Published in RNA on September 01, 1998
Crystal structure of the two-RRM domain of hnRNP A1 (UP1) complexed with single-stranded telomeric DNA. Genes Dev (1999) 3.08
Genome analysis: RNA recognition motif (RRM) and K homology (KH) domain RNA-binding proteins from the flowering plant Arabidopsis thaliana. Nucleic Acids Res (2002) 2.44
Selection of alternative 5' splice sites: role of U1 snRNP and models for the antagonistic effects of SF2/ASF and hnRNP A1. Mol Cell Biol (2000) 2.22
Characterization of dFMR1, a Drosophila melanogaster homolog of the fragile X mental retardation protein. Mol Cell Biol (2000) 2.18
Substrate specificities of SR proteins in constitutive splicing are determined by their RNA recognition motifs and composite pre-mRNA exonic elements. Mol Cell Biol (1999) 2.05
Rna15 interaction with the A-rich yeast polyadenylation signal is an essential step in mRNA 3'-end formation. Mol Cell Biol (2001) 1.82
hnRNP H and hnRNP F complex with Fox2 to silence fibroblast growth factor receptor 2 exon IIIc. Mol Cell Biol (2008) 1.60
Position-dependent splicing activation and repression by SR and hnRNP proteins rely on common mechanisms. RNA (2012) 1.28
hnRNP A1: the Swiss army knife of gene expression. Int J Mol Sci (2013) 1.19
Role of SR protein modular domains in alternative splicing specificity in vivo. Nucleic Acids Res (2000) 1.05
Function of RRM domains of Drosophila melanogaster ELAV: Rnp1 mutations and rrm domain replacements with ELAV family proteins and SXL. Genetics (2000) 0.98
Separable roles in vivo for the two RNA binding domains of Drosophila A1-hnRNP homolog. RNA (1998) 0.97
Solution structure of the two RNA recognition motifs of hnRNP A1 using segmental isotope labeling: how the relative orientation between RRMs influences the nucleic acid binding topology. J Biomol NMR (2012) 0.97
Correlated alternative side chain conformations in the RNA-recognition motif of heterogeneous nuclear ribonucleoprotein A1. Nucleic Acids Res (2002) 0.93
Genetic analysis of functional domains within the Drosophila LARK RNA-binding protein. Genetics (2001) 0.90
High-affinity interaction of hnRNP A1 with conserved RNA structural elements is required for translation and replication of enterovirus 71. RNA Biol (2013) 0.86
The First Crystal Structure of the UP1 Domain of hnRNP A1 Bound to RNA Reveals a New Look for an Old RNA Binding Protein. J Mol Biol (2015) 0.81
Norovirus genome circularization and efficient replication are facilitated by binding of PCBP2 and hnRNP A1. J Virol (2013) 0.78
A truncated hnRNP A1 isoform, lacking the RGG-box RNA binding domain, can efficiently regulate HIV-1 splicing and replication. Biochim Biophys Acta (2014) 0.77
Molecular phylogenetics and functional evolution of major RNA recognition domains of recently cloned and characterized autoimmune RNA-binding particle. Genomics Proteomics Bioinformatics (2003) 0.75
Basic local alignment search tool. J Mol Biol (1990) 659.07
The neighbor-joining method: a new method for reconstructing phylogenetic trees. Mol Biol Evol (1987) 266.90
hnRNP proteins and the biogenesis of mRNA. Annu Rev Biochem (1993) 11.44
Mechanical devices of the spliceosome: motors, clocks, springs, and things. Cell (1998) 10.95
RNA recognition: towards identifying determinants of specificity. Trends Biochem Sci (1991) 9.03
RNA-binding proteins as developmental regulators. Genes Dev (1989) 8.78
Shuttling of pre-mRNA binding proteins between nucleus and cytoplasm. Nature (1992) 8.45
Regulation of alternative pre-mRNA splicing by hnRNP A1 and splicing factor SF2. Cell (1992) 7.90
Crystal structure of the RNA-binding domain of the U1 small nuclear ribonucleoprotein A. Nature (1990) 7.32
Regulation of alternative splicing in vivo by overexpression of antagonistic splicing factors. Science (1994) 7.09
Cloning and domain structure of the mammalian splicing factor U2AF. Nature (1992) 6.55
A role for exon sequences and splice-site proximity in splice-site selection. Cell (1986) 6.41
A nuclear export signal in hnRNP A1: a signal-mediated, temperature-dependent nuclear protein export pathway. Cell (1995) 6.19
