Structural basis for membrane recruitment and allosteric activation of cytohesin family Arf GTPase exchange factors.

PubWeight™: 0.87‹?›

🔗 View Article (PMC 3761562)

Published in Proc Natl Acad Sci U S A on August 12, 2013

Authors

Andrew W Malaby1, Bert van den Berg, David G Lambright

Author Affiliations

1: Program in Molecular Medicine and Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA.

Articles cited by this

PHENIX: a comprehensive Python-based system for macromolecular structure solution. Acta Crystallogr D Biol Crystallogr (2010) 108.52

Features and development of Coot. Acta Crystallogr D Biol Crystallogr (2010) 89.46

REFMAC5 for the refinement of macromolecular crystal structures. Acta Crystallogr D Biol Crystallogr (2011) 39.32

The Buccaneer software for automated model building. 1. Tracing protein chains. Acta Crystallogr D Biol Crystallogr (2006) 18.18

Automated macromolecular model building for X-ray crystallography using ARP/wARP version 7. Nat Protoc (2008) 16.53

GEFs and GAPs: critical elements in the control of small G proteins. Cell (2007) 7.32

The small G proteins of the Arf family and their regulators. Annu Rev Cell Dev Biol (2007) 4.14

Signaling by phosphoinositide-3,4,5-trisphosphate through proteins containing pleckstrin and Sec7 homology domains. Science (1997) 3.91

Structural basis for activation of ARF GTPase: mechanisms of guanine nucleotide exchange and GTP-myristoyl switching. Cell (1998) 3.58

A human exchange factor for ARF contains Sec7- and pleckstrin-homology domains. Nature (1996) 3.54

ARF family G proteins and their regulators: roles in membrane transport, development and disease. Nat Rev Mol Cell Biol (2011) 3.38

A comparative analysis of the phosphoinositide binding specificity of pleckstrin homology domains. J Biol Chem (1997) 3.19

Structural basis for relief of autoinhibition of the Dbl homology domain of proto-oncogene Vav by tyrosine phosphorylation. Cell (2000) 3.08

Specificity and promiscuity in phosphoinositide binding by pleckstrin homology domains. J Biol Chem (1998) 3.07

Structural basis for discrimination of 3-phosphoinositides by pleckstrin homology domains. Mol Cell (2000) 2.86

Membrane-dependent signal integration by the Ras activator Son of sevenless. Nat Struct Mol Biol (2008) 2.82

Alpha L beta 2 integrin/LFA-1 binding to ICAM-1 induced by cytohesin-1, a cytoplasmic regulatory molecule. Cell (1996) 2.66

Regulation of Arf activation: the Sec7 family of guanine nucleotide exchange factors. Traffic (2007) 2.47

Inhibition of cytohesins by SecinH3 leads to hepatic insulin resistance. Nature (2006) 2.40

Structural analysis of autoinhibition in the Ras activator Son of sevenless. Cell (2004) 2.38

Pleckstrin homology domains: not just for phosphoinositides. Biochem Soc Trans (2004) 2.20

Structural snapshots of the mechanism and inhibition of a guanine nucleotide exchange factor. Nature (2003) 2.17

Active Arf6 recruits ARNO/cytohesin GEFs to the PM by binding their PH domains. Mol Biol Cell (2007) 2.15

Structural basis of 3-phosphoinositide recognition by pleckstrin homology domains. Mol Cell (2000) 2.13

Structure and membrane interaction of myristoylated ARF1. Structure (2009) 2.12

Insulin-dependent translocation of ARNO to the plasma membrane of adipocytes requires phosphatidylinositol 3-kinase. Curr Biol (1998) 2.08

Intracellular distribution of Arf proteins in mammalian cells. Arf6 is uniquely localized to the plasma membrane. J Biol Chem (1996) 2.01

Myristoylation of ADP-ribosylation factor 1 facilitates nucleotide exchange at physiological Mg2+ levels. J Biol Chem (1995) 1.98

Arf and its many interactors. Curr Opin Cell Biol (2003) 1.94

Crystal structure of ARF1*Sec7 complexed with Brefeldin A and its implications for the guanine nucleotide exchange mechanism. Mol Cell (2003) 1.85

Selective cellular effects of overexpressed pleckstrin-homology domains that recognize PtdIns(3,4,5)P3 suggest their interaction with protein binding partners. J Cell Sci (2005) 1.80

Structural basis and mechanism of autoregulation in 3-phosphoinositide-dependent Grp1 family Arf GTPase exchange factors. Mol Cell (2007) 1.76

Membrane and juxtamembrane targeting by PH and PTB domains. Biochim Biophys Acta (2006) 1.74

The cytohesin Steppke is essential for insulin signalling in Drosophila. Nature (2006) 1.71

A Ras-induced conformational switch in the Ras activator Son of sevenless. Proc Natl Acad Sci U S A (2006) 1.57

The myristoylated amino terminus of ADP-ribosylation factor 1 is a phospholipid- and GTP-sensitive switch. J Biol Chem (1995) 1.57

