Published in Mol Cell Biol on October 01, 2000
Thermodynamics-based models of transcriptional regulation by enhancers: the roles of synergistic activation, cooperative binding and short-range repression. PLoS Comput Biol (2010) 1.51
The gap gene network. Cell Mol Life Sci (2010) 1.51
The human candidate tumor suppressor gene HIC1 recruits CtBP through a degenerate GLDLSKK motif. Mol Cell Biol (2002) 1.34
cis-regulatory logic of short-range transcriptional repression in Drosophila melanogaster. Mol Cell Biol (2005) 1.23
Brinker is a sequence-specific transcriptional repressor in the Drosophila embryo. Genes Dev (2001) 1.21
Brinker requires two corepressors for maximal and versatile repression in Dpp signalling. EMBO J (2001) 1.14
Organization of developmental enhancers in the Drosophila embryo. Nucleic Acids Res (2009) 1.06
Multiple modular promoter elements drive graded brinker expression in response to the Dpp morphogen gradient. Development (2008) 1.02
Transcriptional repression: conserved and evolved features. Curr Biol (2010) 1.02
The oligomeric state of CtBP determines its role as a transcriptional co-activator and co-repressor of Wingless targets. EMBO J (2011) 1.02
Functional similarity of Knirps CtBP-dependent and CtBP-independent transcriptional repressor activities. Nucleic Acids Res (2003) 0.99
CtBP contributes quantitatively to Knirps repression activity in an NAD binding-dependent manner. Mol Cell Biol (2004) 0.93
Functional interaction between the Drosophila knirps short range transcriptional repressor and RPD3 histone deacetylase. J Biol Chem (2005) 0.90
CtBP-independent repression in the Drosophila embryo. Mol Cell Biol (2003) 0.89
Groucho corepressor functions as a cofactor for the Knirps short-range transcriptional repressor. Proc Natl Acad Sci U S A (2009) 0.88
Structurally related Arabidopsis ANGUSTIFOLIA is functionally distinct from the transcriptional corepressor CtBP. Dev Genes Evol (2007) 0.87
A dissection of the teashirt and tiptop genes reveals a novel mechanism for regulating transcription factor activity. Dev Biol (2011) 0.82
Cell-type specificity of short-range transcriptional repressors. Proc Natl Acad Sci U S A (2001) 0.82
CtBP levels control intergenic transcripts, PHO/YY1 DNA binding, and PcG recruitment to DNA. J Cell Biochem (2010) 0.81
Transcriptional Timers Regulating Mitosis in Early Drosophila Embryos. Cell Rep (2016) 0.75
A Looping-Based Model for Quenching Repression. PLoS Comput Biol (2017) 0.75
Brinker possesses multiple mechanisms for repression because its primary co-repressor, Groucho, may be unavailable in some cell types. Development (2013) 0.75
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature (2000) 20.54
Mutations affecting segment number and polarity in Drosophila. Nature (1980) 18.72
The autosomal FLP-DFS technique for generating germline mosaics in Drosophila melanogaster. Genetics (1996) 5.72
Regulation of even-skipped stripe 2 in the Drosophila embryo. EMBO J (1992) 4.63
A mechanism for synergistic activation of a mammalian gene by GAL4 derivatives. Nature (1990) 4.57
Drosophila Tcf and Groucho interact to repress Wingless signalling activity. Nature (1998) 4.50
An enzymatic activity in the yeast Sir2 protein that is essential for gene silencing. Cell (1999) 4.07
Molecular cloning and characterization of a cellular phosphoprotein that interacts with a conserved C-terminal domain of adenovirus E1A involved in negative modulation of oncogenic transformation. Proc Natl Acad Sci U S A (1995) 3.28
Cloning and characterization of mCtBP2, a co-repressor that associates with basic Krüppel-like factor and other mammalian transcriptional regulators. EMBO J (1998) 3.06
Structure and function of transcriptional activation domains. Curr Opin Genet Dev (1995) 2.94
Drosophila CtBP: a Hairy-interacting protein required for embryonic segmentation and hairy-mediated transcriptional repression. EMBO J (1998) 2.74
From gradients to stripes in Drosophila embryogenesis: filling in the gaps. Trends Genet (1996) 2.72
Interaction of short-range repressors with Drosophila CtBP in the embryo. Science (1998) 2.61