RNA binding specificity of hnRNP A1: significance of hnRNP A1 high-affinity binding sites in pre-mRNA splicing. EMBO J (1994) 6.17
Analysis of the RNA-recognition motif and RS and RGG domains: conservation in metazoan pre-mRNA splicing factors. Nucleic Acids Res (1993) 6.15
A novel receptor-mediated nuclear protein import pathway. Cell (1996) 6.04
A protein factor, ASF, controls cell-specific alternative splicing of SV40 early pre-mRNA in vitro. Cell (1990) 5.92
The essential pre-mRNA splicing factor SF2 influences 5' splice site selection by activating proximal sites. Cell (1990) 5.67
Primary structure and binding activity of the hnRNP U protein: binding RNA through RGG box. EMBO J (1992) 4.73
A nuclear localization domain in the hnRNP A1 protein. J Cell Biol (1995) 4.51
General splicing factors SF2 and SC35 have equivalent activities in vitro, and both affect alternative 5' and 3' splice site selection. Proc Natl Acad Sci U S A (1992) 3.97
The multiple RNA-binding domains of the mRNA poly(A)-binding protein have different RNA-binding activities. Mol Cell Biol (1991) 3.57
Identification and characterization of three members of the human SR family of pre-mRNA splicing factors. EMBO J (1995) 3.56
Functional analysis of pre-mRNA splicing factor SF2/ASF structural domains. EMBO J (1993) 3.51
Function of conserved domains of hnRNP A1 and other hnRNP A/B proteins. EMBO J (1994) 3.35
Phenylalanines that are conserved among several RNA-binding proteins form part of a nucleic acid-binding pocket in the A1 heterogeneous nuclear ribonucleoprotein. J Biol Chem (1988) 3.16
Modulation of exon skipping and inclusion by heterogeneous nuclear ribonucleoprotein A1 and pre-mRNA splicing factor SF2/ASF. Mol Cell Biol (1993) 3.16
Targeted disruption of an essential vertebrate gene: ASF/SF2 is required for cell viability. Genes Dev (1996) 2.99
The A1 and A1B proteins of heterogeneous nuclear ribonucleoparticles modulate 5' splice site selection in vivo. Proc Natl Acad Sci U S A (1994) 2.92
Mammalian heterogeneous nuclear ribonucleoprotein complex protein A1. Large-scale overproduction in Escherichia coli and cooperative binding to single-stranded nucleic acids. J Biol Chem (1988) 2.88
Functional domains of the human splicing factor ASF/SF2. EMBO J (1993) 2.83
RNA annealing activities in HeLa nuclei. EMBO J (1994) 2.35
Xenopus poly(A) binding protein: functional domains in RNA binding and protein-protein interaction. J Mol Biol (1996) 2.33
Renaturation of complementary DNA strands mediated by purified mammalian heterogeneous nuclear ribonucleoprotein A1 protein: implications for a mechanism for rapid molecular assembly. Proc Natl Acad Sci U S A (1990) 2.31
Nucleo-cytoplasmic distribution of human hnRNP proteins: a search for the targeting domains in hnRNP A1. J Cell Sci (1995) 2.27
Characterization of the major hnRNP proteins from Drosophila melanogaster. J Cell Biol (1992) 2.08
Heterogeneous nuclear ribonucleoprotein A1 catalyzes RNA.RNA annealing. Proc Natl Acad Sci U S A (1992) 2.05
Differential effects of aromatic and charged residue substitutions in the RNA binding domains of the yeast poly(A)-binding protein. J Mol Biol (1997) 2.03
Studies of the strand-annealing activity of mammalian hnRNP complex protein A1. Biochemistry (1990) 1.82
Multiple RNA binding domains (RBDs) just don't add up. Nucleic Acids Res (1995) 1.73
Crystal structure of the two RNA binding domains of human hnRNP A1 at 1.75 A resolution. Nat Struct Biol (1997) 1.61
Purification and cDNA cloning of HeLa cell p54nrb, a nuclear protein with two RNA recognition motifs and extensive homology to human splicing factor PSF and Drosophila NONA/BJ6. Nucleic Acids Res (1993) 1.57
Crystal structure of human UP1, the domain of hnRNP A1 that contains two RNA-recognition motifs. Structure (1997) 1.40
Altered levels of the Drosophila HRB87F/hrp36 hnRNP protein have limited effects on alternative splicing in vivo. Mol Biol Cell (1996) 1.26
Isolation and characterization of a novel, low abundance hnRNP protein: A0. RNA (1995) 1.25
Exon skipping by overexpression of a Drosophila heterogeneous nuclear ribonucleoprotein in vivo. Proc Natl Acad Sci U S A (1995) 1.05
