Published in J Natl Cancer Inst on September 20, 2000
Revised Bethesda Guidelines for hereditary nonpolyposis colorectal cancer (Lynch syndrome) and microsatellite instability. J Natl Cancer Inst (2004) 14.97
The frequency of hereditary defective mismatch repair in a prospective series of unselected colorectal carcinomas. Am J Hum Genet (2001) 2.68
Features of colorectal cancers with high-level microsatellite instability occurring in familial and sporadic settings: parallel pathways of tumorigenesis. Am J Pathol (2001) 2.29
Molecular characterization of MSI-H colorectal cancer by MLHI promoter methylation, immunohistochemistry, and mismatch repair germline mutation screening. Cancer Epidemiol Biomarkers Prev (2008) 2.12
Promoter hypermethylation frequency and BRAF mutations distinguish hereditary non-polyposis colon cancer from sporadic MSI-H colon cancer. Fam Cancer (2004) 1.66
The incidence of Lynch syndrome. Fam Cancer (2005) 1.56
The risk of subsequent primary cancers after colorectal cancer in southeast England. Gut (2002) 1.34
Survival after colorectal cancer diagnosis is associated with colorectal cancer family history. Cancer Epidemiol Biomarkers Prev (2008) 1.18
Genetic testing among high-risk individuals in families with hereditary nonpolyposis colorectal cancer. Br J Cancer (2004) 1.13
Polymorphisms of the human UDP-glucuronosyltransferase (UGT) 1A7 gene in colorectal cancer. Gut (2002) 1.12
Family history of colorectal cancer in a Sweden county. Fam Cancer (2003) 1.09
Familial colorectal adenocarcinoma and hereditary nonpolyposis colorectal cancer: a nationwide epidemiological study from Sweden. Br J Cancer (2001) 1.07
The phenotypic expression of three MSH2 mutations in large Newfoundland families with Lynch syndrome. Fam Cancer (2007) 1.01
Associations of a polymorphism in the ornithine decarboxylase gene with colorectal cancer survival. Clin Cancer Res (2009) 1.01
Risk of second primary colorectal cancer among colorectal cancer cases: a population-based analysis. J Carcinog (2011) 1.00
The association between genetic variants in hMLH1 and hMSH2 and the development of sporadic colorectal cancer in the Danish population. BMC Med Genet (2008) 0.97
Evaluation of psychosocial effects of pre-symptomatic testing for breast/ovarian and colon cancer pre-disposing genes: a 12-month follow-up. Fam Cancer (2004) 0.95
Microsatellite instability analysis and/or immunostaining for the diagnosis of hereditary nonpolyposis colorectal cancer? Virchows Arch (2003) 0.93
Clinical characteristics and diagnosis of patients with hereditary nonpolyposis colorectal cancer. World J Gastroenterol (2003) 0.92
Family history of colorectal cancer in Iran. BMC Cancer (2005) 0.91
Clinical phenotype and prevalence of hereditary nonpolyposis colorectal cancer syndrome in Chinese population. World J Gastroenterol (2005) 0.85
Prevalence of pathological germline mutations of hMLH1 and hMSH2 genes in colorectal cancer. PLoS One (2013) 0.82
Establishing a biological profile for interval colorectal cancers. Dig Dis Sci (2014) 0.82
Are there socio-economic inequalities in age of resection of colorectal cancer in people with HNPCC? Fam Cancer (2003) 0.78
Design considerations in a sib-pair study of linkage for susceptibility loci in cancer. BMC Med Genet (2008) 0.78
Epigenetic inactivation of the novel candidate tumor suppressor gene ITIH5 in colon cancer predicts unfavorable overall survival in the CpG island methylator phenotype. Epigenetics (2014) 0.78
Re: Characterization of hereditary nonpolyposis colorectal cancer families from a population-based series of cases. J Natl Cancer Inst (2001) 0.75
Meat consumption, ornithine decarboxylase gene polymorphism, and outcomes after colorectal cancer diagnosis. J Carcinog (2012) 0.75
Re: characterization of hereditary nonpolyposis colorectal cancer families from a population-based series of cases. J Natl Cancer Inst (2001) 0.75
Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case Series unselected for family history: a combined analysis of 22 studies. Am J Hum Genet (2003) 18.67
Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma. Proc Natl Acad Sci U S A (1998) 9.66
Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome. Nat Genet (2001) 9.34
Saccharomyces Ku70, mre11/rad50 and RPA proteins regulate adaptation to G2/M arrest after DNA damage. Cell (1998) 8.31
A novel mutation avoidance mechanism dependent on S. cerevisiae RAD27 is distinct from DNA mismatch repair. Cell (1997) 5.49
Suppression of spontaneous chromosomal rearrangements by S phase checkpoint functions in Saccharomyces cerevisiae. Cell (2001) 4.96
Treatment differences and other prognostic factors related to breast cancer survival. Delivery systems and medical outcomes. JAMA (1994) 4.86
Gross chromosomal rearrangements in Saccharomyces cerevisiae replication and recombination defective mutants. Nat Genet (1999) 4.18
Characterization of insertion mutations in the Saccharomyces cerevisiae MSH1 and MSH2 genes: evidence for separate mitochondrial and nuclear functions. Genetics (1992) 3.97
The BOADICEA model of genetic susceptibility to breast and ovarian cancers: updates and extensions. Br J Cancer (2008) 3.87
Multiple pathways cooperate in the suppression of genome instability in Saccharomyces cerevisiae. Nature (2001) 3.77
Identification and characterization of Saccharomyces cerevisiae EXO1, a gene encoding an exonuclease that interacts with MSH2. Proc Natl Acad Sci U S A (1997) 3.66
Identification and purification of a single-stranded-DNA-specific exonuclease encoded by the recJ gene of Escherichia coli. Proc Natl Acad Sci U S A (1989) 3.65
SGS1, the Saccharomyces cerevisiae homologue of BLM and WRN, suppresses genome instability and homeologous recombination. Nat Genet (2001) 3.60
Interaction between mismatch repair and genetic recombination in Saccharomyces cerevisiae. Genetics (1994) 3.52
MLH1, PMS1, and MSH2 interactions during the initiation of DNA mismatch repair in yeast. Science (1994) 3.19
Meiotic pachytene arrest in MLH1-deficient mice. Cell (1996) 3.18
Medical hypothesis: xenoestrogens as preventable causes of breast cancer. Environ Health Perspect (1993) 3.07
Frequency of recurrent BRCA1 and BRCA2 mutations in Ashkenazi Jewish breast cancer families. Nat Med (1996) 3.07
The Saccharomyces cerevisiae MLH3 gene functions in MSH3-dependent suppression of frameshift mutations. Proc Natl Acad Sci U S A (1998) 2.77
Biochemical interaction of the Escherichia coli RecF, RecO, and RecR proteins with RecA protein and single-stranded DNA binding protein. Proc Natl Acad Sci U S A (1993) 2.77
Exonuclease I of Saccharomyces cerevisiae functions in mitotic recombination in vivo and in vitro. Mol Cell Biol (1997) 2.73
Germ-line msh6 mutations in colorectal cancer families. Cancer Res (1999) 2.68
Mutation analysis of BRCA1 and BRCA2 in a male breast cancer population. Am J Hum Genet (1997) 2.53
Isolation and characterization of two Saccharomyces cerevisiae genes encoding homologs of the bacterial HexA and MutS mismatch repair proteins. Genetics (1992) 2.50
Chromosomal rearrangements occur in S. cerevisiae rfa1 mutator mutants due to mutagenic lesions processed by double-strand-break repair. Mol Cell (1998) 2.49
MutS homolog 4 localization to meiotic chromosomes is required for chromosome pairing during meiosis in male and female mice. Genes Dev (2000) 2.49
The genetic dependence of recombination in recD mutants of Escherichia coli. Genetics (1988) 2.49
The role of heteroduplex correction in gene conversion in Saccharomyces cerevisiae. Nature (1987) 2.38
Molecular characterization and phylogenetic studies of a wound-inducible proteinase inhibitor I gene in Lycopersicon species. Proc Natl Acad Sci U S A (1986) 2.37
Identification of mismatch repair genes and their role in the development of cancer. Curr Opin Genet Dev (1995) 2.37
Genetic analysis of yeast RPA1 reveals its multiple functions in DNA metabolism. Genetics (1998) 2.37
Relationship of cardiovascular risk factors to echocardiographic left ventricular mass in healthy young black and white adult men and women. The CARDIA study. Coronary Artery Risk Development in Young Adults. Circulation (1995) 2.36
