Published in Nat Genet on January 01, 2001
Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J Exp Med (2003) 26.05
Differentiation of effector CD4 T cell populations (*). Annu Rev Immunol (2010) 11.80
How regulatory T cells work. Nat Rev Immunol (2008) 11.66
A census of human transcription factors: function, expression and evolution. Nat Rev Genet (2009) 9.19
FOXP3+ regulatory T cells in the human immune system. Nat Rev Immunol (2010) 8.73
Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo. Nat Immunol (2009) 8.65
Epigenetic control of the foxp3 locus in regulatory T cells. PLoS Biol (2007) 7.86
Enterocolitis in patients with cancer after antibody blockade of cytotoxic T-lymphocyte-associated antigen 4. J Clin Oncol (2006) 7.40
Inflammatory bowel disease. Annu Rev Immunol (2010) 7.10
CD4 T cells: fates, functions, and faults. Blood (2008) 7.03
TGF-beta1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells. J Exp Med (2005) 6.87
PD-L1 regulates the development, maintenance, and function of induced regulatory T cells. J Exp Med (2009) 6.80
The PD-1 pathway in tolerance and autoimmunity. Immunol Rev (2010) 5.99
T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR. Proc Natl Acad Sci U S A (2008) 5.97
Identifying Foxp3-expressing suppressor T cells with a bicistronic reporter. Proc Natl Acad Sci U S A (2005) 5.96
A role for Dicer in immune regulation. J Exp Med (2006) 5.81
Foxp3 occupancy and regulation of key target genes during T-cell stimulation. Nature (2007) 5.81
Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease. J Exp Med (2007) 5.52
In vivo instruction of suppressor commitment in naive T cells. J Exp Med (2004) 5.47
Selective miRNA disruption in T reg cells leads to uncontrolled autoimmunity. J Exp Med (2008) 4.68
Control of regulatory T cell lineage commitment and maintenance. Immunity (2009) 4.63
TGF-beta: a master of all T cell trades. Cell (2008) 4.60
IL-2 regulates FOXP3 expression in human CD4+CD25+ regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo. Blood (2006) 4.46
Foxp3+ regulatory T cells: differentiation, specification, subphenotypes. Nat Immunol (2009) 4.07
In vivo equilibrium of proinflammatory IL-17+ and regulatory IL-10+ Foxp3+ RORgamma t+ T cells. J Exp Med (2008) 3.85
A requisite role for induced regulatory T cells in tolerance based on expanding antigen receptor diversity. Immunity (2011) 3.76
Dicer-dependent microRNA pathway safeguards regulatory T cell function. J Exp Med (2008) 3.70
Mechanisms of impaired regulation by CD4(+)CD25(+)FOXP3(+) regulatory T cells in human autoimmune diseases. Nat Rev Immunol (2010) 3.69
Tumor cells convert immature myeloid dendritic cells into TGF-beta-secreting cells inducing CD4+CD25+ regulatory T cell proliferation. J Exp Med (2005) 3.64
Clinical and molecular features of the immunodysregulation, polyendocrinopathy, enteropathy, X linked (IPEX) syndrome. J Med Genet (2002) 3.61
Analysis of the cellular mechanism of antitumor responses and autoimmunity in patients treated with CTLA-4 blockade. J Immunol (2005) 3.53
FOXP3 is an X-linked breast cancer suppressor gene and an important repressor of the HER-2/ErbB2 oncogene. Cell (2007) 3.46
The RNAseIII enzyme Drosha is critical in T cells for preventing lethal inflammatory disease. J Exp Med (2008) 3.45
HIV infection of naturally occurring and genetically reprogrammed human regulatory T-cells. PLoS Biol (2004) 3.43
Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cells. Proc Natl Acad Sci U S A (2005) 3.33
Coexpression of CD25 and CD27 identifies FoxP3+ regulatory T cells in inflamed synovia. J Exp Med (2005) 3.29