Domains required for nucleic acid binding activities in chloroplast ribonucleoproteins. Nucleic Acids Res (1992) 0.98
cDNA cloning of a novel heterogeneous nuclear ribonucleoprotein gene homologue in Caenorhabditis elegans using hamster prion protein cDNA as a hybridization probe. Nucleic Acids Res (1992) 0.82
cDNA cloning of a hnRNP A1 isoform and its regulation by retinol in monkey tracheobronchial epithelial cells. Biochim Biophys Acta (1993) 0.76
Normal and mutant human beta-globin pre-mRNAs are faithfully and efficiently spliced in vitro. Cell (1984) 12.30
Excision of an intact intron as a novel lariat structure during pre-mRNA splicing in vitro. Cell (1984) 9.13
Regulation of alternative pre-mRNA splicing by hnRNP A1 and splicing factor SF2. Cell (1992) 7.90
Regulation of alternative splicing in vivo by overexpression of antagonistic splicing factors. Science (1994) 7.09
Multiple factors including the small nuclear ribonucleoproteins U1 and U2 are necessary for pre-mRNA splicing in vitro. Cell (1985) 6.85
Analysis of the RNA-recognition motif and RS and RGG domains: conservation in metazoan pre-mRNA splicing factors. Nucleic Acids Res (1993) 6.15
Identification of functional exonic splicing enhancer motifs recognized by individual SR proteins. Genes Dev (1998) 5.79
A mechanism for exon skipping caused by nonsense or missense mutations in BRCA1 and other genes. Nat Genet (2001) 5.02
AT-AC pre-mRNA splicing mechanisms and conservation of minor introns in voltage-gated ion channel genes. Mol Cell Biol (1999) 4.87
Pre-mRNA splicing in the new millennium. Curr Opin Cell Biol (2001) 4.64
General splicing factor SF2/ASF promotes alternative splicing by binding to an exonic splicing enhancer. Genes Dev (1993) 4.40
A specific subset of SR proteins shuttles continuously between the nucleus and the cytoplasm. Genes Dev (1998) 4.19
Regulated tissue-specific expression of antagonistic pre-mRNA splicing factors. RNA (1998) 4.05
General splicing factors SF2 and SC35 have equivalent activities in vitro, and both affect alternative 5' and 3' splice site selection. Proc Natl Acad Sci U S A (1992) 3.97
Role of the modular domains of SR proteins in subnuclear localization and alternative splicing specificity. J Cell Biol (1997) 3.95
Crystal structure of a SIR2 homolog-NAD complex. Cell (2001) 3.57
Identification and characterization of three members of the human SR family of pre-mRNA splicing factors. EMBO J (1995) 3.56
Functional analysis of pre-mRNA splicing factor SF2/ASF structural domains. EMBO J (1993) 3.51
A double-hexamer archaeal minichromosome maintenance protein is an ATP-dependent DNA helicase. Proc Natl Acad Sci U S A (2000) 3.35
Function of conserved domains of hnRNP A1 and other hnRNP A/B proteins. EMBO J (1994) 3.35
Exon identity established through differential antagonism between exonic splicing silencer-bound hnRNP A1 and enhancer-bound SR proteins. Mol Cell (2001) 3.34
The MKK(3/6)-p38-signaling cascade alters the subcellular distribution of hnRNP A1 and modulates alternative splicing regulation. J Cell Biol (2000) 3.34
Modulation of exon skipping and inclusion by heterogeneous nuclear ribonucleoprotein A1 and pre-mRNA splicing factor SF2/ASF. Mol Cell Biol (1993) 3.16
Pathways for selection of 5' splice sites by U1 snRNPs and SF2/ASF. EMBO J (1993) 3.11
Crystal structure of the two-RRM domain of hnRNP A1 (UP1) complexed with single-stranded telomeric DNA. Genes Dev (1999) 3.08
hnRNP A/B proteins are required for inhibition of HIV-1 pre-mRNA splicing. EMBO J (1999) 3.04
Exonic splicing enhancer motif recognized by human SC35 under splicing conditions. Mol Cell Biol (2000) 3.01
Two members of a conserved family of nuclear phosphoproteins are involved in pre-mRNA splicing. Proc Natl Acad Sci U S A (1992) 2.66
Serine phosphorylation of SR proteins is required for their recruitment to sites of transcription in vivo. J Cell Biol (1998) 2.60
Mechanisms for selecting 5' splice sites in mammalian pre-mRNA splicing. Trends Genet (1994) 2.54
Selection of alternative 5' splice sites: role of U1 snRNP and models for the antagonistic effects of SF2/ASF and hnRNP A1. Mol Cell Biol (2000) 2.22
