Published in J Biol Chem on December 01, 2000
International Union of Basic and Clinical Pharmacology. LXXVI. Current progress in the mammalian TRP ion channel family. Pharmacol Rev (2010) 2.66
Fine-tuning of GPCR activity by receptor-interacting proteins. Nat Rev Mol Cell Biol (2009) 2.39
Targeted disruption of the mouse NHERF-1 gene promotes internalization of proximal tubule sodium-phosphate cotransporter type IIa and renal phosphate wasting. Proc Natl Acad Sci U S A (2002) 2.37
Non-selective cationic channels of smooth muscle and the mammalian homologues of Drosophila TRP. J Physiol (2004) 2.03
Identification of common binding sites for calmodulin and inositol 1,4,5-trisphosphate receptors on the carboxyl termini of trp channels. J Biol Chem (2001) 1.99
Multiple roles of calmodulin and other Ca(2+)-binding proteins in the functional regulation of TRP channels. Pflugers Arch (2005) 1.68
A role for Orai in TRPC-mediated Ca2+ entry suggests that a TRPC:Orai complex may mediate store and receptor operated Ca2+ entry. Proc Natl Acad Sci U S A (2009) 1.57
Caveolin-1 contributes to assembly of store-operated Ca2+ influx channels by regulating plasma membrane localization of TRPC1. J Biol Chem (2003) 1.46
Isoform-specific inhibition of TRPC4 channel by phosphatidylinositol 4,5-bisphosphate. J Biol Chem (2008) 1.44
The role of TRP channels in oxidative stress-induced cell death. J Membr Biol (2006) 1.41
Identification of EPI64, a TBC/rabGAP domain-containing microvillar protein that binds to the first PDZ domain of EBP50 and E3KARP. J Cell Biol (2001) 1.26
Suppression of breast cancer cell growth by Na+/H+ exchanger regulatory factor 1 (NHERF1). Breast Cancer Res (2006) 1.26
TRP channels in hypertension. Biochim Biophys Acta (2007) 1.25
Homo- and heteromeric assembly of TRP channel subunits. Pflugers Arch (2005) 1.24
TRPMs and neuronal cell death. Pflugers Arch (2005) 1.19
Nuclear speckles and nucleoli targeting by PIP2-PDZ domain interactions. EMBO J (2005) 1.19
Inhibition of TRPC5 channels by Ca2+-binding protein 1 in Xenopus oocytes. Pflugers Arch (2005) 1.17
Light-regulated interaction of Dmoesin with TRP and TRPL channels is required for maintenance of photoreceptors. J Cell Biol (2005) 1.14
Na+/H+ exchanger regulatory factor 1 inhibits platelet-derived growth factor signaling in breast cancer cells. Breast Cancer Res (2008) 1.14
Ligand-induced recruitment of Na+/H+-exchanger regulatory factor to the PDGF (platelet-derived growth factor) receptor regulates actin cytoskeleton reorganization by PDGF. Biochem J (2003) 1.10
Receptor-operated cation channels formed by TRPC4 and TRPC5. Naunyn Schmiedebergs Arch Pharmacol (2005) 1.10
Insights on TRP channels from in vivo studies in Drosophila. Annu Rev Physiol (2006) 1.09
TRPC4 knockdown suppresses epidermal growth factor-induced store-operated channel activation and growth in human corneal epithelial cells. J Biol Chem (2005) 1.08
Properties and therapeutic potential of transient receptor potential channels with putative roles in adversity: focus on TRPC5, TRPM2 and TRPA1. Curr Drug Targets (2011) 1.06
The protein scaffold NHERF-1 controls the amplitude and duration of localized protein kinase D activity. J Biol Chem (2009) 1.04
A chemokine receptor CXCR2 macromolecular complex regulates neutrophil functions in inflammatory diseases. J Biol Chem (2011) 1.04
Organization and function of TRPC channelosomes. Pflugers Arch (2007) 1.01
The Ca(2+) sensor stromal interaction molecule 1 (STIM1) is necessary and sufficient for the store-operated Ca(2+) entry function of transient receptor potential canonical (TRPC) 1 and 4 channels in endothelial cells. Mol Pharmacol (2011) 1.00
Molecular cloning and characterization of PLC-eta2. Biochem J (2005) 0.99