Extrathymic generation of regulatory T cells in placental mammals mitigates maternal-fetal conflict. Cell (2012) 3.24
Expansion and function of Foxp3-expressing T regulatory cells during tuberculosis. J Exp Med (2007) 3.21
Retinoid-related orphan receptors (RORs): critical roles in development, immunity, circadian rhythm, and cellular metabolism. Nucl Recept Signal (2009) 3.19
An essential role of the transcription factor GATA-3 for the function of regulatory T cells. Immunity (2011) 3.11
TCR stimulation with modified anti-CD3 mAb expands CD8+ T cell population and induces CD8+CD25+ Tregs. J Clin Invest (2005) 3.04
Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cells. J Exp Med (2012) 2.97
CD4+CD25+ regulatory T cells inhibit natural killer cell functions in a transforming growth factor-beta-dependent manner. J Exp Med (2005) 2.93
CD4+ Tregs and immune control. J Clin Invest (2004) 2.85
Intestinal bacteria and the regulation of immune cell homeostasis. Annu Rev Immunol (2010) 2.85
Depleting tumor-specific Tregs at a single site eradicates disseminated tumors. J Clin Invest (2013) 2.77
CD4+ FoxP3+ regulatory T cells confer infectious tolerance in a TGF-beta-dependent manner. J Exp Med (2008) 2.72
Regulatory T cells and Foxp3. Immunol Rev (2011) 2.65
Peripheral CD4+ T-cell differentiation regulated by networks of cytokines and transcription factors. Immunol Rev (2010) 2.61
Where CD4+CD25+ T reg cells impinge on autoimmune diabetes. J Exp Med (2005) 2.61
Transcriptional and DNA binding activity of the Foxp1/2/4 family is modulated by heterotypic and homotypic protein interactions. Mol Cell Biol (2004) 2.48
The effector T cells of diabetic subjects are resistant to regulation via CD4+ FOXP3+ regulatory T cells. J Immunol (2008) 2.39
BACH2 represses effector programs to stabilize T(reg)-mediated immune homeostasis. Nature (2013) 2.36
The emerging role of CTLA4 as a cell-extrinsic regulator of T cell responses. Nat Rev Immunol (2011) 2.36
Expansion of FOXP3high regulatory T cells by human dendritic cells (DCs) in vitro and after injection of cytokine-matured DCs in myeloma patients. Blood (2006) 2.36
FoxP3+CD4+ regulatory T cells play an important role in acute HIV-1 infection in humanized Rag2-/-gammaC-/- mice in vivo. Blood (2008) 2.31
Epigenetic mechanisms of regulation of Foxp3 expression. Blood (2009) 2.27
PD-L1 negatively regulates CD4+CD25+Foxp3+ Tregs by limiting STAT-5 phosphorylation in patients chronically infected with HCV. J Clin Invest (2009) 2.26
CD4+ regulatory T cells require CTLA-4 for the maintenance of systemic tolerance. J Exp Med (2009) 2.23
Aerobic glycolysis promotes T helper 1 cell differentiation through an epigenetic mechanism. Science (2016) 2.20
Role of SMAD and non-SMAD signals in the development of Th17 and regulatory T cells. J Immunol (2010) 2.20
Ectopic lymphoid tissues and local immunity. Semin Immunol (2008) 2.18
Cold urticaria, immunodeficiency, and autoimmunity related to PLCG2 deletions. N Engl J Med (2012) 2.08
Commitment to the regulatory T cell lineage requires CARMA1 in the thymus but not in the periphery. PLoS Biol (2009) 2.07
Intraepithelial effector (CD3+)/regulatory (FoxP3+) T-cell ratio predicts a clinical outcome of human colon carcinoma. Gastroenterology (2009) 2.04
Role of IFN-gamma in induction of Foxp3 and conversion of CD4+ CD25- T cells to CD4+ Tregs. J Clin Invest (2006) 2.02
How do regulatory T cells work? Scand J Immunol (2009) 2.02
Immunomodulatory effects of deacetylase inhibitors: therapeutic targeting of FOXP3+ regulatory T cells. Nat Rev Drug Discov (2009) 2.00
'Yin-Yang' functions of transforming growth factor-beta and T regulatory cells in immune regulation. Immunol Rev (2007) 1.98
