1986) 1.99

K-sam, an amplified gene in stomach cancer, is a member of the heparin-binding growth factor receptor genes. Proc Natl Acad Sci U S A (1990) 1.99

The zinc fingers of human poly(ADP-ribose) polymerase are differentially required for the recognition of DNA breaks and nicks and the consequent enzyme activation. Other structures recognize intact DNA. J Biol Chem (1990) 1.97

Molecular cloning and the total nucleotide sequence of the human c-Ha-ras-1 gene activated in a melanoma from a Japanese patient. Proc Natl Acad Sci U S A (1984) 1.95

Okadaic acid, a potent inhibitor of type 1 and type 2A protein phosphatases, activates cdc2/H1 kinase and transiently induces a premature mitosis-like state in BHK21 cells. EMBO J (1990) 1.93

Okadaic acid: an additional non-phorbol-12-tetradecanoate-13-acetate-type tumor promoter. Proc Natl Acad Sci U S A (1988) 1.92

Allele loss on chromosome 16 associated with progression of human hepatocellular carcinoma. Proc Natl Acad Sci U S A (1990) 1.90

A novel phosphodiesterase from cultured tobacco cells. Biochemistry (1976) 1.90

Poly(ADP-ribose) polymerase gene disruption conferred mice resistant to streptozotocin-induced diabetes. Proc Natl Acad Sci U S A (1999) 1.85

Hypomethylation of LINE1 retrotransposon in human hepatocellular carcinomas, but not in surrounding liver cirrhosis. Jpn J Clin Oncol (2000) 1.84

Molecular cloning of an activated human oncogene, homologous to v-raf, from primary stomach cancer. Proc Natl Acad Sci U S A (1985) 1.83

A new type of hepatitis C virus in patients in Thailand. Biochem Biophys Res Commun (1992) 1.82

Prognostic value of tumor-associated macrophage count in human bladder cancer. Int J Urol (2000) 1.81

Phylogenetic subgroups of human T cell lymphotropic virus (HTLV) type I in the tax gene and their association with different risks for HTLV-I-associated myelopathy/tropical spastic paraparesis. J Infect Dis (2000) 1.80

Isolation of cDNAs for DNA-binding proteins which specifically bind to a tax-responsive enhancer element in the long terminal repeat of human T-cell leukemia virus type I. J Virol (1991) 1.80

Rapid disease progression correlates with instability of mutant SOD1 in familial ALS. Neurology (2005) 1.78

Evidence that multiple residues on both the alpha-helices of the class I MHC molecule are simultaneously recognized by the T cell receptor. Cell (1988) 1.77