Published in J Biol Chem on December 20, 2000
Sgs1 helicase and two nucleases Dna2 and Exo1 resect DNA double-strand break ends. Cell (2008) 7.63
Srs2 and Sgs1-Top3 suppress crossovers during double-strand break repair in yeast. Cell (2003) 5.45
Functional overlap between Sgs1-Top3 and the Mms4-Mus81 endonuclease. Genes Dev (2001) 3.99
A genome-wide screen for methyl methanesulfonate-sensitive mutants reveals genes required for S phase progression in the presence of DNA damage. Proc Natl Acad Sci U S A (2002) 3.46
Rad51-dependent DNA structures accumulate at damaged replication forks in sgs1 mutants defective in the yeast ortholog of BLM RecQ helicase. Genes Dev (2005) 2.91
The mechanism of Mus81-Mms4 cleavage site selection distinguishes it from the homologous endonuclease Rad1-Rad10. Mol Cell Biol (2003) 2.59
Slx1-Slx4 is a second structure-specific endonuclease functionally redundant with Sgs1-Top3. Genes Dev (2003) 2.53
Yeast Rmi1/Nce4 controls genome stability as a subunit of the Sgs1-Top3 complex. Mol Cell Biol (2005) 2.49
Homologous recombination and its regulation. Nucleic Acids Res (2012) 2.44
G4 DNA unwinding by BLM and Sgs1p: substrate specificity and substrate-specific inhibition. Nucleic Acids Res (2002) 2.37
RMI1/NCE4, a suppressor of genome instability, encodes a member of the RecQ helicase/Topo III complex. EMBO J (2005) 2.34
Mechanisms of RecQ helicases in pathways of DNA metabolism and maintenance of genomic stability. Biochem J (2006) 1.99
The RecQ DNA helicases in DNA repair. Annu Rev Genet (2010) 1.85
The HRDC domain of BLM is required for the dissolution of double Holliday junctions. EMBO J (2005) 1.84
Mutations in homologous recombination genes rescue top3 slow growth in Saccharomyces cerevisiae. Genetics (2002) 1.79
Srs2 and Sgs1 DNA helicases associate with Mre11 in different subcomplexes following checkpoint activation and CDK1-mediated Srs2 phosphorylation. Mol Cell Biol (2005) 1.69
Binding and activation of DNA topoisomerase III by the Rmi1 subunit. J Biol Chem (2007) 1.54
A genetic screen for top3 suppressors in Saccharomyces cerevisiae identifies SHU1, SHU2, PSY3 and CSM2: four genes involved in error-free DNA repair. Genetics (2005) 1.46
Sgs1 regulates gene conversion tract lengths and crossovers independently of its helicase activity. Mol Cell Biol (2006) 1.45
Role for the fission yeast RecQ helicase in DNA repair in G2. Mol Cell Biol (2003) 1.45
Functional relation among RecQ family helicases RecQL1, RecQL5, and BLM in cell growth and sister chromatid exchange formation. Mol Cell Biol (2003) 1.43
Role of SGS1 and SLX4 in maintaining rDNA structure in Saccharomyces cerevisiae. Curr Genet (2002) 1.42
Mice lacking DNA topoisomerase IIIbeta develop to maturity but show a reduced mean lifespan. Proc Natl Acad Sci U S A (2001) 1.40
Hed1 regulates Rad51-mediated recombination via a novel mechanism. Genes Dev (2008) 1.30
Sgs1 function in the repair of DNA replication intermediates is separable from its role in homologous recombinational repair. EMBO J (2009) 1.29
SGS1 is a multicopy suppressor of srs2: functional overlap between DNA helicases. Nucleic Acids Res (2002) 1.24
Purification of the yeast Slx5-Slx8 protein complex and characterization of its DNA-binding activity. Nucleic Acids Res (2006) 1.17
Infertility and aneuploidy in mice lacking a type IA DNA topoisomerase III beta. Proc Natl Acad Sci U S A (2003) 1.15
The absence of Top3 reveals an interaction between the Sgs1 and Pif1 DNA helicases in Saccharomyces cerevisiae. Genetics (2006) 1.15
Association of yeast DNA topoisomerase III and Sgs1 DNA helicase: studies of fusion proteins. Proc Natl Acad Sci U S A (2001) 1.11
Evidence that the S.cerevisiae Sgs1 protein facilitates recombinational repair of telomeres during senescence. Nucleic Acids Res (2006) 1.10
Pathways for Holliday junction processing during homologous recombination in Saccharomyces cerevisiae. Mol Cell Biol (2011) 1.09