ADP-ribosylation factor 6 as a target of guanine nucleotide exchange factor GRP1. J Biol Chem (1999) 1.53

Structural and energetic mechanisms of cooperative autoinhibition and activation of Vav1. Cell (2010) 1.51

The structural GDP/GTP cycle of human Arf6. EMBO Rep (2001) 1.50

Distinct polyphosphoinositide binding selectivities for pleckstrin homology domains of GRP1-like proteins based on diglycine versus triglycine motifs. J Biol Chem (2000) 1.45

Structural determinants of phosphoinositide selectivity in splice variants of Grp1 family PH domains. EMBO J (2004) 1.43

Dynamic structure of membrane-anchored Arf*GTP. Nat Struct Mol Biol (2010) 1.35

The structure of RalF, an ADP-ribosylation factor guanine nucleotide exchange factor from Legionella pneumophila, reveals the presence of a cap over the active site. J Biol Chem (2004) 1.33

Kinetic studies of the Arf activator Arno on model membranes in the presence of Arf effectors suggest control by a positive feedback loop. J Biol Chem (2010) 1.28

The Arl4 family of small G proteins can recruit the cytohesin Arf6 exchange factors to the plasma membrane. Curr Biol (2007) 1.27

Structural basis for ARF1-mediated recruitment of ARHGAP21 to Golgi membranes. EMBO J (2007) 1.24

Role of the histone domain in the autoinhibition and activation of the Ras activator Son of Sevenless. Proc Natl Acad Sci U S A (2010) 1.22

The PH domain and the polybasic c domain of cytohesin-1 cooperate specifically in plasma membrane association and cellular function. Mol Biol Cell (1998) 1.20

ARL4D recruits cytohesin-2/ARNO to modulate actin remodeling. Mol Biol Cell (2007) 1.16

Kinetic analysis of GTP hydrolysis catalysed by the Arf1-GTP-ASAP1 complex. Biochem J (2007) 1.14

Regulation of ARNO nucleotide exchange by a PH domain electrostatic switch. Curr Biol (1999) 1.12

Molecular mechanism of membrane targeting by the GRP1 PH domain. J Lipid Res (2008) 1.09

Binding of the PH and polybasic C-terminal domains of ARNO to phosphoinositides and to acidic lipids. Biochemistry (2000) 1.08

The structural basis of Arf effector specificity: the crystal structure of ARF6 in a complex with JIP4. EMBO J (2009) 1.07

Biophysical and computational studies of membrane penetration by the GRP1 pleckstrin homology domain. Structure (2011) 1.05

EGF-and NGF-stimulated translocation of cytohesin-1 to the plasma membrane of PC12 cells requires PI 3-kinase activation and a functional cytohesin-1 PH domain. J Cell Sci (1999) 1.00

Grp1 plays a key role in linking insulin signaling to glut4 recycling. Dev Cell (2012) 0.96

The GRP1 PH domain, like the AKT1 PH domain, possesses a sentry glutamate residue essential for specific targeting to plasma membrane PI(3,4,5)P(3). Biochemistry (2011) 0.93

Toward a structural understanding of arf family:effector specificity. Structure (2010) 0.87

Articles by these authors

Legionella pneumophila proteins that regulate Rab1 membrane cycling. Nature (2007) 3.81

Protein translocation by the Sec61/SecY channel. Annu Rev Cell Dev Biol (2005) 3.09

The Legionella pneumophila effector protein DrrA is a Rab1 guanine nucleotide-exchange factor. Nat Cell Biol (2006) 3.08

TBC-domain GAPs for Rab GTPases accelerate GTP hydrolysis by a dual-finger mechanism. Nature (2006) 3.04

Rab GEFs and GAPs. Curr Opin Cell Biol (2010) 2.73

Structural basis of family-wide Rab GTPase recognition by rabenosyn-5. Nature (2005) 2.23

Structure, exchange determinants, and family-wide rab specificity of the tandem helical bundle and Vps9 domains of Rabex-5. Cell (2004) 2.17

Membrane recognition and targeting by lipid-binding domains. Sci STKE (2003) 1.94

Structural basis and mechanism of autoregulation in 3-phosphoinositide-dependent Grp1 family Arf GTPase exchange factors. Mol Cell (2007) 1.76

The outer membrane protein OmpW forms an eight-stranded beta-barrel with a hydrophobic channel. J Biol Chem (2006) 1.75

Membrane and juxtamembrane targeting by PH and PTB domains. Biochim Biophys Acta (2006) 1.74

Structural basis for Rab GTPase activation by VPS9 domain exchange factors. Nat Struct Mol Biol (2007) 1.66

Transmembrane passage of hydrophobic compounds through a protein channel wall. Nature (2009) 1.55

Signal transduction. MAP kinase signaling specificity. Science (2002) 1.46

Structural basis for Rab11-mediated recruitment of FIP3 to recycling endosomes. J Mol Biol (2006) 1.44

Structural determinants of phosphoinositide selectivity in splice variants of Grp1 family PH domains. EMBO J (2004) 1.43

