Published in EMBO J on May 01, 2001
PPARgamma insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors. J Clin Invest (2004) 5.29
Aging activates adipogenic and suppresses osteogenic programs in mesenchymal marrow stroma/stem cells: the role of PPAR-gamma2 transcription factor and TGF-beta/BMP signaling pathways. Aging Cell (2004) 3.55
Ubiquitin ligase Smurf1 controls osteoblast activity and bone homeostasis by targeting MEKK2 for degradation. Cell (2005) 3.26
Myostatin signals through a transforming growth factor beta-like signaling pathway to block adipogenesis. Mol Cell Biol (2003) 2.90
Altered fracture repair in the absence of MMP9. Development (2003) 2.41
TGF-beta inhibits muscle differentiation through functional repression of myogenic transcription factors by Smad3. Genes Dev (2001) 2.35
Repression of Runx2 function by TGF-beta through recruitment of class II histone deacetylases by Smad3. EMBO J (2005) 2.35
TGF-beta regulates the mechanical properties and composition of bone matrix. Proc Natl Acad Sci U S A (2005) 1.83
Endogenous TGF-beta signaling suppresses maturation of osteoblastic mesenchymal cells. EMBO J (2004) 1.77
A crucial role of caspase-3 in osteogenic differentiation of bone marrow stromal stem cells. J Clin Invest (2004) 1.71
Signaling and transcriptional regulation in osteoblast commitment and differentiation. Front Biosci (2007) 1.61
Pharmacologic inhibition of the TGF-beta type I receptor kinase has anabolic and anti-catabolic effects on bone. PLoS One (2008) 1.60
Bone morphogenetic protein and retinoic acid signaling cooperate to induce osteoblast differentiation of preadipocytes. J Cell Biol (2002) 1.58
Trafficking mesenchymal stem cell engraftment and differentiation in tumor-bearing mice by bioluminescence imaging. Stem Cells (2009) 1.58
Nuclear factor YY1 inhibits transforming growth factor beta- and bone morphogenetic protein-induced cell differentiation. Mol Cell Biol (2003) 1.50
Use and efficacy of bone morphogenetic proteins in fracture healing. Int Orthop (2011) 1.49
Fibrillin-1 and -2 differentially modulate endogenous TGF-β and BMP bioavailability during bone formation. J Cell Biol (2010) 1.49
Integration of Runx and Smad regulatory signals at transcriptionally active subnuclear sites. Proc Natl Acad Sci U S A (2002) 1.47
Microarray gene expression profiling of osteoarthritic bone suggests altered bone remodelling, WNT and transforming growth factor-beta/bone morphogenic protein signalling. Arthritis Res Ther (2007) 1.47
Lysyl oxidase binds transforming growth factor-beta and regulates its signaling via amine oxidase activity. J Biol Chem (2008) 1.47
TGF-beta-activated Smad3 represses MEF2-dependent transcription in myogenic differentiation. EMBO J (2004) 1.42
Congenic mice provide in vivo evidence for a genetic locus that modulates intrinsic transforming growth factor β1-mediated signaling and bone acquisition. J Bone Miner Res (2012) 1.41
Different effects of BMP-2 on marrow stromal cells from human and rat bone. Cells Tissues Organs (2004) 1.29
Age-related molecular genetic changes of murine bone marrow mesenchymal stem cells. BMC Genomics (2010) 1.27
The Interplay between the bone and the immune system. Clin Dev Immunol (2013) 1.26
The ErbB3 binding protein Ebp1 interacts with Sin3A to repress E2F1 and AR-mediated transcription. Nucleic Acids Res (2005) 1.23
Excessive transforming growth factor-β signaling is a common mechanism in osteogenesis imperfecta. Nat Med (2014) 1.21
Smad-dependent recruitment of a histone deacetylase/Sin3A complex modulates the bone morphogenetic protein-dependent transcriptional repressor activity of Nkx3.2. Mol Cell Biol (2003) 1.19
BMP9 signaling in stem cell differentiation and osteogenesis. Am J Stem Cells (2013) 1.17
Concise review: adipose-derived stromal cells for skeletal regenerative medicine. Stem Cells (2011) 1.16
Physical and functional interactions between homeodomain NKX2.1 and winged helix/forkhead FOXA1 in lung epithelial cells. Mol Cell Biol (2007) 1.15
Defective osteogenesis of the stromal stem cells predisposes CD18-null mice to osteoporosis. Proc Natl Acad Sci U S A (2005) 1.13
Tgf-Beta inhibition restores terminal osteoblast differentiation to suppress myeloma growth. PLoS One (2010) 1.11
Signaling networks that control the lineage commitment and differentiation of bone cells. Crit Rev Eukaryot Gene Expr (2009) 1.11
The life cycle of chondrocytes in the developing skeleton. Arthritis Res (2001) 1.11
TIEG-null mice display an osteopenic gender-specific phenotype. Bone (2008) 1.10
