Published in Science on July 04, 1975
Computer analysis of nucleic acid regulatory sequences. Proc Natl Acad Sci U S A (1977) 20.96
How ribosomes select initiator regions in mRNA: base pair formation between the 3' terminus of 16S rRNA and the mRNA during initiation of protein synthesis in Escherichia coli. Proc Natl Acad Sci U S A (1975) 10.60
Viral integration and excision: structure of the lambda att sites. Science (1977) 6.66
DNA sequence from the histidine operon control region: seven histidine codons in a row. Proc Natl Acad Sci U S A (1978) 6.12
Transcription termination at the trp operon attenuators of Escherichia coli and Salmonella typhimurium: RNA secondary structure and regulation of termination. Proc Natl Acad Sci U S A (1977) 6.08
Molecular basis of valine resistance in Escherichia coli K-12. Proc Natl Acad Sci U S A (1981) 3.55
Multivalent translational control of transcription termination at attenuator of ilvGEDA operon of Escherichia coli K-12. Proc Natl Acad Sci U S A (1980) 3.30
Histidine regulation in Salmonella typhimurium: an activator attenuator model of gene regulation. Proc Natl Acad Sci U S A (1975) 3.06
Nucleotide sequence of the attenuator region of the histidine operon of Escherichia coli K-12. Proc Natl Acad Sci U S A (1978) 2.71
Alternative secondary structures of leader RNAs and the regulation of the trp, phe, his, thr, and leu operons. Proc Natl Acad Sci U S A (1979) 2.71
A rho-dependent termination site in the gene coding for tyrosine tRNA su3 of Escherichia coli. Nature (1978) 2.58
Control features within the rplJL-rpoBC transcription unit of Escherichia coli. Proc Natl Acad Sci U S A (1979) 2.43
Regulation of aromatic amino acid transport systems in Escherichia coli K-12. J Bacteriol (1977) 2.41
Single base-pair alterations in the Escherichia coli trp operon leader region that relieve transcription termination at the trp attenuator. Proc Natl Acad Sci U S A (1978) 2.36
Influenza virus messenger RNAs are incomplete transcripts of the genome RNAs. Nucleic Acids Res (1977) 2.26
The nucleotide sequence preceding and including the beginning of the ilvE gene of the ilvGEDA operon of Escherichia coli K12. Nucleic Acids Res (1979) 2.07
Transcription termination and late control in phage lambda. Proc Natl Acad Sci U S A (1975) 2.02
Nucleotide sequence of the region of an origin of replication of the antibiotic resistance plasmid R6K. Proc Natl Acad Sci U S A (1979) 1.95
Transcription termination: nucleotide sequence at 3' end of tryptophan operon in Escherichia coli. Proc Natl Acad Sci U S A (1978) 1.94
Multiple discrete sites for premature RNA chain termination late in adenovirus-2 infection: enhancement by 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole. Proc Natl Acad Sci U S A (1979) 1.92
UGA suppression by normal tRNA Trp in Escherichia coli: codon context effects. Nucleic Acids Res (1981) 1.82
Promoter- and attenuator-related metabolic regulation of the Salmonella typhimurium histidine operon. J Bacteriol (1978) 1.74
Regulation of branched-chain amino acid transport in Escherichia coli. J Bacteriol (1976) 1.67
Determination of nucleotide sequences beyond the sites of transcriptional termination. Proc Natl Acad Sci U S A (1976) 1.61
Identification of a second tetracycline-inducible polypeptide encoded by Tn10. J Bacteriol (1980) 1.47
Characterization of in vitro transcription initiation and termination sites in Col E1 DNA. Nucleic Acids Res (1979) 1.41
Tryptophan-transducing bacteriophages: in vitro studies with restriction endonucleases HindII + III and Escherichia coli ribonucleic acid polymerase. J Bacteriol (1977) 1.39
In vivo and in vitro detection of the leader RNA of the histidine operon of Escherichia coli K-12. Proc Natl Acad Sci U S A (1981) 1.34
Is UAA or UGA part of the recognition signal for ribosomal initiation? Nucleic Acids Res (1979) 1.31
