The role of antimicrobial peptides in animal defenses.

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Published in Proc Natl Acad Sci U S A on August 01, 2000

Authors

R E Hancock1, M G Scott

Author Affiliations

1: Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada V6T 1Z3. bob@cmdr.ubc.ca

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A double-blind and cross-over comparison of once daily doxazosin and placebo with steady-state pharmacokinetics in elderly hypertensive patients. Eur J Clin Pharmacol (1988) 0.75

More on "hook effects" in immunometric assays for prostate-specific antigen. Clin Chem (1989) 0.75

Measurement of cyclosporine concentrations in whole blood: HPLC and radioimmunoassay with a specific monoclonal antibody and 3H- or 125I-labeled ligand compared. Clin Chem (1989) 0.75

Stratus automated creatine kinase-MB assay evaluated: identification and elimination of falsely increased results associated with a high-molecular-mass form of alkaline phosphatase. Clin Chem (1989) 0.75