Published in Cancer Res on December 15, 1995
Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma. Proc Natl Acad Sci U S A (1998) 9.66
Biallelic inactivation of hMLH1 by epigenetic gene silencing, a novel mechanism causing human MSI cancers. Proc Natl Acad Sci U S A (1998) 3.90
hMSH2 forms specific mispair-binding complexes with hMSH3 and hMSH6. Proc Natl Acad Sci U S A (1996) 3.60
The mutation rate and cancer. Genetics (1998) 1.88
Functional overlap in mismatch repair by human MSH3 and MSH6. Genetics (1998) 1.70
The linear process of somatic evolution. Proc Natl Acad Sci U S A (2003) 1.66
Aspirin suppresses the mutator phenotype associated with hereditary nonpolyposis colorectal cancer by genetic selection. Proc Natl Acad Sci U S A (1998) 1.62
Replication errors: cha(lle)nging the genome. EMBO J (1998) 1.62
Mitochondrial DNA somatic mutations (point mutations and large deletions) and mitochondrial DNA variants in human thyroid pathology: a study with emphasis on Hürthle cell tumors. Am J Pathol (2002) 1.61
Evolutionary dynamics of tumor suppressor gene inactivation. Proc Natl Acad Sci U S A (2004) 1.61
Methylation-induced G(2)/M arrest requires a full complement of the mismatch repair protein hMLH1. EMBO J (2003) 1.60
hMutSbeta is required for the recognition and uncoupling of psoralen interstrand cross-links in vitro. Mol Cell Biol (2002) 1.58
Mismatch repair deficiency associated with overexpression of the MSH3 gene. Proc Natl Acad Sci U S A (1998) 1.56
DNA polymerases as potential therapeutic targets for cancers deficient in the DNA mismatch repair proteins MSH2 or MLH1. Cancer Cell (2010) 1.52
Methotrexate induces oxidative DNA damage and is selectively lethal to tumour cells with defects in the DNA mismatch repair gene MSH2. EMBO Mol Med (2009) 1.49
Genome-wide sequence and functional analysis of early replicating DNA in normal human fibroblasts. BMC Genomics (2006) 1.39
Mismatch repair proteins are activators of toxic responses to chromium-DNA damage. Mol Cell Biol (2005) 1.32
Concurrent genetic alterations in DNA polymerase proofreading and mismatch repair in human colorectal cancer. Eur J Hum Genet (2010) 1.30
The oxidized deoxynucleoside triphosphate pool is a significant contributor to genetic instability in mismatch repair-deficient cells. Mol Cell Biol (2004) 1.29
Cell cycle control, checkpoint mechanisms, and genotoxic stress. Environ Health Perspect (1999) 1.22
Hereditary colorectal cancer in the general population: from cancer registration to molecular diagnosis. Gut (1999) 1.19
Novel DNA mismatch-repair activity involving YB-1 in human mitochondria. DNA Repair (Amst) (2009) 1.18
Methylation of hMLH1 promoter correlates with the gene silencing with a region-specific manner in colorectal cancer. Br J Cancer (2002) 1.16
Comprehensive molecular analysis of mismatch repair gene defects in suspected Lynch syndrome (hereditary nonpolyposis colorectal cancer) cases. Cancer Res (2009) 1.14
DNA damage during reoxygenation elicits a Chk2-dependent checkpoint response. Mol Cell Biol (2006) 1.13
A novel approach for characterizing microsatellite instability in cancer cells. PLoS One (2013) 1.10
Stepwise deletions of polyA sequences in mismatch repair-deficient colorectal cancers. Am J Pathol (2001) 1.04
Evidence of chromosomal instability in prostate cancer determined by spectral karyotyping (SKY) and interphase fish analysis. Neoplasia (2001) 1.02
The effect of different chemotherapeutic agents on the enrichment of DNA mismatch repair-deficient tumour cells. Br J Cancer (1998) 1.00
Relation between normal rectal methylation, smoking status, and the presence or absence of colorectal adenomas. Cancer (2010) 0.99
Biased short tract repair of palindromic loop mismatches in mammalian cells. Genetics (1998) 0.99