Role of ribonucleic acid polymerase in gene selection in procaryotes. Bacteriol Rev (1977) 1.22
Site of premature termination of late transcription of simian virus 40 DNA: enhancement by 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole. Proc Natl Acad Sci U S A (1982) 1.20
Isolation of temperature-sensitive tyrosine kinase mutants of v-abl oncogene by screening with antibodies for phosphotyrosine. Proc Natl Acad Sci U S A (1987) 1.18
Ribonuclease P substrate specificity: cleavage of a bacteriophage phi80-induced RNA. Proc Natl Acad Sci U S A (1976) 1.18
Termination of transcription by bacteriophage T3 RNA polymerase: homogeneous 3'-terminal oligonucleotide sequence of in vitro T3 RNA polymerase transcripts. Proc Natl Acad Sci U S A (1979) 1.10
Induction of sigma factor synthesis in Escherichia coli by the N gene product of bacteriophage lambda. Proc Natl Acad Sci U S A (1976) 1.10
Control sites in the sequence at the beginning of T7 gene 1. Nucleic Acids Res (1979) 1.05
In vitro synthesis of the tryptophan operon leader peptides of Escherichia coli, Serratia marcescens, and Salmonella typhimurium. Proc Natl Acad Sci U S A (1983) 1.05
Arrangement and regulation of the nitrogen fixation genes in Klebsiella pneumoniae studied by depression kinetics. J Bacteriol (1976) 1.04
Allosteric regulation of substrate channeling and catalysis in the tryptophan synthase bienzyme complex. Arch Biochem Biophys (2012) 1.03
Comparison of rat liver and Walker 256 carcinosarcoma tRNAs. Nucleic Acids Res (1979) 1.03
Tryptophan operon regulation in interspecific hybrids of enteric bacteria. J Bacteriol (1976) 1.02
Regulation of enzyme synthesis in the tryptophan pathway of Acinetobacter calcoaceticus. J Bacteriol (1976) 1.01
Relationship between messenger ribonucleic acid and enzyme levels specified by the leucine operon of Escherichia coli K-12. J Bacteriol (1977) 1.00
Purification and partial characterization of the B subunit of Serratia marcescens tryptophan synthetase. J Bacteriol (1978) 0.99
Transcriptional termination at the end of the early region of bacteriophages T3 and T7 is not affected by polarity suppressors. J Virol (1977) 0.99
Low molecular weight RNA species encoded by a multiple drug resistance plasmid. Proc Natl Acad Sci U S A (1978) 0.98
Effect of arginine on the stability and size of argECBH messenger ribonucleic acid in Escherichia coli. J Bacteriol (1976) 0.98
Regulation of amino acid transport in Escherichia coli by transcription termination factor rho. J Bacteriol (1977) 0.97
Influence of the stringent control system on the transcription of ribosomal ribonucleic acid and ribosomal protein genes in Escherichia coli. J Bacteriol (1977) 0.97
Initiation of translation with Pseudomonas aeruginosa phage PP7 RNA: nucleotide sequence of the coat cistron ribosome binding site. Nucleic Acids Res (1979) 0.92
Role of transcriptional regulation and enzyme inactivation in the synthesis of Escherichia coli carbamoylphosphate synthase. J Bacteriol (1980) 0.92
Differential expression of selected genes in human leukemia leukocytes. Proc Natl Acad Sci U S A (1982) 0.91
Hyperproduction of tryptophan by Escherichia coli: genetic manipulation of the pathways leading to tryptophan formation. Appl Environ Microbiol (1979) 0.90
Effects of altered rho gene product on the expression of the Escherichia coli histidine operon. J Bacteriol (1978) 0.90
Expression of the cloned uvrB gene of Escherichia coli: mode of transcription and orientation. J Bacteriol (1979) 0.90
Naturally occurring sites within the Shigella dysenteriae tryptophan operon severely limit tryptophan biosynthesis. J Bacteriol (1976) 0.89
Regulation of aromatic amino acid biosynthesis in Escherichia coli K-12: control of the aroF-tyrA operon in the absence of repression control. J Bacteriol (1980) 0.89
