Published in Blood on January 01, 2001
Enhanced autoimmunity, arthritis, and encephalomyelitis in mice with a reduced oxidative burst due to a mutation in the Ncf1 gene. Proc Natl Acad Sci U S A (2004) 2.38
Genetics and immunopathology of chronic granulomatous disease. Semin Immunopathol (2008) 2.22
The role of the NADPH oxidase complex, p38 MAPK, and Akt in regulating human monocyte/macrophage survival. Am J Respir Cell Mol Biol (2006) 1.52
A role for sorting nexin 2 in epidermal growth factor receptor down-regulation: evidence for distinct functions of sorting nexin 1 and 2 in protein trafficking. Mol Biol Cell (2004) 1.50
Chronic Granulomatous Disease; fundamental stages in our understanding of CGD. Med Immunol (2006) 1.39
The Phox homology (PX) domain, a new player in phosphoinositide signalling. Biochem J (2001) 1.31
Hematologically important mutations: the autosomal recessive forms of chronic granulomatous disease (second update). Blood Cells Mol Dis (2010) 1.25
Inverted low-copy repeats and genome instability--a genome-wide analysis. Hum Mutat (2012) 1.09
Genetic disorders coupled to ROS deficiency. Redox Biol (2015) 0.94
p47phox Phox homology domain regulates plasma membrane but not phagosome neutrophil NADPH oxidase activation. J Biol Chem (2010) 0.90
A copy number variation in human NCF1 and its pseudogenes. BMC Genet (2010) 0.86
Functional pseudogenes inhibit the superoxide production. Precis Med (2015) 0.85
First report of clinical, functional, and molecular investigation of chronic granulomatous disease in nine Jordanian families. J Clin Immunol (2008) 0.82
Relevance of laboratory testing for the diagnosis of primary immunodeficiencies: a review of case-based examples of selected immunodeficiencies. Clin Mol Allergy (2011) 0.81
Clinical application of whole-genome sequencing in patients with primary immunodeficiency. J Allergy Clin Immunol (2015) 0.79
Clinical, functional and genetic analysis of twenty-four patients with chronic granulomatous disease - identification of eight novel mutations in CYBB and NCF2 genes. J Clin Immunol (2012) 0.76
The NOXO1β PX domain preferentially targets PtdIns(4,5)P2 and PtdIns(3,4,5)P3. J Mol Biol (2012) 0.75
Biological defense mechanisms. The production by leukocytes of superoxide, a potential bactericidal agent. J Clin Invest (1973) 17.56
Cloning the gene for an inherited human disorder--chronic granulomatous disease--on the basis of its chromosomal location. Nature (1986) 6.34
High resolution mapping of the binding site on human IgG1 for Fc gamma RI, Fc gamma RII, Fc gamma RIII, and FcRn and design of IgG1 variants with improved binding to the Fc gamma R. J Biol Chem (2000) 5.18
The effect of the inhibitor diphenylene iodonium on the superoxide-generating system of neutrophils. Specific labelling of a component polypeptide of the oxidase. Biochem J (1986) 4.35
Defective superoxide production by granulocytes from patients with chronic granulomatous disease. N Engl J Med (1974) 4.21
Regulation of phagocyte oxygen radical production by the GTP-binding protein Rac 2. Science (1991) 3.87
Biological defense mechanisms. The effect of bacteria and serum on superoxide production by granulocytes. J Clin Invest (1974) 3.78
Patterns of association with host and habitat: antibody reactive with Sin Nombre virus in small mammals in the major biotic communities of the southwestern United States. Am J Trop Med Hyg (1997) 3.46
Absence of cytochrome b-245 in chronic granulomatous disease. A multicenter European evaluation of its incidence and relevance. N Engl J Med (1983) 2.89
The enzymic reduction and kinetics of oxidation of cytochrome b-245 of neutrophils. Biochem J (1982) 2.68
Biological defense mechanisms. Evidence for the participation of superoxide in bacterial killing by xanthine oxidase. J Lab Clin Med (1975) 2.65
Molecular basis of chronic granulomatous disease. Blood (1991) 2.60
Oxidation-reduction properties of the cytochrome b found in the plasma-membrane fraction of human neutrophils. A possible oxidase in the respiratory burst. Biochem J (1981) 2.56
Stimulated neutrophils from patients with autosomal recessive chronic granulomatous disease fail to phosphorylate a Mr-44,000 protein. Nature (1985) 2.46
The particulate superoxide-forming system from human neutrophils. Properties of the system and further evidence supporting its participation in the respiratory burst. J Clin Invest (1976) 2.43
Neutrophil nicotinamide adenine dinucleotide phosphate oxidase assembly. Translocation of p47-phox and p67-phox requires interaction between p47-phox and cytochrome b558. J Clin Invest (1991) 2.38
Subcellular localization of the superoxide-forming enzyme in human neutrophils. J Clin Invest (1979) 2.33
