Published in J Biol Chem on September 08, 2000
Caveolae as organizers of pharmacologically relevant signal transduction molecules. Annu Rev Pharmacol Toxicol (2008) 2.57
Endogenous cardiotonic steroids: physiology, pharmacology, and novel therapeutic targets. Pharmacol Rev (2009) 2.17
Binding of Src to Na+/K+-ATPase forms a functional signaling complex. Mol Biol Cell (2005) 1.92
The physiological significance of the cardiotonic steroid/ouabain-binding site of the Na,K-ATPase. Annu Rev Physiol (2010) 1.58
The highly conserved cardiac glycoside binding site of Na,K-ATPase plays a role in blood pressure regulation. Proc Natl Acad Sci U S A (2005) 1.54
Mice expressing ouabain-sensitive α1-Na,K-ATPase have increased susceptibility to pressure overload-induced cardiac hypertrophy. Am J Physiol Heart Circ Physiol (2010) 1.51
The Na/K-ATPase/Src complex and cardiotonic steroid-activated protein kinase cascades. Pflugers Arch (2008) 1.46
Ouabain, a steroid hormone that signals with slow calcium oscillations. Proc Natl Acad Sci U S A (2001) 1.46
Pilot study of huachansu in patients with hepatocellular carcinoma, nonsmall-cell lung cancer, or pancreatic cancer. Cancer (2009) 1.42
Na/K-ATPase tethers phospholipase C and IP3 receptor into a calcium-regulatory complex. Mol Biol Cell (2005) 1.36
The sodium pump and cardiotonic steroids-induced signal transduction protein kinases and calcium-signaling microdomain in regulation of transporter trafficking. Biochim Biophys Acta (2010) 1.17
Changes in sodium pump expression dictate the effects of ouabain on cell growth. J Biol Chem (2009) 1.16
Ouabain modulates epithelial cell tight junction. Proc Natl Acad Sci U S A (2010) 1.13
Constitutively active Src tyrosine kinase changes gating of HCN4 channels through direct binding to the channel proteins. J Cardiovasc Pharmacol (2006) 1.05
A Direct Comparison of the Anticancer Activities of Digitoxin MeON-Neoglycosides and O-Glycosides: Oligosaccharide Chain Length-Dependent Induction of Caspase-9-Mediated Apoptosis. ACS Med Chem Lett (2010) 1.05
STAT3 signaling in pulmonary arterial hypertension. JAKSTAT (2012) 1.04
Zinc induces a Src family kinase-mediated up-regulation of NMDA receptor activity and excitotoxicity. Proc Natl Acad Sci U S A (2001) 1.03
Ouabain binding to Na+,K+-ATPase relaxes cell attachment and sends a specific signal (NACos) to the nucleus. J Membr Biol (2004) 1.00
Regulation of intracellular cholesterol distribution by Na/K-ATPase. J Biol Chem (2009) 0.99
Na,K-ATPase signal transduction triggers CREB activation and dendritic growth. Proc Natl Acad Sci U S A (2009) 0.96
Reduction of Na/K-ATPase potentiates marinobufagenin-induced cardiac dysfunction and myocyte apoptosis. J Biol Chem (2012) 0.95
Regulation of sodium pump endocytosis by cardiotonic steroids: Molecular mechanisms and physiological implications. Pathophysiology (2007) 0.95
Endogenous cardiotonic steroids and salt-sensitive hypertension. Biochim Biophys Acta (2010) 0.94
Redox control of cardiac excitability. Antioxid Redox Signal (2012) 0.94
Cell signaling associated with Na(+)/K(+)-ATPase: activation of phosphatidylinositide 3-kinase IA/Akt by ouabain is independent of Src. Biochemistry (2013) 0.94
Molecular mechanisms of experimental salt-sensitive hypertension. J Am Heart Assoc (2012) 0.90
Alterations of Na+/K+-ATPase function in caveolin-1 knockout cardiac fibroblasts. J Mol Cell Cardiol (2010) 0.90
Anti-inflammatory and antinociceptive activity of ouabain in mice. Mediators Inflamm (2011) 0.88
Ryanodine receptor phosphorylation by oxidized CaMKII contributes to the cardiotoxic effects of cardiac glycosides. Cardiovasc Res (2013) 0.87
Proscillaridin A is cytotoxic for glioblastoma cell lines and controls tumor xenograft growth in vivo. Oncotarget (2014) 0.86
Brain Na(+), K(+)-ATPase Activity In Aging and Disease. Int J Biomed Sci (2014) 0.86
Akt-dependent cell size regulation by the adhesion molecule on glia occurs independently of phosphatidylinositol 3-kinase and Rheb signaling. Mol Cell Biol (2005) 0.85