Mutation in the structural gene for seryl-transfer ribonucleic acid synthetase of Escherichia coli which affects formation of its gene product at high temperature. J Bacteriol (1980) 0.83
In vitro transcription of the Escherichia coli K-12 argA, argE, and argCBH operons. J Bacteriol (1977) 0.82
Isolation of specialized transducing bacteriophages carrying deletions of the regulatory region of the Escherichia coli K-12 tryptophan operon. J Bacteriol (1976) 0.82
Escherichia coli tryptophan operon directs the in vivo synthesis of a leader peptide. J Bacteriol (1986) 0.81
Tryptophan biosynthesis in the marine luminous bacterium Vibrio harveyi. J Bacteriol (1983) 0.79
Isolation and characterization of an endogenous inhibitor of protein synthesis in Escherichia coli K-12. J Bacteriol (1979) 0.79
Synthesis and activities of branched-chain aminoacyl-tRNA synthetases in threonine deaminase mutants of Escherichia coli. J Bacteriol (1978) 0.77
Theoretical analysis of single-round transcription experiments on trp leader region. Biophys J (1987) 0.75
Direct selection and analysis of mutational events which diminish the level of expression of the trp operon. J Bacteriol (1980) 0.75
Metabolism of arginine-specific messenger ribonucleic acid in Escherichia coli K-12. J Bacteriol (1977) 0.75
Symmetry, homology, and phrasing in the recognition of helical regulatory sequences in DNA. Nucleic Acids Res (1977) 0.75
Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma. Science (1994) 39.60
Plasmid ColEl as a molecular vehicle for cloning and amplification of DNA. Proc Natl Acad Sci U S A (1974) 32.46
Polarity and enzyme functions in mutants of the first three genes of the tryptophan operon of Escherichia coli. Genetics (1971) 14.59
Pre-early adenovirus 5 gene product regulates synthesis of early viral messenger RNAs. Cell (1979) 12.83
Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell (1997) 11.35
Cellular control of the synthesis and activity of the bacterial luminescent system. J Bacteriol (1970) 10.35
Transcription termination and the regulation of gene expression. Annu Rev Biochem (1986) 9.97
Attenuation in the control of expression of bacterial operons. Nature (1981) 9.90
Expression and regulation of Escherichia coli lacZ gene fusions in mammalian cells. J Mol Appl Genet (1983) 8.94
Glucocorticoids regulate expression of dihydrofolate reductase cDNA in mouse mammary tumour virus chimaeric plasmids. Nature (1981) 8.66
Comparison of Western blot (immunoblot) and glycoprotein G-specific immunodot enzyme assay for detecting antibodies to herpes simplex virus types 1 and 2 in human sera. J Clin Microbiol (1988) 8.09
Nonsense codons and polarity in the tryptophan operon. J Mol Biol (1966) 6.40
Isolation and characterization of a mouse interleukin cDNA clone that expresses B-cell stimulatory factor 1 activities and T-cell- and mast-cell-stimulating activities. Proc Natl Acad Sci U S A (1986) 6.16
Efficient cloning of genes of Neurospora crassa. Proc Natl Acad Sci U S A (1986) 6.08
Transcription termination at the trp operon attenuators of Escherichia coli and Salmonella typhimurium: RNA secondary structure and regulation of termination. Proc Natl Acad Sci U S A (1977) 6.08
The complete nucleotide sequence of the tryptophan operon of Escherichia coli. Nucleic Acids Res (1981) 5.91
Isolation and characterization of a mouse cDNA clone that expresses mast-cell growth-factor activity in monkey cells. Proc Natl Acad Sci U S A (1984) 5.81
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Translational coupling during expression of the tryptophan operon of Escherichia coli. Genetics (1980) 5.57
Cytokines: coordinators of immune and inflammatory responses. Annu Rev Biochem (1990) 5.36
Amino-terminal sequence analysis of proteins purified on a nanomole scale by gel electrophoresis. J Biol Chem (1972) 5.24