Transforming growth factor β suppresses osteoblast differentiation via the vimentin activating transcription factor 4 (ATF4) axis. J Biol Chem (2012) 1.10
Signal transduction and transcriptional regulation during mesenchymal cell differentiation. J Bone Miner Metab (2008) 1.10
Critical roles of the TGF-beta type I receptor ALK5 in perichondrial formation and function, cartilage integrity, and osteoblast differentiation during growth plate development. Dev Biol (2009) 1.09
Control of mesenchymal lineage progression by microRNAs targeting skeletal gene regulators Trps1 and Runx2. J Biol Chem (2012) 1.09
Anti-transforming growth factor ß antibody treatment rescues bone loss and prevents breast cancer metastasis to bone. PLoS One (2011) 1.08
TGF-beta signaling in chondrocytes. Front Biosci (2005) 1.08
Interleukin-6: an autocrine regulator of the mouse cumulus cell-oocyte complex expansion process. Endocrinology (2009) 1.08
Bone marrow mesenchymal stem cells and TGF-β signaling in bone remodeling. J Clin Invest (2014) 1.08
TGF-beta and BMP7 interactions in tumour progression and bone metastasis. Clin Exp Metastasis (2007) 1.08
Chondrocyte-intrinsic Smad3 represses Runx2-inducible matrix metalloproteinase 13 expression to maintain articular cartilage and prevent osteoarthritis. Arthritis Rheum (2012) 1.08
Signaling via Alk5 controls the ontogeny of lung Clara cells. Development (2010) 1.07
The role of TGF-β in bone metastasis: novel therapeutic perspectives. Bonekey Rep (2012) 1.06
Repression of Runx2 by androgen receptor (AR) in osteoblasts and prostate cancer cells: AR binds Runx2 and abrogates its recruitment to DNA. Mol Endocrinol (2009) 1.06
GATA4 is essential for bone mineralization via ERα and TGFβ/BMP pathways. J Bone Miner Res (2014) 1.04
Lysyl oxidase propeptide inhibits FGF-2-induced signaling and proliferation of osteoblasts. J Biol Chem (2010) 1.03
Oct-1 counteracts autoinhibition of Runx2 DNA binding to form a novel Runx2/Oct-1 complex on the promoter of the mammary gland-specific gene beta-casein. Mol Cell Biol (2005) 1.03
TGF-β family signaling in stem cells. Biochim Biophys Acta (2012) 1.01
A critical role for the Sp1-binding sites in the transforming growth factor-beta-mediated inhibition of lipoprotein lipase gene expression in macrophages. Nucleic Acids Res (2005) 1.00
Smad3 binds Scleraxis and Mohawk and regulates tendon matrix organization. J Orthop Res (2013) 0.98
Transcription factor Smad3 is required for the inhibition of adipogenesis by retinoic acid. J Biol Chem (2010) 0.96
Tissue-specific calibration of extracellular matrix material properties by transforming growth factor-β and Runx2 in bone is required for hearing. EMBO Rep (2010) 0.95
TGF-β regulates sclerostin expression via the ECR5 enhancer. Bone (2011) 0.94
Identification of the GATA factor TRPS1 as a repressor of the osteocalcin promoter. J Biol Chem (2009) 0.94
Inhibition of insulin-like growth factor-1 (IGF-1) expression by prolonged transforming growth factor-β1 (TGF-β1) administration suppresses osteoblast differentiation. J Biol Chem (2012) 0.94
Effect of transforming growth factor beta (TGF-β) receptor I kinase inhibitor on prostate cancer bone growth. Bone (2011) 0.93
Transforming growth factor beta/Smad3 signaling regulates IRF-7 function and transcriptional activation of the beta interferon promoter. Mol Cell Biol (2004) 0.93
Coping with time scales in disease systems analysis: application to bone remodeling. J Pharmacokinet Pharmacodyn (2011) 0.93
Runx2 promotes both osteoblastogenesis and novel osteoclastogenic signals in ST2 mesenchymal progenitor cells. Osteoporos Int (2011) 0.92
Synergistic inhibition of endochondral bone formation by silencing Hif1α and Runx2 in trauma-induced heterotopic ossification. Mol Ther (2011) 0.90
Regulation of postnatal bone homeostasis by TGFβ. Bonekey Rep (2013) 0.90
The transcription factor Runx2 is under circadian control in the suprachiasmatic nucleus and functions in the control of rhythmic behavior. PLoS One (2013) 0.90
Load regulates bone formation and Sclerostin expression through a TGFβ-dependent mechanism. PLoS One (2013) 0.89
Thrombospondin-1 inhibits osteogenic differentiation of human mesenchymal stem cells through latent TGF-β activation. Biochem Biophys Res Commun (2012) 0.89
BMP signaling in mesenchymal stem cell differentiation and bone formation. J Biomed Sci Eng (2013) 0.89
Sca-1 is negatively regulated by TGF-beta1 in myogenic cells. FASEB J (2010) 0.88
Cadmium-induced decrease in RUNX2 mRNA expression and recovery by the antioxidant N-acetylcysteine (NAC) in the human osteoblast-like cell line, Saos-2. Toxicol In Vitro (2008) 0.88
