Published in Nat Cell Biol on August 01, 2000
Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death. Science (2001) 23.42
tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c. Genes Dev (2000) 8.35
Mitochondria and cell death: outer membrane permeabilization and beyond. Nat Rev Mol Cell Biol (2010) 7.95
Stepwise activation of BAX and BAK by tBID, BIM, and PUMA initiates mitochondrial apoptosis. Mol Cell (2009) 4.37
Bax and Bak coalesce into novel mitochondria-associated clusters during apoptosis. J Cell Biol (2001) 3.09
VDAC-dependent permeabilization of the outer mitochondrial membrane by superoxide induces rapid and massive cytochrome c release. J Cell Biol (2001) 2.80
JNK promotes Bax translocation to mitochondria through phosphorylation of 14-3-3 proteins. EMBO J (2004) 2.50
Apoptosis-inducing factor is involved in the regulation of caspase-independent neuronal cell death. J Cell Biol (2002) 2.47
A reversible component of mitochondrial respiratory dysfunction in apoptosis can be rescued by exogenous cytochrome c. EMBO J (2001) 2.44
Lewy bodies. Proc Natl Acad Sci U S A (2006) 2.15
A three-helix homo-oligomerization domain containing BH3 and BH1 is responsible for the apoptotic activity of Bax. Genes Dev (2007) 1.97
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Molecularly targeted nanocarriers deliver the cytolytic peptide melittin specifically to tumor cells in mice, reducing tumor growth. J Clin Invest (2009) 1.78
Malaria parasite CelTOS targets the inner leaflet of cell membranes for pore-dependent disruption. Elife (2016) 1.76
Bax oligomerization in mitochondrial membranes requires tBid (caspase-8-cleaved Bid) and a mitochondrial protein. Biochem J (2002) 1.71
A novel, high conductance channel of mitochondria linked to apoptosis in mammalian cells and Bax expression in yeast. J Cell Biol (2001) 1.63
Bax ablation prevents dopaminergic neurodegeneration in the 1-methyl- 4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease. Proc Natl Acad Sci U S A (2001) 1.62
Essential role of voltage-dependent anion channel in various forms of apoptosis in mammalian cells. J Cell Biol (2001) 1.57
Oligomeric Bax is a component of the putative cytochrome c release channel MAC, mitochondrial apoptosis-induced channel. Mol Biol Cell (2005) 1.55
Mitochondrial outer membrane proteins assist Bid in Bax-mediated lipidic pore formation. Mol Biol Cell (2009) 1.48
Synthesis and characterization of stable fluorocarbon nanostructures as drug delivery vehicles for cytolytic peptides. Nano Lett (2008) 1.47
Mitochondrial carrier homolog 2 is a target of tBID in cells signaled to die by tumor necrosis factor alpha. Mol Cell Biol (2005) 1.43
Conformational changes in BAK, a pore-forming proapoptotic Bcl-2 family member, upon membrane insertion and direct evidence for the existence of BH3-BH3 contact interface in BAK homo-oligomers. J Biol Chem (2010) 1.36
Assembly of the mitochondrial apoptosis-induced channel, MAC. J Biol Chem (2009) 1.35
Spatial and temporal changes in Bax subcellular localization during anoikis. J Cell Biol (2003) 1.34
Bax activation initiates the assembly of a multimeric catalyst that facilitates Bax pore formation in mitochondrial outer membranes. PLoS Biol (2012) 1.26
Pharmacological manipulation of Bcl-2 family members to control cell death. J Clin Invest (2005) 1.19
Peptides derived from apoptotic Bax and Bid reproduce the poration activity of the parent full-length proteins. Biophys J (2005) 1.19
Organization of the mitochondrial apoptotic BAK pore: oligomerization of the BAK homodimers. J Biol Chem (2013) 1.16
Modeling of the role of a Bax-activation switch in the mitochondrial apoptosis decision. Biophys J (2007) 1.14
Cell death and the mitochondria: therapeutic targeting of the BCL-2 family-driven pathway. Br J Pharmacol (2014) 1.13
Assembly of the Bak apoptotic pore: a critical role for the Bak protein α6 helix in the multimerization of homodimers during apoptosis. J Biol Chem (2013) 1.12
Enlargement and contracture of C2-ceramide channels. Biophys J (2003) 1.12