Intrinsic disorder in the C-terminal domain of the Shaker voltage-activated K+ channel modulates its interaction with scaffold proteins. Proc Natl Acad Sci U S A (2007) 0.99
Protein-protein interaction and functionTRPC channels. Pflugers Arch (2005) 0.97
A new role for PTEN in regulating transient receptor potential canonical channel 6-mediated Ca2+ entry, endothelial permeability, and angiogenesis. J Biol Chem (2010) 0.95
Regulation of TRPC1 and TRPC4 cation channels requires an alpha1-syntrophin-dependent complex in skeletal mouse myotubes. J Biol Chem (2009) 0.95
Na+-H+ exchanger regulatory factor 1 is a PDZ scaffold for the astroglial glutamate transporter GLAST. Glia (2007) 0.91
The transient receptor potential, TRP4, cation channel is a novel member of the family of calmodulin binding proteins. Biochem J (2001) 0.90
Muscarinic-induced recruitment of plasma membrane Ca2+-ATPase involves PSD-95/Dlg/Zo-1-mediated interactions. J Biol Chem (2008) 0.89
Structure-function analysis of TRPV channels. Naunyn Schmiedebergs Arch Pharmacol (2005) 0.89
TRP Channels as Sensors and Signal Integrators of Redox Status Changes. Front Pharmacol (2011) 0.88
Transient receptor potential-like channels are essential for calcium signaling and fluid transport in a Drosophila epithelium. Genetics (2005) 0.88
Concerted roles of SGK1 and the Na+/H+ exchanger regulatory factor 2 (NHERF2) in regulation of NHE3. Cell Physiol Biochem (2003) 0.87
The roles of G proteins in the activation of TRPC4 and TRPC5 transient receptor potential channels. Channels (Austin) (2012) 0.84
Expression and functional evaluation of transient receptor potential channel 4 in bovine corneal endothelial cells. Exp Eye Res (2005) 0.82
TRP channels and STIM/ORAI proteins: sensors and effectors of cancer and stroma cell migration. Br J Pharmacol (2014) 0.80
Increased inwardly rectifying potassium currents in HEK-293 cells expressing murine transient receptor potential 4. Biochem J (2001) 0.79
Plasma membrane mechanical stress activates TRPC5 channels. PLoS One (2015) 0.78
Rescue of internalization-defective platelet-activating factor receptor function by EBP50/NHERF1. J Cell Commun Signal (2012) 0.78
Functional interaction between TRP4 and CFTR in mouse aorta endothelial cells. BMC Physiol (2001) 0.78
Cytoskeletal regulation of TRPC channels in the cardiorenal system. Curr Hypertens Rep (2012) 0.77
Apical membrane segregation of phosphatidylinositol-4,5-bisphosphate influences parathyroid hormone 1 receptor compartmental signaling and localization via direct regulation of ezrin in LLC-PK1 cells. Cell Signal (2011) 0.77
The Roles of Rasd1 small G proteins and leptin in the activation of TRPC4 transient receptor potential channels. Channels (Austin) (2015) 0.75
Proteomic analysis of imatinib-resistant CML-T1 cells reveals calcium homeostasis as a potential therapeutic target. Oncol Rep (2016) 0.75
Canonical transient receptor potential 4 and its small molecule modulators. Sci China Life Sci (2014) 0.75
Trans-activation response (TAR) RNA-binding protein 2 is a novel modulator of transient receptor potential canonical 4 (TRPC4) protein. J Biol Chem (2014) 0.75
Dynamic NHERF interaction with TRPC4/5 proteins is required for channel gating by diacylglycerol. Proc Natl Acad Sci U S A (2016) 0.75
FcR gamma chain deletion results in pleiotrophic effector cell defects. Cell (1994) 7.66
Caveolin-1 null mice are viable but show evidence of hyperproliferative and vascular abnormalities. J Biol Chem (2001) 7.03
Primary structure of the receptor for calcium channel blockers from skeletal muscle. Nature (1987) 6.66
Cooperative regulation of cell polarity and growth by Drosophila tumor suppressors. Science (2000) 6.44
TFAR19, a novel apoptosis-related gene cloned from human leukemia cell line TF-1, could enhance apoptosis of some tumor cells induced by growth factor withdrawal. Biochem Biophys Res Commun (1999) 6.33
