Published in Annu Rev Pharmacol Toxicol on January 01, 2014
Physiological activation of Akt by PHLPP1 deletion protects against pathological hypertrophy. Cardiovasc Res (2014) 1.46
Signaling specificity in the Akt pathway in biology and disease. Adv Biol Regul (2014) 1.27
Exome sequencing identifies recurrent mutations in NF1 and RASopathy genes in sun-exposed melanomas. Nat Genet (2015) 1.24
Oncogenic Ras differentially regulates metabolism and anoikis in extracellular matrix-detached cells. Cell Death Differ (2016) 0.92
Cellular prostatic acid phosphatase, a PTEN-functional homologue in prostate epithelia, functions as a prostate-specific tumor suppressor. Biochim Biophys Acta (2014) 0.88
The Mammalian Blood-Testis Barrier: Its Biology and Regulation. Endocr Rev (2015) 0.88
Protein phosphatase PHLPP induces cell apoptosis and exerts anticancer activity by inhibiting Survivin phosphorylation and nuclear export in gallbladder cancer. Oncotarget (2015) 0.87
MYC Drives Pten/Trp53-Deficient Proliferation and Metastasis due to IL6 Secretion and AKT Suppression via PHLPP2. Cancer Discov (2015) 0.85
The PI3K/Akt Pathway in Tumors of Endocrine Tissues. Front Endocrinol (Lausanne) (2016) 0.85
mTORC1-independent Raptor prevents hepatic steatosis by stabilizing PHLPP2. Nat Commun (2016) 0.84
Low expression of PHLPP1 in sacral chordoma and its association with poor prognosis. Int J Clin Exp Pathol (2015) 0.84
Molecular pathways: PI3K pathway phosphatases as biomarkers for cancer prognosis and therapy. Clin Cancer Res (2014) 0.83
Expression and role of oncogenic miRNA-224 in esophageal squamous cell carcinoma. BMC Cancer (2015) 0.80
G-Protein-Coupled Lysophosphatidic Acid Receptors and Their Regulation of AKT Signaling. Int J Mol Sci (2016) 0.78
Akt-ing up on SRPK1: oncogene or tumor suppressor? Mol Cell (2014) 0.77
Depletion of SAG/RBX2 E3 ubiquitin ligase suppresses prostate tumorigenesis via inactivation of the PI3K/AKT/mTOR axis. Mol Cancer (2016) 0.77
Artificial Recruitment of UAF1-USP Complexes by a PHLPP1-E1 Chimeric Helicase Enhances Human Papillomavirus DNA Replication. J Virol (2015) 0.76
Biochemical characterization of the phosphatase domain of the tumor suppressor PH domain leucine-rich repeat protein phosphatase. Biochemistry (2014) 0.76
Curcumin induces apoptosis of upper aerodigestive tract cancer cells by targeting multiple pathways. PLoS One (2015) 0.76
Mutual inhibition of insulin signaling and PHLPP-1 determines cardioprotective efficiency of Akt in aged heart. Aging (Albany NY) (2016) 0.75
Regulation of PI3K effector signalling in cancer by the phosphoinositide phosphatases. Biosci Rep (2017) 0.75
Hyperglycemia and hyperlipidemia blunts the Insulin-Inpp5f negative feedback loop in the diabetic heart. Sci Rep (2016) 0.75
Suppression in PHLPP2 induction by morin promotes Nrf2-regulated cellular defenses against oxidative injury to primary rat hepatocytes. Redox Biol (2015) 0.75
Degradation of PHLPP2 by KCTD17, via a Glucagon-dependent Pathway, Promotes Hepatic Steatosis. Gastroenterology (2017) 0.75
LncRNA MEG3 downregulation mediated by DNMT3b contributes to nickel malignant transformation of human bronchial epithelial cells via modulating PHLPP1 transcription and HIF-1α translation. Oncogene (2017) 0.75
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science (2005) 38.99
AKT/PKB signaling: navigating downstream. Cell (2007) 31.26
Integrative genomic profiling of human prostate cancer. Cancer Cell (2010) 23.61
Human Protein Reference Database--2009 update. Nucleic Acids Res (2008) 21.25
Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal. Sci Signal (2013) 19.54
Mechanism of activation of protein kinase B by insulin and IGF-1. EMBO J (1996) 16.68
Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis. Nature (2005) 15.83
Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1. Dev Cell (2006) 11.48
PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients. Cancer Cell (2004) 10.89
SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity. Cell (2006) 10.50
Intrinsic tumour suppression. Nature (2004) 8.73
Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases. Cell (1992) 8.51
Synthesis and function of 3-phosphorylated inositol lipids. Annu Rev Biochem (2001) 8.47
PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth. Mol Cell (2005) 8.22
PhosphoSitePlus: a comprehensive resource for investigating the structure and function of experimentally determined post-translational modifications in man and mouse. Nucleic Acids Res (2011) 7.84
Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies. Curr Biol (2004) 7.59
The leucine-rich repeat as a protein recognition motif. Curr Opin Struct Biol (2001) 7.39
The functions and regulation of the PTEN tumour suppressor. Nat Rev Mol Cell Biol (2012) 7.32
Reciprocal feedback regulation of PI3K and androgen receptor signaling in PTEN-deficient prostate cancer. Cancer Cell (2011) 7.32
Serine/threonine phosphatases: mechanism through structure. Cell (2009) 6.19
PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms. Mol Cell (2007) 6.00
Molecular genetics of prostate cancer: new prospects for old challenges. Genes Dev (2010) 5.83
An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior. Cell (2005) 5.60
PDK1, the master regulator of AGC kinase signal transduction. Semin Cell Dev Biol (2004) 5.10
Balancing Akt with S6K: implications for both metabolic diseases and tumorigenesis. J Cell Biol (2004) 4.70
SMAD4-dependent barrier constrains prostate cancer growth and metastatic progression. Nature (2011) 4.57
AKT/PKB and other D3 phosphoinositide-regulated kinases: kinase activation by phosphoinositide-dependent phosphorylation. Annu Rev Biochem (1999) 4.49
FKBP51 affects cancer cell response to chemotherapy by negatively regulating Akt. Cancer Cell (2009) 4.48
Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules. Mol Cell Proteomics (2005) 4.33
Identification of a PKB/Akt hydrophobic motif Ser-473 kinase as DNA-dependent protein kinase. J Biol Chem (2004) 4.01
Restraining PI3K: mTOR signalling goes back to the membrane. Trends Biochem Sci (2005) 3.77
Structure of the high affinity complex of inositol trisphosphate with a phospholipase C pleckstrin homology domain. Cell (1995) 3.65
The structure and mechanism of protein phosphatases: insights into catalysis and regulation. Annu Rev Biophys Biomol Struct (1998) 3.64
PTEN: a tumour suppressor that functions as a phospholipid phosphatase. Trends Cell Biol (1999) 3.62
PTEN loss of expression predicts cetuximab efficacy in metastatic colorectal cancer patients. Br J Cancer (2007) 3.61
Targeting the androgen receptor pathway in prostate cancer. Curr Opin Pharmacol (2008) 3.56
Crystal structure of the protein serine/threonine phosphatase 2C at 2.0 A resolution. EMBO J (1996) 3.51
A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis. J Clin Invest (2010) 3.47
Structural and evolutionary relationships among protein tyrosine phosphatase domains. Mol Cell Biol (2001) 3.37
Sustained axon regeneration induced by co-deletion of PTEN and SOCS3. Nature (2011) 3.18
Control of dendritic arborization by the phosphoinositide-3'-kinase-Akt-mammalian target of rapamycin pathway. J Neurosci (2005) 3.13
Akt/protein kinase B is regulated by autophosphorylation at the hypothetical PDK-2 site. J Biol Chem (2000) 2.86
Structural basis for discrimination of 3-phosphoinositides by pleckstrin homology domains. Mol Cell (2000) 2.86
Cellular signaling: pivoting around PDK-1. Cell (2000) 2.86
Genome-wide analysis of membrane targeting by S. cerevisiae pleckstrin homology domains. Mol Cell (2004) 2.83
Pro-senescence therapy for cancer treatment. Nat Rev Cancer (2011) 2.75