Germline mutations affecting Gα11 in hypoparathyroidism. N Engl J Med (2013) 1.43

TBC1D20 is a Rab1 GTPase-activating protein that mediates hepatitis C virus replication. J Biol Chem (2007) 1.36

Crystal structure of the monomeric porin OmpG. J Mol Biol (2006) 1.29

Crystal structure of the bacterial nucleoside transporter Tsx. EMBO J (2004) 1.26

RUTBC1 protein, a Rab9A effector that activates GTP hydrolysis by Rab32 and Rab33B proteins. J Biol Chem (2011) 1.25

Structural mechanisms for regulation of membrane traffic by rab GTPases. Traffic (2009) 1.25

Substrate specificity within a family of outer membrane carboxylate channels. PLoS Biol (2012) 1.23

Structural insight into OprD substrate specificity. Nat Struct Mol Biol (2007) 1.22

Crystal structure of Escherichia coli CusC, the outer membrane component of a heavy metal efflux pump. PLoS One (2011) 1.21

TBC-2 regulates RAB-5/RAB-7-mediated endosomal trafficking in Caenorhabditis elegans. Mol Biol Cell (2010) 1.16

Outer-membrane transport of aromatic hydrocarbons as a first step in biodegradation. Proc Natl Acad Sci U S A (2008) 1.13

Crystal structure of the outer membrane protein OpdK from Pseudomonas aeruginosa. Structure (2008) 1.10

Ligand-gated diffusion across the bacterial outer membrane. Proc Natl Acad Sci U S A (2011) 1.09

An endocytic pathway as a target of tubby for regulation of fat storage. EMBO Rep (2007) 1.07

Structural basis for Rab GTPase recognition and endosome tethering by the C2H2 zinc finger of Early Endosomal Autoantigen 1 (EEA1). Proc Natl Acad Sci U S A (2010) 1.07

Determinants of Rab5 interaction with the N terminus of early endosome antigen 1. J Biol Chem (2002) 1.07

An active site water network in the plasminogen activator pla from Yersinia pestis. Structure (2010) 1.06

The membrane-associated protein, supervillin, accelerates F-actin-dependent rapid integrin recycling and cell motility. Traffic (2010) 1.04

The Rab GTPase-activating protein TBC1D4/AS160 contains an atypical phosphotyrosine-binding domain that interacts with plasma membrane phospholipids to facilitate GLUT4 trafficking in adipocytes. Mol Cell Biol (2012) 1.00

Grp1 plays a key role in linking insulin signaling to glut4 recycling. Dev Cell (2012) 0.96

RUTBC2 protein, a Rab9A effector and GTPase-activating protein for Rab36. J Biol Chem (2012) 0.93

A novel pleckstrin homology domain-containing protein enhances insulin-stimulated Akt phosphorylation and GLUT4 translocation in adipocytes. J Biol Chem (2010) 0.93

The crystal structure of OprG from Pseudomonas aeruginosa, a potential channel for transport of hydrophobic molecules across the outer membrane. PLoS One (2010) 0.93

ART2, a T cell surface mono-ADP-ribosyltransferase, generates extracellular poly(ADP-ribose). J Biol Chem (2006) 0.91

Toward understanding the outer membrane uptake of small molecules by Pseudomonas aeruginosa. J Biol Chem (2013) 0.90

Analysis of gating transitions among the three major open states of the OpdK channel. Biochemistry (2011) 0.89

Structural insights into the interaction of the evolutionarily conserved ZPR1 domain tandem with eukaryotic EF1A, receptors, and SMN complexes. Proc Natl Acad Sci U S A (2007) 0.87

OccK channels from Pseudomonas aeruginosa exhibit diverse single-channel electrical signatures but conserved anion selectivity. Biochemistry (2012) 0.87

The Legionella pneumophila GTPase activating protein LepB accelerates Rab1 deactivation by a non-canonical hydrolytic mechanism. J Biol Chem (2013) 0.86

TBC1D13 is a RAB35 specific GAP that plays an important role in GLUT4 trafficking in adipocytes. Traffic (2012) 0.86

Structural basis for activation of an integral membrane protease by lipopolysaccharide. J Biol Chem (2012) 0.85

An outer membrane protein undergoes enthalpy- and entropy-driven transitions. Biochemistry (2012) 0.85

Cation selectivity is a conserved feature in the OccD subfamily of Pseudomonas aeruginosa. Biochim Biophys Acta (2012) 0.83

Specificity and membrane partitioning of Grsp1 signaling complexes with Grp1 family Arf exchange factors. Biochemistry (2010) 0.81

Bacterial cleanup: lateral diffusion of hydrophobic molecules through protein channel walls. Biomol Concepts (2010) 0.76

ESCRT complexes assembled and GLUEd. Structure (2006) 0.76

Calculating the potential of C2 domains for membrane binding. Dev Cell (2002) 0.75

High-throughput assay for profiling the substrate specificity of Rab GTPase-activating proteins. Methods Mol Biol (2015) 0.75