Analysis of oncogenic signaling networks in glioblastoma identifies ASPM as a molecular target. Proc Natl Acad Sci U S A (2006) 6.33
KSHV antibodies among Americans, Italians and Ugandans with and without Kaposi's sarcoma. Nat Med (1996) 5.96
The earliest angiosperms: evidence from mitochondrial, plastid and nuclear genomes. Nature (1999) 5.85
Influenza A virus NS1 protein prevents activation of NF-kappaB and induction of alpha/beta interferon. J Virol (2000) 5.44
Shape, size, and distribution of Ca(2+) release units and couplons in skeletal and cardiac muscles. Biophys J (1999) 5.37
Cre-mediated gene deletion in the mammary gland. Nucleic Acids Res (1997) 4.89
American College of Rheumatology classification criteria for Sjögren's syndrome: a data-driven, expert consensus approach in the Sjögren's International Collaborative Clinical Alliance cohort. Arthritis Care Res (Hoboken) (2012) 4.82
Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL): II. Clinical efficacy and pharmacokinetics in relapsed patients. Blood (1997) 4.78
Live attenuated malaria vaccine designed to protect through hepatic CD8⁺ T cell immunity. Science (2011) 4.72
A 1.5 million-base pair inversion polymorphism in families with Williams-Beuren syndrome. Nat Genet (2001) 4.58
Noninvasive imaging of in vivo blood flow velocity using optical Doppler tomography. Opt Lett (1997) 4.48
Dicistronic targeting constructs: reporters and modifiers of mammalian gene expression. Proc Natl Acad Sci U S A (1994) 4.44
Seroepidemiology for MERS coronavirus using microneutralisation and pseudoparticle virus neutralisation assays reveal a high prevalence of antibody in dromedary camels in Egypt, June 2013. Euro Surveill (2013) 4.37
Phase-resolved optical coherence tomography and optical Doppler tomography for imaging blood flow in human skin with fast scanning speed and high velocity sensitivity. Opt Lett (2000) 4.33
Neurotoxicity induces cleavage of p35 to p25 by calpain. Nature (2000) 4.31
The effects of frequent nocturnal home hemodialysis: the Frequent Hemodialysis Network Nocturnal Trial. Kidney Int (2011) 4.27
neurogenin1 is essential for the determination of neuronal precursors for proximal cranial sensory ganglia. Neuron (1998) 4.25
Caspase-3-generated fragment of gelsolin: effector of morphological change in apoptosis. Science (1997) 4.19
Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease. Nat Med (2000) 4.18
Signal-induced degradation of I kappa B alpha requires site-specific ubiquitination. Proc Natl Acad Sci U S A (1995) 4.16
DNA sequence and comparative analysis of chimpanzee chromosome 22. Nature (2004) 4.12
Arginine methylation of STAT1 modulates IFNalpha/beta-induced transcription. Cell (2001) 3.97
Insights into the molecular basis of leukocyte tethering and rolling revealed by structures of P- and E-selectin bound to SLe(X) and PSGL-1. Cell (2000) 3.95
15-deoxy-delta 12,14-prostaglandin J2 inhibits multiple steps in the NF-kappa B signaling pathway. Proc Natl Acad Sci U S A (2000) 3.89
Primary structure and functional expression from complementary DNA of a brain calcium channel. Nature (1991) 3.77
The cardiac homeobox gene Csx/Nkx2.5 lies genetically upstream of multiple genes essential for heart development. Development (1999) 3.74
Light control of Arabidopsis development entails coordinated regulation of genome expression and cellular pathways. Plant Cell (2001) 3.60
Y-Chromosome evidence for a northward migration of modern humans into Eastern Asia during the last Ice Age. Am J Hum Genet (1999) 3.60
Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors. Neuron (1998) 3.59
Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL): I. As2O3 exerts dose-dependent dual effects on APL cells. Blood (1997) 3.56
