Published in J Exp Med on June 01, 1993
The qualitative nature of the primary immune response to HIV infection is a prognosticator of disease progression independent of the initial level of plasma viremia. Proc Natl Acad Sci U S A (1997) 2.24
Evidence for rapid disappearance of initially expanded HIV-specific CD8+ T cell clones during primary HIV infection. Proc Natl Acad Sci U S A (1997) 1.99
Breast cancer incidence highest in the range of one species of house mouse, Mus domesticus. Br J Cancer (2000) 1.73
Kinetics of cytokine expression during primary human immunodeficiency virus type 1 infection. Proc Natl Acad Sci U S A (1996) 1.44
Human CD8+ T lymphocyte subsets that express HLA class I-specific inhibitory receptors represent oligoclonally or monoclonally expanded cell populations. Proc Natl Acad Sci U S A (1996) 1.39
Expression of HLA-DR4 and human CD4 transgenes in mice determines the variable region beta-chain T-cell repertoire and mediates an HLA-DR-restricted immune response. Proc Natl Acad Sci U S A (1994) 1.36
Altered IL-7Ralpha expression with aging and the potential implications of IL-7 therapy on CD8+ T-cell immune responses. Blood (2005) 1.28
Analysis of the T-cell receptor beta-chain variable-region (V beta) repertoire in monozygotic twins discordant for human immunodeficiency virus: evidence for perturbations of specific V beta segments in CD4+ T cells of the virus-positive twins. Proc Natl Acad Sci U S A (1994) 1.07
Oligoclonal expansion of circulating and tissue-infiltrating CD8+ T cells with killer/effector phenotypes in juvenile dermatomyositis syndrome. Clin Exp Immunol (2004) 0.95
Human immunodeficiency virus 1 reservoir in CD4+ T cells is restricted to certain V beta subsets. Proc Natl Acad Sci U S A (1995) 0.84
TCR binding differs for a bacterial superantigen (SEE) and a viral superantigen (Mtv-9). J Exp Med (1996) 0.83
Paracrine transfer of mouse mammary tumor virus superantigen. J Exp Med (1997) 0.81
Rat T cell response to superantigens. I. V beta-restricted clonal deletion of rat T cells differentiating in rat-->mouse chimeras. J Exp Med (1994) 0.81
Highly biased CDR3 usage in restricted sets of beta chain variable regions during viral superantigen 9 response. J Exp Med (1998) 0.80
Biased T-cell antigen receptor repertoire in Lyme arthritis. Infect Immun (1998) 0.77
Alternative proteolytic processing of mouse mammary tumor virus superantigens. J Virol (2000) 0.77
Functional analysis of the env open reading frame in human endogenous retrovirus IDDMK(1,2)22 encoding superantigen activity. J Virol (2000) 0.75
A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology (1973) 127.36
The staphylococcal enterotoxins and their relatives. Science (1990) 11.99
A human beta-actin expression vector system directs high-level accumulation of antisense transcripts. Proc Natl Acad Sci U S A (1987) 6.36
Superantigens: mechanism of T-cell stimulation and role in immune responses. Annu Rev Immunol (1991) 5.71
V beta-specific stimulation of human T cells by staphylococcal toxins. Science (1989) 5.34
Structure, organization and polymorphism of murine and human T-cell receptor alpha and beta chain gene families. Immunol Rev (1988) 4.23
Evidence for the effects of a superantigen in rheumatoid arthritis. Science (1991) 3.71
A superantigen encoded in the open reading frame of the 3' long terminal repeat of mouse mammary tumour virus. Nature (1991) 3.47
Linkage of Mls genes to endogenous mammary tumour viruses of inbred mice. Nature (1991) 3.07
A maternally inherited superantigen encoded by a mammary tumour virus. Nature (1991) 2.92
Immunogenetic and biological aspects of in vitro lymphocyte allotransformation (MLR) in the mouse. Transplant Rev (1973) 2.79
Clonal deletion of V beta 14-bearing T cells in mice transgenic for mammary tumour virus. Nature (1991) 2.76
Genes encoding ligands for deletion of V beta 11 T cells cosegregate with mammary tumour virus genomes. Nature (1991) 2.65
An endogenous retrovirus mediating deletion of alpha beta T cells? Nature (1991) 2.57
Transgenic mouse mammary tumor virus superantigen expression prevents viral infection. Cell (1992) 2.55
