Published in Proc Natl Acad Sci U S A on December 05, 2000
Ivermectin mass drug administration to humans disrupts malaria parasite transmission in Senegalese villages. Am J Trop Med Hyg (2011) 1.56
The effect of oral anthelmintics on the survivorship and re-feeding frequency of anthropophilic mosquito disease vectors. Acta Trop (2010) 1.50
Mass drug administration of ivermectin in south-eastern Senegal reduces the survivorship of wild-caught, blood fed malaria vectors. Malar J (2010) 1.45
Breed distribution and history of canine mdr1-1Delta, a pharmacogenetic mutation that marks the emergence of breeds from the collie lineage. Proc Natl Acad Sci U S A (2004) 1.41
Ion channels: molecular targets of neuroactive insecticides. Invert Neurosci (2005) 1.28
Endectocides for malaria control. Trends Parasitol (2011) 1.21
Comparative evaluation of systemic drugs for their effects against Anopheles gambiae. Acta Trop (2011) 1.21
Use of non-mammalian alternative models for neurotoxicological study. Neurotoxicology (2008) 1.17
Spider-venom peptides as bioinsecticides. Toxins (Basel) (2012) 1.14
Ivermectin inhibits the sporogony of Plasmodium falciparum in Anopheles gambiae. Malar J (2012) 1.10
Allosteric modulation of glycine receptors. Br J Pharmacol (2011) 1.01
Glutamate-gated chloride channels. J Biol Chem (2012) 1.00
Molecular mechanisms of Cys-loop ion channel receptor modulation by ivermectin. Front Mol Neurosci (2012) 0.98
Molecular determinants of ivermectin sensitivity at the glycine receptor chloride channel. J Biol Chem (2011) 0.97
Possible pathogenic pathways in the adverse clinical events seen following ivermectin administration to onchocerciasis patients. Filaria J (2003) 0.97
Rationale for the coadministration of albendazole and ivermectin to humans for malaria parasite transmission control. Am J Trop Med Hyg (2014) 0.95
Salmon lice (Lepeophtheirus salmonis) showing varying emamectin benzoate susceptibilities differ in neuronal acetylcholine receptor and GABA-gated chloride channel mRNA expression. BMC Genomics (2013) 0.94
Molecular characterisation of a pH-gated chloride channel from Sarcoptes scabiei. Invert Neurosci (2007) 0.93
Glutamate-activated chloride channels: Unique fipronil targets present in insects but not in mammals. Pestic Biochem Physiol (2010) 0.91
Recent progress in understanding the interaction between avermectins and ligand-gated ion channels: putting the pests to sleep. Invert Neurosci (2010) 0.89
Low doses of ivermectin cause sensory and locomotor disorders in dung beetles. Sci Rep (2015) 0.86
Molecular cloning and characterization of novel glutamate-gated chloride channel subunits from Schistosoma mansoni. PLoS Pathog (2013) 0.86
Total Synthesis of (-)-Nodulisporic Acid D. J Am Chem Soc (2015) 0.85
Altered ivermectin pharmacology and defective visual system in Drosophila mutants for histamine receptor HCLB. Invert Neurosci (2008) 0.84
Age and prior blood feeding of Anopheles gambiae influences their susceptibility and gene expression patterns to ivermectin-containing blood meals. BMC Genomics (2015) 0.83
Hypoxylon pulicicidum sp. nov. (Ascomycota, Xylariales), a pantropical insecticide-producing endophyte. PLoS One (2012) 0.83
Identification and functional expression of a glutamate- and avermectin-gated chloride channel from Caligus rogercresseyi, a southern Hemisphere sea louse affecting farmed fish. PLoS Pathog (2014) 0.80
Purifying selection and demographic expansion affect sequence diversity of the ligand-binding domain of a glutamate-gated chloride channel gene of Haemonchus placei. J Mol Evol (2004) 0.78
The alternative oxidase AOX does not rescue the phenotype of tko25t mutant flies. G3 (Bethesda) (2014) 0.77
Selective targeting of nuclear receptor FXR by avermectin analogues with therapeutic effects on nonalcoholic fatty liver disease. Sci Rep (2015) 0.75