Identification of a mutant α1 Na/K-ATPase that pumps but is defective in signal transduction. J Biol Chem (2013) 0.85
Ouabain facilitates cardiac differentiation of mouse embryonic stem cells through ERK1/2 pathway. Acta Pharmacol Sin (2010) 0.83
Digitoxin activates EGR1 and synergizes with paclitaxel on human breast cancer cells. J Carcinog (2010) 0.83
Membrane potential-dependent inhibition of the Na+,K+-ATPase by para-nitrobenzyltriethylammonium bromide. Mol Pharmacol (2012) 0.82
A novel cell-based high-throughput screen for inhibitors of HIV-1 gene expression and budding identifies the cardiac glycosides. J Antimicrob Chemother (2013) 0.82
Expression of mutant α1 Na/K-ATPase defective in conformational transition attenuates Src-mediated signal transduction. J Biol Chem (2013) 0.82
Chronic administration of KB-R7943 induces up-regulation of cardiac NCX1. J Biol Chem (2009) 0.82
Lipid bilayer composition affects transmembrane protein orientation and function. J Lipids (2011) 0.81
Role and regulation of EGFR in actin remodeling in sperm capacitation and the acrosome reaction. Asian J Androl (2010) 0.81
Preconditioning by subinotropic doses of ouabain in the Langendorff perfused rabbit heart. J Cardiovasc Pharmacol (2010) 0.81
Targeted mutations in the Na,K-ATPase α 2 isoform confer ouabain resistance and result in abnormal behavior in mice. Synapse (2010) 0.80
The Trade-Off between Dietary Salt and Cardiovascular Disease; A Role for Na/K-ATPase Signaling? Front Endocrinol (Lausanne) (2014) 0.80
The effect of SCF and ouabain on small intestinal motility dysfunction induced by gastric cancer peritoneal metastasis. Clin Exp Metastasis (2015) 0.79
Regulation of renal function and structure by the signaling Na/K-ATPase. IUBMB Life (2013) 0.78
Do Src Kinase and Caveolin Interact Directly with Na,K-ATPase? J Biol Chem (2016) 0.78
Regulatory mechanisms for glycogenolysis and K+ uptake in brain astrocytes. Neurochem Int (2013) 0.78
Adaptor protein2 (AP2) orchestrates CXCR2-mediated cell migration. Traffic (2014) 0.78
Expression of rat Na-K-ATPase α2 enables ion pumping but not ouabain-induced signaling in α1-deficient porcine renal epithelial cells. Am J Physiol Cell Physiol (2015) 0.78
ATP1A1-mediated Src signaling inhibits coronavirus entry into host cells. J Virol (2015) 0.78
The alpha1 isoform of the Na+/K+ ATPase is up-regulated in dedifferentiated progenitor cells that mediate lens and retina regeneration in adult newts. Exp Eye Res (2008) 0.76
Specialized Functional Diversity and Interactions of the Na,K-ATPase. Front Physiol (2016) 0.76
Differential roles of caveolin-1 in ouabain-induced Na+/K+-ATPase cardiac signaling and contractility. Physiol Genomics (2016) 0.76
Digoxin-induced retinal degeneration depends on rhodopsin. Cell Death Dis (2017) 0.75
Src-independent ERK signaling through the α3 isoform of Na/K-ATPase. Am J Physiol Cell Physiol (2016) 0.75
"The Lower Threshold" phenomenon in tumor cells toward endogenous digitalis-like compounds: Responsible for tumorigenesis? J Carcinog (2012) 0.75
The physiological and clinical importance of sodium potassium ATPase in cardiovascular diseases. Curr Opin Pharmacol (2016) 0.75
Regulation of Cardiac Remodeling by Cardiac Na(+)/K(+)-ATPase Isoforms. Front Physiol (2016) 0.75
The Influence of Na(+), K(+)-ATPase on Glutamate Signaling in Neurodegenerative Diseases and Senescence. Front Physiol (2016) 0.75
Ouabain-Induced Signaling and Cell Survival in SK-N-SH Neuroblastoma Cells Differentiated by Retinoic Acid. CNS Neurol Disord Drug Targets (2015) 0.75
Na/K-ATPase as a target for anticancer drugs: studies with perillyl alcohol. Mol Cancer (2015) 0.75
Caveolins and cavins in the trafficking, maturation, and degradation of caveolae: implications for cell physiology. Am J Physiol Cell Physiol (2017) 0.75
Ouabain affects cell migration via Na,K-ATPase-p130cas and via nucleus-centrosome association. PLoS One (2017) 0.75
The type IV pilus assembly ATPase PilB functions as a signaling protein to regulate exopolysaccharide production in Myxococcus xanthus. Sci Rep (2017) 0.75
