Published in Science on December 19, 1975
Replication of an origin-containing derivative of plasmid RK2 dependent on a plasmid function provided in trans. Proc Natl Acad Sci U S A (1979) 44.75
Genetic organization of the broad-host-range IncP-1 plasmid R751. J Bacteriol (1980) 3.38
Multiple mechanisms for expression of incompatibility by broad-host-range plasmid RK2. J Bacteriol (1982) 1.42
Broad-host-range IncP-4 plasmid R1162: effects of deletions and insertions on plasmid maintenance and host range. J Bacteriol (1982) 1.38
Measuring genetic stability in bacteria of potential use in genetic engineering. Appl Environ Microbiol (1987) 1.22
Global transcription regulation of RK2 plasmids: a case study in the combined use of dynamical mathematical models and statistical inference for integration of experimental data and hypothesis exploration. BMC Syst Biol (2011) 0.89
Gene transfer system for Rhodopseudomonas viridis. J Bacteriol (1989) 0.89
Isolation and characterization of kikA, a region on IncN group plasmids that determines killing of Klebsiella oxytoca. J Bacteriol (1992) 0.83
Supercoiled circular DNA-protein complex in Escherichia coli: purification and induced conversion to an opern circular DNA form. Proc Natl Acad Sci U S A (1969) 71.62
Broad host range DNA cloning system for gram-negative bacteria: construction of a gene bank of Rhizobium meliloti. Proc Natl Acad Sci U S A (1980) 45.02
Replication of an origin-containing derivative of plasmid RK2 dependent on a plasmid function provided in trans. Proc Natl Acad Sci U S A (1979) 44.75
Plasmid ColEl as a molecular vehicle for cloning and amplification of DNA. Proc Natl Acad Sci U S A (1974) 32.46
Stimulation by cyclic adenosine monophosphate of plasmid deoxyribonucleic acid replication and catabolite repression of the plasmid deoxyribonucleic acid-protein relaxation complex. J Bacteriol (1973) 30.43
Firefly luciferase gene: structure and expression in mammalian cells. Mol Cell Biol (1987) 26.70
Properties of a supercoiled deoxyribonucleic acid-protein relaxation complex and strand specificity of the relaxation event. Biochemistry (1970) 26.22
Circular DNA forms of colicinogenic factors E1, E2 and E3 from Escherichia coli. J Mol Biol (1968) 23.73
Characterization of multiple circular DNA forms of colicinogenic factor E-1 from Proteus mirabilis. Biochemistry (1968) 14.82
Plasmid cloning vehicles derived from plasmids ColE1, F, R6K, and RK2. Methods Enzymol (1979) 13.61
Plasmids related to the broad host range vector, pRK290, useful for gene cloning and for monitoring gene expression. Plasmid (1985) 11.74
Evidence for circular DNA forms of a bacterial plasmid. Proc Natl Acad Sci U S A (1967) 10.45
Circular DNA. Annu Rev Biochem (1971) 9.75
Effect of growth conditions on the formation of the relaxation complex of supercoiled ColE1 deoxyribonucleic acid and protein in Escherichia coli. J Bacteriol (1972) 9.50
DNA polymerase as a requirement for the maintenance of the bacterial plasmid colicinogenic factor E1. Biochem Biophys Res Commun (1970) 8.73
Circular DNA forms of a bacterial sex factor. Proc Natl Acad Sci U S A (1967) 8.55
Trans-complementation-dependent replication of a low molecular weight origin fragment from plasmid R6K. Cell (1978) 8.28
Characterization of a mini-ColC1 plasmid. J Bacteriol (1976) 7.20
Effect of Rec mutations on the activity of colicinogenic factors. J Bacteriol (1967) 7.19
Replication of a bacterial plasmid and an episome in Escherichia coli. Biochemistry (1970) 7.19
The National Depressive and Manic-Depressive Association consensus statement on the undertreatment of depression. JAMA (1997) 6.32
Unidirectional replication of the P-group plasmid RK2. Biochim Biophys Acta (1977) 6.17
Transient and stable expression of the firefly luciferase gene in plant cells and transgenic plants. Science (1986) 5.97
Heme biosynthesis in Rhizobium. Identification of a cloned gene coding for delta-aminolevulinic acid synthetase from Rhizobium meliloti. J Biol Chem (1982) 5.80
Method for the isolation of the replication region of a bacterial replicon: construction of a mini-F'kn plasmid. J Bacteriol (1976) 5.75
Purification and characterization of colicin E2 and colicin E3. J Biol Chem (1967) 5.74