TGF-beta1 on osteoimmunology and the bone component cells. Cell Biosci (2013) 0.88
TIEG1/KLF10 modulates Runx2 expression and activity in osteoblasts. PLoS One (2011) 0.88
TGF-β and BMP signaling in osteoblast, skeletal development, and bone formation, homeostasis and disease. Bone Res (2016) 0.88
Estrogen-TGFbeta cross-talk in bone and other cell types: role of TIEG, Runx2, and other transcription factors. J Cell Biochem (2008) 0.86
Mutation in osteoactivin decreases bone formation in vivo and osteoblast differentiation in vitro. Am J Pathol (2014) 0.85
PTH battles TGF-beta in bone. Nat Cell Biol (2010) 0.84
Loss of Smad3-mediated negative regulation of Runx2 activity leads to an alteration in cell fate determination. Mol Cell Biol (2005) 0.84
Akt activation is required for TGF-β1-induced osteoblast differentiation of MC3T3-E1 pre-osteoblasts. PLoS One (2014) 0.84
Butein is a novel anti-adipogenic compound. J Lipid Res (2013) 0.84
Runt-related transcription factors impair activin induction of the follicle-stimulating hormone {beta}-subunit gene. Endocrinology (2010) 0.83
Loss of Runx2 in committed osteoblasts impairs postnatal skeletogenesis. J Bone Miner Res (2015) 0.82
Sox5 Is a DNA-binding cofactor for BMP R-Smads that directs target specificity during patterning of the early ectoderm. Dev Cell (2014) 0.82
Bone anabolic agents for the treatment of multiple myeloma. Cancer Microenviron (2011) 0.81
Rapid cell culture and pre-clinical screening of a transforming growth factor-beta (TGF-beta) inhibitor for orthopaedics. BMC Musculoskelet Disord (2010) 0.81
GDF11 decreases bone mass by stimulating osteoclastogenesis and inhibiting osteoblast differentiation. Nat Commun (2016) 0.81
Unique sex-based approach identifies transcriptomic biomarkers associated with non-syndromic craniosynostosis. Gene Regul Syst Bio (2012) 0.79
Actin microfilament mediates osteoblast Cbfa1 responsiveness to BMP2 under simulated microgravity. PLoS One (2013) 0.79
TRIP-1: a regulator of osteoblast function. J Bone Miner Res (2012) 0.79
Tendon development and musculoskeletal assembly: emerging roles for the extracellular matrix. Development (2015) 0.79
X-irradiation-induced cell cycle delay and DNA double-strand breaks in the murine osteoblastic cell line OCT-1. Radiat Environ Biophys (2010) 0.79
Different roles of TGF-β in the multi-lineage differentiation of stem cells. World J Stem Cells (2012) 0.79
Treatment of cartilage defects by subchondral drilling combined with covering with atelocollagen membrane induces osteogenesis in a rat model. J Orthop Sci (2013) 0.79
Aberrant gene expression profiles, during in vitro osteoblast differentiation, of telomerase deficient mouse bone marrow stromal stem cells (mBMSCs). J Biomed Sci (2015) 0.79
TGF-β Signaling Regulates Cementum Formation through Osterix Expression. Sci Rep (2016) 0.78
Role of SHIP1 in bone biology. Ann N Y Acad Sci (2013) 0.78
Pro-tumorigenic effects of transforming growth factor beta 1 in canine osteosarcoma. J Vet Intern Med (2014) 0.78
Transcription factor FoxO1 is essential for enamel biomineralization. PLoS One (2012) 0.78
Integrated approaches to miRNAs target definition: time-series analysis in an osteosarcoma differentiative model. BMC Med Genomics (2015) 0.77
Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell (1997) 18.91
TGF-beta signal transduction. Annu Rev Biochem (1998) 17.83
Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation. Cell (1997) 16.78
TGF-beta signalling from cell membrane to nucleus through SMAD proteins. Nature (1997) 15.75
Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development. Cell (1997) 13.53
Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene. EMBO J (1998) 10.01
Transcriptional control by the TGF-beta/Smad signaling system. EMBO J (2000) 8.49
Mutations involving the transcription factor CBFA1 cause cleidocranial dysplasia. Cell (1997) 7.47
Smads: transcriptional activators of TGF-beta responses. Cell (1998) 5.33
Receptor-associated Mad homologues synergize as effectors of the TGF-beta response. Nature (1996) 5.30
Partnership between DPC4 and SMAD proteins in TGF-beta signalling pathways. Nature (1996) 5.21
Two distinct osteoblast-specific cis-acting elements control expression of a mouse osteocalcin gene. Mol Cell Biol (1995) 4.28
Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription. Nature (1998) 4.13
A functional interaction between the histone deacetylase Rpd3 and the corepressor groucho in Drosophila development. Genes Dev (1999) 3.91
