Published in Clin Exp Pharmacol Physiol on January 10, 2001
Identification of genetic loci involved in diabetes using a rat model of depression. Mamm Genome (2009) 0.86
The transcriptional landscape of the mammalian genome. Science (2005) 37.63
Genetic alterations during colorectal-tumor development. N Engl J Med (1988) 26.82
Variable number of tandem repeat (VNTR) markers for human gene mapping. Science (1987) 25.71
Antisense transcription in the mammalian transcriptome. Science (2005) 15.69
Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas. Science (1989) 11.53
Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients. Science (1991) 9.89
Nitric oxide: an endogenous modulator of leukocyte adhesion. Proc Natl Acad Sci U S A (1991) 8.04
Peroral endoscopic myotomy (POEM) for esophageal achalasia. Endoscopy (2010) 7.10
Glutamine repeats as polar zippers: their possible role in inherited neurodegenerative diseases. Proc Natl Acad Sci U S A (1994) 6.96
Quantum computers. Nature (2010) 6.79
A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage. Nature (2000) 6.01
When is cancer pain mild, moderate or severe? Grading pain severity by its interference with function. Pain (1995) 5.97
Peptidyl-prolyl cis-trans isomerase is the cyclosporin A-binding protein cyclophilin. Nature (1989) 5.86
p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53. Cell (2000) 5.64
Allelotype of colorectal carcinomas. Science (1989) 5.54
The action of tetrodotoxin on electrogenic components of squid giant axons. J Gen Physiol (1965) 5.42
AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1. Nat Genet (2000) 5.26
Interleukin-2 receptor gamma chain: a functional component of the interleukin-7 receptor. Science (1993) 5.22
Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene. Hum Mol Genet (1992) 5.14
Induction of maturation in cultured human monocytic leukemia cells by a phorbol diester. Cancer Res (1982) 4.98
Complete genome structure of the nitrogen-fixing symbiotic bacterium Mesorhizobium loti. DNA Res (2000) 4.94
Interleukin-2 receptor gamma chain: a functional component of the interleukin-4 receptor. Science (1993) 4.63
Rapid colorectal adenoma formation initiated by conditional targeting of the Apc gene. Science (1997) 4.62
The gene for familial polyposis coli maps to the long arm of chromosome 5. Science (1987) 4.48
Transient regulation of protein synthesis in Escherichia coli upon shift-up of growth temperature. J Bacteriol (1978) 4.38
A standard reference frame for the description of nucleic acid base-pair geometry. J Mol Biol (2001) 4.29
Complete genomic sequence of the filamentous nitrogen-fixing cyanobacterium Anabaena sp. strain PCC 7120. DNA Res (2001) 4.27
Clinically mild encephalitis/encephalopathy with a reversible splenial lesion. Neurology (2004) 4.24
A primary genetic map of markers of human chromosome 10. Genomics (1988) 4.23
Disruption of the APC gene by a retrotransposal insertion of L1 sequence in a colon cancer. Cancer Res (1992) 4.21
The PILATUS 1M detector. J Synchrotron Radiat (2006) 4.16
Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans and genomic sequence comparison with Bacillus subtilis. Nucleic Acids Res (2000) 4.11
Identification and characterization of the potential promoter regions of 1031 kinds of human genes. Genome Res (2001) 4.03
Multiple endocrine neoplasia type 1 gene maps to chromosome 11 and is lost in insulinoma. Nature (1988) 3.96
An ancient retrotransposal insertion causes Fukuyama-type congenital muscular dystrophy. Nature (1998) 3.86
Cross-contamination potential with dental equipment. Lancet (1992) 3.55
Diverse transcriptional initiation revealed by fine, large-scale mapping of mRNA start sites. EMBO Rep (2001) 3.47