Purification and characterization of human RNPS1: a general activator of pre-mRNA splicing. EMBO J (1999) 2.20
Disruption of pre-mRNA splicing in vivo results in reorganization of splicing factors. J Cell Biol (1994) 2.12
Substrate specificities of SR proteins in constitutive splicing are determined by their RNA recognition motifs and composite pre-mRNA exonic elements. Mol Cell Biol (1999) 2.05
Preparation of HeLa cell nuclear and cytosolic S100 extracts for in vitro splicing. Methods Mol Biol (1999) 2.02
The subcellular localization of SF2/ASF is regulated by direct interaction with SR protein kinases (SRPKs). J Biol Chem (1999) 1.90
Crystal structure of human p32, a doughnut-shaped acidic mitochondrial matrix protein. Proc Natl Acad Sci U S A (1999) 1.86
atSRp30, one of two SF2/ASF-like proteins from Arabidopsis thaliana, regulates splicing of specific plant genes. Genes Dev (1999) 1.82
Post-transcriptional regulation of thyroid hormone receptor expression by cis-acting sequences and a naturally occurring antisense RNA. J Biol Chem (2000) 1.77
U1-mediated exon definition interactions between AT-AC and GT-AG introns. Science (1996) 1.74
RNA splicing specificity determined by the coordinated action of RNA recognition motifs in SR proteins. Proc Natl Acad Sci U S A (1997) 1.72
Pre-mRNA splicing in the absence of an SR protein RS domain. Genes Dev (2000) 1.58
Purification and cDNA cloning of HeLa cell p54nrb, a nuclear protein with two RNA recognition motifs and extensive homology to human splicing factor PSF and Drosophila NONA/BJ6. Nucleic Acids Res (1993) 1.57
Mammalian in vitro splicing assays. Methods Mol Biol (1999) 1.57
A purine-rich intronic element enhances alternative splicing of thyroid hormone receptor mRNA. RNA (2001) 1.55
Expression of the thyroid hormone receptor gene, erbAalpha, in B lymphocytes: alternative mRNA processing is independent of differentiation but correlates with antisense RNA levels. Nucleic Acids Res (1997) 1.55
The type 2C Ser/Thr phosphatase PP2Cgamma is a pre-mRNA splicing factor. Genes Dev (1999) 1.49
A new cyclophilin and the human homologues of yeast Prp3 and Prp4 form a complex associated with U4/U6 snRNPs. RNA (1997) 1.43
Functions of SR proteins in the U12-dependent AT-AC pre-mRNA splicing pathway. RNA (2001) 1.42
RNA splicing at human immunodeficiency virus type 1 3' splice site A2 is regulated by binding of hnRNP A/B proteins to an exonic splicing silencer element. J Virol (2001) 1.41
The intracisternal A-particle proximal enhancer-binding protein activates transcription and is identical to the RNA- and DNA-binding protein p54nrb/NonO. Mol Cell Biol (1997) 1.41
Independent deposition of heterogeneous nuclear ribonucleoproteins and small nuclear ribonucleoprotein particles at sites of transcription. Proc Natl Acad Sci U S A (1992) 1.40
Crystal structure of human UP1, the domain of hnRNP A1 that contains two RNA-recognition motifs. Structure (1997) 1.40
A human protein required for the second step of pre-mRNA splicing is functionally related to a yeast splicing factor. Genes Dev (1997) 1.36
The adenovirus E4-ORF4 splicing enhancer protein interacts with a subset of phosphorylated SR proteins. EMBO J (2001) 1.36
Splicing of a divergent subclass of AT-AC introns requires the major spliceosomal snRNAs. RNA (1997) 1.27
Pre-mRNA splicing in plants: characterization of Ser/Arg splicing factors. Proc Natl Acad Sci U S A (1996) 1.26
The C-protein tetramer binds 230 to 240 nucleotides of pre-mRNA and nucleates the assembly of 40S heterogeneous nuclear ribonucleoprotein particles. Mol Cell Biol (1994) 1.25
Evidence for the function of an exonic splicing enhancer after the first catalytic step of pre-mRNA splicing. Proc Natl Acad Sci U S A (1999) 1.23
Extensive in silico analysis of NF1 splicing defects uncovers determinants for splicing outcome upon 5' splice-site disruption. Hum Mutat (2007) 1.17
NIPP1-mediated interaction of protein phosphatase-1 with CDC5L, a regulator of pre-mRNA splicing and mitotic entry. J Biol Chem (2000) 1.15
Evidence that Myb-related CDC5 proteins are required for pre-mRNA splicing. Proc Natl Acad Sci U S A (1999) 1.14