A Cbfa1-dependent genetic pathway controls bone formation beyond embryonic development. Genes Dev (1999) 3.88
Targeted disruption of Smad3 reveals an essential role in transforming growth factor beta-mediated signal transduction. Mol Cell Biol (1999) 3.55
Differential effects of translational inhibition in cis and in trans on the decay of the unstable yeast MFA2 mRNA. J Biol Chem (1994) 3.37
Roles of bone morphogenetic protein type I receptors and Smad proteins in osteoblast and chondroblast differentiation. Mol Biol Cell (1999) 3.27
Missense mutations abolishing DNA binding of the osteoblast-specific transcription factor OSF2/CBFA1 in cleidocranial dysplasia. Nat Genet (1997) 3.20
A Smad transcriptional corepressor. Cell (1999) 3.07
Association of Smads with lymphoid enhancer binding factor 1/T cell-specific factor mediates cooperative signaling by the transforming growth factor-beta and wnt pathways. Proc Natl Acad Sci U S A (2000) 2.97
Transforming growth factor beta-induced phosphorylation of Smad3 is required for growth inhibition and transcriptional induction in epithelial cells. Proc Natl Acad Sci U S A (1997) 2.97
The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for smad3 in TGF-beta-induced transcriptional activation. Genes Dev (1998) 2.82
The t(8;21) fusion protein interferes with AML-1B-dependent transcriptional activation. Mol Cell Biol (1995) 2.70
Regulation of Smad activity. Cell (2000) 2.53
The Ski oncoprotein interacts with the Smad proteins to repress TGFbeta signaling. Genes Dev (1999) 2.52
Interaction and functional cooperation of PEBP2/CBF with Smads. Synergistic induction of the immunoglobulin germline Calpha promoter. J Biol Chem (1999) 2.44
Smad2, Smad3 and Smad4 cooperate with Sp1 to induce p15(Ink4B) transcription in response to TGF-beta. EMBO J (2000) 2.41
TGF-beta-stimulated cooperation of smad proteins with the coactivators CBP/p300. Genes Dev (1998) 2.40
Signaling of transforming growth factor-beta family members through Smad proteins. Eur J Biochem (2000) 2.39
Increased expression of TGF-beta 2 in osteoblasts results in an osteoporosis-like phenotype. J Cell Biol (1996) 2.36
c-Ski acts as a transcriptional co-repressor in transforming growth factor-beta signaling through interaction with smads. J Biol Chem (1999) 2.32
Role of Smad proteins and transcription factor Sp1 in p21(Waf1/Cip1) regulation by transforming growth factor-beta. J Biol Chem (2000) 2.31
A RUNX2/PEBP2alpha A/CBFA1 mutation displaying impaired transactivation and Smad interaction in cleidocranial dysplasia. Proc Natl Acad Sci U S A (2000) 2.31
Synergistic cooperation of TFE3 and smad proteins in TGF-beta-induced transcription of the plasminogen activator inhibitor-1 gene. Genes Dev (1998) 2.29
Groucho-dependent and -independent repression activities of Runt domain proteins. Mol Cell Biol (1997) 2.27
Role of the alpha2-integrin in osteoblast-specific gene expression and activation of the Osf2 transcription factor. J Biol Chem (1998) 2.26
The oncoprotein Evi-1 represses TGF-beta signalling by inhibiting Smad3. Nature (1998) 2.18
Differential roles for bone morphogenetic protein (BMP) receptor type IB and IA in differentiation and specification of mesenchymal precursor cells to osteoblast and adipocyte lineages. J Cell Biol (1998) 2.17
Two domains unique to osteoblast-specific transcription factor Osf2/Cbfa1 contribute to its transactivation function and its inability to heterodimerize with Cbfbeta. Mol Cell Biol (1998) 2.13
Groucho/TLE/R-esp proteins associate with the nuclear matrix and repress RUNX (CBF(alpha)/AML/PEBP2(alpha)) dependent activation of tissue-specific gene transcription. J Cell Sci (2000) 2.08
Cbfa1 isoforms exert functional differences in osteoblast differentiation. J Biol Chem (1999) 2.06
Osteoblasts synthesize and respond to transforming growth factor-type beta (TGF-beta) in vitro. J Cell Biol (1987) 2.01
Human transforming growth factor-beta 3: recombinant expression, purification, and biological activities in comparison with transforming growth factors-beta 1 and -beta 2. Mol Endocrinol (1989) 2.00
Roles of autocrine TGF-beta receptor and Smad signaling in adipocyte differentiation. J Cell Biol (2000) 1.94
Interaction of the Ski oncoprotein with Smad3 regulates TGF-beta signaling. Mol Cell (1999) 1.91
Regulation of Smad signalling by protein associations and signalling crosstalk. Trends Cell Biol (1999) 1.87
The mouse osteocalcin gene cluster contains three genes with two separate spatial and temporal patterns of expression. J Biol Chem (1994) 1.87
Convergence of transforming growth factor-beta and vitamin D signaling pathways on SMAD transcriptional coactivators. Science (1999) 1.85