XCtBP is a XTcf-3 co-repressor with roles throughout Xenopus development. Development (1999) 2.56
Active repression of transcription by the engrailed homeodomain protein. EMBO J (1991) 2.50
Regulation of two pair-rule stripes by a single enhancer in the Drosophila embryo. Dev Biol (1996) 2.42
Groucho acts as a corepressor for a subset of negative regulators, including Hairy and Engrailed. Genes Dev (1997) 2.38
Short-range transcriptional repressors mediate both quenching and direct repression within complex loci in Drosophila. Genes Dev (1996) 2.36
Groucho-dependent and -independent repression activities of Runt domain proteins. Mol Cell Biol (1997) 2.27
Short-range repression permits multiple enhancers to function autonomously within a complex promoter. Genes Dev (1994) 2.24
dCtBP mediates transcriptional repression by Knirps, Krüppel and Snail in the Drosophila embryo. EMBO J (1998) 2.22
A gap gene, hunchback, regulates the spatial expression of Ultrabithorax. Cell (1986) 2.15
DNA binding by c-Ets-1, but not v-Ets, is repressed by an intramolecular mechanism. EMBO J (1992) 2.15
C-Terminal binding protein is a transcriptional repressor that interacts with a specific class of vertebrate Polycomb proteins. Mol Cell Biol (1999) 1.97
Transcriptional repression in development. Curr Opin Cell Biol (1996) 1.96
Characterization of the cooperative function of inhibitory sequences in Ets-1. Mol Cell Biol (1996) 1.85
A mechanism for Rb/p130-mediated transcription repression involving recruitment of the CtBP corepressor. Proc Natl Acad Sci U S A (1999) 1.80
Solution structure of the DNA-binding domain of Cd2-GAL4 from S. cerevisiae. Nature (1992) 1.79
Abdominal segmentation of the Drosophila embryo requires a hormone receptor-like protein encoded by the gap gene knirps. Nature (1988) 1.77
Zygotic lethal mutations with maternal effect phenotypes in Drosophila melanogaster. II. Loci on the second and third chromosomes identified by P-element-induced mutations. Genetics (1996) 1.76
Net, a negative Ras-switchable TCF, contains a second inhibition domain, the CID, that mediates repression through interactions with CtBP and de-acetylation. EMBO J (1999) 1.76
Two distinct types of repression domain in engrailed: one interacts with the groucho corepressor and is preferentially active on integrated target genes. Mol Cell Biol (1998) 1.76
hairy mediates dominant repression in the Drosophila embryo. EMBO J (1997) 1.74
Groucho and dCtBP mediate separate pathways of transcriptional repression in the Drosophila embryo. Proc Natl Acad Sci U S A (1999) 1.72
The gap protein knirps mediates both quenching and direct repression in the Drosophila embryo. EMBO J (1996) 1.65
Long-range repression in the Drosophila embryo. Proc Natl Acad Sci U S A (1996) 1.65
Auto-inhibition of Ets-1 is counteracted by DNA binding cooperativity with core-binding factor alpha2. Mol Cell Biol (2000) 1.62
Auto-inhibition and partner proteins, core-binding factor beta (CBFbeta) and Ets-1, modulate DNA binding by CBFalpha2 (AML1). Mol Cell Biol (2000) 1.58
Identification of CtBP1 and CtBP2 as corepressors of zinc finger-homeodomain factor deltaEF1. Mol Cell Biol (1999) 1.57
The Rpd3 histone deacetylase is required for segmentation of the Drosophila embryo. Proc Natl Acad Sci U S A (1999) 1.55
The carboxy-terminal region of adenovirus E1A activates transcription through targeting of a C-terminal binding protein-histone deacetylase complex. FEBS Lett (1998) 1.55
Concentration-dependent patterning by an ectopic expression domain of the Drosophila gap gene knirps. Development (1997) 1.48
CNS midline enhancers of the Drosophila slit and Toll genes. Mech Dev (1993) 1.38
Multifunctional role of the Pitx2 homeodomain protein C-terminal tail. Mol Cell Biol (1999) 1.31
Independent repressor domains in ZEB regulate muscle and T-cell differentiation. Mol Cell Biol (1999) 1.29
The transcription factors KNIRPS and KNIRPS RELATED control cell migration and branch morphogenesis during Drosophila tracheal development. Development (1998) 1.27
Transcriptional repression by the Drosophila giant protein: cis element positioning provides an alternative means of interpreting an effector gradient. Development (1999) 1.24