An inherited abnormality of neutrophil adhesion. Its genetic transmission and its association with a missing protein. N Engl J Med (1980) 2.32
Functional changes in human leukemic cell line HL-60. A model for myeloid differentiation. J Cell Biol (1979) 2.28
Ischemic stroke injury is reduced in mice lacking a functional NADPH oxidase. Stroke (1997) 2.14
Infection with Pseudomonas cepacia in chronic granulomatous disease: role of nonoxidative killing by neutrophils in host defense. J Infect Dis (1994) 2.12
Activation of human neutrophil nicotinamide adenine dinucleotide phosphate, reduced (triphosphopyridine nucleotide, reduced) oxidase by arachidonic acid in a cell-free system. J Clin Invest (1985) 2.06
Defect in pyridine nucleotide dependent superoxide production by a particulate fraction from the cranulocytes of patients with chronic granulomatous disease. N Engl J Med (1975) 2.05
Genetic variants of chronic granulomatous disease: prevalence of deficiencies of two cytosolic components of the NADPH oxidase system. N Engl J Med (1989) 1.93
Microtubules grow and shorten at intrinsically variable rates. J Biol Chem (1992) 1.92
Neutrophils and host defense. Ann Intern Med (1988) 1.92
Human neutrophil cytochrome b light chain (p22-phox). Gene structure, chromosomal location, and mutations in cytochrome-negative autosomal recessive chronic granulomatous disease. J Clin Invest (1990) 1.91
A longitudinal study of Junin virus activity in the rodent reservoir of Argentine hemorrhagic fever. Am J Trop Med Hyg (1992) 1.86
Effects of anaerobiosis and inhibitors on O2-production by human granulocytes. Blood (1975) 1.85
Gp91(phox) is the heme binding subunit of the superoxide-generating NADPH oxidase. Proc Natl Acad Sci U S A (1998) 1.82
The superoxide-generating oxidase of leucocytes. NADPH-dependent reduction of flavin and cytochrome b in solubilized preparations. Biochem J (1984) 1.80
Activity and activation of the granulocyte superoxide-generating system. Blood (1980) 1.77
cis-Polyunsaturated fatty acids induce high levels of superoxide production by human neutrophils. J Biol Chem (1981) 1.75
Rac translocates independently of the neutrophil NADPH oxidase components p47phox and p67phox. Evidence for its interaction with flavocytochrome b558. J Biol Chem (1994) 1.74
Mechanism of the superoxide-producing oxidase of neutrophils. O2 is necessary for the fast reduction of cytochrome b-245 by NADPH. Biochem J (1985) 1.73
Purification and characterization of Rac 2. A cytosolic GTP-binding protein that regulates human neutrophil NADPH oxidase. J Biol Chem (1992) 1.69
Activation of neutrophil NADPH oxidase in a cell-free system. Partial purification of components and characterization of the activation process. J Biol Chem (1987) 1.68
Partial correction of the phagocyte defect in patients with X-linked chronic granulomatous disease by subcutaneous interferon gamma. N Engl J Med (1988) 1.64
Cytochrome b-245 of neutrophils is also present in human monocytes, macrophages and eosinophils. Biochem J (1981) 1.61
Constitutive and inducible granulocyte-macrophage functions in mouse, rat, and human myeloid leukemia-derived continuous tissue culture lines. Cancer Res (1978) 1.59
Host defense molecule polymorphisms influence the risk for immune-mediated complications in chronic granulomatous disease. J Clin Invest (1998) 1.58
Effects of free fatty acids on release of superoxide and on change of shape by human neutrophils. Reversibility by albumin. J Biol Chem (1984) 1.57
Hapten-specific IgE antibody responses in mice. IV. Evidence for distinctive sensitivities of IgE and IgG B lymphocytes to the regulatory influence of T cells. J Immunol (1974) 1.57
Pyridine nucleotide-dependent superoxide production by a cell-free system from human granulocytes. J Clin Invest (1975) 1.57
Genomic and proteomic analysis of the myeloid differentiation program. Blood (2001) 1.55
X-Linked chronic granulomatous disease: mutations in the CYBB gene encoding the gp91-phox component of respiratory-burst oxidase. Am J Hum Genet (1998) 1.54
An outbreak of hantavirus pulmonary syndrome, Chile, 1997. Emerg Infect Dis (1999) 1.54
Role of C5a in multiorgan failure during sepsis. J Immunol (2001) 1.53
Chronic granulomatous disease. Adv Hum Genet (1987) 1.48
RNA expression patterns change dramatically in human neutrophils exposed to bacteria. Blood (2001) 1.48
Absence of both the 91kD and 22kD subunits of human neutrophil cytochrome b in two genetic forms of chronic granulomatous disease. Blood (1989) 1.47
A survey of hantavirus antibody in small-mammal populations in selected United States National Parks. Am J Trop Med Hyg (1998) 1.47
A missense mutation in the neutrophil cytochrome b heavy chain in cytochrome-positive X-linked chronic granulomatous disease. J Clin Invest (1989) 1.47
