Published in J Pharmacol Exp Ther on February 01, 2000
The alpha7 nicotinic acetylcholine receptor as a pharmacological target for inflammation. Br J Pharmacol (2007) 2.82
A gating mechanism proposed from a simulation of a human alpha7 nicotinic acetylcholine receptor. Proc Natl Acad Sci U S A (2005) 1.66
Nicotinic agonists, antagonists, and modulators from natural sources. Cell Mol Neurobiol (2005) 1.53
Structural model of nicotinic acetylcholine receptor isotypes bound to acetylcholine and nicotine. BMC Struct Biol (2002) 1.14
Highly enantioselective borane reduction of heteroaryl and heterocyclic ketoxime ethers catalyzed by novel spiroborate ester derived from diphenylvalinol: application to the synthesis of nicotine analogues. J Org Chem (2008) 1.13
Membrane potential fluorescence: a rapid and highly sensitive assay for nicotinic receptor channel function. Proc Natl Acad Sci U S A (2003) 1.13
Chemistry and pharmacology of nicotinic ligands based on 6-[5-(azetidin-2-ylmethoxy)pyridin-3-yl]hex-5-yn-1-ol (AMOP-H-OH) for possible use in depression. ChemMedChem (2009) 1.09
Negative allosteric modulators that target human alpha4beta2 neuronal nicotinic receptors. J Pharmacol Exp Ther (2010) 1.03
α7 Nicotinic Receptor Agonists: Potential Therapeutic Drugs for Treatment of Cognitive Impairments in Schizophrenia and Alzheimer's Disease. Open Med Chem J (2010) 1.00
Effect of novel negative allosteric modulators of neuronal nicotinic receptors on cells expressing native and recombinant nicotinic receptors: implications for drug discovery. J Pharmacol Exp Ther (2008) 0.98
Synthesis, nicotinic acetylcholine receptor binding, antinociceptive and seizure properties of methyllycaconitine analogs. Bioorg Med Chem (2006) 0.98
Effects of nicotine and mecamylamine on cognition in rhesus monkeys. Psychopharmacology (Berl) (2004) 0.96
Synthesis, nicotinic acetylcholine receptor binding, and antinociceptive properties of 3'-(substituted phenyl)epibatidine analogues. Nicotinic partial agonists. J Nat Prod (2010) 0.89
A New and Efficient Approach to the Synthesis of Nicotine and Anabasine Analogues. J Heterocycl Chem (2009) 0.88
Interaction of bupropion with muscle-type nicotinic acetylcholine receptors in different conformational states. Biochemistry (2009) 0.88
From smoking to lung cancer: the CHRNA5/A3/B4 connection. Oncogene (2010) 0.87
The analgesic and toxic effects of nornicotine enantiomers alone and in interaction with morphine in rodent models of acute and persistent pain. Pharmacol Biochem Behav (2009) 0.85
A practical and efficient route for the highly enantioselective synthesis of mexiletine analogues and novel beta-thiophenoxy and pyridyl ethers. J Org Chem (2008) 0.85
Spiroborate ester-mediated asymmetric synthesis of beta-hydroxy ethers and its conversion to highly enantiopure beta-amino ethers. J Org Chem (2009) 0.85
Cloning and spatiotemporal expression of zebrafish neuronal nicotinic acetylcholine receptor alpha 6 and alpha 4 subunit RNAs. Dev Dyn (2009) 0.85
Structure-activity relationship studies of sulfonylpiperazine analogues as novel negative allosteric modulators of human neuronal nicotinic receptors. J Med Chem (2011) 0.81
3D-QSAR and 3D-QSSR models of negative allosteric modulators facilitate the design of a novel selective antagonist of human α4β2 neuronal nicotinic acetylcholine receptors. Bioorg Med Chem Lett (2011) 0.80
Synthesis and pharmacological evaluation of novel 9- and 10-substituted cytisine derivatives. Nicotinic ligands of enhanced subtype selectivity. J Med Chem (2006) 0.80
Novel information on the non-neuronal cholinergic system in orthopedics provides new possible treatment strategies for inflammatory and degenerative diseases. Orthop Rev (Pavia) (2009) 0.79
