Published in Mol Cell on August 01, 2000
PIP2 is a necessary cofactor for ion channel function: how and why? Annu Rev Biophys (2008) 3.89
Svp1p defines a family of phosphatidylinositol 3,5-bisphosphate effectors. EMBO J (2004) 2.73
Binding of phosphatidylinositol 3,4,5-trisphosphate to the pleckstrin homology domain of protein kinase B induces a conformational change. Biochem J (2003) 2.15
Binding of the PX domain of p47(phox) to phosphatidylinositol 3,4-bisphosphate and phosphatidic acid is masked by an intramolecular interaction. EMBO J (2002) 2.09
A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange. EMBO J (2002) 2.07
Translation of the phosphoinositide code by PI effectors. Nat Chem Biol (2010) 1.86
Structural insights into the regulation of PDK1 by phosphoinositides and inositol phosphates. EMBO J (2004) 1.77
Structural basis and mechanism of autoregulation in 3-phosphoinositide-dependent Grp1 family Arf GTPase exchange factors. Mol Cell (2007) 1.76
Exo84 and Sec5 are competitive regulatory Sec6/8 effectors to the RalA GTPase. EMBO J (2005) 1.75
Pleckstrin homology (PH) domains and phosphoinositides. Biochem Soc Symp (2007) 1.74
Comprehensive identification of PIP3-regulated PH domains from C. elegans to H. sapiens by model prediction and live imaging. Mol Cell (2008) 1.73
Targeting of the GTPase Irgm1 to the phagosomal membrane via PtdIns(3,4)P(2) and PtdIns(3,4,5)P(3) promotes immunity to mycobacteria. Nat Immunol (2009) 1.70
Interactions between Ras1, dMyc, and dPI3K signaling in the developing Drosophila wing. Genes Dev (2002) 1.69
Membrane binding domains. Biochim Biophys Acta (2006) 1.67
The PTEN-AKT3 signaling cascade as a therapeutic target in melanoma. Pigment Cell Melanoma Res (2009) 1.62
Conditional peripheral membrane proteins: facing up to limited specificity. Structure (2011) 1.55
The pleckstrin homology domain proteins Slm1 and Slm2 are required for actin cytoskeleton organization in yeast and bind phosphatidylinositol-4,5-bisphosphate and TORC2. Mol Biol Cell (2005) 1.50
GRP1 pleckstrin homology domain: activation parameters and novel search mechanism for rare target lipid. Biochemistry (2004) 1.48
A PH domain in ACAP1 possesses key features of the BAR domain in promoting membrane curvature. Dev Cell (2014) 1.47
Akt: a double-edged sword in cell proliferation and genome stability. J Oncol (2012) 1.44
Single-molecule fluorescence studies of a PH domain: new insights into the membrane docking reaction. Biophys J (2009) 1.44
Structural determinants of phosphoinositide selectivity in splice variants of Grp1 family PH domains. EMBO J (2004) 1.43
ARF-GEP(100), a guanine nucleotide-exchange protein for ADP-ribosylation factor 6. Proc Natl Acad Sci U S A (2001) 1.41
Structural and mechanistic insights into the association of PKCalpha-C2 domain to PtdIns(4,5)P2. Proc Natl Acad Sci U S A (2009) 1.39
Determinants of molecular specificity in phosphoinositide regulation. Phosphatidylinositol (4,5)-bisphosphate (PI(4,5)P2) is the endogenous lipid regulating TRPV1. J Biol Chem (2008) 1.37
An alpha-helical extension of the ELMO1 pleckstrin homology domain mediates direct interaction to DOCK180 and is critical in Rac signaling. Mol Biol Cell (2008) 1.36
Single molecule diffusion of membrane-bound proteins: window into lipid contacts and bilayer dynamics. Biophys J (2010) 1.35
Inositol 1,3,4,5-tetrakisphosphate negatively regulates phosphatidylinositol-3,4,5- trisphosphate signaling in neutrophils. Immunity (2007) 1.33
A carboxy-terminal inter-helix linker as the site of phosphatidylinositol 4,5-bisphosphate action on Kv7 (M-type) K+ channels. J Gen Physiol (2008) 1.33
Structural and functional studies of the Ras-associating and pleckstrin-homology domains of Grb10 and Grb14. Nat Struct Mol Biol (2009) 1.32
Drawing the PDB: Protein-Ligand Complexes in Two Dimensions. ACS Med Chem Lett (2010) 1.31
The Phox homology (PX) domain, a new player in phosphoinositide signalling. Biochem J (2001) 1.31
Kindlin-2 regulates podocyte adhesion and fibronectin matrix deposition through interactions with phosphoinositides and integrins. J Cell Sci (2011) 1.27
Crystal structure of the phosphatidylinositol 3,4-bisphosphate-binding pleckstrin homology (PH) domain of tandem PH-domain-containing protein 1 (TAPP1): molecular basis of lipid specificity. Biochem J (2001) 1.27