hairy stripe 7 element mediates activation and repression in response to different domains and levels of Krüppel in the Drosophila embryo. Mech Dev (1999) 1.08
The knirps and knirps-related genes organize development of the second wing vein in Drosophila. Development (1998) 1.03
Transcriptional repression in the Drosophila embryo. Philos Trans R Soc Lond B Biol Sci (1995) 1.02
Conservation of regulatory elements controlling hairy pair-rule stripe formation. Development (1993) 0.96
Two evolutionarily conserved repression domains in the Drosophila Kruppel protein differ in activator specificity. Mol Cell Biol (1997) 0.94
The Drosophila dorsal morphogen represses the tolloid gene by interacting with a silencer element. Mol Cell Biol (1994) 0.94
Functional and conserved domains of the Drosophila transcription factor encoded by the segmentation gene knirps. Mol Cell Biol (1994) 0.93
The Biomolecular Interaction Network Database and related tools 2005 update. Nucleic Acids Res (2005) 12.94
TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease. Nature (2000) 6.54
Alcohol, tobacco and breast cancer--collaborative reanalysis of individual data from 53 epidemiological studies, including 58,515 women with breast cancer and 95,067 women without the disease. Br J Cancer (2002) 5.83
General internal medicine and specialty medicine--time to rethink the relationship. J R Coll Physicians Lond (1999) 5.41
CREB-binding protein/p300 are transcriptional coactivators of p65. Proc Natl Acad Sci U S A (1997) 4.71
Amino acid analysis: aqueous dimethyl sulfoxide as solvent for the ninhydrin reaction. J Biol Chem (1968) 4.62
Human gene expression first occurs between the four- and eight-cell stages of preimplantation development. Nature (1988) 3.70
Characterization of heat shock in Bacillus subtilis. J Bacteriol (1986) 3.30
Ribonuclease inhibitor from human placenta. Purification and properties. J Biol Chem (1977) 2.95
Epidemiology of contralateral breast cancer. Cancer Epidemiol Biomarkers Prev (1999) 2.74
Determination of the tryptophan content of proteins by ion exchange chromatography of alkaline hydrolysates. J Biol Chem (1972) 2.72
The Oregon report. Don't ask, don't tell. Hastings Cent Rep (1999) 2.69
Hemodialysis versus peritoneal dialysis: a comparison of adjusted mortality rates. Am J Kidney Dis (1997) 2.63
Increasing thyroid cancer incidence in Canada, 1970-1996: time trends and age-period-cohort effects. Br J Cancer (2001) 2.36
Carboxypeptidase from yeast. Large scale preparation and the application to COOH-terminal analysis of peptides and proteins. J Biol Chem (1973) 2.28
Calcium influx via TRP channels is required to maintain PIP2 levels in Drosophila photoreceptors. Neuron (2001) 2.21
One hospital's experience with a "Do not resuscitate" policy. Can Med Assoc J (1981) 2.20
Medicare home health before and after the BBA. Health Aff (Millwood) (2001) 2.18
Farming and prostate cancer mortality. Am J Epidemiol (1993) 2.10
The pathologic measurement of polyp size is preferable to the endoscopic estimate. Gastrointest Endosc (1997) 2.10
THE CONCENTRATIONS OF CYSTEINE AND CYSTINE IN HUMAN BLOOD PLASMA. J Clin Invest (1960) 2.07
Mechanism of action of camptothecin. Ann N Y Acad Sci (2000) 2.01
Mortality study of Canadian male farm operators: non-Hodgkin's lymphoma mortality and agricultural practices in Saskatchewan. J Natl Cancer Inst (1990) 2.00
Transcriptional adaptor and histone acetyltransferase proteins in Arabidopsis and their interactions with CBF1, a transcriptional activator involved in cold-regulated gene expression. Nucleic Acids Res (2001) 1.96
Prostate cancer trends in Canada: rising incidence or increased detection? CMAJ (1993) 1.91
General practitioners' awareness of COSHH regulations. BMJ (1991) 1.88
Thromboatherosclerosis in normolipemic rabbits. A result of continued endothelial damage. Lab Invest (1973) 1.87
Genetic dissection of autoimmune type I diabetes in the BB rat. Nat Genet (1992) 1.87
Pepsin from pepsinogen. Preparation and properties. J Biol Chem (1966) 1.83