The Bloom's syndrome helicase stimulates the activity of human topoisomerase IIIalpha. Nucleic Acids Res (2002) 1.08
The dissolution of double Holliday junctions. Cold Spring Harb Perspect Biol (2014) 1.03
Holliday junction-containing DNA structures persist in cells lacking Sgs1 or Top3 following exposure to DNA damage. Proc Natl Acad Sci U S A (2011) 1.02
An N-terminal acidic region of Sgs1 interacts with Rpa70 and recruits Rad53 kinase to stalled forks. EMBO J (2012) 0.99
Top3 processes recombination intermediates and modulates checkpoint activity after DNA damage. Mol Biol Cell (2006) 0.99
Sumoylation of the BLM ortholog, Sgs1, promotes telomere-telomere recombination in budding yeast. Nucleic Acids Res (2009) 0.98
Structural and mechanistic insight into Holliday-junction dissolution by topoisomerase IIIα and RMI1. Nat Struct Mol Biol (2014) 0.97
The BLM dissolvasome in DNA replication and repair. Cell Mol Life Sci (2013) 0.97
An essential DNA strand-exchange activity is conserved in the divergent N-termini of BLM orthologs. EMBO J (2010) 0.94
WRN helicase defective in the premature aging disorder Werner syndrome genetically interacts with topoisomerase 3 and restores the top3 slow growth phenotype of sgs1 top3. Aging (Albany NY) (2009) 0.92
Essential functions of C terminus of Drosophila Topoisomerase IIIα in double holliday junction dissolution. J Biol Chem (2012) 0.91
Biochemical characterization of the small isoform of Drosophila melanogaster RECQ5 helicase. Nucleic Acids Res (2001) 0.91
The genetic consequences of ablating helicase activity and the Top3 interaction domain of Sgs1. DNA Repair (Amst) (2008) 0.91
Role of Blm and collaborating factors in recombination and survival following replication stress in Ustilago maydis. DNA Repair (Amst) (2009) 0.87
Development of autoimmunity in mice lacking DNA topoisomerase 3beta. Proc Natl Acad Sci U S A (2007) 0.85
The N-terminal region of the Schizosaccharomyces pombe RecQ helicase, Rqh1p, physically interacts with Topoisomerase III and is required for Rqh1p function. Mol Genet Genomics (2005) 0.84
Defining the roles of the N-terminal region and the helicase activity of RECQ4A in DNA repair and homologous recombination in Arabidopsis. Nucleic Acids Res (2013) 0.83
Sgs1 truncations induce genome rearrangements but suppress detrimental effects of BLM overexpression in Saccharomyces cerevisiae. J Mol Biol (2010) 0.83
Defective p53 engagement after the induction of DNA damage in cells deficient in topoisomerase 3beta. Proc Natl Acad Sci U S A (2008) 0.81
A transient α-helical molecular recognition element in the disordered N-terminus of the Sgs1 helicase is critical for chromosome stability and binding of Top3/Rmi1. Nucleic Acids Res (2013) 0.80
Resolution by unassisted Top3 points to template switch recombination intermediates during DNA replication. J Biol Chem (2013) 0.78
The roles of the Saccharomyces cerevisiae RecQ helicase SGS1 in meiotic genome surveillance. PLoS One (2010) 0.78
A Delicate Balance Between Repair and Replication Factors Regulates Recombination Between Divergent DNA Sequences in Saccharomyces cerevisiae. Genetics (2015) 0.76
Multimerization domains are associated with apparent strand exchange activity in BLM and WRN DNA helicases. DNA Repair (Amst) (2014) 0.75
Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci U S A (1979) 365.71
A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. Genetics (1989) 105.30
Use of T7 RNA polymerase to direct expression of cloned genes. Methods Enzymol (1990) 61.47
New heterologous modules for classical or PCR-based gene disruptions in Saccharomyces cerevisiae. Yeast (1994) 24.57
Positional cloning of the Werner's syndrome gene. Science (1996) 10.98
The Bloom's syndrome gene product is homologous to RecQ helicases. Cell (1995) 9.91
The yeast type I topoisomerase Top3 interacts with Sgs1, a DNA helicase homolog: a potential eukaryotic reverse gyrase. Mol Cell Biol (1994) 7.31
BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures. Genes Dev (2000) 7.29
A manyfold increase in sister chromatid exchanges in Bloom's syndrome lymphocytes. Proc Natl Acad Sci U S A (1974) 6.51
PML is critical for ND10 formation and recruits the PML-interacting protein daxx to this nuclear structure when modified by SUMO-1. J Cell Biol (1999) 5.83
A hyper-recombination mutation in S. cerevisiae identifies a novel eukaryotic topoisomerase. Cell (1989) 5.52
The Bloom's syndrome gene product promotes branch migration of holliday junctions. Proc Natl Acad Sci U S A (2000) 4.67
SGS1, a homologue of the Bloom's and Werner's syndrome genes, is required for maintenance of genome stability in Saccharomyces cerevisiae. Genetics (1996) 4.62
Mutations in RECQL4 cause a subset of cases of Rothmund-Thomson syndrome. Nat Genet (1999) 4.56
Positionally cloned human disease genes: patterns of evolutionary conservation and functional motifs. Proc Natl Acad Sci U S A (1997) 4.40
rqh1+, a fission yeast gene related to the Bloom's and Werner's syndrome genes, is required for reversible S phase arrest. EMBO J (1997) 4.31
Sgs1: a eukaryotic homolog of E. coli RecQ that interacts with topoisomerase II in vivo and is required for faithful chromosome segregation. Cell (1995) 4.08
The Werner syndrome protein is a DNA helicase. Nat Genet (1997) 4.03
The Bloom's syndrome gene product interacts with topoisomerase III. J Biol Chem (2000) 3.52
The yeast Sgs1p helicase acts upstream of Rad53p in the DNA replication checkpoint and colocalizes with Rad53p in S-phase-specific foci. Genes Dev (2000) 3.40
The Bloom's syndrome gene product is a 3'-5' DNA helicase. J Biol Chem (1997) 3.32
DNA topoisomerases: why so many? J Biol Chem (1991) 3.28
Escherichia coli RecQ protein is a DNA helicase. Proc Natl Acad Sci U S A (1990) 3.27
Cell-cycle-regulated phosphorylation of DNA replication factor A from human and yeast cells. Genes Dev (1990) 3.15
Bloom's and Werner's syndrome genes suppress hyperrecombination in yeast sgs1 mutant: implication for genomic instability in human diseases. Proc Natl Acad Sci U S A (1998) 3.14
The premature ageing syndrome protein, WRN, is a 3'-->5' exonuclease. Nat Genet (1998) 3.12
RecQ and RecJ process blocked replication forks prior to the resumption of replication in UV-irradiated Escherichia coli. Mol Gen Genet (1999) 2.91
Role of Schizosaccharomyces pombe RecQ homolog, recombination, and checkpoint genes in UV damage tolerance. Mol Cell Biol (1997) 2.76
Human homologues of yeast helicase. Nature (1996) 2.71
Defending genome integrity during DNA replication: a proposed role for RecQ family helicases. Bioessays (1999) 2.71
RecQ helicase and topoisomerase III comprise a novel DNA strand passage function: a conserved mechanism for control of DNA recombination. Mol Cell (1999) 2.64
Bipartite structure of the SGS1 DNA helicase in Saccharomyces cerevisiae. Genetics (2000) 2.55
Purification and characterization of the Sgs1 DNA helicase activity of Saccharomyces cerevisiae. J Biol Chem (1998) 2.20
Identification of a potent decatenating enzyme from Escherichia coli. J Biol Chem (1988) 2.19
Interaction between yeast sgs1 helicase and DNA topoisomerase III. J Biol Chem (2000) 2.19
Association of the Bloom syndrome protein with topoisomerase IIIalpha in somatic and meiotic cells. Cancer Res (2000) 2.13
Oligomeric ring structure of the Bloom's syndrome helicase. Curr Biol (1999) 2.01
Identification of the yeast TOP3 gene product as a single strand-specific DNA topoisomerase. J Biol Chem (1992) 1.97
A role for PML and the nuclear body in genomic stability. Oncogene (1999) 1.97
The essential role of yeast topoisomerase III in meiosis depends on recombination. EMBO J (1999) 1.88
Cytogenetics of Werner's syndrome cultured skin fibroblasts: variegated translocation mosaicism. Cytogenet Cell Genet (1981) 1.85
The Werner syndrome gene product co-purifies with the DNA replication complex and interacts with PCNA and topoisomerase I. J Biol Chem (1999) 1.84