The type Ialpha inositol polyphosphate 4-phosphatase generates and terminates phosphoinositide 3-kinase signals on endosomes and the plasma membrane. Mol Biol Cell (2005) 1.26
Molecular characteristics of phosphoinositide binding. Pflugers Arch (2007) 1.22
Molecular basis of phosphatidylinositol 4-phosphate and ARF1 GTPase recognition by the FAPP1 pleckstrin homology (PH) domain. J Biol Chem (2011) 1.21
Computational docking and solution x-ray scattering predict a membrane-interacting role for the histone domain of the Ras activator son of sevenless. Proc Natl Acad Sci U S A (2005) 1.20
Phosphoinositide 3-kinase-dependent membrane recruitment of p62(dok) is essential for its negative effect on mitogen-activated protein (MAP) kinase activation. J Exp Med (2001) 1.19
Intracellular phosphatidylserine is essential for retrograde membrane traffic through endosomes. Proc Natl Acad Sci U S A (2011) 1.16
Turning off AKT: PHLPP as a drug target. Annu Rev Pharmacol Toxicol (2014) 1.12
Structural bioinformatics prediction of membrane-binding proteins. J Mol Biol (2006) 1.12
X-ray reflectivity studies of cPLA2{alpha}-C2 domains adsorbed onto Langmuir monolayers of SOPC. Biophys J (2005) 1.11
Pathogen destruction versus intracellular survival: the role of lipids as phagosomal fate determinants. J Clin Invest (2008) 1.10
Molecular mechanism of membrane targeting by the GRP1 PH domain. J Lipid Res (2008) 1.09
Myosin 1G is an abundant class I myosin in lymphocytes whose localization at the plasma membrane depends on its ancient divergent pleckstrin homology (PH) domain (Myo1PH). J Biol Chem (2010) 1.09
Molecular modeling of the membrane targeting of phospholipase C pleckstrin homology domains. Protein Sci (2003) 1.08
Evidence that the tandem-pleckstrin-homology-domain-containing protein TAPP1 interacts with Ptd(3,4)P2 and the multi-PDZ-domain-containing protein MUPP1 in vivo. Biochem J (2002) 1.08
Solution structure and backbone dynamics of the pleckstrin homology domain of the human protein kinase B (PKB/Akt). Interaction with inositol phosphates. J Biomol NMR (2004) 1.06
Biophysical and computational studies of membrane penetration by the GRP1 pleckstrin homology domain. Structure (2011) 1.05
3-D structure and dynamics of protein kinase B-new mechanism for the allosteric regulation of an AGC kinase. J Chem Biol (2009) 1.05
The Caenorhabditis elegans Kinesin-3 motor UNC-104/KIF1A is degraded upon loss of specific binding to cargo. PLoS Genet (2010) 1.04
Structural basis of membrane targeting by the Dock180 family of Rho family guanine exchange factors (Rho-GEFs). J Biol Chem (2010) 1.04
A unique autophosphorylation site on Tie2/Tek mediates Dok-R phosphotyrosine binding domain binding and function. Mol Cell Biol (2003) 1.00
CHARMM Additive All-Atom Force Field for Phosphate and Sulfate Linked to Carbohydrates. J Chem Theory Comput (2011) 1.00
Small-molecule inhibitors of the PI3K signaling network. Future Med Chem (2011) 0.98
Structural basis of the myosin X PH1(N)-PH2-PH1(C) tandem as a specific and acute cellular PI(3,4,5)P(3) sensor. Mol Biol Cell (2011) 0.96
FGD2, a CDC42-specific exchange factor expressed by antigen-presenting cells, localizes to early endosomes and active membrane ruffles. J Biol Chem (2008) 0.96
Inositol phospholipids regulate the guanine-nucleotide-exchange factor Tiam1 by facilitating its binding to the plasma membrane and regulating GDP/GTP exchange on Rac1. Biochem J (2004) 0.95
TIPE3 is the transfer protein of lipid second messengers that promote cancer. Cancer Cell (2014) 0.95
SWAP-70 identifies a transitional subset of actin filaments in motile cells. Mol Biol Cell (2003) 0.94
Structural analysis of the carboxy terminal PH domain of pleckstrin bound to D-myo-inositol 1,2,3,5,6-pentakisphosphate. BMC Struct Biol (2007) 0.93
Conformational snapshots of Tec kinases during signaling. Immunol Rev (2009) 0.93
The GRP1 PH domain, like the AKT1 PH domain, possesses a sentry glutamate residue essential for specific targeting to plasma membrane PI(3,4,5)P(3). Biochemistry (2011) 0.93
A PH domain in the Arf GTPase-activating protein (GAP) ARAP1 binds phosphatidylinositol 3,4,5-trisphosphate and regulates Arf GAP activity independently of recruitment to the plasma membranes. J Biol Chem (2009) 0.92