David and Goliath: chemical perturbation of eukaryotes by bacteria. J Ind Microbiol Biotechnol (2015) 0.75
In vivo protection against strychnine toxicity in mice by the glycine receptor agonist ivermectin. Biomed Res Int (2014) 0.75
The Wiggle Index: An Open Source Bioassay to Assess Sub-Lethal Insecticide Response in Drosophila melanogaster. PLoS One (2015) 0.75
Actions of agonists, fipronil and ivermectin on the predominant in vivo splice and edit variant (RDLbd, I/V) of the Drosophila GABA receptor expressed in Xenopus laevis oocytes. PLoS One (2014) 0.75
Abamectin treatment affects glutamate decarboxylase expression and induces higher GABA levels in the citrus red mite, Panonychus citri. Exp Appl Acarol (2017) 0.75
Glutamate-gated chloride channel subunit cDNA sequencing of Cochliomyia hominivorax (Diptera: Calliphoridae): cDNA variants and polymorphisms. Invert Neurosci (2014) 0.75
Ivermectin: a complimentary weapon against the spread of malaria? Expert Rev Anti Infect Ther (2016) 0.75
The FlyBase database of the Drosophila Genome Projects and community literature. Nucleic Acids Res (1999) 26.10
Sites of alcohol and volatile anaesthetic action on GABA(A) and glycine receptors. Nature (1997) 7.49
Cloning of an avermectin-sensitive glutamate-gated chloride channel from Caenorhabditis elegans. Nature (1994) 2.92
A point mutation in a Drosophila GABA receptor confers insecticide resistance. Nature (1993) 2.75
The genetics of ivermectin resistance in Caenorhabditis elegans. Proc Natl Acad Sci U S A (2000) 1.99
Indirect Suppression Involving Behavioral Mutants with Altered Nerve Excitability in DROSOPHILA MELANOGASTER. Genetics (1982) 1.95
Clinical observations in collies given ivermectin orally. Am J Vet Res (1987) 1.83
Decreased agonist affinity and chloride conductance of mutant glycine receptors associated with human hereditary hyperekplexia. EMBO J (1994) 1.71
Inhibition of calcium/calmodulin-dependent protein kinase in Drosophila disrupts behavioral plasticity. Neuron (1993) 1.51
Actions of the insecticide fipronil, on dieldrin-sensitive and- resistant GABA receptors of Drosophila melanogaster. Br J Pharmacol (1995) 1.33
Identification of a Drosophila melanogaster glutamate-gated chloride channel sensitive to the antiparasitic agent avermectin. J Biol Chem (1996) 1.28
Diversification of Drosophila chloride channel gene by multiple posttranscriptional mRNA modifications. J Neurochem (1999) 1.25
Genetic dissection of short-term and long-term facilitation at the Drosophila neuromuscular junction. Proc Natl Acad Sci U S A (1978) 1.20
P-glycoprotein deficiency in a subpopulation of CF-1 mice enhances avermectin-induced neurotoxicity. Toxicol Appl Pharmacol (1997) 1.18
Learning without performance in PKC-deficient Drosophila. Neuron (1997) 1.16
From fruit flies to barnacles, histamine is the neurotransmitter of arthropod photoreceptors. Neuron (1999) 1.08
Morphological defects in oraJK84 photoreceptors caused by mutation in R1-6 opsin gene of Drosophila. J Neurogenet (1989) 1.08
Effect of ivermectin on gamma-aminobutyric acid-induced chloride currents in mouse hippocampal embryonic neurones. Eur J Pharmacol (1994) 1.00
Nodulisporic acid opens insect glutamate-gated chloride channels: identification of a new high affinity modulator. Biochemistry (2000) 0.99
A patch-clamp study of effects of dihydroavermectin on Ascaris muscle. Br J Pharmacol (1989) 0.97
Avermectin binding in Caenorhabditis elegans. A two-state model for the avermectin binding site. Biochem Pharmacol (1989) 0.93
Discovery of a novel indole diterpene insecticide using first instars of Lucilia sericata. Med Vet Entomol (1997) 0.89
Avermectin B1a binds to high- and low-affinity sites with dual effects on the gamma-aminobutyric acid-gated chloride channel of cultured cerebellar granule neurons. J Pharmacol Exp Ther (1997) 0.88
Novel genetic screen for genes involved in posterior body patterning in Drosophila. Dev Genet (1996) 0.87