Microsatellite instability, mismatch repair deficiency, and genetic defects in human cancer cell lines. Cancer Res (1995) 2.35
Specificity of mismatch repair following transformation of Saccharomyces cerevisiae with heteroduplex plasmid DNA. Proc Natl Acad Sci U S A (1989) 2.33
Echocardiographic design of a multicenter investigation of free-living elderly subjects: the Cardiovascular Health Study. J Am Soc Echocardiogr (1992) 2.31
Human papillomavirus type 18: association with poor prognosis in early stage cervical cancer. J Natl Cancer Inst (1996) 2.30
An essential Saccharomyces cerevisiae single-stranded DNA binding protein is homologous to the large subunit of human RP-A. EMBO J (1990) 2.28
Strand exchange protein 1 from Saccharomyces cerevisiae. A novel multifunctional protein that contains DNA strand exchange and exonuclease activities. J Biol Chem (1991) 2.26
Protein interactions in genetic recombination in Escherichia coli. Interactions involving RecO and RecR overcome the inhibition of RecA by single-stranded DNA-binding protein. J Biol Chem (1994) 2.26
Repair of retinal detachment caused by cytomegalovirus retinitis in patients with the acquired immunodeficiency syndrome. Am J Ophthalmol (1991) 2.24
Genetic and physical analysis of plasmid recombination in recB recC sbcB and recB recC sbcA Escherichia coli K-12 mutants. Genetics (1989) 2.22
Characterization of DNA-binding and strand-exchange stimulation properties of y-RPA, a yeast single-strand-DNA-binding protein. J Mol Biol (1992) 2.19
Interpretation of genetic test results for hereditary nonpolyposis colorectal cancer: implications for clinical predisposition testing. JAMA (1999) 2.14
Sensitivity and specificity of clinical criteria for hereditary non-polyposis colorectal cancer associated mutations in MSH2 and MLH1. J Med Genet (2000) 2.05
Proliferating cell nuclear antigen and Msh2p-Msh6p interact to form an active mispair recognition complex. Nat Genet (2000) 2.05
Hormone replacement therapy in breast cancer survivors: a cohort study. Am J Obstet Gynecol (1996) 2.04
Racial and ethnic colorectal cancer patterns affect the cost-effectiveness of colorectal cancer screening in the United States. Gastroenterology (2001) 2.00
Repair of heteroduplex plasmid DNA after transformation into Saccharomyces cerevisiae. Mol Cell Biol (1986) 1.98
Correction of hypermutability, N-methyl-N'-nitro-N-nitrosoguanidine resistance, and defective DNA mismatch repair by introducing chromosome 2 into human tumor cells with mutations in MSH2 and MSH6. Cancer Res (1997) 1.96
Chloroplast DNA from higher plants replicates by both the Cairns and the rolling circle mechanism. Nature (1975) 1.94
Sex, age, and disease affect echocardiographic left ventricular mass and systolic function in the free-living elderly. The Cardiovascular Health Study. Circulation (1995) 1.93
Molecular and genetic analysis of the gene encoding the Saccharomyces cerevisiae strand exchange protein Sep1. Mol Cell Biol (1991) 1.92
Breast and ovarian cancer risks to carriers of the BRCA1 5382insC and 185delAG and BRCA2 6174delT mutations: a combined analysis of 22 population based studies. J Med Genet (2005) 1.91
Hypertension, diuretics and breast cancer risk. J Hum Hypertens (2006) 1.90
Synthetic lethality of sep1 (xrn1) ski2 and sep1 (xrn1) ski3 mutants of Saccharomyces cerevisiae is independent of killer virus and suggests a general role for these genes in translation control. Mol Cell Biol (1995) 1.88
Biochemical characterization of the interaction between the Saccharomyces cerevisiae MSH2-MSH6 complex and mispaired bases in DNA. J Biol Chem (1999) 1.84
exo1-Dependent mutator mutations: model system for studying functional interactions in mismatch repair. Mol Cell Biol (2001) 1.79
Targeting of nonexpressed genes in embryonic stem cells via homologous recombination. Science (1989) 1.75
