Published in J Biol Chem on September 08, 2000
Endogenous cardiotonic steroids: physiology, pharmacology, and novel therapeutic targets. Pharmacol Rev (2009) 2.17
Binding of Src to Na+/K+-ATPase forms a functional signaling complex. Mol Biol Cell (2005) 1.92
Ouabain triggers preconditioning through activation of the Na+,K+-ATPase signaling cascade in rat hearts. Cardiovasc Res (2006) 1.67
A high-throughput screening strategy identifies cardiotonic steroids as alternative splicing modulators. Proc Natl Acad Sci U S A (2008) 1.56
Na/K-ATPase tethers phospholipase C and IP3 receptor into a calcium-regulatory complex. Mol Biol Cell (2005) 1.36
Na,K-ATPase activity is required for formation of tight junctions, desmosomes, and induction of polarity in epithelial cells. Mol Biol Cell (2001) 1.34
The sodium pump and cardiotonic steroids-induced signal transduction protein kinases and calcium-signaling microdomain in regulation of transporter trafficking. Biochim Biophys Acta (2010) 1.17
Arrhythmogenic adverse effects of cardiac glycosides are mediated by redox modification of ryanodine receptors. J Physiol (2011) 1.08
Na+/Ca2+ exchange and Na+/K+-ATPase in the heart. J Physiol (2015) 1.06
A Direct Comparison of the Anticancer Activities of Digitoxin MeON-Neoglycosides and O-Glycosides: Oligosaccharide Chain Length-Dependent Induction of Caspase-9-Mediated Apoptosis. ACS Med Chem Lett (2010) 1.05
Zinc induces a Src family kinase-mediated up-regulation of NMDA receptor activity and excitotoxicity. Proc Natl Acad Sci U S A (2001) 1.03
Regulation of sodium pump endocytosis by cardiotonic steroids: Molecular mechanisms and physiological implications. Pathophysiology (2007) 0.95
Extracellular signal-regulated kinase and GEF-H1 mediate depolarization-induced Rho activation and paracellular permeability increase. Am J Physiol Cell Physiol (2010) 0.95
Endogenous cardiotonic steroids and salt-sensitive hypertension. Biochim Biophys Acta (2010) 0.94
Identification of small-molecule inhibitors of the colorectal cancer oncogene Krüppel-like factor 5 expression by ultrahigh-throughput screening. Mol Cancer Ther (2011) 0.94
Cell signaling associated with Na(+)/K(+)-ATPase: activation of phosphatidylinositide 3-kinase IA/Akt by ouabain is independent of Src. Biochemistry (2013) 0.94
Ouabain-induced perturbations in intracellular ionic homeostasis regulate death receptor-mediated apoptosis. Apoptosis (2010) 0.93
Different roles of the cardiac Na+/Ca2+-exchanger in ouabain-induced inotropy, cell signaling, and hypertrophy. Am J Physiol Heart Circ Physiol (2012) 0.93
Ouabain stimulates protein kinase B (Akt) phosphorylation in opossum kidney proximal tubule cells through an ERK-dependent pathway. Am J Physiol Cell Physiol (2007) 0.92
Ouabain-stimulated trafficking regulation of the Na/K-ATPase and NHE3 in renal proximal tubule cells. Mol Cell Biochem (2012) 0.91
Intracellular potassium stabilizes human ether-à-go-go-related gene channels for export from endoplasmic reticulum. Mol Pharmacol (2009) 0.91
Molecular mechanisms of experimental salt-sensitive hypertension. J Am Heart Assoc (2012) 0.90
Reactive Oxygen Species Modulation of Na/K-ATPase Regulates Fibrosis and Renal Proximal Tubular Sodium Handling. Int J Nephrol (2012) 0.90
Involvement of reactive oxygen species in a feed-forward mechanism of Na/K-ATPase-mediated signaling transduction. J Biol Chem (2013) 0.89
Curcumin modulation of Na,K-ATPase: phosphoenzyme accumulation, decreased K+ occlusion, and inhibition of hydrolytic activity. Br J Pharmacol (2005) 0.88
In silico investigation of potential SRC kinase ligands from traditional Chinese medicine. PLoS One (2012) 0.86
Akt-dependent cell size regulation by the adhesion molecule on glia occurs independently of phosphatidylinositol 3-kinase and Rheb signaling. Mol Cell Biol (2005) 0.85
A novel cell-based high-throughput screen for inhibitors of HIV-1 gene expression and budding identifies the cardiac glycosides. J Antimicrob Chemother (2013) 0.82
Preconditioning by subinotropic doses of ouabain in the Langendorff perfused rabbit heart. J Cardiovasc Pharmacol (2010) 0.81