Mls--a retrovirus exploits the immune system. Immunol Today (1991) 2.54
Identification of the region of T cell receptor beta chain that interacts with the self-superantigen MIs-1a. Cell (1990) 2.42
Limited T-cell receptor beta-chain heterogeneity among interleukin 2 receptor-positive synovial T cells suggests a role for superantigen in rheumatoid arthritis. Proc Natl Acad Sci U S A (1991) 2.29
Evidence for a viral superantigen in humans. Nature (1992) 2.01
Selective depletion in HIV infection of T cells that bear specific T cell receptor V beta sequences. Science (1991) 1.92
A virus-encoded "superantigen" in a retrovirus-induced immunodeficiency syndrome of mice. Science (1991) 1.80
A third T-cell receptor beta-chain variable region gene encodes reactivity to Mls-1a gene products. Proc Natl Acad Sci U S A (1989) 1.68
The T-cell-receptor repertoire in the synovial fluid of a patient with rheumatoid arthritis is polyclonal. Proc Natl Acad Sci U S A (1991) 1.67
A susceptibility locus for multiple sclerosis is linked to the T cell receptor beta chain complex. Cell (1989) 1.63
Inherited polymorphism of the human T-cell antigen receptor detected by a monoclonal antibody. Proc Natl Acad Sci U S A (1986) 1.61
Restricted expression of T cell receptor V beta but not V alpha genes in rheumatoid arthritis. Eur J Immunol (1991) 1.55
Allelic variations in the human T cell receptor V beta 6.7 gene products. J Exp Med (1990) 1.55
Studies on the human T cell receptor alpha/beta variable region genes. II. Identification of four additional V beta subfamilies. Eur J Immunol (1991) 1.53
An exogenous mouse mammary tumor virus with properties of Mls-1a (Mtv-7). J Exp Med (1992) 1.45
Mls-1 is encoded by the long terminal repeat open reading frame of the mouse mammary tumor provirus Mtv-7. Proc Natl Acad Sci U S A (1992) 1.37
Endogenous superantigen expression is controlled by mouse mammary tumor proviral loci. J Exp Med (1991) 1.34
Qualitative and quantitative studies of antigen-presenting cell function by using I-A-expressing L cells. J Immunol (1985) 1.26
Superantigen implicated in dependence of HIV-1 replication in T cells on TCR V beta expression. Nature (1992) 1.22
Expression on human thymocytes of the idiotypic structures (Ti) from two leukemia T cell lines Jurkat and HPB-ALL. Eur J Immunol (1986) 1.22
Analysis of the interaction site for the self superantigen Mls-1a on T cell receptor V beta. J Exp Med (1991) 1.13
Allelic sequence variations in the hypervariable region of a T-cell receptor beta chain: correlation with restriction fragment length polymorphism in human families and populations. Proc Natl Acad Sci U S A (1989) 1.08
Response of mature unprimed CD8+ T cells to Mlsa determinants. J Exp Med (1990) 1.08
Insertion/deletion-related polymorphisms in the human T cell receptor beta gene complex. J Exp Med (1989) 1.06
Activation requirements of cloned inducer T cells. III. Need for two stimulator cells in the response of a cloned line to Mls determinants. J Immunol (1986) 1.05
The immunobiology of T cell responses to Mls-locus-disparate stimulator cells. II. Effects of Mls-locus-disparate stimulator cells on cloned, protein antigen-specific, Ia-restricted T cell lines. J Immunol (1985) 1.00
CD8+ T cells respond clonally to Mls-1a-encoded determinants. J Exp Med (1990) 0.99
Murine AIDS superantigen reactivity of the T cells bearing V beta 5 T cell antigen receptor. J Immunol (1992) 0.90
Acquired Mls-1a-like clonal deletion in Mls-1b mice. J Exp Med (1992) 0.84
Skewed maturation of memory HIV-specific CD8 T lymphocytes. Nature (2001) 7.90
Identification of LFA-1 as a candidate autoantigen in treatment-resistant Lyme arthritis. Science (1998) 3.68
Linkage of Mls genes to endogenous mammary tumour viruses of inbred mice. Nature (1991) 3.07
Lack of evidence for the dichotomy of TH1 and TH2 predominance in HIV-infected individuals. Science (1994) 2.92
A novel method for producing anti-peptide antibodies. Production of site-specific antibodies to the T cell antigen receptor beta-chain. J Biol Chem (1988) 2.70