Regional modification of [(3)H]Ethynylbicycloorthobenzoate binding in mouse brain GABA(A) receptor by endosulfan, fipronil, and avermectin B(1a). Toxicol Appl Pharmacol (2000) 0.83
Actions of insecticides on the insect GABA receptor complex. J Recept Res (1991) 0.83
Affinity probes for the avermectin binding proteins. J Med Chem (1992) 0.81
Chemical modification of nodulisporic acid A: preliminary structure-activity relationships. Bioorg Med Chem Lett (2000) 0.81
Nucleotide sequence of bacteriophage phi X174 DNA. Nature (1977) 95.69
CD4+ count-guided interruption of antiretroviral treatment. N Engl J Med (2006) 22.76
Oligonucleotide-directed mutagenesis of DNA fragments cloned into M13 vectors. Methods Enzymol (1983) 17.47
Oligonucleotide-directed mutagenesis: a simple method using two oligonucleotide primers and a single-stranded DNA template. DNA (1984) 14.55
The nucleotide sequence of bacteriophage phiX174. J Mol Biol (1978) 13.55
Oligonucleotide-directed mutagenesis using M13-derived vectors: an efficient and general procedure for the production of point mutations in any fragment of DNA. Nucleic Acids Res (1982) 13.52
A general method for defining restriction enzyme cleavage and recognition sites. Methods Enzymol (1980) 13.26
Effects of long-term fenofibrate therapy on cardiovascular events in 9795 people with type 2 diabetes mellitus (the FIELD study): randomised controlled trial. Lancet (2005) 13.18
Sequence of the gene for iso-1-cytochrome c in Saccharomyces cerevisiae. Cell (1979) 10.86
Stress hyperglycaemia and increased risk of death after myocardial infarction in patients with and without diabetes: a systematic overview. Lancet (2000) 8.46
Routine versus clinically driven laboratory monitoring of HIV antiretroviral therapy in Africa (DART): a randomised non-inferiority trial. Lancet (2009) 7.96
Mutagenesis at a specific position in a DNA sequence. J Biol Chem (1978) 7.56
Report of the Committee on the Genetic Constitution of Chromosomes 7, 8 and 9. Cytogenet Cell Genet (1985) 7.28
REST: a mammalian silencer protein that restricts sodium channel gene expression to neurons. Cell (1995) 6.43
The specific non-symmetrical sequence recognized by restriction endonuclease MboII. J Mol Biol (1980) 6.36
Stress hyperglycemia and prognosis of stroke in nondiabetic and diabetic patients: a systematic overview. Stroke (2001) 6.32
Deletion mapping of sequences essential for in vivo transcription of the iso-1-cytochrome c gene. Proc Natl Acad Sci U S A (1981) 6.26
The cost effectiveness of combination antiretroviral therapy for HIV disease. N Engl J Med (2001) 5.89
Small-conductance, calcium-activated potassium channels from mammalian brain. Science (1996) 5.88
Environmental lead and children's intelligence: a systematic review of the epidemiological evidence. BMJ (1994) 5.55
A receptor in pituitary and hypothalamus that functions in growth hormone release. Science (1996) 5.45
The sequence of the DNAs coding for the mating-type loci of Saccharomyces cerevisiae. Cell (1981) 5.23
A position effect in the control of transcription at yeast mating type loci. Nature (1981) 5.23
Lidocaine block of cardiac sodium channels. J Gen Physiol (1983) 5.13
The alcohol use disorder and associated disabilities interview schedule (AUDADIS): reliability of alcohol and drug modules in a clinical sample. Drug Alcohol Depend (1997) 5.10
The distal transcription signals of the herpesvirus tk gene share a common hexanucleotide control sequence. Cell (1984) 5.10
Four mating-type genes control sexual differentiation in the fission yeast. EMBO J (1988) 5.00
Site-specific mutagenesis using synthetic oligodeoxyribonucleotide primers: II. In vitro selection of mutant DNA. Gene (1979) 4.99
Mechanism of calcium gating in small-conductance calcium-activated potassium channels. Nature (1998) 4.94
The DNA sequence and analysis of human chromosome 6. Nature (2003) 4.75
Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing. Nature (2000) 4.68
Requirement for the homeobox gene Hb9 in the consolidation of motor neuron identity. Neuron (1999) 4.68
HIV-1 protease inhibitors. A review for clinicians. JAMA (1997) 4.34
Pericentrin and gamma-tubulin form a protein complex and are organized into a novel lattice at the centrosome. J Cell Biol (1998) 4.23
Work system design for patient safety: the SEIPS model. Qual Saf Health Care (2006) 4.21
How biomedical investigators use library books. Bull Med Libr Assoc (1966) 4.20
CENP-E forms a link between attachment of spindle microtubules to kinetochores and the mitotic checkpoint. Nat Cell Biol (2000) 3.96
Identification of yeast Rho1p GTPase as a regulatory subunit of 1,3-beta-glucan synthase. Science (1996) 3.85
Diabetes-associated sustained activation of the transcription factor nuclear factor-kappaB. Diabetes (2001) 3.83
Report of the committee on the genetic constitution of chromosomes 9 and 10. Cytogenet Cell Genet (1989) 3.79
Risk for opportunistic disease and death after reinitiating continuous antiretroviral therapy in patients with HIV previously receiving episodic therapy: a randomized trial. Ann Intern Med (2008) 3.68
Stimulation of microtubule aster formation and spindle assembly by the small GTPase Ran. Science (1999) 3.66
Isolation and sequence of the gene for iso-2-cytochrome c in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1980) 3.62
Orexigenic action of peripheral ghrelin is mediated by neuropeptide Y and agouti-related protein. Endocrinology (2004) 3.54
Rapid multi-element analysis of groundwater by high-resolution inductively coupled plasma mass spectrometry. Anal Bioanal Chem (2004) 3.50
The Dbl family of oncogenes. Curr Opin Cell Biol (1996) 3.50
The Internet and evidence-based decision-making: a needed synergy for efficient knowledge management in health care. CMAJ (2000) 3.46
Undergraduate research. Genomics Education Partnership. Science (2008) 3.45
Identification and isolation of the yeast cytochrome c gene. Cell (1978) 3.39
Inhibition of RhoA by p120 catenin. Nat Cell Biol (2000) 3.33
The mapping and sequence determination of the single site in phiX174am3 replicative form DNA cleaved by restriction endonuclease Pst I. FEBS Lett (1976) 3.31
Prostate Testing for Cancer and Treatment (ProtecT) feasibility study. Health Technol Assess (2003) 3.25
Mutations in ATP2A2, encoding a Ca2+ pump, cause Darier disease. Nat Genet (1999) 3.25
Mutations of the yeast SUP4 tRNATyr locus: transcription of the mutant genes in vitro. Cell (1980) 3.24
Molecular cloning and characterization of protective outer membrane protein P.69 from Bordetella pertussis. Proc Natl Acad Sci U S A (1989) 3.13
A human intermediate conductance calcium-activated potassium channel. Proc Natl Acad Sci U S A (1997) 3.12
Impact of diabetes on long-term prognosis in patients with unstable angina and non-Q-wave myocardial infarction: results of the OASIS (Organization to Assess Strategies for Ischemic Syndromes) Registry. Circulation (2000) 3.12
The base-pairing specificity of cellulose-pdT9. Nucleic Acids Res (1975) 3.11
The Epstein-Barr virus BMLF1 promoter contains an enhancer element that is responsive to the BZLF1 and BRLF1 transactivators. J Virol (1989) 3.11
In vitro mutation analysis of the mating-type locus in yeast. Cell (1981) 3.09
Site-specific mutagenesis using synthetic oligodeoxyribonucleotide primers: I. Optimum conditions and minimum ologodeoxyribonucleotide length. Gene (1979) 3.05
Cellular transformation and guanine nucleotide exchange activity are catalyzed by a common domain on the dbl oncogene product. J Biol Chem (1994) 3.03
Cerebral vasomotion: a 0.1-Hz oscillation in reflected light imaging of neural activity. Neuroimage (1996) 2.98
5-methylcytosine-DNA glycosylase activity is present in a cloned G/T mismatch DNA glycosylase associated with the chicken embryo DNA demethylation complex. Proc Natl Acad Sci U S A (2000) 2.98