c-Fos expression in ouabain-treated vascular smooth muscle cells from rat aorta: evidence for an intracellular-sodium-mediated, calcium-independent mechanism. J Physiol (2002) 0.81
The Trade-Off between Dietary Salt and Cardiovascular Disease; A Role for Na/K-ATPase Signaling? Front Endocrinol (Lausanne) (2014) 0.80
Pivotal role of α2 Na(+) pumps and their high affinity ouabain binding site in cardiovascular health and disease. J Physiol (2016) 0.79
Characteristics of deslanoside-induced modulation on jejunal contractility. World J Gastroenterol (2012) 0.79
pNaKtide inhibits Na/K-ATPase reactive oxygen species amplification and attenuates adipogenesis. Sci Adv (2015) 0.79
ATP1A1-mediated Src signaling inhibits coronavirus entry into host cells. J Virol (2015) 0.78
Effect of ouabain on myocardial ultrastructure and cytoskeleton during the development of ventricular hypertrophy. Heart Vessels (2012) 0.78
Identification of hydroxyxanthones as Na/K-ATPase ligands. Mol Pharmacol (2010) 0.78
Novel role of ouabain as a cystogenic factor in autosomal dominant polycystic kidney disease. Am J Physiol Renal Physiol (2013) 0.78
Evidence for an ATP-sensitive K+ channel in mitoplasts isolated from Trypanosoma cruzi and Crithidia fasciculata. Int J Parasitol (2009) 0.78
Do Src Kinase and Caveolin Interact Directly with Na,K-ATPase? J Biol Chem (2016) 0.78
Expression of rat Na-K-ATPase α2 enables ion pumping but not ouabain-induced signaling in α1-deficient porcine renal epithelial cells. Am J Physiol Cell Physiol (2015) 0.78
The influence of Ouabain on human dendritic cells maturation. Mediators Inflamm (2014) 0.77
A synthetic thiourea-based tripodal receptor that impairs the function of human first trimester cytotrophoblast cells. Int J Environ Res Public Health (2014) 0.76
The alpha1 isoform of the Na+/K+ ATPase is up-regulated in dedifferentiated progenitor cells that mediate lens and retina regeneration in adult newts. Exp Eye Res (2008) 0.76
Ion dependence of Na-K-ATPase-mediated epithelial cell adhesion and migration. Am J Physiol Cell Physiol (2015) 0.76
Specialized Functional Diversity and Interactions of the Na,K-ATPase. Front Physiol (2016) 0.76
Ouabain inhibits monocyte activation in vitro: prevention of the proinflammatory mCD14(+)/CD16(+) subset appearance and cell-size progression. J Exp Pharmacol (2012) 0.76
The physiological and clinical importance of sodium potassium ATPase in cardiovascular diseases. Curr Opin Pharmacol (2016) 0.75
Carbonylation Modification Regulates Na/K-ATPase Signaling and Salt Sensitivity: A Review and a Hypothesis. Front Physiol (2016) 0.75
Conformational changes required for reovirus cell entry are sensitive to pH. Virology (2015) 0.75
Time- and dose dependent actions of cardiotonic steroids on transcriptome and intracellular content of Na(+) and K(+): a comparative analysis. Sci Rep (2017) 0.75
Protein Carbonylation of an Amino Acid Residue of the Na/K-ATPase α1 Subunit Determines Na/K-ATPase Signaling and Sodium Transport in Renal Proximal Tubular Cells. J Am Heart Assoc (2016) 0.75
Regulation of Cardiac Remodeling by Cardiac Na(+)/K(+)-ATPase Isoforms. Front Physiol (2016) 0.75
Carnosine prevents necrotic and apoptotic death of rat thymocytes via ouabain-sensitive Na/K-ATPase. Cell Biochem Funct (2012) 0.75
Suppression of Adenovirus Replication by Cardiotonic Steroids. J Virol (2016) 0.75
The Molecular Basis of Toxins' Interactions with Intracellular Signaling via Discrete Portals. Toxins (Basel) (2017) 0.75
Na/K-ATPase Signaling and Salt Sensitivity: The Role of Oxidative Stress. Antioxidants (Basel) (2017) 0.75
Attenuation of Na/K-ATPase Mediated Oxidant Amplification with pNaKtide Ameliorates Experimental Uremic Cardiomyopathy. Sci Rep (2016) 0.75
"The Lower Threshold" phenomenon in tumor cells toward endogenous digitalis-like compounds: Responsible for tumorigenesis? J Carcinog (2012) 0.75
Mono-2-ethylhexyl phthalate disrupts neurulation and modifies the embryonic redox environment and gene expression. Reprod Toxicol (2016) 0.75