Mechanisms balancing skeletal matrix synthesis and degradation. Biochem J (2002) 1.12
Single-point mutations of a lysine residue change function of Bax and Bcl-xL expressed in Bax- and Bak-less mouse embryonic fibroblasts: novel insights into the molecular mechanisms of Bax-induced apoptosis. Cell Death Differ (2010) 1.09
Reconstitution of proapoptotic BAK function in liposomes reveals a dual role for mitochondrial lipids in the BAK-driven membrane permeabilization process. J Biol Chem (2011) 1.08
The C- and N-Terminal Residues of Synthetic Heptapeptide Ion Channels Influence Transport Efficacy Through Phospholipid Bilayers. New J Chem (2005) 1.08
Response of yeast to the regulated expression of proteins in the Bcl-2 family. Biochem J (2003) 1.07
Biphasic translocation of Bax to mitochondria. Biochem J (2002) 1.07
Myxoma virus M11L blocks apoptosis through inhibition of conformational activation of Bax at the mitochondria. J Virol (2006) 1.06
The use of therapeutic peptides to target and to kill cancer cells. Curr Med Chem (2012) 1.04
Proapoptotic Bax and Bak proteins form stable protein-permeable pores of tunable size. J Biol Chem (2013) 1.01
Three-dimensional structure of Bax-mediated pores in membrane bilayers. Cell Death Dis (2013) 1.00
Analysis of endogenous Bax complexes during apoptosis using blue native PAGE: implications for Bax activation and oligomerization. Biochem J (2008) 1.00
Use of human cancer cell lines mitochondria to explore the mechanisms of BH3 peptides and ABT-737-induced mitochondrial membrane permeabilization. PLoS One (2010) 1.00
DNA-damage response network at the crossroads of cell-cycle checkpoints, cellular senescence and apoptosis. J Zhejiang Univ Sci B (2007) 0.99
The role of the mitochondrial apoptosis induced channel MAC in cytochrome c release. J Bioenerg Biomembr (2005) 0.99
Small-molecule Bax agonists for cancer therapy. Nat Commun (2014) 0.99
Evidence for dimer formation by an amphiphilic heptapeptide that mediates chloride and carboxyfluorescein release from liposomes. Org Biomol Chem (2005) 0.96
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Sphingosine forms channels in membranes that differ greatly from those formed by ceramide. J Bioenerg Biomembr (2005) 0.96
Bid induces cytochrome c-impermeable Bax channels in liposomes. Biochem J (2002) 0.96
Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2)-dependent oligomerization of fibroblast growth factor 2 (FGF2) triggers the formation of a lipidic membrane pore implicated in unconventional secretion. J Biol Chem (2012) 0.96
Cholesterol effects on BAX pore activation. J Mol Biol (2008) 0.95
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Mitofusins and the mitochondrial permeability transition: the potential downside of mitochondrial fusion. Am J Physiol Heart Circ Physiol (2012) 0.93
Anion Transport in Liposomes Responds to Variations in the Anchor Chains and the Fourth Amino Acid of Heptapeptide Ion Channels. New J Chem (2005) 0.91
Copper compound induces autophagy and apoptosis of glioma cells by reactive oxygen species and JNK activation. BMC Cancer (2012) 0.91
Cardiolipin and phosphatidylglycerol are not required for the in vivo action of Bcl-2 family proteins. Cell Death Differ (2005) 0.89
Radiation-induced alterations in mitochondria of the rat heart. Radiat Res (2014) 0.88
Sphingosine, a product of ceramide hydrolysis, influences the formation of ceramide channels. Biophys J (2006) 0.88
Heterologous expression of the Na(+),K(+)-ATPase gamma subunit in Xenopus oocytes induces an endogenous, voltage-gated large diameter pore. J Physiol (2001) 0.87
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Herpes simplex virus blocks apoptosis by precluding mitochondrial cytochrome c release independent of caspase activation in infected human epithelial cells. Apoptosis (2007) 0.87
The Rubella virus capsid is an anti-apoptotic protein that attenuates the pore-forming ability of Bax. PLoS Pathog (2011) 0.87