The role of chemotherapy in microsatellite unstable (MSI-H) colorectal cancer. Int J Colorectal Dis (2006) 0.94
Cancerous stem cells: deviant stem cells with cancer-causing misbehavior. Stem Cell Res Ther (2010) 0.91
Mismatch repair by efficient nick-directed, and less efficient mismatch-specific, mechanisms in homologous recombination intermediates in Chinese hamster ovary cells. Genetics (1997) 0.91
Discriminatory suppression of homologous recombination by p53. Nucleic Acids Res (2004) 0.89
Population-based study of the association of variants in mismatch repair genes with prostate cancer risk and outcomes. Cancer Epidemiol Biomarkers Prev (2010) 0.89
Presence of two signaling TGF-beta receptors in human pancreatic cancer correlates with advanced tumor stage. Dig Dis Sci (1997) 0.88
Folate status and risk of colorectal polyps in African Americans. Dig Dis Sci (2007) 0.87
Interaction between human mismatch repair recognition proteins and checkpoint sensor Rad9-Rad1-Hus1. DNA Repair (Amst) (2010) 0.87
Loss of heterozygosity and base substitution at the APRT locus in mismatch-repair-proficient and -deficient colorectal carcinoma cell lines. Mol Cell Biol (1996) 0.86
Mismatch repair mutants in yeast are not defective in transcription-coupled DNA repair of UV-induced DNA damage. Genetics (1996) 0.84
Cooperative nuclear localization sequences lend a novel role to the N-terminal region of MSH6. PLoS One (2011) 0.83
Synthetic genetic targeting of genome instability in cancer. Cancers (Basel) (2013) 0.83
Loss of DNA mismatch repair facilitates reactivation of a reporter plasmid damaged by cisplatin. Br J Cancer (1999) 0.82
A new isoquinolinium derivative, Cadein1, preferentially induces apoptosis in p53-defective cancer cells with functional mismatch repair via a p38-dependent pathway. J Biol Chem (2009) 0.82
p53 protein regulates the effects of amifostine on apoptosis, cell cycle progression, and cytoprotection. Br J Cancer (2003) 0.81
Microsatellite instability in thyroid tumours and tumour-like lesions. Br J Cancer (1999) 0.81
Cell context dependent p53 genome-wide binding patterns and enrichment at repeats. PLoS One (2014) 0.80
The absence of Msh2 alters abelson virus pre-B-cell transformation by influencing p53 mutation. Mol Cell Biol (2000) 0.80
DNA mismatch repair gene MLH1 induces apoptosis in prostate cancer cells. Oncotarget (2014) 0.79
Deficiency of a novel mismatch repair activity in a bladder tumor cell line. Nucleic Acids Res (2002) 0.78
Brostallicin (PNU-166196)--a new DNA minor groove binder that retains sensitivity in DNA mismatch repair-deficient tumour cells. Br J Cancer (2003) 0.78
UV radiation induces delayed hyperrecombination associated with hypermutation in human cells. Mol Cell Biol (2006) 0.78
Photodynamic therapy of DNA mismatch repair-deficient and -proficient tumour cells. Br J Cancer (2002) 0.78
DNA damage and repair in epithelium after allogeneic hematopoietic stem cell transplantation. Int J Mol Sci (2012) 0.77
Influence of Helicobacter pylori infection on the expression of MLH1 and MGMT in patients with chronic gastritis and gastric cancer. Eur J Clin Microbiol Infect Dis (2008) 0.77
hMSH2 and GTBP expression in advanced stage epithelial ovarian cancer. Br J Cancer (1999) 0.77
Nature of nontargeted radiation effects observed during fractionated irradiation-induced thymic lymphomagenesis in mice. J Radiat Res (2013) 0.76
Role of Deficient Mismatch Repair in the Personalized Management of Colorectal Cancer. Int J Environ Res Public Health (2016) 0.75
A generic, cost-effective, and scalable cell lineage analysis platform. Genome Res (2016) 0.75
Functional role of DNA mismatch repair gene PMS2 in prostate cancer cells. Oncotarget (2015) 0.75