Gemcitabine and cytosine arabinoside cytotoxicity: association with lymphoblastoid cell expression. Cancer Res (2008) 2.58
Novel protein serine/threonine phosphatases: variety is the spice of life. Trends Biochem Sci (1997) 2.54
Loss of PHLPP expression in colon cancer: role in proliferation and tumorigenesis. Oncogene (2008) 2.48
mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide. EMBO J (2010) 2.35
Histone deacetylase (HDAC) inhibitors in recent clinical trials for cancer therapy. Clin Epigenetics (2010) 2.26
AKAP mediated signal transduction. Annu Rev Pharmacol Toxicol (2002) 2.26
The phosphatase PHLPP controls the cellular levels of protein kinase C. J Biol Chem (2007) 2.24
Characterization of sporadic colon cancer by patterns of genomic instability. Cancer Res (2003) 2.24
Protein kinase B/Akt at a glance. J Cell Sci (2005) 2.18
The association of NHERF adaptor proteins with g protein-coupled receptors and receptor tyrosine kinases. Annu Rev Physiol (2006) 2.18
Protein tyrosine phosphatase function: the substrate perspective. Biochem J (2007) 2.17
Excessive activation of mTOR in postnatally generated granule cells is sufficient to cause epilepsy. Neuron (2012) 2.17
PTEN tumor suppressor associates with NHERF proteins to attenuate PDGF receptor signaling. EMBO J (2006) 2.16
Proteolytic degradation of SCOP in the hippocampus contributes to activation of MAP kinase and memory. Cell (2007) 2.12
Akt-dependent and -independent mechanisms of mTOR regulation in cancer. Cell Signal (2009) 2.11
Platelet-derived growth factor receptor association with Na(+)/H(+) exchanger regulatory factor potentiates receptor activity. Mol Cell Biol (2000) 2.11
PDZ domains and their binding partners: structure, specificity, and modification. Cell Commun Signal (2010) 2.07
Spatio-temporal dynamics of protein kinase B/Akt signaling revealed by a genetically encoded fluorescent reporter. J Biol Chem (2004) 1.96
PHLPP-1 negatively regulates Akt activity and survival in the heart. Circ Res (2010) 1.93
PHLiPPing the switch on Akt and protein kinase C signaling. Trends Endocrinol Metab (2008) 1.92
Allele loss on chromosome 16 associated with progression of human hepatocellular carcinoma. Proc Natl Acad Sci U S A (1990) 1.90
PTEN signaling in brain: neuropathology and tumorigenesis. Oncogene (2008) 1.79
Identification of PHLPP1 as a tumor suppressor reveals the role of feedback activation in PTEN-mutant prostate cancer progression. Cancer Cell (2011) 1.74
Comprehensive identification of PIP3-regulated PH domains from C. elegans to H. sapiens by model prediction and live imaging. Mol Cell (2008) 1.73
The hydrophobic phosphorylation motif of conventional protein kinase C is regulated by autophosphorylation. Curr Biol (1999) 1.68
Protein kinases as mediators of phosphoinositide 3-kinase signaling. Mol Pharmacol (2000) 1.59
PTEN, NHERF1 and PHLPP form a tumor suppressor network that is disabled in glioblastoma. Oncogene (2011) 1.59
Structure, function and evolution of microbial adenylyl and guanylyl cyclases. Mol Microbiol (2004) 1.57
The Na+/H+ exchanger regulatory factor stabilizes epidermal growth factor receptors at the cell surface. Mol Biol Cell (2004) 1.48
Scribble-mediated membrane targeting of PHLPP1 is required for its negative regulation of Akt. EMBO Rep (2011) 1.45
PTEN signaling in autism spectrum disorders. Curr Opin Neurobiol (2012) 1.43
Suprachiasmatic nucleus circadian oscillatory protein, a novel binding partner of K-Ras in the membrane rafts, negatively regulates MAPK pathway. J Biol Chem (2003) 1.41
The biology of HDAC in cancer: the nuclear and epigenetic components. Handb Exp Pharmacol (2011) 1.41
Mst1 is an interacting protein that mediates PHLPPs' induced apoptosis. Mol Cell (2010) 1.40
PI3K/Akt signaling requires spatial compartmentalization in plasma membrane microdomains. Proc Natl Acad Sci U S A (2011) 1.39