Acetylcholine promotes binding of α-conotoxin MII at α3 β2 nicotinic acetylcholine receptors. Chembiochem (2014) 0.79
Synthesis, nicotinic acetylcholine receptor binding, and antinociceptive properties of 2'-fluoro-3'-(substituted pyridinyl)-7-deschloroepibatidine analogues. J Med Chem (2014) 0.79
Synthesis and biological evaluation of novel carbon-11 labeled pyridyl ethers: candidate ligands for in vivo imaging of alpha4beta2 nicotinic acetylcholine receptors (alpha4beta2-nAChRs) in the brain with positron emission tomography. Bioorg Med Chem (2009) 0.78
The influence of a chronic adolescent nicotine exposure on ethanol withdrawal severity during adulthood in C3H mice. Alcohol (2010) 0.78
Molecular modeling of mono- and bis-quaternary ammonium salts as ligands at the alpha4beta2 nicotinic acetylcholine receptor subtype using nonlinear techniques. AAPS J (2005) 0.77
Defining the putative inhibitory site for a selective negative allosteric modulator of human α4β2 neuronal nicotinic receptors. ACS Chem Neurosci (2012) 0.77
Characterization of a novel alpha4/4-conotoxin, Qc1.2, from vermivorous Conus quercinus. Acta Biochim Biophys Sin (Shanghai) (2009) 0.77
Escherichia coli Protein Expression System for Acetylcholine Binding Proteins (AChBPs). PLoS One (2016) 0.76
Selectivity of Imidacloprid for fruit fly versus rat nicotinic acetylcholine receptors by molecular modeling. J Mol Model (2009) 0.76
Analgesic, antiallodynic, and anticonvulsant activity of novel hybrid molecules derived from N-benzyl-2-(2,5-dioxopyrrolidin-1-yl)propanamide and 2-(2,5-dioxopyrrolidin-1-yl)butanamide in animal models of pain and epilepsy. Naunyn Schmiedebergs Arch Pharmacol (2017) 0.75
In vivo pharmacological profile of substituted (3-pyridyl)-2-phenylisoxazolidine analogues of nicotine as novel antinociceptives. Res Pharm Sci (2015) 0.75
Improved Syntheses of Precursors for PET Radioligands [F]XTRA and [F]AZAN. Tetrahedron Lett (2010) 0.75
N,N-disubstituted piperazines: synthesis and affinities at alpha4beta2(*) and alpha7(*) neuronal nicotinic acetylcholine receptors. Bioorg Med Chem Lett (2003) 0.75
Establishing Natural Nootropics: Recent Molecular Enhancement Influenced by Natural Nootropic. Evid Based Complement Alternat Med (2016) 0.75
Structural mechanisms for α-conotoxin activity at the human α3β4 nicotinic acetylcholine receptor. Sci Rep (2017) 0.75
Investigating the hydrogen-bond acceptor site of the nicotinic pharmacophore model: a computational and experimental study using epibatidine-related molecular probes. J Comput Aided Mol Des (2013) 0.75
Thermodynamic conformational analysis and structural stability of the nicotinic analgesic ABT-594. J Comput Aided Mol Des (2003) 0.75
A Transcriptomic Survey of Ion Channel-Based Conotoxins in the Chinese Tubular Cone Snail (Conus betulinus). Mar Drugs (2017) 0.75
The sequence of the human genome. Science (2001) 101.55
Expression of VEGFR-2 and AC133 by circulating human CD34(+) cells identifies a population of functional endothelial precursors. Blood (2000) 9.24
Nomenclature and classification of purinoceptors. Pharmacol Rev (1994) 5.32
A Critical Study of the Methods of Estimating Cholesterol and Allied Substances. Biochem J (1921) 4.58
A comparison of survival, growth, and pulmonary function in patients with cystic fibrosis in Boston and Toronto. J Clin Epidemiol (1988) 4.41
Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase. EMBO J (2001) 4.40
Lymphocyte trafficking and regional immunity. Adv Immunol (1999) 4.21
[3H]CGS 21680, a selective A2 adenosine receptor agonist directly labels A2 receptors in rat brain. J Pharmacol Exp Ther (1989) 4.18