Topoisomerase III is essential for accurate nuclear division in Schizosaccharomyces pombe. Nucleic Acids Res (1999) 1.71
Human RecQ5beta, a large isomer of RecQ5 DNA helicase, localizes in the nucleoplasm and interacts with topoisomerases 3alpha and 3beta. Nucleic Acids Res (2000) 1.63
RecQ DNA helicase of Escherichia coli. Characterization of the helix-unwinding activity with emphasis on the effect of single-stranded DNA-binding protein. J Mol Biol (1993) 1.50
Human TOP3: a single-copy gene encoding DNA topoisomerase III. Proc Natl Acad Sci U S A (1996) 1.46
The dnaB gene product of Escherichia coli. I. Purification, homogeneity, and physical properties. J Biol Chem (1978) 1.45
The top3(+) gene is essential in Schizosaccharomyces pombe and the lethality associated with its loss is caused by Rad12 helicase activity. Nucleic Acids Res (1999) 1.44
Bloom's syndrome gene suppresses premature ageing caused by Sgs1 deficiency in yeast. Genes Cells (1999) 1.39
Genetic analysis of the Saccharomyces cerevisiae Sgs1 helicase defines an essential function for the Sgs1-Top3 complex in the absence of SRS2 or TOP1. Mol Gen Genet (2000) 1.17
Analysis of a protein-binding domain of p53. Mol Cell Biol (1993) 1.10
Chromosomal instability in fibroblasts and mesenchymal tumors from 2 sibs with Rothmund-Thomson syndrome. Int J Cancer (1998) 1.10
Hyper-recombination and Bloom's syndrome: microbes again provide clues about cancer. Genome Res (1995) 1.06
A new human topoisomerase III that interacts with SGS1 protein. Nucleic Acids Res (1999) 1.05
Functional characterization of Caenorhabditis elegans DNA topoisomerase IIIalpha. Nucleic Acids Res (2000) 0.92
Requirement for three novel protein complexes in the absence of the Sgs1 DNA helicase in Saccharomyces cerevisiae. Genetics (2001) 4.73
Functional overlap between Sgs1-Top3 and the Mms4-Mus81 endonuclease. Genes Dev (2001) 3.99
Need for DNA topoisomerase activity as a swivel for DNA replication for transcription of ribosomal RNA. Nature (1987) 3.56
Cell-cycle-regulated phosphorylation of DNA replication factor A from human and yeast cells. Genes Dev (1990) 3.15
Human homologues of yeast helicase. Nature (1996) 2.71
Bipartite structure of the SGS1 DNA helicase in Saccharomyces cerevisiae. Genetics (2000) 2.55
Topoisomerases and yeast rRNA transcription: negative supercoiling stimulates initiation and topoisomerase activity is required for elongation. Genes Dev (1992) 1.84
A hierarchy of SSB protomers in replication protein A. Genes Dev (1996) 1.80
Rfc4 interacts with Rpa1 and is required for both DNA replication and DNA damage checkpoints in Saccharomyces cerevisiae. Mol Cell Biol (2001) 1.58
A single-stranded DNA binding protein required for mitochondrial DNA replication in S. cerevisiae is homologous to E. coli SSB. EMBO J (1992) 1.56
Functional analysis of the four DNA binding domains of replication protein A. The role of RPA2 in ssDNA binding. J Biol Chem (2001) 1.52
Characterization of a high mobility group 1/2 homolog in yeast. J Biol Chem (1996) 1.34
Assessing the requirements for nucleotide excision repair proteins of Saccharomyces cerevisiae in an in vitro system. J Biol Chem (1996) 1.12
Analysis of a meiosis-specific URS1 site: sequence requirements and involvement of replication protein A. Mol Cell Biol (1997) 1.12
Roles of replication protein-A subunits 2 and 3 in DNA replication fork movement in Saccharomyces cerevisiae. Genetics (1997) 1.01
Phosphorylation of replication protein A: a role for cdc2 kinase in G1/S regulation. Cold Spring Harb Symp Quant Biol (1991) 0.91
DNA topoisomerase activity is required as a swivel for DNA replication and for ribosomal RNA transcription. NCI Monogr (1987) 0.85
Acute parotitis associated with influenza type A: a report of twelve cases. N Engl J Med (1977) 0.84
[Hyperglycemia and insulin resistance during glucagon infusion]. Conn Med (1972) 0.75