A catenated DNA molecule as an intermediate in the replication of the resistance transfer factor R6K in Escherichia coli. Biochem Biophys Res Commun (1973) 5.47
Regions of broad-host-range plasmid RK2 which are essential for replication and maintenance. J Bacteriol (1980) 5.45
Temperature-sensitive mutants for the replication of plasmids in Escherichia coli: requirement for deoxyribonucleic acid polymerase I in the replication of the plasmid ColE 1 . J Bacteriol (1973) 5.24
Gene cloning and containment properties of plasmid Col E1 and its derivatives. Science (1977) 5.21
Comparative study of the events associated with colicin induction. J Bacteriol (1967) 5.14
Strand-specific supercoiled DNA-protein relaxation complexes: comparison of the complexes of bacterial plasmids ColE1 and ColE2. Proc Natl Acad Sci U S A (1971) 4.76
Suppression of Co1E1 replication properties by the Inc P-1 plasmid RK2 in hybrid plasmids constructed in vitro. J Mol Biol (1979) 4.69
The DNA-protein relaxation complex of the plasmid RK2: location of the site-specific nick in the region of the proposed origin of transfer. Mol Gen Genet (1979) 4.48
Isolation of supercoiled colicinogenic factor E 1 DNA sensitive to ribonuclease and alkali. Proc Natl Acad Sci U S A (1972) 4.46
A haemoprotein with kinase activity encoded by the oxygen sensor of Rhizobium meliloti. Nature (1991) 4.45
Generation in vitro of deletions in the broad host range plasmid RK2 using phage Mu insertions and a restriction endonuclease. Gene (1976) 4.35
Physical and genetic studies with restriction endonucleases on the broad host-range plasmid RK2. Mol Gen Genet (1977) 4.28
Purification and characterization of colicin E1. J Biol Chem (1971) 4.27
Unidirectional replication of plasmid ColE1 DNA. Nature (1974) 4.27
Complete nucleotide sequence of Birmingham IncP alpha plasmids. Compilation and comparative analysis. J Mol Biol (1994) 4.23
Generation of higher multiple circular DNA forms in bacteria. Proc Natl Acad Sci U S A (1968) 3.98
Regions of broad-host-range plasmid RK2 involved in replication and stable maintenance in nine species of gram-negative bacteria. J Bacteriol (1985) 3.93
Diagnosis of iron-deficiency anemia in the elderly. Am J Med (1990) 3.77
Accumulation of chlorpyrifos on residential surfaces and toys accessible to children. Environ Health Perspect (1998) 3.75
Rhizobium meliloti genes required for nodule development are related to chromosomal virulence genes in Agrobacterium tumefaciens. Proc Natl Acad Sci U S A (1986) 3.38
Cloning of firefly luciferase cDNA and the expression of active luciferase in Escherichia coli. Proc Natl Acad Sci U S A (1985) 3.35
Structural relationships among Rhizobium meliloti symbiotic promoters. Cell (1983) 3.23
Construction of plasmid cloning vehicles that promote gene expression from the bacteriophage lambda pL promoter. Gene (1979) 3.00
Isolation and characterization of the recA gene of Rhizobium meliloti. J Bacteriol (1983) 2.89
Strand and site specificity of the relaxation event for the relaxation complex of the antibiotic resistance plasmid R6K. Biochemistry (1974) 2.81
Use of the lambda phage promoter PL to promote gene expression in hybrid plasmid cloning vehicles. Methods Enzymol (1979) 2.74
Excessive infant crying: a controlled study of mothers helping mothers. Pediatrics (1994) 2.72
Clustering of nitrogen fixation (nif) genes in Rhizobium meliloti. J Bacteriol (1982) 2.66
F 1 sex factor of Escherichia coli. Size and purification in the form of a strand-specific relaxation complex of supercoiled deoxyribonucleic acid and protein. Biochemistry (1971) 2.63
The ankyrin repeat domains of the NF-kappa B precursor p105 and the protooncogene bcl-3 act as specific inhibitors of NF-kappa B DNA binding. Proc Natl Acad Sci U S A (1992) 2.56
The FixL protein of Rhizobium meliloti can be separated into a heme-binding oxygen-sensing domain and a functional C-terminal kinase domain. Proc Natl Acad Sci U S A (1992) 2.51
The ndvA gene product of Rhizobium meliloti is required for beta-(1----2)glucan production and has homology to the ATP-binding export protein HlyB. J Bacteriol (1988) 2.45
A sensitive and specific method for the determination of histomine in human whole blood and plasma. Hoppe Seylers Z Physiol Chem (1972) 2.43