The association between splenocyte apoptosis and alterations of Bax, Bcl-2 and caspase-3 mRNA expression, and oxidative stress induced by dietary nickel chloride in broilers. Int J Environ Res Public Health (2013) 0.87
Active Bax and Bak are functional holins. Genes Dev (2011) 0.87
Mitochondrial carrier homolog 2: a clue to cracking the BCL-2 family riddle? J Bioenerg Biomembr (2005) 0.87
p53 target Siva regulates apoptosis in ischemic kidneys. Am J Physiol Renal Physiol (2011) 0.87
Mitochondrial damage: a target for new therapeutic horizons. Neurotherapeutics (2010) 0.87
Detergent-activated BAX protein is a monomer. J Biol Chem (2009) 0.85
Acid destabilization of the solution conformation of Bcl-xL does not drive its pH-dependent insertion into membranes. Protein Sci (2005) 0.85
Membrane perturbations induced by the apoptotic Bax protein. Biochem J (2002) 0.84
Cationic nanocarriers induce cell necrosis through impairment of Na(+)/K(+)-ATPase and cause subsequent inflammatory response. Cell Res (2015) 0.83
The channel of death. J Cell Biol (2001) 0.83
Cytotoxicity and apoptotic activities of alpha-, gamma- and delta-tocotrienol isomers on human cancer cells. BMC Complement Altern Med (2014) 0.81
Fatty acids enhance membrane permeabilization by pro-apoptotic Bax. Biochem J (2004) 0.81
The dual role of calcium as messenger and stressor in cell damage, death, and survival. Int J Cell Biol (2010) 0.81
The C. elegans B-cell lymphoma 2 (Bcl-2) homolog cell death abnormal 9 (CED-9) associates with and remodels LIPID membranes. Protein Sci (2011) 0.80
Pore formation by dimeric Bak and Bax: an unusual pore? Philos Trans R Soc Lond B Biol Sci (2017) 0.80
Inhibition of δ-opioid receptors induces brain glioma cell apoptosis through the mitochondrial and protein kinase C pathways. Oncol Lett (2013) 0.79
Regulation of ceramide channel formation and disassembly: Insights on the initiation of apoptosis. Saudi J Biol Sci (2015) 0.79
Bax forms two types of channels, one of which is voltage-gated. Biophys J (2011) 0.79
The deadly landscape of pro-apoptotic BCL-2 proteins in the outer mitochondrial membrane. FEBS J (2016) 0.78
Interactions of Bax and tBid with lipid monolayers. J Membr Biol (2005) 0.78
Ethanol influences on Bax associations with mitochondrial membrane proteins in neonatal rat cerebellum. Dev Neurobiol (2012) 0.78
Lytic and non-lytic permeabilization of cardiolipin-containing lipid bilayers induced by cytochrome C. PLoS One (2013) 0.78
In Situ Characterization of Bak Clusters Responsible for Cell Death Using Single Molecule Localization Microscopy. Sci Rep (2016) 0.77
Synthetic, biologically active amphiphilic peptides. Chem Biodivers (2007) 0.77
Embelin-induced apoptosis of HepG2 human hepatocellular carcinoma cells and blockade of HepG2 cells in the G2/M phase via the mitochondrial pathway. Exp Ther Med (2012) 0.76
Assembly of Bak homodimers into higher order homooligomers in the mitochondrial apoptotic pore. Sci Rep (2016) 0.76
Inhibition of A20 expression in tumor microenvironment exerts anti-tumor effect through inducing myeloid-derived suppressor cells apoptosis. Sci Rep (2015) 0.76
Embelin-induced MCF-7 breast cancer cell apoptosis and blockade of MCF-7 cells in the G2/M phase via the mitochondrial pathway. Oncol Lett (2012) 0.76
Vanadium toxicity in the thymic development. Oncotarget (2015) 0.75
Oncogenic Mutations Differentially Affect Bax Monomer, Dimer, and Oligomeric Pore Formation in the Membrane. Sci Rep (2016) 0.75
Yeast as a tool for studying proteins of the Bcl-2 family. Microb Cell (2015) 0.75
BAX to basics: How the BCL2 gene family controls the death of retinal ganglion cells. Prog Retin Eye Res (2017) 0.75
Ceramide-induced apoptosis in renal tubular cells: a role of mitochondria and sphingosine-1-phoshate. Int J Mol Sci (2015) 0.75
TJ-41 Induces Apoptosis and Potentiates the Apoptotic Effects of 5-FU in Breast Cancer Cell Lines. J Oncol (2009) 0.75
Modulation of Bax and mTOR for cancer therapeutics. Cancer Res (2017) 0.75
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