Effect of calcium supplementation on pregnancy-induced hypertension and preeclampsia: a meta-analysis of randomized controlled trials. JAMA (1996) 2.98
Loss of heterozygosity on chromosome 16p13.3 in hamartomas from tuberous sclerosis patients. Nat Genet (1994) 2.93
Cloning of an avermectin-sensitive glutamate-gated chloride channel from Caenorhabditis elegans. Nature (1994) 2.92
Characterization of a short, cis-acting DNA sequence which conveys cell cycle stage-dependent transcription in Saccharomyces cerevisiae. Mol Cell Biol (1991) 2.91
The implementation of nutritional advice for people with diabetes. Diabet Med (2003) 2.89
Characterization of two related Drosophila gamma-tubulin complexes that differ in their ability to nucleate microtubules. J Cell Biol (1999) 2.88
Multisystem involvement in chronic liver disease. Studies on the incidence and pathogenesis. Am J Med (1973) 2.88
Role of importin-beta in coupling Ran to downstream targets in microtubule assembly. Science (2001) 2.87
Evidence-based disease management. JAMA (1997) 2.85
Nucleotide sequence of the yeast alcohol dehydrogenase II gene. J Biol Chem (1983) 2.82
Do all men attending departments of genitourinary medicine need to be screened for non-gonococcal urethritis? Int J STD AIDS (2002) 2.81
Structure of the 3' hairpin termini of four rodent parvovirus genomes: nucleotide sequence homology at origins of DNA replication. Cell (1979) 2.78
Ran stimulates spindle assembly by altering microtubule dynamics and the balance of motor activities. Nat Cell Biol (2001) 2.78
In vitro mutagenesis. Annu Rev Genet (1985) 2.72
Measles vaccination and antibody response in autism spectrum disorders. Arch Dis Child (2008) 2.71
Constitutive expression of a c-myb cDNA blocks Friend murine erythroleukemia cell differentiation. Mol Cell Biol (1988) 2.70
Genetic deletion of the Pten tumor suppressor gene promotes cell motility by activation of Rac1 and Cdc42 GTPases. Curr Biol (2000) 2.67
Hormone replacement therapy and breast cancer: what are the facts? Med J Aust (1995) 2.66
Increased incidence of renal cell tumors in a cohort of cardboard workers exposed to trichloroethene. Arch Toxicol (1995) 2.64
Redesigning enzyme structure by site-directed mutagenesis: tyrosyl tRNA synthetase and ATP binding. Nature (1982) 2.63
An essential role of the NF-kappa B/Toll-like receptor pathway in induction of inflammatory and tissue-repair gene expression by necrotic cells. J Immunol (2001) 2.62
Primary sequence and immunological characterization of beta-subunit of high conductance Ca(2+)-activated K+ channel from smooth muscle. J Biol Chem (1994) 2.62
Prevalence of diabetes and impaired glucose tolerance in the biracial (Melanesian and Indian) population of Fiji: a rural-urban comparison. Am J Epidemiol (1983) 2.60
Treatment decision-making at the end of life: a survey of Australian doctors' attitudes towards patients' wishes and euthanasia. Med J Aust (1996) 2.59
Chlamydia trachomatis and reactive arthritis: the missing link. Lancet (1987) 2.59
Regulation of cortical actin cytoskeleton assembly during polarized cell growth in budding yeast. J Cell Biol (1995) 2.59
Oligonucleotide-directed mutagenesis: a simple method using two oligonucleotide primers and a single-stranded DNA template. Methods Enzymol (1987) 2.59
The hemodynamic and adrenergic effects of perioperative dexmedetomidine infusion after vascular surgery. Anesth Analg (2000) 2.56
DNA sequences of two yeast promoter-up mutants. Nature (1983) 2.50
Regional gene assignment of human porphobilinogen deaminase and esterase A4 to chromosome 11q23 leads to 11qter. Proc Natl Acad Sci U S A (1981) 2.50
Evidence for a role of IL-17 in organ allograft rejection: IL-17 promotes the functional differentiation of dendritic cell progenitors. J Immunol (1999) 2.48