Plasmid determined resistance to antibiotics: molecular properties of R factors. Annu Rev Microbiol (1973) 2.39
Nucleotide sequence of the region of the origin of replication of the broad host range plasmid RK2. Mol Gen Genet (1981) 2.38
Identification and expression of delta-isoforms of the multifunctional Ca2+/calmodulin-dependent protein kinase in failing and nonfailing human myocardium. Circ Res (1999) 2.38
Plasmid R6K DNA replication. I. Complete nucleotide sequence of an autonomously replicating segment. J Mol Biol (1982) 2.30
Genetic characterization of the stabilizing functions of a region of broad-host-range plasmid RK2. J Bacteriol (1990) 2.26
Relaxation complexes of plasmids ColE1 and ColE2: unique site of the nick in the open circular DNA of the relaxed complexes. Proc Natl Acad Sci U S A (1974) 2.22
Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Nature (2000) 2.16
Weaning from mechanical cardiac support in patients with idiopathic dilated cardiomyopathy. Circulation (1997) 2.16
Chromogenic immunodetection of human serum albumin and alpha-L-fucosidase clones in a human hepatoma cDNA expression library. DNA (1984) 2.15
Plasmid R6K DNA replication. III. Regulatory properties of the pi initiation protein. J Mol Biol (1982) 2.12
Behavioural problems in children who weigh 1000 g or less at birth in four countries. Lancet (2001) 2.08
Estrogen receptor alpha rapidly activates the IGF-1 receptor pathway. J Biol Chem (2000) 2.07
Temperature-sensitive mutants for the replication of plasmids in Escherichia coli. I. Isolation and specificity of host and plasmid mutations. Genetics (1973) 2.01
Interaction between colicinogenic factor V and the integrated F factor in an Hfr strain of Escherichia coli. J Bacteriol (1965) 2.01
Isolation of inc P-2 plasmid DNA from Pseudomonas aeruginosa. Plasmid (1978) 2.00
Morphological, biochemical, and electrophysiological characterization of a clonal cell (H9c2) line from rat heart. Circ Res (1991) 1.99
Heterogeneous circular DNA elements in vegetative cultures of Bacillus megaterium. Proc Natl Acad Sci U S A (1969) 1.99
Nucleotide sequence of the region of an origin of replication of the antibiotic resistance plasmid R6K. Proc Natl Acad Sci U S A (1979) 1.95
Bidirectional replication of plasmid R6K DNA in Escherichia coli; correspondence between origin of replication and position of single-strand break in relaxed complex. Proc Natl Acad Sci U S A (1975) 1.95
Deletion analysis of Rhizobium meliloti symbiotic promoters. EMBO J (1985) 1.84
Requirement of a plasmid-encoded protein for replication in vitro of plasmid R6K. Proc Natl Acad Sci U S A (1978) 1.83
Relaxation complexes of poasmid DNA and protein. III. Association of protein with the 5' terminus of the broken DNA strand in the relaxed complex of plasmid ColE1. J Biol Chem (1975) 1.82
Transposition of DNA inserted into deletions of the Tn5 kanamycin resistance element. Mol Gen Genet (1979) 1.81
Construction of plasmid R6K derivatives in vitro: characterization of the R6K replication region. Plasmid (1978) 1.79
Measurement of right and left ventricular systolic time intervals by echocardiography. Circulation (1975) 1.79
Negative control of plasmid R6K replication: possible role of intermolecular coupling of replication origins. Proc Natl Acad Sci U S A (1989) 1.77
Second malignancy risk associated with treatment of Hodgkin's lymphoma: meta-analysis of the randomised trials. Ann Oncol (2006) 1.74
Comparing the German versions of the Strengths and Difficulties Questionnaire (SDQ-Deu) and the Child Behavior Checklist. Eur Child Adolesc Psychiatry (2000) 1.72
Bidirection replication from a unique origin in a mini-F plasmid. Proc Natl Acad Sci U S A (1977) 1.70
Cognitive status, language attainment, and prereading skills of 6-year-old very preterm children and their peers: the Bavarian Longitudinal Study. Dev Med Child Neurol (1999) 1.70
Common regulatory elements control symbiotic and microaerobic induction of nifA in Rhizobium meliloti. Proc Natl Acad Sci U S A (1988) 1.69
Evidence for the existence of the colicinogenic factors E2 and E3 as supercoiled circular DNA-protein relaxation complexes. Biochem Biophys Res Commun (1970) 1.68
The echocardiographic assessment of pulmonary artery pressure and pulmonary vascular resistance. Circulation (1975) 1.68