Deoxyinosine triphosphate induces MLH1/PMS2- and p53-dependent cell growth arrest and DNA instability in mammalian cells. Sci Rep (2016) 0.75
Rapid and efficient site-specific mutagenesis without phenotypic selection. Proc Natl Acad Sci U S A (1985) 68.48
Rapid and efficient site-specific mutagenesis without phenotypic selection. Methods Enzymol (1987) 66.52
The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer. Cell (1993) 13.54
Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma. Proc Natl Acad Sci U S A (1998) 9.66
Fidelity of DNA synthesis by the Thermus aquaticus DNA polymerase. Biochemistry (1988) 9.66
Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome. Nat Genet (2001) 9.34
Saccharomyces Ku70, mre11/rad50 and RPA proteins regulate adaptation to G2/M arrest after DNA damage. Cell (1998) 8.31
The accuracy of reverse transcriptase from HIV-1. Science (1988) 8.24
Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary non-polyposis colon cancer. Nature (1994) 8.04
Efficient site-directed mutagenesis using uracil-containing DNA. Methods Enzymol (1991) 7.94
Fidelity of DNA synthesis. Annu Rev Biochem (1982) 6.54
Mutational specificity of depurination. Proc Natl Acad Sci U S A (1984) 6.51
The Y-family of DNA polymerases. Mol Cell (2001) 6.49
A novel mutation avoidance mechanism dependent on S. cerevisiae RAD27 is distinct from DNA mismatch repair. Cell (1997) 5.49
Osteogenic protein-1 (bone morphogenetic protein-7) in the treatment of tibial nonunions. J Bone Joint Surg Am (2001) 5.13
Integration of hepatitis B vaccination into national immunisation programmes. Viral Hepatitis Prevention Board. BMJ (1997) 5.10
Suppression of spontaneous chromosomal rearrangements by S phase checkpoint functions in Saccharomyces cerevisiae. Cell (2001) 4.96
Unsafe injections in the developing world and transmission of bloodborne pathogens: a review. Bull World Health Organ (1999) 4.80
Requirement for PCNA in DNA mismatch repair at a step preceding DNA resynthesis. Cell (1996) 4.47
Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts. Proc Natl Acad Sci U S A (1996) 4.33
DNA polymerase fidelity and the polymerase chain reaction. PCR Methods Appl (1991) 4.31
The base substitution fidelity of eucaryotic DNA polymerases. Mispairing frequencies, site preferences, insertion preferences, and base substitution by dislocation. J Biol Chem (1986) 4.25
Gross chromosomal rearrangements in Saccharomyces cerevisiae replication and recombination defective mutants. Nat Genet (1999) 4.18
Deoxynucleoside [1-thio]triphosphates prevent proofreading during in vitro DNA synthesis. Proc Natl Acad Sci U S A (1981) 4.14
High fidelity DNA synthesis by the Thermus aquaticus DNA polymerase. Nucleic Acids Res (1990) 4.12
The mutational specificity of DNA polymerase-beta during in vitro DNA synthesis. Production of frameshift, base substitution, and deletion mutations. J Biol Chem (1985) 3.98
KAI1, a metastasis suppressor gene for prostate cancer on human chromosome 11p11.2. Science (1995) 3.97
Characterization of insertion mutations in the Saccharomyces cerevisiae MSH1 and MSH2 genes: evidence for separate mitochondrial and nuclear functions. Genetics (1992) 3.97
Aromatic hydrogen bond in sequence-specific protein DNA recognition. Nat Struct Biol (1996) 3.91
Specificity and mechanism of error-prone replication by human immunodeficiency virus-1 reverse transcriptase. J Biol Chem (1989) 3.80
Multiple pathways cooperate in the suppression of genome instability in Saccharomyces cerevisiae. Nature (2001) 3.77
High-resolution serum proteomic features for ovarian cancer detection. Endocr Relat Cancer (2004) 3.75
Identification and characterization of Saccharomyces cerevisiae EXO1, a gene encoding an exonuclease that interacts with MSH2. Proc Natl Acad Sci U S A (1997) 3.66