Foxp3 transcription factor is proapoptotic and lethal to developing regulatory T cells unless counterbalanced by cytokine survival signals. Immunity (2013) 1.96
Foxp3 expression in human cancer cells. J Transl Med (2008) 1.94
Interleukin-2 receptor signaling in regulatory T cell development and homeostasis. Immunol Lett (2007) 1.91
Checkpoints in lymphocyte development and autoimmune disease. Nat Immunol (2009) 1.84
Dual roles of immune cells and their factors in cancer development and progression. Int J Biol Sci (2011) 1.84
PD-1 and LAG-3 inhibitory co-receptors act synergistically to prevent autoimmunity in mice. J Exp Med (2011) 1.80
TGF-beta-induced Foxp3+ regulatory T cells rescue scurfy mice. Eur J Immunol (2008) 1.80
FOXP3 is a novel transcriptional repressor for the breast cancer oncogene SKP2. J Clin Invest (2007) 1.76
The origin of FOXP3-expressing CD4+ regulatory T cells: thymus or periphery. J Clin Invest (2003) 1.75
FOXP3 promoter demethylation reveals the committed Treg population in humans. PLoS One (2008) 1.73
FoxP3+ regulatory T cells promote influenza-specific Tfh responses by controlling IL-2 availability. Nat Commun (2014) 1.72
miR-155 activates cytokine gene expression in Th17 cells by regulating the DNA-binding protein Jarid2 to relieve polycomb-mediated repression. Immunity (2014) 1.70
Effector and regulatory T-cell subsets in autoimmunity and tissue inflammation. Scand J Immunol (2010) 1.70
The Scurfy mutation of FoxP3 in the thymus stroma leads to defective thymopoiesis. J Exp Med (2005) 1.70
An integrated view of suppressor T cell subsets in immunoregulation. J Clin Invest (2004) 1.69
Genetic susceptibility to autoimmune thyroid disease: past, present, and future. Thyroid (2010) 1.67
TGF-beta and IL-6 signals modulate chromatin binding and promoter occupancy by acetylated FOXP3. Proc Natl Acad Sci U S A (2008) 1.65
Cutting edge: Broad expression of the FoxP3 locus in epithelial cells: a caution against early interpretation of fatal inflammatory diseases following in vivo depletion of FoxP3-expressing cells. J Immunol (2008) 1.64
IL-15 and dermal fibroblasts induce proliferation of natural regulatory T cells isolated from human skin. Blood (2006) 1.64
Regulatory T cells are strong promoters of acute ischemic stroke in mice by inducing dysfunction of the cerebral microvasculature. Blood (2012) 1.64
TGF-β activation and function in immunity. Annu Rev Immunol (2013) 1.63
Identification and in vitro expansion of functional antigen-specific CD25+ FoxP3+ regulatory T cells in hepatitis C virus infection. J Virol (2008) 1.63
Natural regulatory T cells and persistent viral infection. J Virol (2007) 1.62
Neonatal diabetes mellitus: a disease linked to multiple mechanisms. Orphanet J Rare Dis (2007) 1.61
CD40 ligand and MHC class II expression are essential for human peripheral B cell tolerance. J Exp Med (2007) 1.61
Autoimmune polyglandular syndromes. Nat Rev Endocrinol (2010) 1.60
Mechanisms of regulatory T-cell suppression - a diverse arsenal for a moving target. Immunology (2008) 1.59
GPR15-mediated homing controls immune homeostasis in the large intestine mucosa. Science (2013) 1.58
Suppression of murine allergic airway disease by IL-2:anti-IL-2 monoclonal antibody-induced regulatory T cells. J Immunol (2008) 1.58
Treg cells expressing the coinhibitory molecule TIGIT selectively inhibit proinflammatory Th1 and Th17 cell responses. Immunity (2014) 1.57
Induction of CD4+CD25+ regulatory T cells by copolymer-I through activation of transcription factor Foxp3. Proc Natl Acad Sci U S A (2005) 1.57
The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3. Nat Genet (2001) 15.27
