Published in J Exp Med on February 17, 2003
In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes. J Exp Med (2004) 8.00
Developmental stage, phenotype, and migration distinguish naive- and effector/memory-like CD4+ regulatory T cells. J Exp Med (2004) 5.08
In vivo dynamics of antigen-specific regulatory T cells not predicted from behavior in vitro. Proc Natl Acad Sci U S A (2003) 4.18
Homeostatic proliferation is a barrier to transplantation tolerance. Nat Med (2003) 4.12
The role of T helper 17 (Th17) and regulatory T cells (Treg) in human organ transplantation and autoimmune disease. Clin Exp Immunol (2007) 3.51
Where CD4+CD25+ T reg cells impinge on autoimmune diabetes. J Exp Med (2005) 2.61
PTEN inhibits IL-2 receptor-mediated expansion of CD4+ CD25+ Tregs. J Clin Invest (2006) 1.93
Microbiota innate stimulation is a prerequisite for T cell spontaneous proliferation and induction of experimental colitis. J Exp Med (2010) 1.86
Mesenteric B cells centrally inhibit CD4+ T cell colitis through interaction with regulatory T cell subsets. Proc Natl Acad Sci U S A (2005) 1.71
Induction of antigen-specific tolerance to bone marrow allografts with CD4+CD25+ T lymphocytes. Blood (2004) 1.69
Aging, autoimmunity and arthritis: T-cell senescence and contraction of T-cell repertoire diversity - catalysts of autoimmunity and chronic inflammation. Arthritis Res Ther (2003) 1.61
An obligate cell-intrinsic function for CD28 in Tregs. J Clin Invest (2013) 1.46
Interleukin-2-dependent mechanisms of tolerance and immunity in vivo. J Immunol (2006) 1.43
Anti-CD3 therapy permits regulatory T cells to surmount T cell receptor-specified peripheral niche constraints. J Exp Med (2010) 1.41
Control of homeostatic proliferation by regulatory T cells. J Clin Invest (2005) 1.40
Age-associated increase in lifespan of naive CD4 T cells contributes to T-cell homeostasis but facilitates development of functional defects. Proc Natl Acad Sci U S A (2009) 1.34
Unique role of CD4+CD62L+ regulatory T cells in the control of autoimmune diabetes in T cell receptor transgenic mice. Proc Natl Acad Sci U S A (2004) 1.32
Alloantigen-enhanced accumulation of CCR5+ 'effector' regulatory T cells in the gravid uterus. Proc Natl Acad Sci U S A (2006) 1.27
T cell epitope immunotherapy induces a CD4+ T cell population with regulatory activity. PLoS Med (2005) 1.24
Specificity of CD4+CD25+ regulatory T cell function in alloimmunity. J Immunol (2006) 1.19
Diversity of regulatory CD4+T cells controlling distinct organ-specific autoimmune diseases. Proc Natl Acad Sci U S A (2003) 1.14
Donor-specific transplantation tolerance: the paradoxical behavior of CD4+CD25+ T cells. Proc Natl Acad Sci U S A (2004) 1.11
Type 1 regulatory T cells: a new mechanism of peripheral immune tolerance. Cell Mol Immunol (2015) 1.11
Tolerance, suppression and the fetal allograft. J Mol Med (Berl) (2004) 1.02
Construction of self-recognizing regulatory T cells from conventional T cells by controlling CTLA-4 and IL-2 expression. Proc Natl Acad Sci U S A (2013) 1.00
Quorum-Sensing in CD4(+) T Cell Homeostasis: A Hypothesis and a Model. Front Immunol (2012) 0.99
Immunology and mathematics: crossing the divide. Immunology (2005) 0.98
IL-2 coordinates IL-2-producing and regulatory T cell interplay. J Exp Med (2013) 0.97
An early age-related increase in the frequency of CD4+ Foxp3+ cells in BDC2.5NOD mice. Immunology (2007) 0.96
Cell therapy for autoimmune diseases. Arthritis Res Ther (2007) 0.95
The concept of space and competition in immune regulation. Immunology (2004) 0.95
Regulation and privilege in transplantation tolerance. J Clin Immunol (2008) 0.93
Restoring the balance: immunotherapeutic combinations for autoimmune disease. Dis Model Mech (2014) 0.92