Cloning and characterization of the gene for beta-tubulin from a benomyl-resistant mutant of Neurospora crassa and its use as a dominant selectable marker. Mol Cell Biol (1986) 5.16
High-efficiency cloning of full-length cDNA; construction and screening of cDNA expression libraries for mammalian cells. Methods Enzymol (1987) 5.08
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Lac repressor. Specific proteolytic destruction of the NH 2 -terminal region and loss of the deoxyribonucleic acid-binding activity. J Biol Chem (1973) 4.96
Autotrophic picoplankton in the tropical ocean. Science (1983) 4.80
Isolation and characterization of a human interleukin cDNA clone, homologous to mouse B-cell stimulatory factor 1, that expresses B-cell- and T-cell-stimulating activities. Proc Natl Acad Sci U S A (1986) 4.59
The L-arabinose operon in Escherichia coli B-r: a genetic demonstration of two functional states of the product of a regulator gene. Proc Natl Acad Sci U S A (1969) 4.57
Yeast gene TRP5: structure, function, regulation. J Biol Chem (1982) 4.48
An electrophoretic karyotype of Neurospora crassa. Mol Cell Biol (1988) 4.46
Translation of the leader region of the Escherichia coli tryptophan operon. J Bacteriol (1978) 4.45
Termination of transcription in E. coli. Cell (1983) 4.42
Termination of transcription and its regulation in the tryptophan operon of E. coli. Cell (1981) 4.39
Nucleotide sequence and expression of Escherichia coli trpR, the structural gene for the trp aporepressor. Proc Natl Acad Sci U S A (1980) 4.35
The unusual mutagenic specificity of an E. Coli mutator gene. Proc Natl Acad Sci U S A (1966) 4.26
Regulated in vitro synthesis of Escherichia coli tryptophan operon messenger ribonucleic acid and enzymes. J Biol Chem (1974) 4.25
Nucleotide sequence of the leader region of the phenylalanine operon of Escherichia coli. Proc Natl Acad Sci U S A (1978) 4.01
Use of a cDNA expression vector for isolation of mouse interleukin 2 cDNA clones: expression of T-cell growth-factor activity after transfection of monkey cells. Proc Natl Acad Sci U S A (1985) 3.95
An intercistronic region and ribosome-binding site in bacterial messenger RNA. Proc Natl Acad Sci U S A (1975) 3.95
Novel form of transcription attenuation regulates expression the Bacillus subtilis tryptophan operon. J Bacteriol (1986) 3.90
Tryptophan messenger ribonucleic acid elongation rates and steady-state levels of tryptophan operon enzymes under various growth conditions. J Mol Biol (1970) 3.89
Nucleotide sequences of trpA of Salmonella typhimurium and Escherichia coli: an evolutionary comparison. Proc Natl Acad Sci U S A (1979) 3.87
Attenuation and processing of RNA from the rplJL--rpoBC transcription unit of Escherichia coli. Proc Natl Acad Sci U S A (1980) 3.86
RNA polymerase interaction at the promoter--operator region of the tryptophan operon of Escherichia coli and Salmonella typhimurium. J Mol Biol (1978) 3.84
Nucleotide sequence of the 5' end of tryptophan messenger RNA of Escherichia coli. J Mol Biol (1976) 3.60
Altered base ratios in the DNA of an Escherichia coli mutator strain. Proc Natl Acad Sci U S A (1967) 3.53
ClpB is the Escherichia coli heat shock protein F84.1. J Bacteriol (1991) 3.38
Conservation of the regulatory subunit for the Clp ATP-dependent protease in prokaryotes and eukaryotes. Proc Natl Acad Sci U S A (1990) 3.33
Control of rRNA transcription in Escherichia coli. Microbiol Rev (1995) 3.31
Isolation of cDNA for a human granulocyte-macrophage colony-stimulating factor by functional expression in mammalian cells. Proc Natl Acad Sci U S A (1985) 3.31
Attenuation in the Escherichia coli tryptophan operon: role of RNA secondary structure involving the tryptophan codon region. Proc Natl Acad Sci U S A (1979) 3.28
Interleukins and IgA synthesis. Human and murine interleukin 6 induce high rate IgA secretion in IgA-committed B cells. J Exp Med (1989) 3.28