Identification and purification of a single-stranded-DNA-specific exonuclease encoded by the recJ gene of Escherichia coli. Proc Natl Acad Sci U S A (1989) 3.65
Human chromosome 3 corrects mismatch repair deficiency and microsatellite instability and reduces N-methyl-N'-nitro-N-nitrosoguanidine tolerance in colon tumor cells with homozygous hMLH1 mutation. Cancer Res (1994) 3.63
Somatic mutation hotspots correlate with DNA polymerase eta error spectrum. Nat Immunol (2001) 3.60
SGS1, the Saccharomyces cerevisiae homologue of BLM and WRN, suppresses genome instability and homeologous recombination. Nat Genet (2001) 3.60
Interaction between mismatch repair and genetic recombination in Saccharomyces cerevisiae. Genetics (1994) 3.52
A sensitive genetic assay for the detection of cytosine deamination: determination of rate constants and the activation energy. Biochemistry (1990) 3.51
Eukaryotic DNA polymerase amino acid sequence required for 3'----5' exonuclease activity. Proc Natl Acad Sci U S A (1991) 3.44
Novel features in the genetic code and codon reading patterns in Neurospora crassa mitochondria based on sequences of six mitochondrial tRNAs. Proc Natl Acad Sci U S A (1980) 3.19
MLH1, PMS1, and MSH2 interactions during the initiation of DNA mismatch repair in yeast. Science (1994) 3.19
Meiotic pachytene arrest in MLH1-deficient mice. Cell (1996) 3.18
Heteroduplex repair in extracts of human HeLa cells. J Biol Chem (1991) 3.13
Biomarkers of oxidative stress study II: are oxidation products of lipids, proteins, and DNA markers of CCl4 poisoning? Free Radic Biol Med (2005) 3.13
Frequency of recurrent BRCA1 and BRCA2 mutations in Ashkenazi Jewish breast cancer families. Nat Med (1996) 3.07
Transcript cleavage by RNA polymerase II arrested by a cyclobutane pyrimidine dimer in the DNA template. Proc Natl Acad Sci U S A (1994) 3.02
Fidelity of two retroviral reverse transcriptases during DNA-dependent DNA synthesis in vitro. Mol Cell Biol (1989) 3.00
Transmission of hepatitis B, hepatitis C and human immunodeficiency viruses through unsafe injections in the developing world: model-based regional estimates. Bull World Health Organ (1999) 2.97
Infidelity of DNA synthesis associated with bypass of apurinic sites. Proc Natl Acad Sci U S A (1983) 2.95
New IBD genetics: common pathways with other diseases. Gut (2011) 2.95
PTEN/MMAC1 mutations in endometrial cancers. Cancer Res (1997) 2.89
Analysis of the cell population kinetics of transplanted tumours of widely-differing growth rate. Br J Cancer (1966) 2.88
Low fidelity DNA synthesis by human DNA polymerase-eta. Nature (2000) 2.85
Defective mismatch repair in extracts of colorectal and endometrial cancer cell lines exhibiting microsatellite instability. J Biol Chem (1994) 2.82
Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinase. Nat Genet (1999) 2.81
The Saccharomyces cerevisiae MLH3 gene functions in MSH3-dependent suppression of frameshift mutations. Proc Natl Acad Sci U S A (1998) 2.77
Biochemical interaction of the Escherichia coli RecF, RecO, and RecR proteins with RecA protein and single-stranded DNA binding protein. Proc Natl Acad Sci U S A (1993) 2.77
Exonuclease I of Saccharomyces cerevisiae functions in mitotic recombination in vivo and in vitro. Mol Cell Biol (1997) 2.73
The mutational specificity of DNA polymerases-alpha and -gamma during in vitro DNA synthesis. J Biol Chem (1985) 2.66
Passing the baton in base excision repair. Nat Struct Biol (2000) 2.65
Nucleotide repeats. Slippery DNA and diseases. Nature (1993) 2.56
Analyzing fidelity of DNA polymerases. Methods Enzymol (1995) 2.52
Isolation and characterization of two Saccharomyces cerevisiae genes encoding homologs of the bacterial HexA and MutS mismatch repair proteins. Genetics (1992) 2.50