Early activation of caspases during T lymphocyte stimulation results in selective substrate cleavage in nonapoptotic cells. J Exp Med (1999) 2.12
Genetic and functional analyses of FH mutations in multiple cutaneous and uterine leiomyomatosis, hereditary leiomyomatosis and renal cancer, and fumarate hydratase deficiency. Hum Mol Genet (2003) 2.04
Association of antibiotic treatment-resistant Lyme arthritis with T cell responses to dominant epitopes of outer surface protein A of Borrelia burgdorferi. Arthritis Rheum (1999) 2.01
Association of tyrosine kinase p56lck with CD4 inhibits the induction of growth through the alpha beta T-cell receptor. Nature (1992) 1.81
Cholera toxin discriminates between T helper 1 and 2 cells in T cell receptor-mediated activation: role of cAMP in T cell proliferation. J Exp Med (1990) 1.81
Epstein-Barr virus transactivates the human endogenous retrovirus HERV-K18 that encodes a superantigen. Immunity (2001) 1.75
Two monoclonal rat antibodies with specificity for the beta-chain variable region V beta 6 of the murine T-cell receptor. Proc Natl Acad Sci U S A (1988) 1.75
Direct evidence for thymic function in adult humans. J Exp Med (1999) 1.70
A phase I trial of the selective oral cyclin-dependent kinase inhibitor seliciclib (CYC202; R-Roscovitine), administered twice daily for 7 days every 21 days. Br J Cancer (2006) 1.66
Direct enumeration of Borrelia-reactive CD4 T cells ex vivo by using MHC class II tetramers. Proc Natl Acad Sci U S A (2000) 1.61
B cells are essential for murine mammary tumor virus transmission, but not for presentation of endogenous superantigens. J Exp Med (1994) 1.56
Fluorescent light photosensitivity in patients with systemic lupus erythematosus. Arthritis Rheum (1992) 1.54
(E)-1-[4-(Methyl-sulfan-yl)phen-yl]-3-phenyl-prop-2-en-1-one. Acta Crystallogr Sect E Struct Rep Online (2008) 1.41
A mutational analysis of the binding of staphylococcal enterotoxins B and C3 to the T cell receptor beta chain and major histocompatibility complex class II. J Exp Med (1998) 1.39
Mls-1 is encoded by the long terminal repeat open reading frame of the mouse mammary tumor provirus Mtv-7. Proc Natl Acad Sci U S A (1992) 1.37
IL-4 and IL-2 selectively rescue Th cell subsets from glucocorticoid-induced apoptosis. J Immunol (1992) 1.37
T helper 1 response is dominant and localized to the synovial fluid in patients with Lyme arthritis. J Immunol (1998) 1.35
T cell antigen receptor V gene usage. Increases in V beta 8+ T cells in Crohn's disease. J Clin Invest (1990) 1.33
Cross-linking of major histocompatibility complex class II molecules by staphylococcal enterotoxin A superantigen is a requirement for inflammatory cytokine gene expression. J Exp Med (1995) 1.30
Inhibition of dipeptidyl aminopeptidase IV (DP-IV) by Xaa-boroPro dipeptides and use of these inhibitors to examine the role of DP-IV in T-cell function. Proc Natl Acad Sci U S A (1991) 1.29
Invariant chain protects class II histocompatibility antigens from binding intact polypeptides in the endoplasmic reticulum. EMBO J (1996) 1.28
Cutting edge: detection of antigen-specific CD4+ T cells by HLA-DR1 oligomers is dependent on the T cell activation state. J Immunol (2001) 1.27
Longitudinal assessment of changes in HIV-specific effector activity in HIV-infected patients starting highly active antiretroviral therapy in primary infection. J Immunol (2003) 1.25
Subsets of HLA-DR1 molecules defined by SEB and TSST-1 binding. Science (1994) 1.24
Human immunodeficiency virus 1 Tat binds to dipeptidyl aminopeptidase IV (CD26): a possible mechanism for Tat's immunosuppressive activity. Proc Natl Acad Sci U S A (1994) 1.23
Valproic acid in association with highly active antiretroviral therapy for reducing systemic HIV-1 reservoirs: results from a multicentre randomized clinical study. HIV Med (2012) 1.23
Assessment and reporting of the clinical immunogenicity of therapeutic proteins and peptides-harmonized terminology and tactical recommendations. AAPS J (2014) 1.22
Class II MHC molecules and the HIV gp 120 envelope protein interact with functionally distinct regions of the CD4 molecule. EMBO J (1989) 1.20