X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy. Nat Genet (2001) 10.92
Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice. J Exp Med (1994) 8.97
Interleukin-2 receptor gamma chain: a functional component of the interleukin-7 receptor. Science (1993) 5.22
Nucleotide sequence of a bovine clone encoding the angiogenic protein, basic fibroblast growth factor. Science (1986) 5.12
Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein. Am J Hum Genet (2001) 4.97
Fas ligand mediates activation-induced cell death in human T lymphocytes. J Exp Med (1995) 4.34
Defective IL7R expression in T(-)B(+)NK(+) severe combined immunodeficiency. Nat Genet (1998) 4.32
Scurfin (FOXP3) acts as a repressor of transcription and regulates T cell activation. J Biol Chem (2001) 4.23
Characterization of the virA locus of Agrobacterium tumefaciens: a transcriptional regulator and host range determinant. EMBO J (1987) 4.22
Cloning of the human and murine interleukin-7 receptors: demonstration of a soluble form and homology to a new receptor superfamily. Cell (1990) 4.15
Cloning of the murine thymic stromal lymphopoietin (TSLP) receptor: Formation of a functional heteromeric complex requires interleukin 7 receptor. J Exp Med (2000) 3.51
Single-sperm typing: determination of genetic distance between the G gamma-globin and parathyroid hormone loci by using the polymerase chain reaction and allele-specific oligomers. Proc Natl Acad Sci U S A (1989) 3.50
Cloning of a receptor subunit required for signaling by thymic stromal lymphopoietin. Nat Immunol (2000) 3.42
Candidate gene associated with a mutation causing recessive polycystic kidney disease in mice. Science (1994) 3.31
Fas and FasL in the homeostatic regulation of immune responses. Immunol Today (1995) 3.24
X-linked lymphoreticular disease in the scurfy (sf) mutant mouse. Am J Pathol (1991) 3.16
Fas transduces activation signals in normal human T lymphocytes. J Exp Med (1993) 3.04
The activation antigen CD69. Stem Cells (1994) 3.03
Neoplastic transformation induced by an activated lymphocyte-specific protein tyrosine kinase (pp56lck). Mol Cell Biol (1988) 2.80
Thymic stromal lymphopoietin: a cytokine that promotes the development of IgM+ B cells in vitro and signals via a novel mechanism. J Immunol (1999) 2.57
Novel protein-tyrosine kinase gene (hck) preferentially expressed in cells of hematopoietic origin. Mol Cell Biol (1987) 2.52
A new five-year plan for the U.S. Human Genome Project. Science (1993) 2.43
The DNA sequence and biological annotation of human chromosome 1. Nature (2006) 2.42
Cellular and molecular characterization of the scurfy mouse mutant. J Immunol (1999) 2.19
Human cell hybrids: analysis of transformation and tumorigenicity. Science (1982) 2.16
Fatal lymphoreticular disease in the scurfy (sf) mouse requires T cells that mature in a sf thymic environment: potential model for thymic education. Proc Natl Acad Sci U S A (1991) 2.09
Replication of pSC101: effects of mutations in the E. coli DNA binding protein IHF. Mol Gen Genet (1986) 1.98
Requirement for stat5 in thymic stromal lymphopoietin-mediated signal transduction. J Immunol (1999) 1.84
CD4+CD8- T cells are the effector cells in disease pathogenesis in the scurfy (sf) mouse. J Immunol (1994) 1.83
Developmental regulation of lck gene expression in T lymphocytes. J Exp Med (1991) 1.82
Interleukin 7 induces cytokine secretion and tumoricidal activity by human peripheral blood monocytes. J Exp Med (1991) 1.81
A rare polyadenylation signal mutation of the FOXP3 gene (AAUAAA-->AAUGAA) leads to the IPEX syndrome. Immunogenetics (2001) 1.72