Distribution of NHS funds between fundholding and non-fundholding practices. BMJ (1994) 4.05
Enrichment of gene-coding sequences in maize by genome filtration. Science (2003) 3.41
Preserving renal function in adults with hypertension and diabetes: a consensus approach. National Kidney Foundation Hypertension and Diabetes Executive Committees Working Group. Am J Kidney Dis (2000) 3.37
Alternate-day prednisone reduces morbidity and improves pulmonary function in cystic fibrosis. Lancet (1985) 3.32
Deprivation and cause specific morbidity: evidence from the Somerset and Avon survey of health. BMJ (1996) 3.18
Dihydrofolate reductase: x-ray structure of the binary complex with methotrexate. Science (1977) 2.88
Reliability of the Washington University in St. Louis Kiddie Schedule for Affective Disorders and Schizophrenia (WASH-U-KSADS) mania and rapid cycling sections. J Am Acad Child Adolesc Psychiatry (2001) 2.83
Final results from a meta-analysis of remedial interventions with drink/drive offenders. Addiction (1995) 2.66
Identification of inbred mouse strains harboring genetic modifiers of mammary tumor age of onset and metastatic progression. Int J Cancer (1998) 2.36
Double-blind and placebo-controlled study of lithium for adolescent bipolar disorders with secondary substance dependency. J Am Acad Child Adolesc Psychiatry (1998) 2.16
Incentive spirometry decreases respiratory complications following major abdominal surgery. Surgeon (2007) 2.15
Possible discrimination in recruitment of psychiatry residents? Am J Psychiatry (1997) 2.14
The adenosine/neutrophil paradox resolved: human neutrophils possess both A1 and A2 receptors that promote chemotaxis and inhibit O2 generation, respectively. J Clin Invest (1990) 2.12
Prepubertal and young adolescent bipolarity versus ADHD: assessment and validity using the WASH-U-KSADS, CBCL and TRF. J Affect Disord (1998) 2.10
Towards a revised nomenclature for P1 and P2 receptors. Trends Pharmacol Sci (1997) 2.09
British HIV Association guidelines for the routine investigation and monitoring of adult HIV-1-infected individuals 2011. HIV Med (2012) 2.05
Correlation between fragment size at D4F104S1 and age at onset or at wheelchair use, with a possible generational effect, accounts for much phenotypic variation in 4q35-facioscapulohumeral muscular dystrophy (FSHD) Hum Mol Genet (1995) 2.02
Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential. J Med Chem (1992) 2.01
The segment polarity gene armadillo interacts with the wingless signaling pathway in both embryonic and adult pattern formation. Development (1991) 2.01
Quality of life measured by the St George's Respiratory Questionnaire and spirometry. Eur Respir J (2009) 1.99
CGS 21680C, an A2 selective adenosine receptor agonist with preferential hypotensive activity. J Pharmacol Exp Ther (1989) 1.99
Purine receptors in mammalian tissues: pharmacology and functional significance. Annu Rev Pharmacol Toxicol (1987) 1.97
Histopathology of the upper small intestines in typhoid fever. Biopsy study of experimental disease in man. Am J Dig Dis (1966) 1.97
Detection of single mammalian cells by high-resolution magnetic resonance imaging. Biophys J (1999) 1.90
Broad-spectrum, non-opioid analgesic activity by selective modulation of neuronal nicotinic acetylcholine receptors. Science (1998) 1.87
P2 purinergic receptors: modulation of cell function and therapeutic potential. J Pharmacol Exp Ther (2000) 1.85
Behavioural abnormalities and selective neuronal loss in HD transgenic mice expressing mutated full-length HD cDNA. Nat Genet (1998) 1.83
Activation of expression of hedgehog target genes in basal cell carcinomas. J Invest Dermatol (2001) 1.77