Cardiotonic Steroids Stimulate Macrophage Inflammatory Responses Through a Pathway Involving CD36, TLR4, and Na/K-ATPase. Arterioscler Thromb Vasc Biol (2017) 0.75
DAMBE: software package for data analysis in molecular biology and evolution. J Hered (2001) 9.96
Control of RNA polymerase II elongation potential by a novel carboxyl-terminal domain kinase. J Biol Chem (1996) 6.78
Bax directly induces release of cytochrome c from isolated mitochondria. Proc Natl Acad Sci U S A (1998) 6.69
Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis. Science (1998) 4.84
Cytochrome c release and apoptosis induced by mitochondrial targeting of nuclear orphan receptor TR3. Science (2000) 4.57
Unstable angina pectoris. N Engl J Med (2000) 3.58
Channel formation by antiapoptotic protein Bcl-2. Proc Natl Acad Sci U S A (1997) 3.45
Oligomerization of mu- and delta-opioid receptors. Generation of novel functional properties. J Biol Chem (2000) 3.22
An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators. J Biol Chem (1999) 2.97
Oocyte apoptosis is suppressed by disruption of the acid sphingomyelinase gene or by sphingosine-1-phosphate therapy. Nat Med (2000) 2.96
BAG-1 modulates the chaperone activity of Hsp70/Hsc70. EMBO J (1997) 2.91
Impact of chronic kidney disease on postoperative outcome following colorectal cancer surgery. Colorectal Dis (2014) 2.04
A 3,000-year record of penguin populations. Nature (2000) 1.94
Release of caspase-9 from mitochondria during neuronal apoptosis and cerebral ischemia. Proc Natl Acad Sci U S A (1999) 1.93
Mice lacking inducible nitric oxide synthase have improved left ventricular contractile function and reduced apoptotic cell death late after myocardial infarction. Circ Res (2001) 1.70
Identification of a novel family of nonclassic yeast phosphatidylinositol transfer proteins whose function modulates phospholipase D activity and Sec14p-independent cell growth. Mol Biol Cell (2000) 1.66
Absence of protease-resistant prion protein in the cerebrospinal fluid of Creutzfeldt-Jakob disease. J Pathol (2001) 1.61
Bcl-2 and Bax regulate the channel activity of the mitochondrial adenine nucleotide translocator. Oncogene (2000) 1.61
Ouabain interaction with cardiac Na+/K+-ATPase initiates signal cascades independent of changes in intracellular Na+ and Ca2+ concentrations. J Biol Chem (2000) 1.60
Yeast Sec14p deficient in phosphatidylinositol transfer activity is functional in vivo. Mol Cell (1999) 1.60
Apoptosis control in syncytia induced by the HIV type 1-envelope glycoprotein complex: role of mitochondria and caspases. J Exp Med (2000) 1.59
Aggregation-induced emission of 1-methyl-1,2,3,4,5-pentaphenylsilole. Chem Commun (Camb) (2001) 1.59
A novel enhancer of the Apaf1 apoptosome involved in cytochrome c-dependent caspase activation and apoptosis. J Biol Chem (2000) 1.57
Exaggerated left ventricular dilation and reduced collagen deposition after myocardial infarction in mice lacking osteopontin. Circ Res (2001) 1.56
Pleiotropic alterations in lipid metabolism in yeast sac1 mutants: relationship to "bypass Sec14p" and inositol auxotrophy. Mol Biol Cell (1999) 1.55
Intracellular reactive oxygen species mediate the linkage of Na+/K+-ATPase to hypertrophy and its marker genes in cardiac myocytes. J Biol Chem (1999) 1.52
Uptake of some quaternary ammonium ions by human erythrocytes. J Gen Physiol (1966) 1.52
Multiple signal transduction pathways link Na+/K+-ATPase to growth-related genes in cardiac myocytes. The roles of Ras and mitogen-activated protein kinases. J Biol Chem (1998) 1.51
Alginate, inorganic polyphosphate, GTP and ppGpp synthesis co-regulated in Pseudomonas aeruginosa: implications for stationary phase survival and synthesis of RNA/DNA precursors. Mol Microbiol (1998) 1.50
Sensitivity of 14-3-3 protein test varies in subtypes of sporadic Creutzfeldt-Jakob disease. Neurology (2004) 1.49
Periodontal therapy reduces the severity of active rheumatoid arthritis in patients treated with or without tumor necrosis factor inhibitors. J Periodontol (2009) 1.44
Calcium- and vitamin D-regulated keratinocyte differentiation. Mol Cell Endocrinol (2001) 1.38