beta-TrCP-mediated ubiquitination and degradation of PHLPP1 are negatively regulated by Akt. Mol Cell Biol (2009) 1.37
SCOP, a novel gene product expressed in a circadian manner in rat suprachiasmatic nucleus. FEBS Lett (1999) 1.31
Genome-wide analysis of allelic imbalance in prostate cancer using the Affymetrix 50K SNP mapping array. Br J Cancer (2007) 1.26
PTEN at a glance. J Cell Sci (2012) 1.26
The emerging multiple roles of nuclear Akt. Biochim Biophys Acta (2012) 1.25
Protein phosphatase PHLPP1 controls the light-induced resetting of the circadian clock. Proc Natl Acad Sci U S A (2010) 1.20
The phosphatase PHLPP1 regulates Akt2, promotes pancreatic cancer cell death, and inhibits tumor formation. Gastroenterology (2011) 1.19
Recognizing phosphatidylinositol 3-phosphate. Cell (2001) 1.18
Endoplasmic reticulum is a main localization site of mTORC2. Biochem Biophys Res Commun (2011) 1.17
Ndfip1 regulates nuclear Pten import in vivo to promote neuronal survival following cerebral ischemia. J Cell Biol (2012) 1.13
Common polymorphism in the phosphatase PHLPP2 results in reduced regulation of Akt and protein kinase C. J Biol Chem (2009) 1.11
mTOR-dependent regulation of PHLPP expression controls the rapamycin sensitivity in cancer cells. J Biol Chem (2010) 1.09
Uncoupling insulin signalling by serine/threonine phosphorylation: a molecular basis for insulin resistance. Biochem Soc Trans (2004) 1.09
Histone deacetylase 3 suppression increases PH domain and leucine-rich repeat phosphatase (Phlpp)1 expression in chondrocytes to suppress Akt signaling and matrix secretion. J Biol Chem (2013) 1.07
PTEN depletion rescues axonal growth defect and improves survival in SMN-deficient motor neurons. Hum Mol Genet (2010) 1.06
Chromosome 16 tumor-suppressor genes in breast cancer. Genes Chromosomes Cancer (2006) 1.05
PHLPP-mediated dephosphorylation of S6K1 inhibits protein translation and cell growth. Mol Cell Biol (2011) 1.05
Isoform-specific defects of insulin stimulation of Akt/protein kinase B (PKB) in skeletal muscle cells from type 2 diabetic patients. Diabetologia (2008) 1.04
Cutting edge: PHLPP regulates the development, function, and molecular signaling pathways of regulatory T cells. J Immunol (2011) 1.04
Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis. Nature (2005) 15.83
NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN. Cell (2007) 5.20
Subtle variations in Pten dose determine cancer susceptibility. Nat Genet (2010) 4.19
SUMO modification of Huntingtin and Huntington's disease pathology. Science (2004) 3.85
A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis. J Clin Invest (2010) 3.47
Identification of PHLPP1 as a tumor suppressor reveals the role of feedback activation in PTEN-mutant prostate cancer progression. Cancer Cell (2011) 1.74
Towards patient-based cancer therapeutics. Nat Biotechnol (2010) 1.63
Nuclear targeting of adenovirus type 2 requires CRM1-mediated nuclear export. Mol Biol Cell (2005) 1.16
Ndfip1 regulates nuclear Pten import in vivo to promote neuronal survival following cerebral ischemia. J Cell Biol (2012) 1.13
PTP1B is an androgen receptor-regulated phosphatase that promotes the progression of prostate cancer. Cancer Res (2012) 1.10
The effect of deleting p110delta on the phenotype and function of PTEN-deficient B cells. J Immunol (2008) 1.04
PTEN regulation of local and long-range connections in mouse auditory cortex. J Neurosci (2012) 0.95
RapidCaP, a novel GEM model for metastatic prostate cancer analysis and therapy, reveals myc as a driver of Pten-mutant metastasis. Cancer Discov (2014) 0.93
Prostate cancer genetic-susceptibility locus on chromosome 20q13 is amplified and coupled to androgen receptor-regulation in metastatic tumors. Mol Cancer Res (2013) 0.83
PTEN plasticity: how the taming of a lethal gene can go too far. Trends Cell Biol (2013) 0.82