Update on angiotensin II: new endocrine connections between the brain, adrenal glands and the cardiovascular system. Endocr Connect (2017) 0.75
Ouabain targets the Na(+)/K(+)-ATPase α3 isoform to inhibit cancer cell proliferation and induce apoptosis. Oncol Lett (2017) 0.75
DAMBE: software package for data analysis in molecular biology and evolution. J Hered (2001) 9.96
Banff 07 classification of renal allograft pathology: updates and future directions. Am J Transplant (2008) 8.09
Prevalence of abnormal serum vitamin D, PTH, calcium, and phosphorus in patients with chronic kidney disease: results of the study to evaluate early kidney disease. Kidney Int (2006) 7.02
Control of RNA polymerase II elongation potential by a novel carboxyl-terminal domain kinase. J Biol Chem (1996) 6.78
Bax directly induces release of cytochrome c from isolated mitochondria. Proc Natl Acad Sci U S A (1998) 6.69
The pCL vector system: rapid production of helper-free, high-titer, recombinant retroviruses. J Virol (1996) 6.62
Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes. Nature (1993) 5.47
Banff '05 Meeting Report: differential diagnosis of chronic allograft injury and elimination of chronic allograft nephropathy ('CAN'). Am J Transplant (2007) 5.39
Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis. Science (1998) 4.84
Evolution of organic aerosols in the atmosphere. Science (2009) 4.82
Cytochrome c release and apoptosis induced by mitochondrial targeting of nuclear orphan receptor TR3. Science (2000) 4.57
Decreased atherosclerosis in mice deficient in both macrophage colony-stimulating factor (op) and apolipoprotein E. Proc Natl Acad Sci U S A (1995) 4.31
Unstable angina pectoris. N Engl J Med (2000) 3.58
Control of cell cycle progression by c-Jun is p53 dependent. Genes Dev (1999) 3.51
Channel formation by antiapoptotic protein Bcl-2. Proc Natl Acad Sci U S A (1997) 3.45
Banff '09 meeting report: antibody mediated graft deterioration and implementation of Banff working groups. Am J Transplant (2010) 3.29
Oligomerization of mu- and delta-opioid receptors. Generation of novel functional properties. J Biol Chem (2000) 3.22
Targetting of the gene encoding fibrillin-1 recapitulates the vascular aspect of Marfan syndrome. Nat Genet (1997) 2.98
An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators. J Biol Chem (1999) 2.97
Oocyte apoptosis is suppressed by disruption of the acid sphingomyelinase gene or by sphingosine-1-phosphate therapy. Nat Med (2000) 2.96
Crucial role of the interleukin 1 receptor family member T1/ST2 in T helper cell type 2-mediated lung mucosal immune responses. J Exp Med (1999) 2.92
BAG-1 modulates the chaperone activity of Hsp70/Hsc70. EMBO J (1997) 2.91
The CD28-related molecule ICOS is required for effective T cell-dependent immune responses. Immunity (2000) 2.70
Attitudes on immunization: a survey of American chiropractors. J Manipulative Physiol Ther (1995) 2.44
Rapid concentration and purification of polyoma virus and SV40 with polyethylene glycol. Virology (1970) 2.37
Interexaminer reliability of eight evaluative dimensions of lumbar segmental abnormality: Part II. J Manipulative Physiol Ther (1993) 2.32
Banff 2011 Meeting report: new concepts in antibody-mediated rejection. Am J Transplant (2012) 2.28
Randomized controlled trial of yoga and exercise in multiple sclerosis. Neurology (2004) 2.20
Enzymatic modification of aminoglycoside antibiotics: a new 3-N-acetylating enzyme from a Pseudomonas aeruginosa isolate. Antimicrob Agents Chemother (1976) 2.10
Envelope gene and long terminal repeat determine the different biological properties of Rauscher, Friend, and Moloney mink cell focus-inducing viruses. J Virol (1985) 2.08
Efficient high-frequency body coil for high-field MRI. Magn Reson Med (2004) 2.07
Impact of chronic kidney disease on postoperative outcome following colorectal cancer surgery. Colorectal Dis (2014) 2.04
Frequent mutations in the p53 tumor suppressor gene in human leukemia T-cell lines. Mol Cell Biol (1990) 2.03