Homeostatic T cell proliferation as a barrier to T cell tolerance. Philos Trans R Soc Lond B Biol Sci (2005) 0.91
Innate memory T cells. Adv Immunol (2015) 0.89
The ambiguity in immunology. Front Immunol (2012) 0.87
Apoptosis regulators Fas and Bim synergistically control T-lymphocyte homeostatic proliferation. Eur J Immunol (2010) 0.86
Integration of B cells and CD8+ T in the protective regulation of systemic epithelial inflammation. Clin Immunol (2008) 0.86
Induction of tolerance to bone marrow allografts by donor-derived host nonreactive ex vivo-induced central memory CD8 T cells. Blood (2009) 0.85
Immune tolerance induction by integrating innate and adaptive immune regulators. Cell Transplant (2009) 0.84
CD122+CD8+ Treg suppress vaccine-induced antitumor immune responses in lymphodepleted mice. Eur J Immunol (2010) 0.84
Characterization of T-regulatory cells, induced by immature dendritic cells, which inhibit enteroantigen-reactive colitis-inducing T-cell responses in vitro and in vivo. Immunology (2004) 0.83
The companions: regulatory T cells and gene therapy. Immunology (2009) 0.82
T cell tolerance induced by therapeutic antibodies. Philos Trans R Soc Lond B Biol Sci (2005) 0.81
The molecular mechanisms of regulatory T cell immunosuppression. Front Immunol (2011) 0.81
A novel role for CD4+ T cells in the control of cachexia. J Immunol (2008) 0.81
Abnormal regulatory and effector T cell function predispose to autoimmunity following xenogeneic thymic transplantation. J Immunol (2008) 0.81
CD4+CD25+Foxp3+ regulatory T cells optimize diversity of the conventional T cell repertoire during reconstitution from lymphopenia. J Immunol (2010) 0.81
Heligmosomoides polygyrus antigens inhibit the intrinsic pathway of apoptosis by overexpression of survivin and Bcl-2 protein in CD4 T cells. Prion (2013) 0.80
The influence of CD4 T-cell subsets on control of CD4 T-cell-mediated graft-versus-host disease. Immunology (2008) 0.80
Natural and induced regulatory T cells: targets for immunotherapy of autoimmune disease and allergy. Inflamm Allergy Drug Targets (2006) 0.80
A prospective study of influenza vaccination and a comparison of immunologic parameters in children and adults with chromosome 22q11.2 deletion syndrome (digeorge syndrome/velocardiofacial syndrome). J Clin Immunol (2011) 0.80
Fas (CD95/APO-1) limits the expansion of T lymphocytes in an environment of limited T-cell antigen receptor/MHC contacts. Int Immunol (2011) 0.78
TGF-β in tolerance, development and regulation of immunity. Cell Immunol (2015) 0.78
Glutamic acid decarboxylase-derived epitopes with specific domains expand CD4(+)CD25(+) regulatory T cells. PLoS One (2009) 0.78
Murine CD4⁺CD25⁻ cells activated in vitro with PMA/ionomycin and anti-CD3 acquire regulatory function and ameliorate experimental colitis in vivo. BMC Gastroenterol (2012) 0.77
CD18 is required for optimal lymphopenia-induced proliferation of mouse T cells. Am J Physiol Gastrointest Liver Physiol (2012) 0.77
Colitis promotes adaptation of an intestinal nematode: a Heligmosomoides polygyrus mouse model system. PLoS One (2013) 0.77
Mechanisms of autoimmunity in the non-obese diabetic mouse: effector/regulatory cell equilibrium during peak inflammation. Immunology (2016) 0.76
Origin of Enriched Regulatory T Cells in Patients Receiving Combined Kidney-Bone Marrow Transplantation to Induce Transplantation Tolerance. Am J Transplant (2017) 0.75
DiGeorge Syndrome Presenting as Hypocalcaemia-Induced Seizures in Adulthood. Case Rep Med (2013) 0.75
Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol (1995) 29.42
Interleukin-10 and the interleukin-10 receptor. Annu Rev Immunol (2001) 25.63
CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J Exp Med (1998) 19.03
A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature (1997) 16.28
Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation. J Exp Med (2000) 16.09
Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4. J Exp Med (2000) 13.13
Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo. Nat Immunol (2000) 12.81
CD4+ CD25+ suppressor T cells: more questions than answers. Nat Rev Immunol (2002) 12.73
Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide. Nat Immunol (2001) 12.00
Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state. Int Immunol (1998) 11.26
Regulatory T cells: key controllers of immunologic self-tolerance. Cell (2000) 10.19
Phenotypically distinct subsets of CD4+ T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice. Int Immunol (1993) 9.97
Regulatory T cells in autoimmmunity*. Annu Rev Immunol (2000) 9.36
Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance. Nat Immunol (2002) 9.18
CD4(+)CD25(+) immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor. Immunity (2002) 8.28
Regulation of immune responses by TGF-beta. Annu Rev Immunol (1998) 8.01
Induction of tumor immunity by removing CD25+CD4+ T cells: a common basis between tumor immunity and autoimmunity. J Immunol (1999) 7.60
Origin of regulatory T cells with known specificity for antigen. Nat Immunol (2002) 7.49
CD4+CD25+ T cells inhibit both the induction and effector function of autoreactive T cells and represent a unique lineage of immunoregulatory cells. J Immunol (1998) 7.31
Regulatory T cells in the control of immune pathology. Nat Immunol (2001) 6.98
A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB(low) CD4+ T cells. J Exp Med (1996) 6.73
Extrathymic tolerance of mature T cells: clonal elimination as a consequence of immunity. Cell (1990) 6.33
Homeostasis and anergy of CD4(+)CD25(+) suppressor T cells in vivo. Nat Immunol (2001) 5.95
The induction of tolerance by dendritic cells that have captured apoptotic cells. J Exp Med (2000) 5.74
CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2. Immunity (2002) 5.38
The emerging role of CTLA-4 as an immune attenuator. Immunity (1997) 5.35
CD25+ CD4+ T cells regulate the expansion of peripheral CD4 T cells through the production of IL-10. J Immunol (2001) 4.07
CD5 expression is developmentally regulated by T cell receptor (TCR) signals and TCR avidity. J Exp Med (1998) 3.82
Engagement of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) induces transforming growth factor beta (TGF-beta) production by murine CD4(+) T cells. J Exp Med (1998) 3.56
Homeostasis of peripheral CD4+ T cells: IL-2R alpha and IL-2 shape a population of regulatory cells that controls CD4+ T cell numbers. J Immunol (2002) 3.35
Homeostatic expansion and phenotypic conversion of naïve T cells in response to self peptide/MHC ligands. Proc Natl Acad Sci U S A (1999) 3.06
T cell deletion in high antigen dose therapy of autoimmune encephalomyelitis. Science (1994) 3.00
CD25 is a marker for CD4+ thymocytes that prevent autoimmune diabetes in rats, but peripheral T cells with this function are found in both CD25+ and CD25- subpopulations. J Immunol (2000) 2.98
Population biology of lymphocytes: the flight for survival. Annu Rev Immunol (2000) 2.96
A role for CD5 in TCR-mediated signal transduction and thymocyte selection. Science (1995) 2.84
T cells down-modulate peptide-MHC complexes on APCs in vivo. Nat Immunol (2001) 2.80
Interleukin-7: master regulator of peripheral T-cell homeostasis? Trends Immunol (2001) 2.65
Autologous regulation of naive T cell homeostasis within the T cell compartment. J Immunol (2001) 2.52
Impairment of immunological memory in the absence of MHC despite survival of memory T cells. Nat Immunol (2002) 2.42