Chromosomal rearrangements occur in S. cerevisiae rfa1 mutator mutants due to mutagenic lesions processed by double-strand-break repair. Mol Cell (1998) 2.49
MutS homolog 4 localization to meiotic chromosomes is required for chromosome pairing during meiosis in male and female mice. Genes Dev (2000) 2.49
The genetic dependence of recombination in recD mutants of Escherichia coli. Genetics (1988) 2.49
Mutation in the mismatch repair gene Msh6 causes cancer susceptibility. Cell (1997) 2.46
Biomarker risk assessment and bladder cancer detection in a cohort exposed to benzidine. J Natl Cancer Inst (2001) 2.41
Frameshift mutagenesis by eucaryotic DNA polymerases in vitro. J Biol Chem (1986) 2.40
Depurination-induced infidelity of deoxyribonucleic acid synthesis with purified deoxyribonucleic acid replication proteins in vitro. Biochemistry (1983) 2.38
The role of heteroduplex correction in gene conversion in Saccharomyces cerevisiae. Nature (1987) 2.38
Identification of mismatch repair genes and their role in the development of cancer. Curr Opin Genet Dev (1995) 2.37
Genetic analysis of yeast RPA1 reveals its multiple functions in DNA metabolism. Genetics (1998) 2.37
Characterization of hereditary nonpolyposis colorectal cancer families from a population-based series of cases. J Natl Cancer Inst (2000) 2.37
The fidelity of DNA synthesis catalyzed by derivatives of Escherichia coli DNA polymerase I. J Biol Chem (1990) 2.36
A mathematical model of the mitotic cycle and its application to the interpretation of percentage labeled mitoses data. J Natl Cancer Inst (1966) 2.36
Dietary restriction reduces insulin-like growth factor I levels, which modulates apoptosis, cell proliferation, and tumor progression in p53-deficient mice. Cancer Res (1997) 2.34
Specificity of mismatch repair following transformation of Saccharomyces cerevisiae with heteroduplex plasmid DNA. Proc Natl Acad Sci U S A (1989) 2.33
Cloning and characterization of the promoter region of human telomerase reverse transcriptase gene. Cancer Res (1999) 2.32
An essential Saccharomyces cerevisiae single-stranded DNA binding protein is homologous to the large subunit of human RP-A. EMBO J (1990) 2.28
Mutator phenotypes conferred by MLH1 overexpression and by heterozygosity for mlh1 mutations. Mol Cell Biol (1999) 2.26
Strand exchange protein 1 from Saccharomyces cerevisiae. A novel multifunctional protein that contains DNA strand exchange and exonuclease activities. J Biol Chem (1991) 2.26
Protein interactions in genetic recombination in Escherichia coli. Interactions involving RecO and RecR overcome the inhibition of RecA by single-stranded DNA-binding protein. J Biol Chem (1994) 2.26
A gene involved in control of human cellular senescence on human chromosome 1q. Mol Cell Biol (1994) 2.26
Genetic and physical analysis of plasmid recombination in recB recC sbcB and recB recC sbcA Escherichia coli K-12 mutants. Genetics (1989) 2.22
On the fidelity of DNA replication. Effect of divalent metal ion activators and deoxyrionucleoside triphosphate pools on in vitro mutagenesis. J Biol Chem (1979) 2.20
Characterization of DNA-binding and strand-exchange stimulation properties of y-RPA, a yeast single-strand-DNA-binding protein. J Mol Biol (1992) 2.19
DNA loop repair by human cell extracts. Science (1994) 2.19
Evidence for a connection between the mismatch repair system and the G2 cell cycle checkpoint. Cancer Res (1995) 2.17
Fidelity of mammalian DNA polymerases. Science (1981) 2.17
The 3'-->5' exonuclease of DNA polymerase delta can substitute for the 5' flap endonuclease Rad27/Fen1 in processing Okazaki fragments and preventing genome instability. Proc Natl Acad Sci U S A (2001) 2.16