Clinical characteristics of clear cell carcinoma of the ovary: a distinct histologic type with poor prognosis and resistance to platinum-based chemotherapy. Cancer (2000) 3.46
Results of surgical and nonsurgical treatment for small-sized hepatocellular carcinomas: a retrospective and nationwide survey in Japan. The Liver Cancer Study Group of Japan. Hepatology (2000) 3.42
A new form of amyloid protein associated with chronic hemodialysis was identified as beta 2-microglobulin. Biochem Biophys Res Commun (1985) 3.40
Altered urinary bladder function in mice lacking the vanilloid receptor TRPV1. Nat Neurosci (2002) 3.28
Bacterial genomic reorganization upon DNA replication. Science (2001) 3.25
Rapid confirmation of single copy lambda prophage integration by PCR. Nucleic Acids Res (1994) 3.19
Genome-wide analysis of gene expression in human hepatocellular carcinomas using cDNA microarray: identification of genes involved in viral carcinogenesis and tumor progression. Cancer Res (2001) 3.18
A high-throughput SNP typing system for genome-wide association studies. J Hum Genet (2001) 3.18
Isolation and mapping of a polymorphic DNA sequence (pTHH22) on chromosome 9 [D9S12]. Nucleic Acids Res (1988) 3.17
Alymphoplasia is caused by a point mutation in the mouse gene encoding Nf-kappa b-inducing kinase. Nat Genet (1999) 3.17
IL-6 is produced by osteoblasts and induces bone resorption. J Immunol (1990) 3.14
Apoptosis induction by antisense oligonucleotides against miR-17-5p and miR-20a in lung cancers overexpressing miR-17-92. Oncogene (2007) 3.11
Gene organization deduced from the complete sequence of liverwort Marchantia polymorpha mitochondrial DNA. A primitive form of plant mitochondrial genome. J Mol Biol (1992) 3.11
A novel transgenic technique that allows specific marking of the neural crest cell lineage in mice. Dev Biol (1999) 3.11
Development of an MRI-compatible needle insertion manipulator for stereotactic neurosurgery. J Image Guid Surg (1995) 3.07
Visualization of neurogenesis in the central nervous system using nestin promoter-GFP transgenic mice. Neuroreport (2000) 3.04
Introduction of disease-related mitochondrial DNA deletions into HeLa cells lacking mitochondrial DNA results in mitochondrial dysfunction. Proc Natl Acad Sci U S A (1991) 3.00
Molecular detection of microscopic and submicroscopic deletions associated with Miller-Dieker syndrome. Am J Hum Genet (1988) 2.97
Mapping of mutation causing Friedreich's ataxia to human chromosome 9. Nature (1988) 2.96
A tripeptide 'anticodon' deciphers stop codons in messenger RNA. Nature (2000) 2.90
Localisation of atopy and beta subunit of high-affinity IgE receptor (Fc epsilon RI) on chromosome 11q. Lancet (1993) 2.88
Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinase. Nat Genet (1999) 2.81
Specific deficit of the ON response in visual transmission by targeted disruption of the mGluR6 gene. Cell (1995) 2.81
A mapped set of genetic markers for human chromosome 9. Genomics (1988) 2.80
Genetic mapping of autosomal dominant Charcot-Marie-Tooth disease in a large French-Acadian kindred: identification of new linked markers on chromosome 17. Am J Hum Genet (1990) 2.77
Mutation in Npps in a mouse model of ossification of the posterior longitudinal ligament of the spine. Nat Genet (1998) 2.77
Experimental investigation of geologically produced antineutrinos with KamLAND. Nature (2005) 2.75
Correlation between the location of germ-line mutations in the APC gene and the number of colorectal polyps in familial adenomatous polyposis patients. Cancer Res (1992) 2.72
A primary genetic linkage map for human chromosome 12. Genomics (1987) 2.72
Targeted pharmacological depletion of serum amyloid P component for treatment of human amyloidosis. Nature (2002) 2.71
Mutations in the integrin alpha7 gene cause congenital myopathy. Nat Genet (1998) 2.66