Mutants of Escherichia coli with an altered tryptophanyl-transfer ribonucleic acid synthetase. J Bacteriol (1968) 3.27
An analysis of "revertants" of a deletion mutant in the C gene of the L-arabinose gene complex in Escherichia coli B-r: isolation of initiator constitutive mutants (Ic). J Mol Biol (1969) 3.25
Attenuation in amino acid biosynthetic operons. Annu Rev Genet (1982) 3.23
Human recombinant interleukin 4 induces Fc epsilon receptors (CD23) on normal human B lymphocytes. J Exp Med (1987) 3.22
Polarity and the degradation of mRNA. Nature (1969) 3.13
Nucleotide sequence of region preceding trp mRNA initiation site and its role in promoter and operator function. Proc Natl Acad Sci U S A (1976) 3.13
Mitomycin C-induced expression of trpA of Salmonella typhimurium inserted into the plasmid ColE1. J Bacteriol (1977) 3.06
Structure of the chromosomal gene for granulocyte-macrophage colony stimulating factor: comparison of the mouse and human genes. EMBO J (1985) 3.04
Amino acid replacements and the genetic code. Cold Spring Harb Symp Quant Biol (1966) 3.03
Construction of plasmid cloning vehicles that promote gene expression from the bacteriophage lambda pL promoter. Gene (1979) 3.00
Ribosome-protected regions in the leader-trpE sequence of Escherichia coli tryptophan operon messenger RNA. J Mol Biol (1976) 2.93
Nucleotide sequence of the structural gene for tryptophanase of Escherichia coli K-12. J Bacteriol (1981) 2.91
Structure of the trifunctional trp-1 gene from Neurospora crassa and its aberrant expression in Escherichia coli. J Mol Appl Genet (1983) 2.91
Neurospora crassa a mating-type region. Proc Natl Acad Sci U S A (1990) 2.91
The nature of the anthranilic acid synthetase complex of Escherichia coli. J Biol Chem (1966) 2.89
Mutations affecting tRNATrp and its charging and their effect on regulation of transcription termination at the attenuator of the tryptophan operon. J Mol Biol (1977) 2.89
Translational control of transcription termination at the attenuator of the Escherichia coli tryptophan operon. Proc Natl Acad Sci U S A (1978) 2.89
rRNA operon multiplicity in Escherichia coli and the physiological implications of rrn inactivation. J Bacteriol (1995) 2.87
The periodicity of RNA polymerase initiations: a new regulatory feature of transcription. Proc Natl Acad Sci U S A (1968) 2.87
Comparison of the nucleotide sequences of the initial transcribed regions of the tryptophan operons of Escherichia coli and Salmonella typhimurium. J Mol Biol (1978) 2.86
An Escherichia coli strain with all chromosomal rRNA operons inactivated: complete exchange of rRNA genes between bacteria. Proc Natl Acad Sci U S A (1999) 2.85
DNA microarray analysis of gene expression in response to physiological and genetic changes that affect tryptophan metabolism in Escherichia coli. Proc Natl Acad Sci U S A (2000) 2.83
Basin-scale coherence in phenology of shrimps and phytoplankton in the North Atlantic Ocean. Science (2009) 2.81
Interleukin-6-deficient mice are highly susceptible to Listeria monocytogenes infection: correlation with inefficient neutrophilia. Infect Immun (1995) 2.80
Purification and characterization of trp aporepressor. Proc Natl Acad Sci U S A (1983) 2.70
Maximizing gene expression from plasmid vectors containing the lambda PL promoter: strategies for overproducing transcription termination factor rho. Proc Natl Acad Sci U S A (1985) 2.70
Antitermination of E. coli rRNA transcription is caused by a control region segment containing lambda nut-like sequences. Cell (1984) 2.68
Structural and functional analysis of cloned deoxyribonucleic acid containing the trpR-thr region of the Escherichia coli chromosome. J Bacteriol (1979) 2.65
Synthetic sites for transcription termination and a functional comparison with tryptophan operon termination sites in vitro. Proc Natl Acad Sci U S A (1981) 2.62