CC chemokine receptor (CCR)3/eotaxin is followed by CCR4/monocyte-derived chemokine in mediating pulmonary T helper lymphocyte type 2 recruitment after serial antigen challenge in vivo. J Exp Med (2000) 2.02
Loss of simian virus 40 DNA-RNA hybrids from nitrocellulose membranes; implications for the study of virus--host DNA interactions. Proc Natl Acad Sci U S A (1972) 2.00
A 3,000-year record of penguin populations. Nature (2000) 1.94
Release of caspase-9 from mitochondria during neuronal apoptosis and cerebral ischemia. Proc Natl Acad Sci U S A (1999) 1.93
ICOS is critical for T helper cell-mediated lung mucosal inflammatory responses. Nat Immunol (2001) 1.85
Enzymatic modification of aminoglycoside antibiotics: a new 6'-N-acetylating enzyme from a Pseudomonas aeruginosa isolate. Antimicrob Agents Chemother (1976) 1.81
Enterobacter sakazakii infections in neonates associated with intrinsic contamination of a powdered infant formula. Infect Control Hosp Epidemiol (1989) 1.74
Non-invasive physical treatments for chronic/recurrent headache. Cochrane Database Syst Rev (2004) 1.74
Mice lacking inducible nitric oxide synthase have improved left ventricular contractile function and reduced apoptotic cell death late after myocardial infarction. Circ Res (2001) 1.70
Immunopathology of B-cell lymphomas induced in C57BL/6 mice by dualtropic murine leukemia virus (MuLV). Am J Pathol (1982) 1.66
Identification of a novel family of nonclassic yeast phosphatidylinositol transfer proteins whose function modulates phospholipase D activity and Sec14p-independent cell growth. Mol Biol Cell (2000) 1.66
Chromosomal mapping of the mink cell focus-inducing and xenotropic env gene family in the mouse. Proc Natl Acad Sci U S A (1983) 1.65
Strongly linked current flow in polycrystalline forms of the superconductor MgB2. Nature (2001) 1.64
Involvement of Src and epidermal growth factor receptor in the signal-transducing function of Na+/K+-ATPase. J Biol Chem (2000) 1.63
Absence of protease-resistant prion protein in the cerebrospinal fluid of Creutzfeldt-Jakob disease. J Pathol (2001) 1.61
Bcl-2 and Bax regulate the channel activity of the mitochondrial adenine nucleotide translocator. Oncogene (2000) 1.61
Yeast Sec14p deficient in phosphatidylinositol transfer activity is functional in vivo. Mol Cell (1999) 1.60
Apoptosis control in syncytia induced by the HIV type 1-envelope glycoprotein complex: role of mitochondria and caspases. J Exp Med (2000) 1.59
Aggregation-induced emission of 1-methyl-1,2,3,4,5-pentaphenylsilole. Chem Commun (Camb) (2001) 1.59
Effects of hypernatremia on organic brain osmoles. J Clin Invest (1990) 1.57
A novel enhancer of the Apaf1 apoptosome involved in cytochrome c-dependent caspase activation and apoptosis. J Biol Chem (2000) 1.57
Exaggerated left ventricular dilation and reduced collagen deposition after myocardial infarction in mice lacking osteopontin. Circ Res (2001) 1.56
Pleiotropic alterations in lipid metabolism in yeast sac1 mutants: relationship to "bypass Sec14p" and inositol auxotrophy. Mol Biol Cell (1999) 1.55
Intracellular reactive oxygen species mediate the linkage of Na+/K+-ATPase to hypertrophy and its marker genes in cardiac myocytes. J Biol Chem (1999) 1.52
In vitro infection of lymphoid cells by thymotropic radiation leukemia virus grown in vitro. Proc Natl Acad Sci U S A (1975) 1.52
Uptake of some quaternary ammonium ions by human erythrocytes. J Gen Physiol (1966) 1.52
Multiple signal transduction pathways link Na+/K+-ATPase to growth-related genes in cardiac myocytes. The roles of Ras and mitogen-activated protein kinases. J Biol Chem (1998) 1.51
In vitro and in vivo resistance to cisplatin in cells that have lost DNA mismatch repair. Cancer Res (1997) 1.50
Alginate, inorganic polyphosphate, GTP and ppGpp synthesis co-regulated in Pseudomonas aeruginosa: implications for stationary phase survival and synthesis of RNA/DNA precursors. Mol Microbiol (1998) 1.50
Sensitivity of 14-3-3 protein test varies in subtypes of sporadic Creutzfeldt-Jakob disease. Neurology (2004) 1.49
Defective bacteriophage PBSH in Bacillus subtilis. II. Intracellular development of the induced prophage. J Virol (1969) 1.49