Requirement of CD9 on the egg plasma membrane for fertilization. Science (2000) 2.65
Enhanced expression of a glyceraldehyde-3-phosphate dehydrogenase gene in human lung cancers. Cancer Res (1987) 2.65
Complete structure of the chloroplast genome of Arabidopsis thaliana. DNA Res (1999) 2.63
Mutations of the APC (adenomatous polyposis coli) gene. Hum Mutat (1993) 2.63
A new mutation, aly, that induces a generalized lack of lymph nodes accompanied by immunodeficiency in mice. Eur J Immunol (1994) 2.62
Impairment of suckling response, trigeminal neuronal pattern formation, and hippocampal LTD in NMDA receptor epsilon 2 subunit mutant mice. Neuron (1996) 2.62
Allelotype of breast cancer: cumulative allele losses promote tumor progression in primary breast cancer. Cancer Res (1990) 2.57
A radiation hybrid map of the rat genome containing 5,255 markers. Nat Genet (1999) 2.54
Extracellular ATP or ADP induce chemotaxis of cultured microglia through Gi/o-coupled P2Y receptors. J Neurosci (2001) 2.54
Association studies of 33 single nucleotide polymorphisms (SNPs) in 29 candidate genes for bronchial asthma: positive association a T924C polymorphism in the thromboxane A2 receptor gene. Hum Genet (2000) 2.50
A novel mode of DNA recognition by a beta-sheet revealed by the solution structure of the GCC-box binding domain in complex with DNA. EMBO J (1998) 2.48
p53DINP1, a p53-inducible gene, regulates p53-dependent apoptosis. Mol Cell (2001) 2.47
Helium-3 emission related to volcanic activity. Science (1984) 2.43
Activation of the beta-catenin gene in primary hepatocellular carcinomas by somatic alterations involving exon 3. Cancer Res (1998) 2.42
Spectrodensitometric determination of trichothecene mycotoxins with 4-(p-nitrobenzyl)pyridine on silica gel thin-layer chromatograms. J Chromatogr (1979) 2.38
Modulation of the Ca2 permeable cation channel TRPV4 by cytochrome P450 epoxygenases in vascular endothelium. Circ Res (2005) 2.38
Loss of imprinting of the insulin-like growth factor II gene occurs by biallelic methylation in a core region of H19-associated CTCF-binding sites in colorectal cancer. Proc Natl Acad Sci U S A (2000) 2.38
Musashi1: an evolutionally conserved marker for CNS progenitor cells including neural stem cells. Dev Neurosci (2000) 2.36
Mutually exclusive expression of odorant receptor transgenes. Nat Neurosci (2000) 2.36
A large scale analysis of cDNA in Arabidopsis thaliana: generation of 12,028 non-redundant expressed sequence tags from normalized and size-selected cDNA libraries. DNA Res (2000) 2.33
Truncated CBP protein leads to classical Rubinstein-Taybi syndrome phenotypes in mice: implications for a dominant-negative mechanism. Hum Mol Genet (1999) 2.32
Genetic analysis of an inherited predisposition to colon cancer in a family with a variable number of adenomatous polyps. N Engl J Med (1990) 2.32
Physiological role of silent receptors of atrial natriuretic factor. Science (1987) 2.31
The human CCG1 gene, essential for progression of the G1 phase, encodes a 210-kilodalton nuclear DNA-binding protein. Mol Cell Biol (1991) 2.30
Clinical and pathological associations with allelic loss in colorectal carcinoma [corrected]. JAMA (1989) 2.29
Biochemical and genetic analysis of the effects of amylose-extender mutation in rice endosperm. Plant Physiol (2001) 2.28
Genetic approaches in mice to understand Rel/NF-kappaB and IkappaB function: transgenics and knockouts. Oncogene (1999) 2.27
Growth-suppressive effects of BPOZ and EGR2, two genes involved in the PTEN signaling pathway. Oncogene (2001) 2.25
Altered cochlear fibrocytes in a mouse model of DFN3 nonsyndromic deafness. Science (1999) 2.25
Induction of microRNAs, mir-155, mir-222, mir-424 and mir-503, promotes monocytic differentiation through combinatorial regulation. Leukemia (2009) 2.24