The association of FAD with the cytochrome b-245 of human neutrophils. Biochem J (1982) 1.45
Microtubule solutions display nematic liquid crystalline structure. J Biol Chem (1990) 1.41
The effects of irradiation on blood components. Transfusion (1981) 1.40
RNA-binding proteins that specifically recognize the selenocysteine insertion sequence of human cellular glutathione peroxidase mRNA. J Biol Chem (1995) 1.39
Sequences in the 3'-untranslated region of the human cellular glutathione peroxidase gene are necessary and sufficient for selenocysteine incorporation at the UGA codon. J Biol Chem (1993) 1.38
Börjeson-Forssman-Lehmann syndrome: clinical manifestations and gene localization to Xq26-27. Am J Med Genet (1989) 1.38
Functional expression of NADPH oxidase components (alpha- and beta-subunits of cytochrome b558 and 45-kDa flavoprotein) by intrinsic human glomerular mesangial cells. J Biol Chem (1991) 1.38
Recombinant interferon gamma augments phagocyte superoxide production and X-chronic granulomatous disease gene expression in X-linked variant chronic granulomatous disease. J Clin Invest (1987) 1.38
Further evidence for the involvement of a phosphoprotein in the respiratory burst oxidase of human neutrophils. Biochem J (1986) 1.35
Investigation of neutrophil signal transduction using a specific inhibitor of phosphatidylinositol 3-kinase. J Immunol (1995) 1.35
Identification of a superoxide-generating NADPH oxidase system in human fibroblasts. Biochem J (1991) 1.34
Kinetic microplate assay for superoxide production by neutrophils and other phagocytic cells. Methods Enzymol (1990) 1.34
Bcl-2 and the outer mitochondrial membrane in the inactivation of cytochrome c during Fas-mediated apoptosis. J Biol Chem (1997) 1.33
Identification and molecular cloning of a human selenocysteine insertion sequence-binding protein. A bifunctional role for DNA-binding protein B. J Biol Chem (1998) 1.33
The FRE1 ferric reductase of Saccharomyces cerevisiae is a cytochrome b similar to that of NADPH oxidase. J Biol Chem (1996) 1.32
Chronic granulomatous disease presenting in a 69-year-old man. N Engl J Med (1991) 1.31
A p47-phox pseudogene carries the most common mutation causing p47-phox- deficient chronic granulomatous disease. J Clin Invest (1997) 1.30
Point mutation in the cytoplasmic domain of the neutrophil p22-phox cytochrome b subunit is associated with a nonfunctional NADPH oxidase and chronic granulomatous disease. Proc Natl Acad Sci U S A (1991) 1.29
The inhibitory effects of some iodonium compounds on the superoxide generating system of neutrophils and their failure to inhibit diaphorase activity. Biochem Pharmacol (1987) 1.29
Activation of the leukocyte NADPH oxidase by phorbol ester requires the phosphorylation of p47PHOX on serine 303 or 304. J Biol Chem (1998) 1.29
Requirement for posttranslational processing of Rac GTP-binding proteins for activation of human neutrophil NADPH oxidase. Mol Biol Cell (1993) 1.28
Superoxide-dependent nitroblue tetrazolium reduction and expression of cytochrome b-245 components by human tonsillar B lymphocytes and B cell lines. J Immunol (1989) 1.27
The superoxide generating system of B cell lines. Structural homology with the phagocytic oxidase and triggering via surface Ig. J Immunol (1988) 1.26
Spontaneous activation of NADPH oxidase in a cell-free system: unexpected multiple effects of magnesium ion concentrations. Biochem J (1999) 1.24
Measurement of superoxide release in the phagovacuoles of immune complex-stimulated human neutrophils. J Immunol Methods (1990) 1.24
Studies on the electron-transfer mechanism of the human neutrophil NADPH oxidase. Biochem J (1989) 1.23
Dye transfer between cells of the lens. J Membr Biol (1996) 1.23
Fluoride-mediated activation of the respiratory burst in human neutrophils. A reversible process. J Clin Invest (1979) 1.23
Activation of the respiratory burst oxidase in a fully soluble system from human neutrophils. J Biol Chem (1987) 1.22
Studies on the mechanism of superoxide release from human neutrophils stimulated with arachidonate. J Biol Chem (1984) 1.22
Kinetics of activation of the respiratory burst oxidase in a fully soluble system from human neutrophils. J Biol Chem (1988) 1.21
Dissociation of opsonized particle phagocytosis and respiratory burst activity in an Epstein-Barr virus-infected myeloid cell line. J Cell Biol (1980) 1.19
The purification and properties of the soluble cytochromes c of the obligate methylotroph Methylophilus methylotrophus. Biochem J (1980) 1.19
Hematologically important mutations: X-linked chronic granulomatous disease (second update). Blood Cells Mol Dis (2001) 1.19
Structure and function of the selenium translation element in the 3'-untranslated region of human cellular glutathione peroxidase mRNA. RNA (1995) 1.18