Macrophage accumulation associated with rat cardiac allograft rejection detected by magnetic resonance imaging with ultrasmall superparamagnetic iron oxide particles. Circulation (2001) 1.74
Psychosocial functioning in a prepubertal and early adolescent bipolar disorder phenotype. J Am Acad Child Adolesc Psychiatry (2000) 1.74
Peer discussion on training physicians to be competent communicators: support for a multiple discourse approach. South Med J (1997) 1.73
Identification of GS 4104 as an orally bioavailable prodrug of the influenza virus neuraminidase inhibitor GS 4071. Antimicrob Agents Chemother (1998) 1.72
A phosphatocopid crustacean with appendages from the Lower Cambrian. Science (2001) 1.70
Adherence by African American men to prostate cancer education and early detection. Cancer (1999) 1.69
Liver cells. Methods Enzymol (1979) 1.67
The carbon balance of Africa: synthesis of recent research studies. Philos Trans A Math Phys Eng Sci (2011) 1.65
Sensitivity of Shah, Vanclay and Cooper's modified Barthel Index. Clin Rehabil (1999) 1.62
Gene rearrangements in the diagnosis of lymphoma/leukemia. Guidelines for use based on a multiinstitutional study. Am J Clin Pathol (1991) 1.61
Diagnostic characteristics of 93 cases of a prepubertal and early adolescent bipolar disorder phenotype by gender, puberty and comorbid attention deficit hyperactivity disorder. J Child Adolesc Psychopharmacol (2000) 1.61
Guidelines for pre-transfusion compatibility procedures in blood transfusion laboratories. British Committee for Standards in Haematology. Transfus Med (2012) 1.60
Bipolar disorder at prospective follow-up of adults who had prepubertal major depressive disorder. Am J Psychiatry (2001) 1.59
HIV risk behaviors associated with the injection process: multiperson use of drug injection equipment and paraphernalia in injection drug user networks. Subst Use Misuse (1998) 1.58
UK Back pain Exercise And Manipulation (UK BEAM) trial--national randomised trial of physical treatments for back pain in primary care: objectives, design and interventions [ISRCTN32683578]. BMC Health Serv Res (2003) 1.57
One minute wisdom. All you need to know about CS gas. Nurs Stand (1994) 1.55
Assessment of functional capacity in clinical and research applications: An advisory from the Committee on Exercise, Rehabilitation, and Prevention, Council on Clinical Cardiology, American Heart Association. Circulation (2000) 1.55
Autonomic orienting responses in 15-year-old male subjects and criminal behavior at age 24. Am J Psychiatry (1990) 1.54
Sale of sex for drugs and drugs for sex: an economic context of sexual risk behavior for STDs. Sex Transm Dis (1999) 1.53
Recent advances in understanding the pathogenesis of Huntington's disease. Trends Neurosci (1999) 1.53
CT appearances of talc pleurodesis. Clin Radiol (2007) 1.52
Identification of the A2 adenosine receptor binding subunit by photoaffinity crosslinking. Proc Natl Acad Sci U S A (1989) 1.50
Strong constraints on the rare decays B(s)(0) → μ+ μ- and B0 → μ+ μ-. Phys Rev Lett (2012) 1.50
First observation of the decays B(0) → D(+)K(-)π(+)π(-) and B(-) → D(0)K(-)π(+)π(-). Phys Rev Lett (2012) 1.50
22q13.3 deletion syndrome: clinical and molecular analysis using array CGH. Am J Med Genet A (2010) 1.49
Progression of cystic fibrosis lung disease as a function of serum immunoglobulin G levels: a 5-year longitudinal study. J Pediatr (1984) 1.48
The hypronosticon test in breast cancer. Clin Oncol (1975) 1.47
Gut microbes define liver cancer risk in mice exposed to chemical and viral transgenic hepatocarcinogens. Gut (2010) 1.47