Combination therapy an ACE inhibitor and an angiotensin receptor blocker for IgA nephropathy: a meta-analysis. Int J Clin Pract (2012) 1.47
Efficacy of spinal manipulation for chronic headache: a systematic review. J Manipulative Physiol Ther (2001) 1.45
Galectin-1 prolongs survival of mouse liver allografts from Flt3L-pretreated donors. Am J Transplant (2013) 1.44
Periodontal therapy reduces the severity of active rheumatoid arthritis in patients treated with or without tumor necrosis factor inhibitors. J Periodontol (2009) 1.44
Class I and III polyhydroxyalkanoate synthases from Ralstonia eutropha and Allochromatium vinosum: characterization and substrate specificity studies. Arch Biochem Biophys (2001) 1.42
Primary structure, functional expression, and chromosomal localization of the bumetanide-sensitive Na-K-Cl cotransporter in human colon. J Biol Chem (1995) 1.40
Gain-of-function mutations of the p53 gene induce lymphohematopoietic metastatic potential and tissue invasiveness. Am J Pathol (1994) 1.39
Calcium- and vitamin D-regulated keratinocyte differentiation. Mol Cell Endocrinol (2001) 1.38
Highly frequent frameshift DNA synthesis by human DNA polymerase mu. Mol Cell Biol (2001) 1.38
Observation of an antimatter hypernucleus. Science (2010) 1.38
BAR: An apoptosis regulator at the intersection of caspases and Bcl-2 family proteins. Proc Natl Acad Sci U S A (2000) 1.38
Calcium carbonate and the premenstrual syndrome: effects on premenstrual and menstrual symptoms. Premenstrual Syndrome Study Group. Am J Obstet Gynecol (1998) 1.38
[Comparative studies on the teaching of oral pathology]. Dtsch Zahnarztl Z (1976) 1.37
Catecholamine-stimulated ion transport in duck red cells. Gradient effects in electrically neutral [Na + K + 2Cl] Co-transport. J Gen Physiol (1982) 1.36
On the regulation of the initiation of DNA replication in bacteria. Cold Spring Harb Symp Quant Biol (1968) 1.35
The use of antibody to complement protein C5 for salvage treatment of severe antibody-mediated rejection. Am J Transplant (2008) 1.34
Arsenite induces apoptosis via a direct effect on the mitochondrial permeability transition pore. Exp Cell Res (1999) 1.33
Reticulum cell neoplasms induced in C57BL/6 mice by cultured virus grown in stromal hematopoietic cell lines. J Natl Cancer Inst (1979) 1.33
Study of brain electrolytes and organic osmolytes during correction of chronic hyponatremia. Implications for the pathogenesis of central pontine myelinolysis. J Clin Invest (1991) 1.33
Aberrant metal binding by prion protein in human prion disease. J Neurochem (2001) 1.33
Non-thymic malignant lymphomas induced in C57BL/6 mice by cloned dualtropic viruses isolated from hematopoietic stromal cell lines. Eur J Cancer (1980) 1.31
Apoptosis. Molecules and mechanisms. Adv Exp Med Biol (1999) 1.30
Adherence to yoga and exercise interventions in a 6-month clinical trial. BMC Complement Altern Med (2007) 1.30
Pain, disability, and satisfaction outcomes and predictors of outcomes: a practice-based study of chronic low back pain patients attending primary care and chiropractic physicians. J Manipulative Physiol Ther (2001) 1.30
Role of protein kinase C in the signal pathways that link Na+/K+-ATPase to ERK1/2. J Biol Chem (2001) 1.28
Expression of Bcl-2-related genes in normal and AML progenitors: changes induced by chemotherapy and retinoic acid. Leukemia (1999) 1.28
Calcium and 1,25(OH)2D: interacting drivers of epidermal differentiation. J Steroid Biochem Mol Biol (2004) 1.28
Initial evidence of endothelial cell apoptosis as a mechanism of systemic capillary leak syndrome. Chest (2001) 1.28
A distinctive pediatric renal neoplasm characterized by epithelioid morphology, basement membrane production, focal HMB45 immunoreactivity, and t(6;11)(p21.1;q12) chromosome translocation. Am J Pathol (2001) 1.27
Anaesthetic neurotoxicity and neuroplasticity: an expert group report and statement based on the BJA Salzburg Seminar. Br J Anaesth (2013) 1.26
Neoadjuvant treatment of borderline resectable and non-resectable pancreatic cancer. Ann Oncol (2013) 1.26