Mechanism of HIV-1 Tat induced inhibition of antigen-specific T cell responsiveness. J Immunol (1993) 1.18
Direct cleavage of the human DNA fragmentation factor-45 by granzyme B induces caspase-activated DNase release and DNA fragmentation. EMBO J (2001) 1.17
An Epstein-Barr virus-associated superantigen. J Exp Med (1996) 1.17
Taking immunogenicity assessment of therapeutic proteins to the next level. Biologicals (2011) 1.12
Molecular analysis of antigen recognition by insulin-specific T-cell hybridomas from B6 wild-type and bm12 mutant mice. Mol Cell Biol (1987) 1.11
Biologic significance of constitutive and subliminal growth factor production by bone marrow stroma. Blood (1992) 1.10
B cell differentiation antigens as probes for functional B cell subsets. Immunol Rev (1982) 1.08
Sequence, purification, and cloning of an intracellular serine protease, quiescent cell proline dipeptidase. J Biol Chem (1999) 1.07
Regulation of the epithelial Na+ channel by membrane tension. J Gen Physiol (1998) 1.06
A novel apoptotic pathway in quiescent lymphocytes identified by inhibition of a post-proline cleaving aminodipeptidase: a candidate target protease, quiescent cell proline dipeptidase. J Immunol (1999) 1.06
Vitamin E-enhanced IL-2 production in old mice: naive but not memory T cells show increased cell division cycling and IL-2-producing capacity. J Immunol (2001) 1.05
Macrophages and T cells do not express Mlsa determinants. J Immunol (1989) 1.05
Association of p56lck with the cytoplasmic domain of CD4 modulates HIV-1 expression. EMBO J (1994) 1.04
The xid gene controls Ia.W39-associated immune response gene function. J Exp Med (1981) 1.04
Role of the T cell receptor alpha chain in stabilizing TCR-superantigen-MHC class II complexes. Immunity (1999) 1.04
Anti-JC virus (JCV) antibody prevalence in the JCV Epidemiology in MS (JEMS) trial. Eur J Neurol (2013) 1.03
A class II gene conversion event defines an antigen-specific Ir gene epitope. J Exp Med (1984) 1.03
Repression of human immunodeficiency virus type 1 long terminal repeat-driven gene expression by binding of the virus to its primary cellular receptor, the CD4 molecule. J Virol (1996) 1.02
Quantification of T cell receptor rearrangement excision circles to estimate thymic function: an important new tool for endocrine-immune physiology. J Endocrinol (2003) 1.02
Molecular mimicry in Lyme arthritis demonstrated at the single cell level: LFA-1 alpha L is a partial agonist for outer surface protein A-reactive T cells. J Immunol (2001) 1.02
Understanding the mechanism of action of bacterial superantigens from a decade of research. Immunol Rev (1999) 1.02
Transcriptional repression of the IL-2 gene in Th cells by ZEB. J Immunol (1998) 1.01
Autoimmune mechanisms in antibiotic treatment-resistant lyme arthritis. J Autoimmun (2001) 1.01
Antimicrobial activity of clerodane diterpenoids from Polyalthia longifolia seeds. Fitoterapia (2005) 1.01
Detection of low avidity anti-DNA antibodies in systemic lupus erythematosus. Arthritis Rheum (1979) 1.01
Antigenic marker on a functional subpopulation of B cells, controlled by the I-A subregion of the H-2 complex. Proc Natl Acad Sci U S A (1979) 1.00
The T cell receptor V beta repertoire in HIV-1 infection and disease. Semin Immunol (1993) 1.00
Recombinant adenovirus coexpressing covalent peptide/MHC class II complex and B7-1: in vitro and in vivo activation of myelin basic protein-specific T cells. J Immunol (2001) 0.99
IL-1 activates two separate signal transduction pathways in T helper type II cells. J Immunol (1990) 0.99
The large subunit of replication factor C is a substrate for caspase-3 in vitro and is cleaved by a caspase-3-like protease during Fas-mediated apoptosis. EMBO J (1997) 0.98
Specific activation of the cysteine protease CPP32 during the negative selection of T cells in the thymus. J Exp Med (1997) 0.98
IL-1 signal transduction pathways. I. Two functional IL-1 receptors are expressed in T cells. J Immunol (1991) 0.98
Superinduction of IL-2 gene transcription in the presence of cycloheximide. J Immunol (1991) 0.98