A familial hypertrophic cardiomyopathy locus maps to chromosome 15q2. Proc Natl Acad Sci U S A (1993) 1.47
Beta 3-endonexin, a novel polypeptide that interacts specifically with the cytoplasmic tail of the integrin beta 3 subunit. J Cell Biol (1995) 1.46
Beta-adrenergic growth regulation of human cancer cell lines derived from pancreatic ductal carcinomas. Carcinogenesis (2001) 1.44
Improved therapies for Parkinson's disease: life beyond dopamine D2/D3 receptor agonists. Trends Pharmacol Sci (1997) 1.44
Agonist derived molecular probes for A2 adenosine receptors. J Mol Recognit (1989) 1.43
Determination of the X(3872) meson quantum numbers. Phys Rev Lett (2013) 1.42
An investigation of psychological distress in patients who have been treated for head and neck cancer. Br J Oral Maxillofac Surg (2001) 1.42
Phosphorylation-dephosphorylation of pyruvate dehydrogenase complex from pea leaf mitochondria. Arch Biochem Biophys (1981) 1.42
Assessing dopamine concentrations: an evidence-based approach. Am J Crit Care (2000) 1.41
Mutant huntingtin expression in clonal striatal cells: dissociation of inclusion formation and neuronal survival by caspase inhibition. J Neurosci (1999) 1.40
Nursing orientation: a continuous quality improvement story. Clin Nurse Spec (1996) 1.40
Is GIFT (gamete intrafallopian transfer) the best treatment for unexplained infertility? Br J Obstet Gynaecol (1991) 1.40
Maternal fatigue: implications of second stage labor nursing care. J Obstet Gynecol Neonatal Nurs (1999) 1.40
Hypogammaglobulinemia in patients with cystic fibrosis. N Engl J Med (1980) 1.40
Adolescent health care: can an international approach help? Can Fam Physician (1990) 1.39
Bayesian analysis of pentaquark signals from CLAS data. Phys Rev Lett (2008) 1.39
An international survey in postgraduate training in Oral Medicine. Oral Dis (2011) 1.39
Barriers and incentives for primary-care physicians in cancer prevention and detection. Cancer (1987) 1.38
Airway difficulties associated with severe epistaxis. Anaesthesia (1999) 1.38
Measurement of two- and three-nucleon short-range correlation probabilities in nuclei. Phys Rev Lett (2006) 1.37
Prepubertal and early adolescent bipolarity differentiate from ADHD by manic symptoms, grandiose delusions, ultra-rapid or ultradian cycling. J Affect Disord (1998) 1.36
The electrocardiogram predicts one-year outcome of patients with unstable angina and non-Q wave myocardial infarction: results of the TIMI III Registry ECG Ancillary Study. Thrombolysis in Myocardial Ischemia. J Am Coll Cardiol (1997) 1.34
2-(Arylalkylamino)adenosin-5'-uronamides: a new class of highly selective adenosine A2 receptor ligands. J Med Chem (1990) 1.34
Novel 3-Pyridyl ethers with subnanomolar affinity for central neuronal nicotinic acetylcholine receptors. J Med Chem (1996) 1.33
Crowd influence on decisions in association football. Lancet (1999) 1.33
Disruption of the varicella-zoster virus dUTPase and the adjacent ORF9A gene results in impaired growth and reduced syncytia formation in vitro. Virology (1997) 1.32
An insight into early reproductive processes through the in vivo model of ovum donation. J Clin Endocrinol Metab (1991) 1.31
The reliability of selected pain provocation tests for sacroiliac joint pathology. Spine (Phila Pa 1976) (1994) 1.30
The self-reporting of cocaine use. JAMA (1992) 1.29
Cardiovascular disease risk factors and diet of Fulani pastoralists of northern Nigeria. Am J Clin Nutr (2001) 1.29
Gender-age environmental associates of adolescent low back pain. Appl Ergon (2000) 1.28
Measurement of respiratory morbidity in general practice in the United Kingdom during the acid transport event of January 1985. Environ Health Perspect (1989) 1.27