ATF-2 is a common nuclear target of Smad and TAK1 pathways in transforming growth factor-beta signaling. J Biol Chem (1999) 1.83
Smads bind directly to the Jun family of AP-1 transcription factors. Proc Natl Acad Sci U S A (1999) 1.81
The genetic transformation of bone biology. Genes Dev (1999) 1.80
Cbfa1 contributes to the osteoblast-specific expression of type I collagen genes. J Biol Chem (2000) 1.77
Transforming growth factor-beta gene family members and bone. Endocr Rev (1994) 1.66
Transforming growth factor-beta (TGF-beta)-induced down-regulation of cyclin A expression requires a functional TGF-beta receptor complex. Characterization of chimeric and truncated type I and type II receptors. J Biol Chem (1995) 1.64
Functional hierarchy between two OSE2 elements in the control of osteocalcin gene expression in vivo. J Biol Chem (1998) 1.63
Positive and negative regulation of TGF-beta signaling. J Cell Sci (2000) 1.62
Complementation between kinase-defective and activation-defective TGF-beta receptors reveals a novel form of receptor cooperativity essential for signaling. EMBO J (1996) 1.61
Ascorbic acid-dependent activation of the osteocalcin promoter in MC3T3-E1 preosteoblasts: requirement for collagen matrix synthesis and the presence of an intact OSE2 sequence. Mol Endocrinol (1997) 1.58
Antagonistic regulation of type I collagen gene expression by interferon-gamma and transforming growth factor-beta. Integration at the level of p300/CBP transcriptional coactivators. J Biol Chem (2000) 1.55
Transient upregulation of CBFA1 in response to bone morphogenetic protein-2 and transforming growth factor beta1 in C2C12 myogenic cells coincides with suppression of the myogenic phenotype but is not sufficient for osteoblast differentiation. J Cell Biochem (1999) 1.54
Ligand-independent activation of transforming growth factor (TGF) beta signaling pathways by heteromeric cytoplasmic domains of TGF-beta receptors. J Biol Chem (1996) 1.47
Differentiation of human marrow stromal precursor cells: bone morphogenetic protein-2 increases OSF2/CBFA1, enhances osteoblast commitment, and inhibits late adipocyte maturation. J Bone Miner Res (1999) 1.44
The tissue-specific nuclear matrix protein, NMP-2, is a member of the AML/CBF/PEBP2/runt domain transcription factor family: interactions with the osteocalcin gene promoter. Biochemistry (1995) 1.40
CREB binding protein is a required coactivator for Smad-dependent, transforming growth factor beta transcriptional responses in endothelial cells. Proc Natl Acad Sci U S A (1998) 1.39
Localization of Smads, the TGF-beta family intracellular signaling components during endochondral ossification. J Bone Miner Res (1999) 1.38
CBF alpha3 (AML2) is induced by TGF-beta1 to bind and activate the mouse germline Ig alpha promoter. J Immunol (1998) 1.36
A PEBP2 alpha/AML-1-related factor increases osteocalcin promoter activity through its binding to an osteoblast-specific cis-acting element. J Biol Chem (1995) 1.33
Immortalized murine osteoblasts derived from BMP 2-T-antigen expressing transgenic mice. Endocrinology (1996) 1.32
Role of active and latent transforming growth factor beta in bone formation. J Cell Biochem (1994) 1.32
A novel smad nuclear interacting protein, SNIP1, suppresses p300-dependent TGF-beta signal transduction. Genes Dev (2000) 1.32
Transforming growth factor-beta stimulates the production of osteoprotegerin/osteoclastogenesis inhibitory factor by bone marrow stromal cells. J Biol Chem (1998) 1.31
Specificity in transforming growth factor beta-induced transcription of the plasminogen activator inhibitor-1 gene: interactions of promoter DNA, transcription factor muE3, and Smad proteins. Proc Natl Acad Sci U S A (1999) 1.30
Regulation of transcription of the germ-line Ig alpha constant region gene by an ATF element and by novel transforming growth factor-beta 1-responsive elements. J Immunol (1992) 1.29
Ultrastructural analysis of bone nodules formed in vitro by isolated fetal rat calvaria cells. Bone (1988) 1.28
Osteoblastic responses to TGF-beta during bone remodeling. Mol Biol Cell (1998) 1.28
Tumor necrosis factor-alpha inhibits transforming growth factor-beta /Smad signaling in human dermal fibroblasts via AP-1 activation. J Biol Chem (2000) 1.26
Follicle stimulating hormone-regulated expression of serum/glucocorticoid-inducible kinase in rat ovarian granulosa cells: a functional role for the Sp1 family in promoter activity. Mol Endocrinol (1997) 1.24