Homeostasis of alpha beta TCR+ T cells. Nat Immunol (2000) 2.29
CD4+ T cell division in irradiated mice requires peptides distinct from those responsible for thymic selection. J Exp Med (1999) 2.04
Immunosuppression by CD4+ regulatory T cells induced by chronic retroviral infection. Proc Natl Acad Sci U S A (2001) 2.04
Retracted The Fas/Fas ligand pathway and Bcl-2 regulate T cell responses to model self and foreign antigens. Immunity (1998) 2.02
Regulatory T cells in spontaneous autoimmune encephalomyelitis. Immunol Rev (2001) 1.99
Regulatory T cells and inflammatory bowel disease. Immunol Today (1999) 1.94
Generation and maintenance of memory T cells. Curr Opin Immunol (2001) 1.79
Repertoire requirements of CD4+ T cells that prevent spontaneous autoimmune encephalomyelitis. J Immunol (2000) 1.70
Sensory adaptation in naive peripheral CD4 T cells. J Exp Med (2001) 1.65
Dependence of lymphopenia-induced T cell proliferation on the abundance of peptide/ MHC epitopes and strength of their interaction with T cell receptors. Proc Natl Acad Sci U S A (2001) 1.61
Organ-specific autoimmunity induced by lymphopenia. Immunol Rev (1996) 1.50
The anatomy of T-cell activation and tolerance. Proc Natl Acad Sci U S A (1996) 1.42
Peripheral T cell survival. Curr Opin Immunol (1999) 1.42
The organization of mature T-cell pools. Immunol Today (1998) 1.34
Dynamic tuning of T cell reactivity by self-peptide-major histocompatibility complex ligands. J Exp Med (2001) 1.33
Lymphopenia and abnormal lymphocyte subsets in the "BB" rat: relationship to the diabetic syndrome. Endocrinology (1982) 1.28
Differential survival of naive CD4 and CD8 T cells. J Immunol (2000) 1.24
Conversion of naive T cells to a memory-like phenotype in lymphopenic hosts is not related to a homeostatic mechanism that fills the peripheral naive T cell pool. J Immunol (2002) 1.23
T cell regulation: a special job or everyone's responsibility? Nat Immunol (2001) 1.20
Induction of cytotoxic T lymphocyte antigen 4 (CTLA-4) restricts clonal expansion of helper T cells. J Exp Med (2001) 1.17
Self-tolerance: context dependent tuning of T cell antigen recognition. Semin Immunol (2000) 1.15
Suppressor T cells: Rebirth, function and homeostasis. Curr Biol (2000) 1.07
Circulating lymphocyte populations and autoantibodies in non-obese diabetic (NOD) mice: a longitudinal study. Clin Exp Immunol (1987) 1.04
Naive CD4(+) lymphocytes convert to anergic or memory-like cells in T cell-deprived recipients. Eur J Immunol (2001) 1.00
Structure and specificity of the T cell antigen receptor. Semin Immunol (1991) 0.96
TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity (2006) 29.29
The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins. Nature (2008) 10.15
Onset and progression in inherited ALS determined by motor neurons and microglia. Science (2006) 9.42
Transforming growth factor-beta 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset. Nat Immunol (2008) 6.76
Interleukin-17-producing gammadelta T cells selectively expand in response to pathogen products and environmental signals. Immunity (2009) 6.05
Fate mapping of IL-17-producing T cells in inflammatory responses. Nat Immunol (2011) 5.98
Highly purified Th17 cells from BDC2.5NOD mice convert into Th1-like cells in NOD/SCID recipient mice. J Clin Invest (2009) 4.74
Signals mediated by transforming growth factor-beta initiate autoimmune encephalomyelitis, but chronic inflammation is needed to sustain disease. Nat Immunol (2006) 4.44
Natural agonists for aryl hydrocarbon receptor in culture medium are essential for optimal differentiation of Th17 T cells. J Exp Med (2008) 3.50