The U6 small nuclear RNA from Trypanosoma brucei. Nucleic Acids Res (1988) 1.14
Human p32: a coactivator for Epstein-Barr virus nuclear antigen-1-mediated transcriptional activation and possible role in viral latent cycle DNA replication. Virology (2000) 1.10
Purine-rich enhancers function in the AT-AC pre-mRNA splicing pathway and do so independently of intact U1 snRNP. RNA (1998) 1.05
Splice site consensus sequences are preferentially accessible to nucleases in isolated adenovirus RNA. Nucleic Acids Res (1986) 1.02
Secondary structure of splice sites in adenovirus mRNA precursors. Nucleic Acids Res (1984) 0.96
Characterization of a SR protein from Trypanosoma brucei with homology to RNA-binding cis-splicing proteins. Mol Biochem Parasitol (1999) 0.95
Optical studies of complexes of quinacrine with DNA and chromatin: implications for the fluorescence of cytological chromosome preparations. Chromosoma (1974) 0.95
Multiple splicing factors are released from endogenous complexes during in vitro pre-mRNA splicing. Mol Cell Biol (1989) 0.94
Ribonucleoprotein organization of eukaryotic RNA. XV. Different nucleoprotein structures of globin messenger RNA sequences in nuclear and polyribosomal ribonucleoprotein particles. J Mol Biol (1981) 0.94
Messenger RNA sequences in nuclear ribonucleoprotein particles are complexed with protein as shown by nuclease protection. J Mol Biol (1981) 0.92
A large inverted repeat sequence overlaps two acceptor splice sites in adenovirus. Nucleic Acids Res (1983) 0.92
Crystal structure of the functional domain of the splicing factor Prp18. Proc Natl Acad Sci U S A (2000) 0.92
Spatio-temporal expression of the trans-acting splicing factors SF2/ASF and heterogeneous ribonuclear proteins A1/A1B in the myometrium of the pregnant human uterus: a molecular mechanism for regulating regional protein isoform expression in vivo. J Clin Endocrinol Metab (2000) 0.89
A putative homolog of U2AF65 in S. cerevisiae. Nucleic Acids Res (1992) 0.88
[Characteristics of CO2 expiration of skin on limb segment of large intestine and stomach meridian]. Zhongguo Zhong Xi Yi Jie He Za Zhi (1995) 0.88
Evaluation of porous biphasic calcium phosphate ceramics for anterior cervical interbody fusion in a caprine model. Spine (Phila Pa 1976) (1995) 0.88
Ribonucleoprotein structure of adenovirus nuclear RNA probed by nuclease digestion. J Mol Biol (1982) 0.85
Mapping the SF2/ASF binding sites in the bovine growth hormone exonic splicing enhancer. J Biol Chem (2000) 0.84
Control of Aedes aegypti larvae in household water containers by Chinese cat fish. Bull World Health Organ (1987) 0.83
Crystallization and preliminary X-ray diffraction studies of UP1, the two-RRM domain of hnRNP A1. Acta Crystallogr D Biol Crystallogr (1997) 0.81
[Morphological study on the low impedance line along channels]. Zhen Ci Yan Jiu (1987) 0.81
RCC1 and nuclear organization. Mol Biol Cell (1997) 0.79
Comparison of the subunit organization of early and late replicating chromatin. Exp Cell Res (1977) 0.78
Non-radioactive detection of m3G capped RNAs by immunoblotting. Nucleic Acids Res (1994) 0.75
[Antiulcer effect of polycyclicamine compound HH01 on experimental gastric ulcer in rats]. Yao Xue Xue Bao (1995) 0.75
[Protection of dl-(15R)-15 methyl-PGE2 methyl ester (PG6E) on experimental ulcers in rats]. Yao Xue Xue Bao (1996) 0.75
[Use of high-field nulear magnetic resonance spectroscopy for the analysis of stereoselective metabolites of ibuprofen (R)-enantiomer in rat urine]. Yao Xue Xue Bao (2000) 0.75
[Preliminary report on approaches of the essence of meridian sound]. Zhen Ci Yan Jiu (1988) 0.75
[A preliminary report on the low impedance nature of the epidermis of the line of latent propagating sensation along the channel]. Zhen Ci Yan Jiu (1986) 0.75
Long-term storage of concentrated tris-borate-EDTA electrophoresis buffers without precipitation. Biotechniques (1991) 0.75
A putative homology of U2AF65 in S. cerevisiae. Nucleic Acids Res (1993) 0.75
Two new species of Tabanus from Hubei, China (Diptera: Tabanidae). Acta Acad Med Wuhan (1984) 0.75