Smad and AML proteins synergistically confer transforming growth factor beta1 responsiveness to human germ-line IgA genes. J Biol Chem (2000) 1.23
An AML-1 consensus sequence binds an osteoblast-specific complex and transcriptionally activates the osteocalcin gene. Proc Natl Acad Sci U S A (1996) 1.21
Transcriptional regulation of the transforming growth factor-beta -inducible mouse germ line Ig alpha constant region gene by functional cooperation of Smad, CREB, and AML family members. J Biol Chem (2000) 1.18
The osteoblast-specific transcription factor Cbfa1 contributes to the expression of osteoprotegerin, a potent inhibitor of osteoclast differentiation and function. J Biol Chem (2000) 1.15
c-Jun inhibits transforming growth factor beta-mediated transcription by repressing Smad3 transcriptional activity. J Biol Chem (2000) 1.11
Potential role of cbfa1, an essential transcriptional factor for osteoblast differentiation, in osteoclastogenesis: regulation of mRNA expression of osteoclast differentiation factor (ODF). Biochem Biophys Res Commun (1998) 1.10
Reduction in transforming growth factor beta receptor I expression and transcription factor CBFa1 on bone cells by glucocorticoid. J Biol Chem (1998) 1.06
Structural and functional characterization of the transforming growth factor-beta -induced Smad3/c-Jun transcriptional cooperativity. J Biol Chem (2000) 1.05
E1A inhibits transforming growth factor-beta signaling through binding to Smad proteins. J Biol Chem (1999) 1.03
Transcriptional regulation of osteocalcin production by transforming growth factor-beta in rat osteoblast-like cells. Endocrinology (1989) 0.93
1,25-dihydroxyvitamin D3 inhibits Osteocalcin expression in mouse through an indirect mechanism. J Biol Chem (1997) 0.92
Smad2 overexpression enhances Smad4 gene expression and suppresses CBFA1 gene expression in osteoblastic osteosarcoma ROS17/2.8 cells and primary rat calvaria cells. J Biol Chem (1998) 0.92
AML and Ets proteins regulate the I alpha1 germ-line promoter. Eur J Immunol (1999) 0.82
Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation. Cell (1997) 16.78
Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin. Nature (1985) 13.04
Human transforming growth factor-beta complementary DNA sequence and expression in normal and transformed cells. Nature (1985) 10.13
Production of transforming growth factor beta by human T lymphocytes and its potential role in the regulation of T cell growth. J Exp Med (1986) 9.86
Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass. Cell (2000) 7.87
Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein. Nature (1997) 7.10
Expression of human immune interferon cDNA in E. coli and monkey cells. Nature (1982) 6.55
TGF-beta induced transdifferentiation of mammary epithelial cells to mesenchymal cells: involvement of type I receptors. J Cell Biol (1994) 6.00
Human transforming growth factor-alpha: precursor structure and expression in E. coli. Cell (1984) 5.39
Receptor-associated Mad homologues synergize as effectors of the TGF-beta response. Nature (1996) 5.30
Increased bone formation in osteocalcin-deficient mice. Nature (1996) 4.91
TGF-beta signaling in cancer--a double-edged sword. Trends Cell Biol (2001) 4.87
Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor. Nature (1995) 4.56
Synthesis of messenger RNAs for transforming growth factors alpha and beta and the epidermal growth factor receptor by human tumors. Cancer Res (1987) 4.44
Two distinct osteoblast-specific cis-acting elements control expression of a mouse osteocalcin gene. Mol Cell Biol (1995) 4.28
Production and auto-induction of transforming growth factor-alpha in human keratinocytes. Nature (1987) 4.19
Mapping of transforming growth factor alpha gene on human chromosome 2 close to the breakpoint of the Burkitt's lymphoma t(2;8) variant translocation. Cancer Res (1985) 4.17
Isolation and structure of a human fibroblast interferon gene. Nature (1980) 4.16
Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription. Nature (1998) 4.13
The osteoblast: a sophisticated fibroblast under central surveillance. Science (2000) 3.93
A Cbfa1-dependent genetic pathway controls bone formation beyond embryonic development. Genes Dev (1999) 3.88
BMP-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterning. Genes Dev (1995) 3.84
A nuclear factor 1 binding site mediates the transcriptional activation of a type I collagen promoter by transforming growth factor-beta. Cell (1988) 3.72
The murine transforming growth factor-beta precursor. J Biol Chem (1986) 3.67
Structural analysis of the sequence coding for an inducible 26-kDa protein in human fibroblasts. Eur J Biochem (1986) 3.63