A prospective study of prevalence and association of peripheral neuropathy in Indian patients with newly diagnosed type 2 diabetes mellitus. J Postgrad Med (2014) 3.53
Vancomycin derivatives that inhibit peptidoglycan biosynthesis without binding D-Ala-D-Ala. Science (1999) 3.40
Human epilepsy associated with dysfunction of the brain P/Q-type calcium channel. Lancet (2001) 3.39
Assembly of the mitochondrial membrane system: sequences of yeast mitochondrial valine and an unusual threonine tRNA gene. Cell (1979) 3.39
Control of pollen tube tip growth by a Rop GTPase-dependent pathway that leads to tip-localized calcium influx. Plant Cell (1999) 3.32
Structure of Rhodopseudomonas sphaeroides R-26 reaction center. FEBS Lett (1986) 3.28
Obesity, body size, and risk of postmenopausal breast cancer: the Women's Health Initiative (United States). Cancer Causes Control (2002) 3.27
Phosphotyrosyl peptides block Stat3-mediated DNA binding activity, gene regulation, and cell transformation. J Biol Chem (2001) 3.27
A family of proteins that inhibit signalling through tyrosine kinase receptors. Nature (1997) 3.26
The FERM domain: a unique module involved in the linkage of cytoplasmic proteins to the membrane. Trends Biochem Sci (1998) 3.24
Crystal structure and functional analysis of the HERG potassium channel N terminus: a eukaryotic PAS domain. Cell (1998) 3.22
Phenotypic spectrum associated with mutations of the mitochondrial polymerase gamma gene. Brain (2006) 3.16
Codon recognition rules in yeast mitochondria. Proc Natl Acad Sci U S A (1980) 3.11
Genetically engineered Saccharomyces yeast capable of effective cofermentation of glucose and xylose. Appl Environ Microbiol (1998) 3.05
High-dose intravenous immune globulin for stiff-person syndrome. N Engl J Med (2001) 3.04
Middle East Respiratory Syndrome (MERS) coronavirus seroprevalence in domestic livestock in Saudi Arabia, 2010 to 2013. Euro Surveill (2013) 2.99
A stoichiometric complex of neurexins and dystroglycan in brain. J Cell Biol (2001) 2.98
The roles of the subunits in the function of the calcium channel. Science (1991) 2.97
Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease. Nature (1999) 2.97
Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein. Proc Natl Acad Sci U S A (2000) 2.96
Effect of trends on detrended fluctuation analysis. Phys Rev E Stat Nonlin Soft Matter Phys (2001) 2.95
Lack of an endothelial store-operated Ca2+ current impairs agonist-dependent vasorelaxation in TRP4-/- mice. Nat Cell Biol (2001) 2.94
Evidence for in vivo but not in vitro expression of a Borrelia burgdorferi outer surface protein F (OspF) homologue. Mol Microbiol (1995) 2.92
Evidence for an important role of WRKY DNA binding proteins in the regulation of NPR1 gene expression. Plant Cell (2001) 2.90
Alcohol drinking and all cancer mortality: a meta-analysis. Ann Oncol (2012) 2.83
Dynamics and folding of single two-stranded coiled-coil peptides studied by fluorescent energy transfer confocal microscopy. Proc Natl Acad Sci U S A (2000) 2.75
Positional cloning of the mouse saccharin preference (Sac) locus. Chem Senses (2001) 2.75
Dentinogenesis imperfecta 1 with or without progressive hearing loss is associated with distinct mutations in DSPP. Nat Genet (2001) 2.75
Identification of the paromomycin-resistance mutation in the 15 S rRNA gene of yeast mitochondria. J Biol Chem (1982) 2.70
Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function. Oncogene (2007) 2.68
Dosimetric effects of needle divergence in prostate seed implant using 125I and 103Pd radioactive seeds. Med Phys (2000) 2.67
A genetic analysis of neural progenitor differentiation. Neuron (2001) 2.66
Dual bidirectional promoters at the mouse dhfr locus: cloning and characterization of two mRNA classes of the divergently transcribed Rep-1 gene. Mol Cell Biol (1989) 2.66