Identification of residues in the V domain of CD80 (B7-1) implicated in functional interactions with CD28 and CTLA4. J Exp Med (1995) 0.97
Presence in peripheral blood of healthy individuals of autoreactive T cells to a membrane antigen present on bone marrow-derived cells. Blood (1996) 0.97
Immune recognition of insulin by H-2b mice: the mutation in the I-Ab beta gene of the B6.C-H-2bm12 mouse alters the self-I-A-restricted T cell repertoire. Eur J Immunol (1984) 0.97
Vesicular localization and characterization of a novel post-proline-cleaving aminodipeptidase, quiescent cell proline dipeptidase. J Immunol (2000) 0.96
Stimulation and expansion of a human T-cell subpopulation by a monoclonal antibody to T-cell receptor molecule. Hybridoma (1986) 0.96
Phagocytosis of virulent and avirulent leptospires by guinea-pig and human polymorphonuclear leukocytes in vitro. Pathology (1984) 0.95
Localization of spontaneously hyperactive B cells of NZB mice to a specific B cell subset. Proc Natl Acad Sci U S A (1979) 0.95
A longitudinal study of high and low avidity antibodies to double-stranded DNA in systemic lupus erythematosus. Arthritis Rheum (1985) 0.95
T cell receptor-major histocompatibility complex class II interaction is required for the T cell response to bacterial superantigens. J Exp Med (1994) 0.94
Human endogenous retrovirus-K18 Env as a risk factor in multiple sclerosis. Mult Scler (2008) 0.94
Staphylococcal enterotoxin D is a promiscuous superantigen offering multiple modes of interactions with the MHC class II receptors. J Immunol (1998) 0.93
Degradation of CD4 induced by human immunodeficiency virus type 1 Vpu protein: a predicted alpha-helix structure in the proximal cytoplasmic region of CD4 contributes to Vpu sensitivity. Virology (1995) 0.92
Increased thermohaline stratification as a possible cause for an ocean anoxic event in the Cretaceous period. Nature (2001) 0.91
Lack of MMTV superantigen presentation in MHC class II-deficient mice. Cell Immunol (1996) 0.91
Mls-1-like superantigen in the MA/MyJ mouse is encoded by a new mammary tumor provirus that is distinct from Mtv-7. J Exp Med (1992) 0.91
Binding sites for bacterial and endogenous retroviral superantigens can be dissociated on major histocompatibility complex class II molecules. J Exp Med (1994) 0.91
Direct binding of the Mtv7 superantigen (Mls-1) to soluble MHC class II molecules. Immunity (1995) 0.90
Ultraviolet-A light prolongs survival and improves immune function in (New Zealand black x New Zealand white)F1 hybrid mice. Arthritis Rheum (1987) 0.89
Interleukin-1 induces protein tyrosine phosphorylation in T cells. Eur J Immunol (1992) 0.89
Metabolic characteristics of a naturally occurring preneoplastic tissue. I. Glycolytic enzyme activities of hyperplastic alveolar nodule outgrowth and adenocarcinomas of mouse mammary gland. Cancer Res (1966) 0.89
Association of mouse mammary tumor virus superantigen with MHC class II during biosynthesis. J Immunol (2001) 0.88
Epidermal lipid metabolism in psoriasis and lichen simplex. Br J Dermatol (1976) 0.88
Longterm ultraviolet-A1 irradiation therapy in systemic lupus erythematosus. J Rheumatol (1997) 0.87
Molecular analysis of the cytoplasmic domain of CD4: overlapping but noncompetitive requirement for lck association and down-regulation by Nef. J Immunol (1996) 0.87
Learning to remember: generation and maintenance of T-cell memory. DNA Cell Biol (2001) 0.86
Homodimerization via a leucine zipper motif is required for enzymatic activity of quiescent cell proline dipeptidase. J Biol Chem (2000) 0.86
Regulation of macrophage activation markers by IL-4 and IFN-gamma is subpopulation-specific. Cell Immunol (1991) 0.86
Karoushi--death by overwork in the immune system. J Immunol (1995) 0.86
Production and characterization of an Mls-1-specific monoclonal antibody. J Exp Med (1993) 0.85
Minor lymphocyte stimulatory antigen-bearing stimulator cells require lipopolysaccharide activation to induce programmed cell death in T cell hybridomas. J Immunol (1992) 0.85
Shared promoter elements between a viral superantigen and the major histocompatibility complex class II-associated invariant chain. J Virol (1997) 0.85