IL-10-secreting regulatory T cells do not express Foxp3 but have comparable regulatory function to naturally occurring CD4+CD25+ regulatory T cells. J Immunol (2004) 3.46
Effector T cell plasticity: flexibility in the face of changing circumstances. Nat Immunol (2010) 3.12
An IL-9 fate reporter demonstrates the induction of an innate IL-9 response in lung inflammation. Nat Immunol (2011) 2.69
Impairment of immunological memory in the absence of MHC despite survival of memory T cells. Nat Immunol (2002) 2.42
Plasticity of Th17 cells in Peyer's patches is responsible for the induction of T cell-dependent IgA responses. Nat Immunol (2013) 2.24
The aryl hydrocarbon receptor in immunity. Trends Immunol (2009) 2.19
CD4+ memory T cells: functional differentiation and homeostasis. Immunol Rev (2006) 1.84
Resurrection of endogenous retroviruses in antibody-deficient mice. Nature (2012) 1.81
IL-9-mediated survival of type 2 innate lymphoid cells promotes damage control in helminth-induced lung inflammation. J Exp Med (2013) 1.75
The functional plasticity of T cell subsets. Nat Rev Immunol (2009) 1.74
Involvement of avidity for major histocompatibility complex in homeostasis of naive and memory T cells. J Exp Med (2003) 1.71
The resolution of inflammation. Nat Rev Immunol (2012) 1.58
TGFbeta1, a "Jack of all trades": the link with pro-inflammatory IL-17-producing T cells. Trends Immunol (2006) 1.46
CD25+ CD4+ T cells compete with naive CD4+ T cells for IL-2 and exploit it for the induction of IL-10 production. Int Immunol (2005) 1.40
Apoptosis of oligodendrocytes via Fas and TNF-R1 is a key event in the induction of experimental autoimmune encephalomyelitis. J Immunol (2005) 1.34
Ablation of thymic export causes accelerated decay of naive CD4 T cells in the periphery because of activation by environmental antigen. Proc Natl Acad Sci U S A (2008) 1.32
Modulation of dendritic cell function by naive and regulatory CD4+ T cells. J Immunol (2006) 1.31
Differentiation of human T(H)-17 cells does require TGF-beta! Nat Immunol (2008) 1.27
Homeostasis and T cell regulation. Curr Opin Immunol (2004) 1.26
Generalized immune activation as a direct result of activated CD4+ T cell killing. J Biol (2009) 1.22
Differential influences of the aryl hydrocarbon receptor on Th17 mediated responses in vitro and in vivo. PLoS One (2013) 1.21
Retrovirus-specificity of regulatory T cells is neither present nor required in preventing retrovirus-induced bone marrow immune pathology. Immunity (2008) 1.20
A major role for memory CD4 T cells in the control of lymphopenia-induced proliferation of naive CD4 T cells. J Immunol (2005) 1.17
Emv2, the only endogenous ecotropic murine leukemia virus of C57BL/6J mice. Retrovirology (2012) 1.15
Regulation and function of innate and adaptive interleukin-17-producing cells. EMBO Rep (2012) 1.14
The many lives of IL-9: a question of survival? Nat Immunol (2012) 1.11
CD4 memory T cells survive and proliferate but fail to differentiate in the absence of CD40. J Exp Med (2006) 1.07
B lymphocyte activation by coinfection prevents immune control of friend virus infection. J Immunol (2008) 1.06
Race between retroviral spread and CD4+ T-cell response determines the outcome of acute Friend virus infection. J Virol (2009) 1.05
Cross presentation of antigen on MHC class II via the draining lymph node after corneal transplantation in mice. J Immunol (2008) 1.04
CD4 T-cell memory. Semin Immunol (2004) 1.01
Suppression of innate immune pathology by regulatory T cells during Influenza A virus infection of immunodeficient mice. J Virol (2010) 1.01
Identification of early gene expression changes during human Th17 cell differentiation. Blood (2012) 0.99
T cell homeostasis in steady state and lymphopenic conditions. Immunol Lett (2006) 0.99