Highly frequent frameshift DNA synthesis by human DNA polymerase mu. Mol Cell Biol (2001) 1.38
BAR: An apoptosis regulator at the intersection of caspases and Bcl-2 family proteins. Proc Natl Acad Sci U S A (2000) 1.38
Arsenite induces apoptosis via a direct effect on the mitochondrial permeability transition pore. Exp Cell Res (1999) 1.33
Aberrant metal binding by prion protein in human prion disease. J Neurochem (2001) 1.33
Apoptosis. Molecules and mechanisms. Adv Exp Med Biol (1999) 1.30
Role of protein kinase C in the signal pathways that link Na+/K+-ATPase to ERK1/2. J Biol Chem (2001) 1.28
Expression of Bcl-2-related genes in normal and AML progenitors: changes induced by chemotherapy and retinoic acid. Leukemia (1999) 1.28
Calcium and 1,25(OH)2D: interacting drivers of epidermal differentiation. J Steroid Biochem Mol Biol (2004) 1.28
Anaesthetic neurotoxicity and neuroplasticity: an expert group report and statement based on the BJA Salzburg Seminar. Br J Anaesth (2013) 1.26
Apoptotic protease activating factor 1 (Apaf-1)-independent cell death suppression by Bcl-2. J Exp Med (2000) 1.26
Lonidamine triggers apoptosis via a direct, Bcl-2-inhibited effect on the mitochondrial permeability transition pore. Oncogene (1999) 1.26
Streptococcal co-infection augments Candida pathogenicity by amplifying the mucosal inflammatory response. Cell Microbiol (2013) 1.24
Inhibition of phosphatidylinositol 3-kinase dephosphorylates BAD and promotes apoptosis in myeloid leukemias. Leukemia (2004) 1.24
Bacteriophage HK97 head assembly. FEMS Microbiol Rev (1995) 1.23
Characterization of interactions between the anti-apoptotic protein BAG-1 and Hsc70 molecular chaperones. J Biol Chem (1998) 1.23
Sjögren's syndrome: a critical review of clinical management. J Rheumatol (1999) 1.20
Partial inhibition of Na+/K+-ATPase by ouabain induces the Ca2+-dependent expressions of early-response genes in cardiac myocytes. J Biol Chem (1996) 1.19
Examination of the hdrRM regulon yields insight into the competence system of Streptococcus mutans. Mol Oral Microbiol (2010) 1.17
A novel human actin-binding protein homologue that binds to platelet glycoprotein Ibalpha. Blood (1998) 1.16
Steroid myopathy in connective tissue disease. Am J Med (1976) 1.15
25 Hydroxyvitamin D 1 alpha-hydroxylase is required for optimal epidermal differentiation and permeability barrier homeostasis. J Invest Dermatol (2004) 1.15
Tryptophan hydroxylase-2 gene polymorphisms in rhesus monkeys: association with hypothalamic-pituitary-adrenal axis function and in vitro gene expression. Mol Psychiatry (2006) 1.10
Control of interneuron dendritic growth through NRG1/erbB4-mediated kalirin-7 disinhibition. Mol Psychiatry (2011) 1.09
Association between IgE antibody against soluble egg antigen and resistance to reinfection with Schistosoma japonicum. Trans R Soc Trop Med Hyg (1998) 1.08
Holocene--late pleistocene climatic ice core records from qinghai-tibetan plateau. Science (1989) 1.07
The mosaic of brain glial hyperactivity during normal ageing and its attenuation by food restriction. Neuroscience (1999) 1.06
Genetic manipulation of the odor-evoked distributed neural activity in the Drosophila mushroom body. Neuron (2001) 1.06
Lymphotactin gene-modified bone marrow dendritic cells act as more potent adjuvants for peptide delivery to induce specific antitumor immunity. J Immunol (1998) 1.06
A pathway for the biosynthesis of straight and branched, odd- and even-length, medium-chain fatty acids in plants. Proc Natl Acad Sci U S A (1994) 1.05
Isoflurane and sevoflurane increase interleukin-6 levels through the nuclear factor-kappa B pathway in neuroglioma cells. Br J Anaesth (2013) 1.05
Signal-transducing function of Na+-K+-ATPase is essential for ouabain's effect on [Ca2+]i in rat cardiac myocytes. Am J Physiol Heart Circ Physiol (2001) 1.04
TNF-alpha enhances cardiac myocyte NO production through MAP kinase-mediated NF-kappaB activation. Am J Physiol (1999) 1.02
A luciferase transgenic mouse model: visualization of prostate development and its androgen responsiveness in live animals. J Mol Endocrinol (2005) 1.02