Specialized protein tyrosine kinase proto-oncogenes in hematopoietic cells. Biochim Biophys Acta (1989) 1.71
Ectopic expression of the agouti gene in transgenic mice causes obesity, features of type II diabetes, and yellow fur. Proc Natl Acad Sci U S A (1995) 1.69
The amount of scurfin protein determines peripheral T cell number and responsiveness. J Immunol (2001) 1.64
Transplantation of T cell-mediated, lymphoreticular disease from the scurfy (sf) mouse. Am J Pathol (1994) 1.59
Non-invasive pulsed cavitational ultrasound for fetal tissue ablation: feasibility study in a fetal sheep model. Ultrasound Obstet Gynecol (2011) 1.59
Thymic selection in CD8 transgenic mice supports an instructive model for commitment to a CD4 or CD8 lineage. Cell (1991) 1.54
The level of CD8 expression can determine the outcome of thymic selection. Cell (1992) 1.53
Molecular characterization of murine and human OX40/OX40 ligand systems: identification of a human OX40 ligand as the HTLV-1-regulated protein gp34. EMBO J (1994) 1.52
Deregulation of Pax-2 expression in transgenic mice generates severe kidney abnormalities. Nature (1993) 1.51
Progression of the transformed phenotype in clonal lines of Abelson virus-infected lymphocytes. Mol Cell Biol (1983) 1.48
Analysis of cDNA clones encoding the entire B-26 region of human apolipoprotein B. Proc Natl Acad Sci U S A (1986) 1.48
Translational control of transposition activity of the bacterial insertion sequence IS1. EMBO J (1991) 1.46
The role of the agouti gene in the yellow obese syndrome. J Nutr (1997) 1.43
Structure and expression of lck transcripts in human lymphoid cells. J Cell Biochem (1988) 1.42
Specificity of insertion of IS1. J Mol Biol (1985) 1.41
The regulatory role of the IS1-encoded InsA protein in transposition. Mol Microbiol (1990) 1.37
Organization of the murine and human interleukin-7 receptor genes: two mRNAs generated by differential splicing and presence of a type I-interferon-inducible promoter. Mol Cell Biol (1991) 1.37
Differentiation of cloned populations of immature B cells after transformation with Abelson murine leukemia virus. Cell (1983) 1.36
Molecular characterization of the early activation antigen CD69: a type II membrane glycoprotein related to a family of natural killer cell activation antigens. Eur J Immunol (1993) 1.34
The mouse CD69 gene. Structure, expression, and mapping to the NK gene complex. J Immunol (1994) 1.33
Reconstitution of the response to leukemia inhibitory factor, oncostatin M, and ciliary neurotrophic factor in hepatoma cells. J Biol Chem (1993) 1.30
Genetic analysis of transpositions in the lac region of Escherichia coli. J Mol Biol (1980) 1.29
New class of limited-host-range Agrobacterium mega-tumor-inducing plasmids lacking homology to the transferred DNA of a wide-host-range, tumor-inducing plasmid. J Bacteriol (1985) 1.28
Epidermal growth factor receptor activity mediates renal cyst formation in polycystic kidney disease. J Clin Invest (1998) 1.26
DNA sequence at the end of IS1 required for transposition. Nature (1985) 1.21
Multiple regions within the cytoplasmic domains of the leukemia inhibitory factor receptor and gp130 cooperate in signal transduction in hepatic and neuronal cells. Mol Cell Biol (1994) 1.20
Insertional mutagenesis and molecular analysis of a new gene associated with polycystic kidney disease. Proc Assoc Am Physicians (1995) 1.20
The influence of TSLP on the allergic response. Mucosal Immunol (2009) 1.20
CD40 ligand is a T cell growth factor. Eur J Immunol (1993) 1.19
Proliferative responses and binding properties of hematopoietic cells transfected with low-affinity receptors for leukemia inhibitory factor, oncostatin M, and ciliary neurotrophic factor. Proc Natl Acad Sci U S A (1994) 1.19