Chronic exposure to low levels of antigen in the periphery causes reversible functional impairment correlating with changes in CD5 levels in monoclonal CD8 T cells. J Immunol (2003) 0.99
Are human endogenous retroviruses pathogenic? An approach to testing the hypothesis. Bioessays (2013) 0.98
Anatomical heterogeneity of memory CD4+ T cells due to reversible adaptation to the microenvironment. J Immunol (2004) 0.96
Functional specialization of memory Th cells revealed by expression of integrin CD49b. J Immunol (2006) 0.96
Negative selection by an endogenous retrovirus promotes a higher-avidity CD4+ T cell response to retroviral infection. PLoS Pathog (2012) 0.95
The concept of space and competition in immune regulation. Immunology (2004) 0.95
Noncognate interaction with MHC class II molecules is essential for maintenance of T cell metabolism to establish optimal memory CD4 T cell function. J Immunol (2007) 0.95
CD25+CD4+ regulatory T cells and memory T cells prevent lymphopenia-induced proliferation of naive T cells in transient states of lymphopenia. J Immunol (2006) 0.94
IL-22 Protects Against Liver Pathology and Lethality of an Experimental Blood-Stage Malaria Infection. Front Immunol (2012) 0.94
Roles for TGF-beta and programmed cell death 1 ligand 1 in regulatory T cell expansion and diabetes suppression by zymosan in nonobese diabetic mice. J Immunol (2010) 0.91
Mechanisms of control of acute Friend virus infection by CD4+ T helper cells and their functional impairment by regulatory T cells. J Gen Virol (2009) 0.91
Tumor necrosis factor-alpha regulation of insulin-like growth factor-I, type 1 IGF receptor, and IGF binding protein expression in cerebellum of transgenic mice. J Neurosci Res (2003) 0.91
Activation of CD8 T cells by antigen expressed in the pituitary gland. J Immunol (2002) 0.90
CD4 T cells guarantee optimal competitive fitness of CD8 memory T cells. Eur J Immunol (2004) 0.90
B cells and TCR avidity determine distinct functions of CD4+ T cells in retroviral infection. J Immunol (2011) 0.90
Distinct roles of CD4+ T cell subpopulations in retroviral immunity: lessons from the Friend virus mouse model. Retrovirology (2011) 0.89
IL-2-independent and TNF-α-dependent expansion of Vβ5+ natural regulatory T cells during retrovirus infection. J Immunol (2013) 0.86
IL-22 mediates goblet cell hyperplasia and worm expulsion in intestinal helminth infection. PLoS Pathog (2013) 0.86
Negative impact of IFN-γ on early host immune responses to retroviral infection. J Immunol (2012) 0.85
The role of TNF/TNFR in organ-specific and systemic autoimmunity: implications for the design of optimized 'anti-TNF' therapies. Curr Dir Autoimmun (2002) 0.85
Th17 cells: An orphan with influence. Immunol Cell Biol (2007) 0.84
Counterpoise between the microbiome, host immune activation and pathology. Curr Opin Immunol (2013) 0.83
Phenotypic and functional profiling of CD4 T cell compartment in distinct populations of healthy adults with different antigenic exposure. PLoS One (2013) 0.83
Factors affecting the susceptibility of the mouse pituitary gland to CD8 T-cell-mediated autoimmunity. Immunology (2004) 0.83
The influence of CD4 T-cell subsets on control of CD4 T-cell-mediated graft-versus-host disease. Immunology (2008) 0.80
Tumor and CD4 T-cell interactions: tumor escape as result of reciprocal inactivation. Blood (2003) 0.79
Immunology: Cause of death matters. Nature (2009) 0.77
Innate lymphoid cells and type 2 (th2) mediated immune responses - pathogenic or beneficial? Front Immunol (2011) 0.76
Transduction of naive CD4 T cells with kinase-deficient Lck-HIV-Tat fusion protein dampens T cell activation and provokes a switch to regulatory function. Eur J Immunol (2005) 0.75