Macrophage deactivating factor and transforming growth factors-beta 1 -beta 2 and -beta 3 inhibit induction of macrophage nitrogen oxide synthesis by IFN-gamma. J Immunol (1990) 3.55
Toward a molecular understanding of skeletal development. Cell (1995) 3.55
Transforming growth factor-alpha: a more potent angiogenic mediator than epidermal growth factor. Science (1986) 3.52
Smooth muscle cell phenotypic transition associated with calcification: upregulation of Cbfa1 and downregulation of smooth muscle lineage markers. Circ Res (2001) 3.50
Evidence that transforming growth factor-beta is a hormonally regulated negative growth factor in human breast cancer cells. Cell (1987) 3.45
Continuous expression of Cbfa1 in nonhypertrophic chondrocytes uncovers its ability to induce hypertrophic chondrocyte differentiation and partially rescues Cbfa1-deficient mice. Genes Dev (2001) 3.43
Molecular characterization and chromosomal mapping of melanoma growth stimulatory activity, a growth factor structurally related to beta-thromboglobulin. EMBO J (1988) 3.26
Missense mutations abolishing DNA binding of the osteoblast-specific transcription factor OSF2/CBFA1 in cleidocranial dysplasia. Nat Genet (1997) 3.20
Deletion of Ku86 causes early onset of senescence in mice. Proc Natl Acad Sci U S A (1999) 2.97
Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase. Proc Natl Acad Sci U S A (2001) 2.91
MAPK pathways activate and phosphorylate the osteoblast-specific transcription factor, Cbfa1. J Biol Chem (2000) 2.83
The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for smad3 in TGF-beta-induced transcriptional activation. Genes Dev (1998) 2.82
Expression of a truncated, kinase-defective TGF-beta type II receptor in mouse skeletal tissue promotes terminal chondrocyte differentiation and osteoarthritis. J Cell Biol (1997) 2.72
The primary structure of the Saccharomyces cerevisiae gene for 3-phosphoglycerate kinase. Nucleic Acids Res (1982) 2.67
Transmembrane TGF-alpha precursors activate EGF/TGF-alpha receptors. Cell (1989) 2.65
Overexpression of transforming growth factor alpha in psoriatic epidermis. Science (1989) 2.63
The tumor suppressor Smad4/DPC 4 as a central mediator of Smad function. Curr Biol (1997) 2.61
The family of bone morphogenetic proteins. Kidney Int (2000) 2.41
Expression in rat fibroblasts of a human transforming growth factor-alpha cDNA results in transformation. Cell (1986) 2.41
Smad2, Smad3 and Smad4 cooperate with Sp1 to induce p15(Ink4B) transcription in response to TGF-beta. EMBO J (2000) 2.41
Increased expression of TGF-beta 2 in osteoblasts results in an osteoporosis-like phenotype. J Cell Biol (1996) 2.36
Inactivation of the type II receptor reveals two receptor pathways for the diverse TGF-beta activities. Science (1993) 2.35
TGF-beta inhibits muscle differentiation through functional repression of myogenic transcription factors by Smad3. Genes Dev (2001) 2.35
The platelet-derived growth factor-inducible KC gene encodes a secretory protein related to platelet alpha-granule proteins. J Biol Chem (1989) 2.29
Role of the alpha2-integrin in osteoblast-specific gene expression and activation of the Osf2 transcription factor. J Biol Chem (1998) 2.26
Cloning of a type I TGF-beta receptor and its effect on TGF-beta binding to the type II receptor. Science (1993) 2.20
Differential roles for bone morphogenetic protein (BMP) receptor type IB and IA in differentiation and specification of mesenchymal precursor cells to osteoblast and adipocyte lineages. J Cell Biol (1998) 2.17
Genetic ablation of parathyroid glands reveals another source of parathyroid hormone. Nature (2000) 2.13
Two domains unique to osteoblast-specific transcription factor Osf2/Cbfa1 contribute to its transactivation function and its inability to heterodimerize with Cbfbeta. Mol Cell Biol (1998) 2.13
Selective activation of transcription by a novel CCAAT binding factor. Science (1988) 2.12
Cyclosporin increases the rate and length of remissions in insulin-dependent diabetes of recent onset. Results of a multicentre double-blind trial. Lancet (1986) 2.10
Ectodomain shedding of TGF-alpha and other transmembrane proteins is induced by receptor tyrosine kinase activation and MAP kinase signaling cascades. EMBO J (1999) 2.06
Heteromeric and homomeric interactions correlate with signaling activity and functional cooperativity of Smad3 and Smad4/DPC4. Mol Cell Biol (1997) 2.05
Direct transfer of transforming growth factor beta 1 gene into arteries stimulates fibrocellular hyperplasia. Proc Natl Acad Sci U S A (1993) 2.03