Novel proteasome inhibitor PS-341 inhibits activation of nuclear factor-kappa B, cell survival, tumor growth, and angiogenesis in squamous cell carcinoma. Clin Cancer Res (2001) 2.65
Molecular basis for Ca2+ channel diversity. Annu Rev Neurosci (1994) 2.65
Optical Doppler tomographic imaging of fluid flow velocity in highly scattering media. Opt Lett (1997) 2.64
Caveolin-3 null mice show a loss of caveolae, changes in the microdomain distribution of the dystrophin-glycoprotein complex, and t-tubule abnormalities. J Biol Chem (2001) 2.62
A comprehensive biochemical and genetic analysis of the yeast U1 snRNP reveals five novel proteins. RNA (1998) 2.55
Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia. Nat Genet (2001) 2.55
Arsenic-induced PML targeting onto nuclear bodies: implications for the treatment of acute promyelocytic leukemia. Proc Natl Acad Sci U S A (1997) 2.54
Modulation of Ca(2+) entry by polypeptides of the inositol 1,4, 5-trisphosphate receptor (IP3R) that bind transient receptor potential (TRP): evidence for roles of TRP and IP3R in store depletion-activated Ca(2+) entry. Proc Natl Acad Sci U S A (1999) 2.52
Structural evidence for gene duplication in the evolution of the acid proteases. Nature (1978) 2.47
Crystal structure of human cytosolic phospholipase A2 reveals a novel topology and catalytic mechanism. Cell (1999) 2.45
Purified dihydropyridine-binding site from skeletal muscle t-tubules is a functional calcium channel. Nature (1986) 2.41
Ketamine anesthesia during the first week of life can cause long-lasting cognitive deficits in rhesus monkeys. Neurotoxicol Teratol (2011) 2.41
Apoptosis and growth inhibition in malignant lymphocytes after treatment with arsenic trioxide at clinically achievable concentrations. J Natl Cancer Inst (1999) 2.41
Primary structure of the beta subunit of the DHP-sensitive calcium channel from skeletal muscle. Science (1989) 2.40
Kinetics of CD4+ T cell repopulation of lymphoid tissues after treatment of HIV-1 infection. Proc Natl Acad Sci U S A (1998) 2.39
Primary structure of rat brain sodium channel III deduced from the cDNA sequence. FEBS Lett (1988) 2.39
Deregulation of cell growth by the K1 gene of Kaposi's sarcoma-associated herpesvirus. Nat Med (1998) 2.38
The gut as a portal of entry for bacteremia. Role of protein malnutrition. Ann Surg (1987) 2.38
Fire and flood management of coastal swamp enabled first rice paddy cultivation in east China. Nature (2007) 2.36
Injection of subunits of cyclic AMP-dependent protein kinase into cardiac myocytes modulates Ca2+ current. Nature (1982) 2.33
The essential role of MEKK3 in TNF-induced NF-kappaB activation. Nat Immunol (2001) 2.32
Platelet glycoprotein ibalpha is a counterreceptor for the leukocyte integrin Mac-1 (CD11b/CD18). J Exp Med (2000) 2.31
Abnormalities of retinal metabolism in diabetes and experimental galactosemia. VII. Effect of long-term administration of antioxidants on the development of retinopathy. Diabetes (2001) 2.30
Regulation of Ca2+ signaling in transgenic mouse cardiac myocytes overexpressing calsequestrin. J Clin Invest (1998) 2.29
Incidence of fractures compared to cardiovascular disease and breast cancer: the Women's Health Initiative Observational Study. Osteoporos Int (2008) 2.27
Lower BMI cut-off value to define obesity in Hong Kong Chinese: an analysis based on body fat assessment by bioelectrical impedance. Br J Nutr (2001) 2.25
Development of a species-specific PCR assay for detection of Leishmania donovani in clinical samples from patients with kala-azar and post-kala-azar dermal leishmaniasis. J Clin Microbiol (2001) 2.23
A radiation hybrid map of the cat genome: implications for comparative mapping. Genome Res (2000) 2.22
Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. Genome Res (2000) 2.21