Structure-function study of the N-terminal domain of exocyst subunit Sec3. J Biol Chem (2010) 0.92
Structure basis and unconventional lipid membrane binding properties of the PH-C1 tandem of rho kinases. J Biol Chem (2008) 0.90
Regulation of PI3K by PKC and MARCKS: Single-Molecule Analysis of a Reconstituted Signaling Pathway. Biophys J (2016) 0.90
Interaction of the protein tyrosine phosphatase PTPL1 with the PtdIns(3,4)P2-binding adaptor protein TAPP1. Biochem J (2003) 0.89
The Akt signaling pathway: an emerging therapeutic target in malignant melanoma. Cancer Biol Ther (2011) 0.89
Structures of the pleckstrin homology domain of Saccharomyces cerevisiae Avo1 and its human orthologue Sin1, an essential subunit of TOR complex 2. Acta Crystallogr Sect F Struct Biol Cryst Commun (2012) 0.89
A screen for novel phosphoinositide 3-kinase effector proteins. Mol Cell Proteomics (2011) 0.88
CARMIL leading edge localization depends on a non-canonical PH domain and dimerization. Nat Commun (2013) 0.88
Molecular mechanism of membrane binding of the GRP1 PH domain. J Mol Biol (2013) 0.87
Structural basis for membrane recruitment and allosteric activation of cytohesin family Arf GTPase exchange factors. Proc Natl Acad Sci U S A (2013) 0.87
Requirement of phosphatidylinositol(3,4,5)trisphosphate in phosphatidylinositol 3-kinase-induced oncogenic transformation. Mol Cancer Res (2009) 0.86
Signal transduction mechanism of TRB3 in rats with non-alcoholic fatty liver disease. World J Gastroenterol (2009) 0.85
IQGAP proteins reveal an atypical phosphoinositide (aPI) binding domain with a pseudo C2 domain fold. J Biol Chem (2012) 0.85
Therapeutic Implications of Targeting AKT Signaling in Melanoma. Enzyme Res (2011) 0.85
Structural basis for autoinhibition of the guanine nucleotide exchange factor FARP2. Structure (2013) 0.84
Anomalous Dynamics of a Lipid Recognition Protein on a Membrane Surface. Sci Rep (2015) 0.84
Rho GTPases control specific cytoskeleton-dependent functions of hematopoietic stem cells. Immunol Rev (2013) 0.83
The Cdc42 guanine nucleotide exchange factor FGD6 coordinates cell polarity and endosomal membrane recycling in osteoclasts. J Biol Chem (2014) 0.83
Structural analyses of the Slm1-PH domain demonstrate ligand binding in the non-canonical site. PLoS One (2012) 0.83
Phosphoinositide binding by the SNX27 FERM domain regulates its localization at the immune synapse of activated T-cells. J Cell Sci (2015) 0.82
Association of Peripheral Membrane Proteins with Membranes: Free Energy of Binding of GRP1 PH Domain with Phosphatidylinositol Phosphate-Containing Model Bilayers. J Phys Chem Lett (2016) 0.81
5-Stabilized phosphatidylinositol 3,4,5-trisphosphate analogues bind Grp1 PH, inhibit phosphoinositide phosphatases, and block neutrophil migration. Chembiochem (2010) 0.80
Molecular analysis of protein-phosphoinositide interactions. Curr Top Microbiol Immunol (2012) 0.80
Membrane and Protein Interactions of the Pleckstrin Homology Domain Superfamily. Membranes (Basel) (2015) 0.79
The cytohesin paralog Sec7 of Dictyostelium discoideum is required for phagocytosis and cell motility. Cell Commun Signal (2013) 0.79
Specificity of Collybistin-Phosphoinositide Interactions: IMPACT OF THE INDIVIDUAL PROTEIN DOMAINS. J Biol Chem (2015) 0.79
Structural determinants of RGS-RhoGEF signaling critical to Entamoeba histolytica pathogenesis. Structure (2012) 0.79
The inner membrane complex sub-compartment proteins critical for replication of the apicomplexan parasite Toxoplasma gondii adopt a pleckstrin homology fold. J Biol Chem (2014) 0.79
Role of PTEN in modulation of ADP-dependent signaling pathways in vascular endothelial cells. Biochim Biophys Acta (2013) 0.79
Interactions of Pleckstrin Homology Domains with Membranes: Adding Back the Bilayer via High-Throughput Molecular Dynamics. Structure (2016) 0.78
Structural basis for PI(4)P-specific membrane recruitment of the Legionella pneumophila effector DrrA/SidM. Structure (2014) 0.78
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Synergistic activation of p21-activated kinase 1 by phosphatidylinositol 4,5-bisphosphate and Rho GTPases. J Biol Chem (2013) 0.77
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