Mice lacking 25OHD 1alpha-hydroxylase demonstrate decreased epidermal differentiation and barrier function. J Steroid Biochem Mol Biol (2004) 1.01
Expression of tobacco class II catalase gene activates the endogenous homologous gene and is associated with disease resistance in transgenic potato plants. Plant Mol Biol (1999) 1.00
Screening differential expression of serum proteins in AFP-negative HBV-related hepatocellular carcinoma using iTRAQ -MALDI-MS/MS. Neoplasma (2014) 0.99
Nitric oxide mediates activity-dependent synaptic suppression at developing neuromuscular synapses. Nature (1995) 0.97
Determination of total (Na+ + K+)-ATPase activity of isolated or cultured cells. Anal Biochem (1989) 0.97
HIV gp120 enhances NO production by cardiac myocytes through p38 MAP kinase-mediated NF-kappaB activation. Am J Physiol Heart Circ Physiol (2000) 0.96
Isoflurane affects the cytoskeleton but not survival, proliferation, or synaptogenic properties of rat astrocytes in vitro. Br J Anaesth (2013) 0.96
Genetic variability of group A and B human respiratory syncytial viruses isolated from 3 provinces in China. Arch Virol (2007) 0.96
Sequential regulation of keratinocyte differentiation by 1,25(OH)2D3, VDR, and its coregulators. J Steroid Biochem Mol Biol (2007) 0.96
A human RNA polymerase II transcription termination factor is a SWI2/SNF2 family member. J Biol Chem (1998) 0.96
Intracellular Ca(2+) and Ca(2+)/calmodulin-dependent kinase II mediate acute potentiation of neurotransmitter release by neurotrophin-3. J Cell Biol (2000) 0.94
Overexpression of clusterin correlates with tumor progression, metastasis in gastric cancer: a study on tissue microarrays. Neoplasma (2010) 0.94
The negative cell cycle regulator, Tob (transducer of ErbB-2), is a multifunctional protein involved in hippocampus-dependent learning and memory. Neuroscience (2005) 0.94
Expression and structural characterization of the recombinant human doppel protein. Biochemistry (2000) 0.94
Oligomerization of dopamine and serotonin receptors. Neuropsychopharmacology (2000) 0.94
Cloning genes encoding receptors related to chemoattractant receptors. Genomics (1998) 0.94
Phosphatidylinositol/phosphatidylcholine transfer proteins in yeast. Biochim Biophys Acta (2000) 0.93
Ouabain-induced hypertrophy in cultured cardiac myocytes is accompanied by changes in expression of several late response genes. J Mol Cell Cardiol (1997) 0.92
Infiltration of eosinophils into the asthmatic airways caused by interleukin 5. Am J Respir Cell Mol Biol (1997) 0.92
Evidence for heterogeneity in hereditary hemochromatosis. Evaluation of 174 persons in nine families. Am J Med (1984) 0.91
Prognostic significance of cyclinD1 amplification and the co-alteration of cyclinD1/pRb/ppRb in patients with esophageal squamous cell carcinoma. Dis Esophagus (2011) 0.91
Insomnia associated with thalamic involvement in E200K Creutzfeldt-Jakob disease. Neurology (2002) 0.91
Palmitoylation occurs at cysteine 347 and cysteine 351 of the dopamine D(1) receptor. Eur J Pharmacol (1999) 0.90
Molecular cloning of two rat Na+/Pi cotransporters: evidence for differential tissue expression of transcripts. Cell Mol Biol Res (1995) 0.90
(Na+ + K+)-ATPase: on the number of the ATP sites of the functional unit. J Bioenerg Biomembr (1987) 0.90
Synergistic antileukemic effects between ABT-869 and chemotherapy involve downregulation of cell cycle-regulated genes and c-Mos-mediated MAPK pathway. Leukemia (2007) 0.90
Apoptosis induction by the photosensitizer verteporfin: identification of mitochondrial adenine nucleotide translocator as a critical target. Cancer Res (2001) 0.90
Regulation of AMP deaminase by 2,3-diphosphoglyceric acid: a possible mechanism for the control of adenine nucleotide metabolism in human erythrocytes. Biochim Biophys Acta (1968) 0.90
The effects of antibodies to Na+, K+-ATPase on the reactions catalyzed by the enzyme. Ann N Y Acad Sci (1974) 0.89
Alkali cation-activated AMP deaminase of erythrocytes: some properties of the membrane-bound enzyme. Biochim Biophys Acta (1968) 0.89