Regulation and intracellular localization of Saccharomyces cerevisiae strand exchange protein 1 (Sep1/Xrn1/Kem1), a multifunctional exonuclease. Mol Cell Biol (1995) 1.74
Erythropoietin and erythropoietin receptor expression in human cancer. Cancer Res (2001) 1.74
Saccharomyces cerevisiae MSH2, a mispaired base recognition protein, also recognizes Holliday junctions in DNA. J Mol Biol (1997) 1.71
Denaturation mapping studies on the circular chloroplast deoxyribonucleic acid from pea leaves. J Biol Chem (1975) 1.70
Purification and preliminary characterization of the Escherichia coli K-12 recF protein. J Bacteriol (1990) 1.70
MSH2 and MSH6 are required for removal of adenine misincorporated opposite 8-oxo-guanine in S. cerevisiae. Mol Cell (1999) 1.69
The DNA mismatch repair genes Msh3 and Msh6 cooperate in intestinal tumor suppression. Cancer Res (2000) 1.68
Functional communication between endogenous BRCA1 and its partner, BARD1, during Xenopus laevis development. Proc Natl Acad Sci U S A (2001) 1.67
Smoking and lung function in elderly men and women. The Cardiovascular Health Study. JAMA (1993) 1.65
Links between replication, recombination and genome instability in eukaryotes. Trends Biochem Sci (2000) 1.64
Molecular cloning of human testicular angiotensin-converting enzyme: the testis isozyme is identical to the C-terminal half of endothelial angiotensin-converting enzyme. Proc Natl Acad Sci U S A (1989) 1.64
Identification and characterization of the Escherichia coli RecT protein, a protein encoded by the recE region that promotes renaturation of homologous single-stranded DNA. J Bacteriol (1993) 1.63
Identification of a human gene encoding a homologue of Saccharomyces cerevisiae EXO1, an exonuclease implicated in mismatch repair and recombination. Cancer Res (1998) 1.59
Role of lysines in human angiogenin: chemical modification and site-directed mutagenesis. Biochemistry (1989) 1.58
Somatic mutations in the hMSH2 gene in microsatellite unstable colorectal carcinomas. Hum Mol Genet (1995) 1.57
Breast cancer, passive and active cigarette smoking and N-acetyltransferase 2 genotype. Pharmacogenetics (2000) 1.55
Intron splice acceptor site sequence variation in the hereditary non-polyposis colorectal cancer gene hMSH2. Eur J Cancer (1994) 1.54
Saccharomyces cerevisiae pol30 (proliferating cell nuclear antigen) mutations impair replication fidelity and mismatch repair. Mol Cell Biol (1999) 1.54
Validating genetic risk associations for ovarian cancer through the international Ovarian Cancer Association Consortium. Br J Cancer (2009) 1.54
Checkpoint-dependent activation of mutagenic repair in Saccharomyces cerevisiae pol3-01 mutants. Mol Cell (2000) 1.53
Mapping of Escherichia coli chromosomal Tn5 and F insertions by pulsed field gel electrophoresis. Genetics (1988) 1.53
Purification and characterization of MSH1, a yeast mitochondrial protein that binds to DNA mismatches. J Biol Chem (1994) 1.52
Initial description of the human NLRP3 promoter. Genes Immun (2008) 1.52
Identification of a locus on chromosome 1q44 for familial cold urticaria. Am J Hum Genet (2000) 1.51
Nucleotide sequence of the Escherichia coli recJ chromosomal region and construction of recJ-overexpression plasmids. J Bacteriol (1991) 1.49
Characteristics of BRCA1 mutations in a population-based case series of breast and ovarian cancer. Eur J Cancer (2000) 1.47
BRCA1 R841W: a strong candidate for a common mutation with moderate phenotype. Genet Epidemiol (1996) 1.45
Cancer risk estimates for family members of a population-based family registry for breast and ovarian cancer. Cancer Epidemiol Biomarkers Prev (2000) 1.44
Homologous pairing and strand exchange promoted by the Escherichia coli RecT protein. Proc Natl Acad Sci U S A (1994) 1.43
DNA strand invasion promoted by Escherichia coli RecT protein. J Biol Chem (1998) 1.42
Isolation and culture of pulmonary artery endothelial cells. Tissue Cell (1978) 1.40
Comparison of functional testing for resistance to activated protein C and molecular biological testing for factor V R506Q in 370 patients. Arch Pathol Lab Med (1998) 1.37