Sequence analysis of a 101-kilobase plasmid required for agar degradation by a Microscilla isolate. Appl Environ Microbiol (2001) 1.15
Expression of F transfer functions depends on the Escherichia coli integration host factor. Mol Gen Genet (1987) 1.10
Renal ablation by histotripsy--does it spare the collecting system? J Urol (2008) 1.10
Recombinant CD40 ligand exerts potent biologic effects on T cells. J Immunol (1994) 1.07
Signaling by the cytoplasmic domain of hematopoietin receptors involves two distinguishable mechanisms in hepatic cells. J Biol Chem (1994) 1.07
A high-throughput plasmid DNA preparation method. Anal Biochem (1994) 1.06
The murine mutation scurfy (sf) results in an antigen-dependent lymphoproliferative disease with altered T cell sensitivity. Eur J Immunol (2001) 1.06
Differential rescue of the renal and hepatic disease in an autosomal recessive polycystic kidney disease mouse mutant. A new model to study the liver lesion. Am J Pathol (1997) 1.05
Magnitude of the inflammatory response to cardiopulmonary bypass and its relation to adverse clinical outcomes. Inflamm Res (2002) 1.05
Functional correction of renal defects in a mouse model for ARPKD through expression of the cloned wild-type Tg737 cDNA. Kidney Int (1996) 1.04
The mouse homolog of the Wiskott-Aldrich syndrome protein (WASP) gene is highly conserved and maps near the scurfy (sf) mutation on the X chromosome. Genomics (1995) 1.03
Identification of a distinct low-affinity receptor for human interleukin-4 on pre-B cells. Blood (1993) 1.03
Immunomodulatory effects of mixed hematopoietic chimerism: immune tolerance in canine model of lung transplantation. Am J Transplant (2009) 1.02
Spontaneous and inducible epidermal hyperplasia in transgenic mice expressing HIV-1 Nef. Virology (1993) 1.02
Thymic stromal lymphopoietin (TSLP)-mediated dermal inflammation aggravates experimental asthma. Mucosal Immunol (2012) 1.02
Electronic spectra of crystalline 9-ethylguanine and guanine hydrochloride. J Am Chem Soc (1977) 1.01
Regulation of human monocyte cell-surface and soluble CD23 (Fc epsilon RII) by granulocyte-macrophage colony-stimulating factor and IL-3. J Immunol (1992) 0.98
A study of forty-nine consecutive Whipple resections for periampullary adenocarcinoma. Am J Surg (1997) 0.98
Identification of a novel low-affinity receptor for human interleukin-7. Blood (1992) 0.98
Long-term cultured B lymphocytes and their precursors reconstitute the B-lymphocyte lineage in vivo. Proc Natl Acad Sci U S A (1984) 0.96
The mouse scurfy (sf) mutation is tightly linked to Gata1 and Tfe3 on the proximal X chromosome. Mamm Genome (1994) 0.95
Granulocyte colony-stimulating factor rapidly activates a distinct STAT-like protein in normal myeloid cells. Blood (1995) 0.95
T-cell tolerance. Curr Opin Immunol (1993) 0.94
A self-reactive T cell population that is not subject to negative selection. Int Immunol (1992) 0.93
A mathematical analysis of in vitro molecular selection-amplification. J Mol Biol (1996) 0.92
The combination of epidermal growth factor and transforming growth factor-beta induces novel phenotypic changes in mouse liver stem cell lines. J Cell Sci (1997) 0.91
Vacuum ultraviolet circular dichroism as an indicator of helical handedness in nucleic acids. Nucleic Acids Res (1986) 0.91
Characterization of the human and murine IL-7 genes. J Immunol (1990) 0.91
Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region. Gene (2000) 0.90
Optimizing restriction fragment fingerprinting methods for ordering large genomic libraries. Genomics (1990) 0.88