Cbfa1 is required for epithelial-mesenchymal interactions regulating tooth development in mice. Development (1999) 2.03
Transforming growth factor-beta activation in irradiated murine mammary gland. J Clin Invest (1994) 2.01
Human transforming growth factor-beta 3: recombinant expression, purification, and biological activities in comparison with transforming growth factors-beta 1 and -beta 2. Mol Endocrinol (1989) 2.00
Serum leptin level is a regulator of bone mass. Proc Natl Acad Sci U S A (2004) 1.99
Roles of autocrine TGF-beta receptor and Smad signaling in adipocyte differentiation. J Cell Biol (2000) 1.94
Cellular interpretation of multiple TGF-beta signals: intracellular antagonism between activin/BVg1 and BMP-2/4 signaling mediated by Smads. Development (1997) 1.91
Effects of MGSA/GRO alpha on melanocyte transformation. Oncogene (1991) 1.88
Regulation of Smad signalling by protein associations and signalling crosstalk. Trends Cell Biol (1999) 1.87
The mouse osteocalcin gene cluster contains three genes with two separate spatial and temporal patterns of expression. J Biol Chem (1994) 1.87
Extracellular matrix regulates expression of the TGF-beta 1 gene. J Cell Biol (1993) 1.84
Genetic control of skeletal development. Curr Opin Genet Dev (2001) 1.79
Developmental expression of transforming growth factors alpha and beta in mouse fetus. Mol Cell Biol (1988) 1.79
Regulation of adipocyte gene expression in differentiation and syndromes of obesity/diabetes. J Biol Chem (1993) 1.78
Cbfa1 contributes to the osteoblast-specific expression of type I collagen genes. J Biol Chem (2000) 1.77
Different transforming growth factor-alpha species are derived from a glycosylated and palmitoylated transmembrane precursor. Cell (1987) 1.76
Complex regulation of transforming growth factor beta 1, beta 2, and beta 3 mRNA expression in mouse fibroblasts and keratinocytes by transforming growth factors beta 1 and beta 2. Mol Cell Biol (1989) 1.76
Fourier transform infrared microspectroscopic analysis of bones of osteocalcin-deficient mice provides insight into the function of osteocalcin. Bone (1998) 1.76
Alpha and beta human transforming growth factors stimulate prostaglandin production and bone resorption in cultured mouse calvaria. Proc Natl Acad Sci U S A (1985) 1.75
Epidermal growth factor and transforming growth factor-alpha: differential intracellular routing and processing of ligand-receptor complexes. Cell Regul (1991) 1.73
CBFA1 mutation analysis and functional correlation with phenotypic variability in cleidocranial dysplasia. Hum Mol Genet (1999) 1.72
Expression of human fibroblast interferon gene in Escherichia coli. Nature (1980) 1.72
Expression and secretion of gro/MGSA by stimulated human endothelial cells. EMBO J (1989) 1.70
Tissue-specific expression of the mouse alpha 2(I) collagen promoter. Studies in transgenic mice and in tissue culture cells. J Biol Chem (1992) 1.69
Inhibition of TGF-beta receptor signaling in osteoblasts leads to decreased bone remodeling and increased trabecular bone mass. Development (1999) 1.69
Human recombinant transforming growth factor alpha stimulates bone resorption and inhibits formation in vitro. Proc Natl Acad Sci U S A (1986) 1.69
Evidence for a unique human fibroblast interferon (IFN-beta 1) chromosomal gene, devoid of intervening sequences. Nucleic Acids Res (1981) 1.67
Determination of type I receptor specificity by the type II receptors for TGF-beta or activin. Science (1993) 1.66
A kinase subdomain of transforming growth factor-beta (TGF-beta) type I receptor determines the TGF-beta intracellular signaling specificity. EMBO J (1997) 1.65
Transforming growth factor-beta (TGF-beta)-induced down-regulation of cyclin A expression requires a functional TGF-beta receptor complex. Characterization of chimeric and truncated type I and type II receptors. J Biol Chem (1995) 1.64
Functional hierarchy between two OSE2 elements in the control of osteocalcin gene expression in vivo. J Biol Chem (1998) 1.63
Dissociation between bone resorption and bone formation in osteopenic transgenic mice. Proc Natl Acad Sci U S A (1998) 1.63
Molecular mechanisms of nucleotide-sequence rearrangements in cDNA clones of human fibroblast interferon mRNA. Gene (1981) 1.60
Epidermal growth factor receptor function is necessary for normal craniofacial development and palate closure. Nat Genet (1999) 1.60
Ascorbic acid-dependent activation of the osteocalcin promoter in MC3T3-E1 preosteoblasts: requirement for collagen matrix synthesis and the presence of an intact OSE2 sequence. Mol Endocrinol (1997) 1.58