Isolation of membrane components associated with human red cell antigens Rh(D), (c), (E) and Fy. Nature (1982) 1.82
Identification of L-methionine S-sulfoximine as the diastereoisomer of L-methionine SR-sulfoximine that inhibits glutamine synthetase. Biochemistry (1969) 1.82
Sustained endotoxemia leads to marked down-regulation of early steps in the insulin-signaling cascade. Crit Care Med (2001) 1.78
Trends in childhood injury mortality in Canada, 1979-2002. Inj Prev (2006) 1.73
Effect of divalent cations on the reduction and re-formation of the disulfide bonds of deoxyribonuclease. J Biol Chem (1969) 1.70
Cost containment through risk-sharing by primary-care physicians. N Engl J Med (1979) 1.70
Transverse-momentum and pseudorapidity distributions of charged hadrons in pp collisions at square root of s = 7 TeV. Phys Rev Lett (2010) 1.67
Phase I dose-escalation and pharmacokinetic study of temozolomide (SCH 52365) for refractory or relapsing malignancies. Br J Cancer (1999) 1.66
Cancer incidence among Canadian kidney transplant recipients. Am J Transplant (2007) 1.66
Long-range repression in the Drosophila embryo. Proc Natl Acad Sci U S A (1996) 1.65
Determination of D- and L-amino acids by ion exchange chromatography as L-D and L-L dipeptides. J Biol Chem (1968) 1.63
Specific probiotic therapy attenuates antibiotic induced visceral hypersensitivity in mice. Gut (2005) 1.63
Proteomic comparison of human and great ape blood plasma reveals conserved glycosylation and differences in thyroid hormone metabolism. Am J Phys Anthropol (2001) 1.62
Serum iron and risk of fatal acute myocardial infarction. Epidemiology (1994) 1.61
Passive and active smoking and breast cancer risk in Canada, 1994-97. Cancer Causes Control (2000) 1.60
Inhibition of injury induced thromboatherosclerotic lesions by anti-platelet serum in rabbits. Thromb Haemost (1976) 1.60
The carboxyl-terminal sequence of porcine pepsin. J Biol Chem (1967) 1.59
Coronectomy - oral surgery's answer to modern day conservative dentistry. Br Dent J (2010) 1.58
The effect of thrombocytopenia on experimental arteriosclerotic lesion formation in rabbits. Smooth muscle cell proliferation and re-endothelialization. J Clin Invest (1977) 1.58
Horse vision and an explanation for the visual behaviour originally explained by the 'ramp retina'. Equine Vet J (1999) 1.56
Study of the mass and spin-parity of the Higgs boson candidate via its decays to Z boson pairs. Phys Rev Lett (2013) 1.56
Nodular breast lesion caused by Bancroft's filariasis. Can Med Assoc J (1965) 1.55
The inactivation of pepsin by diazoacetylnorleucine methyl ester. J Biol Chem (1966) 1.54
Validating genetic risk associations for ovarian cancer through the international Ovarian Cancer Association Consortium. Br J Cancer (2009) 1.54
The changing face of femoral artery false aneurysms. Eur J Vasc Endovasc Surg (2004) 1.53
Spacing ensures autonomous expression of different stripe enhancers in the even-skipped promoter. Development (1993) 1.53
Fatal accidental childhood injuries in Canada. Can J Public Health (1987) 1.52
Cervical cancer screening: are the 1989 recommendations still valid? National Workshop on Screening for Cancer of the Cervix. CMAJ (1996) 1.49
Female-biased expression of odourant receptor genes in the adult antennae of the silkworm, Bombyx mori. Insect Mol Biol (2007) 1.47
Premature deaths in Canada: impact, trends and opportunities for prevention. Can J Public Health (1991) 1.42
Mortality on Canadian Indian Reserves 1977-1982. Can J Public Health (1986) 1.42
Simultaneous Kawasaki disease and group A streptococcal pharyngitis. Clin Pediatr (Phila) (1993) 1.42
Unusually shaped Guedel airways. Anaesthesia (2005) 1.42
Effect of cold submersion on intramuscular temperature of the gastrocnemius muscle. Phys Ther (1979) 1.40
Bovine pancreatic deoxyribonuclease A. Isolation of cyanogen bromide peptides; complete covalent structure of the polypeptide chain. J Biol Chem (1973) 1.40
Out-of-hospital defibrillation with automated external defibrillators: postshock analysis should be delayed. Ann Emerg Med (2001) 1.40
Artificial urinary sphincters. Treatment for post-prostatectomy incontinence. AORN J (1993) 1.39
Cryosurgical ablation of the prostate. AORN J (1995) 1.39
Bet1p activates the v-SNARE Bos1p. Mol Biol Cell (1997) 1.39
Nurses' experience of delivering a supportive intervention for family members of patients with lung cancer. Eur J Cancer Care (Engl) (2011) 1.38
Wegener's granulomatosis mimicking temporal arteritis. Neurology (1991) 1.38
Thromboatheromatous complications of umbilical arterial catheterization in the newborn period. Clinicopathological study. Arch Dis Child (1976) 1.38
The isolation and characterisation of a platelet-specific beta-globulin (beta-thromboglobulin) and the detection of antiurokinase and antiplasmin released from thrombin-aggregated washed human platelets. Biochim Biophys Acta (1975) 1.37
Neuronal density in the human retinal ganglion cell layer from 16-77 years. Anat Rec (2000) 1.33
Caspase-2 deficiency promotes aberrant DNA-damage response and genetic instability. Cell Death Differ (2012) 1.33
Risk factors for prostate cancer: results from the Canadian National Enhanced Cancer Surveillance System. The Canadian Cancer Registries Epidemiology Research Group. Cancer Causes Control (1999) 1.32
The release of a human platelet specific protein measured by a radioimmunoassay. Thromb Res (1975) 1.31
The carbohydrate moiety of bovine pancreatic deoxyribonuclease. J Biol Chem (1969) 1.30
Ethics committees identify four key factors for success. HEC Forum (1998) 1.29
Stimulation of topoisomerase II-mediated DNA damage via a mechanism involving protein thiolation. Biochemistry (2001) 1.29
Human herpesvirus 8-encoded thymidine kinase and phosphotransferase homologues confer sensitivity to ganciclovir. J Virol (1999) 1.27
Inhibitory effects of Lactobacillus reuteri on visceral pain induced by colorectal distension in Sprague-Dawley rats. Gut (2005) 1.27
Reaction of Cr(VI) with ascorbate and hydrogen peroxide generates hydroxyl radicals and causes DNA damage: role of a Cr(IV)-mediated Fenton-like reaction. Carcinogenesis (1994) 1.26
Factors affecting the severity of motor vehicle traffic crashes involving elderly drivers in Ontario. Accid Anal Prev (2000) 1.26
Properties of chromatographically purified bovine pancreatic deoxyribonuclease. J Biol Chem (1969) 1.26
An apaH mutation causes AppppA to accumulate and affects motility and catabolite repression in Escherichia coli. Proc Natl Acad Sci U S A (1989) 1.25
Activation of topoisomerase II-mediated excision of chromosomal DNA loops during oxidative stress. Genes Dev (1999) 1.25
Trends in rates of admission to hospital and death from asthma among children and young adults in Canada during the 1980s. CMAJ (1993) 1.25
Transcriptional repression by the Drosophila giant protein: cis element positioning provides an alternative means of interpreting an effector gradient. Development (1999) 1.24
Measurement of the electron charge asymmetry in inclusive W production in pp collisions at sqrt[s]=7 TeV. Phys Rev Lett (2012) 1.23
Increased patient concern after false-positive mammograms: clinician documentation and subsequent ambulatory visits. J Gen Intern Med (2001) 1.22
Thrombin generation and fibrin formation following injury to rabbit neointima. Studies of vessel wall reactivity and platelet survival. Lab Invest (1982) 1.22
Physical activity, anthropometric factors and risk of pancreatic cancer: results from the Canadian enhanced cancer surveillance system. Int J Cancer (2001) 1.21
Lifetime probability of developing lung cancer, by smoking status, Canada. Can J Public Health (1995) 1.20
Cancer mortality among a group of fluorspar miners exposed to radon progeny. Am J Epidemiol (1988) 1.20
Search for new physics in the multijet and missing transverse momentum final state in proton-proton collisions at √s = 7 TeV. Phys Rev Lett (2012) 1.19
Azimuthal anisotropy of charged particles at high transverse momenta in Pb-Pb collisions at sqrt[s(NN)] = 2.76 TeV. Phys Rev Lett (2012) 1.19
Cervical cancer: the increasing incidence of adenocarcinoma and adenosquamous carcinoma in younger women. CMAJ (2001) 1.17
On the specificity of streptococcal proteinase. J Biol Chem (1966) 1.17