Published in Science on July 06, 2001
DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA. Nature (2007) 11.14
Aberrant silencing of imprinted genes on chromosome 12qF1 in mouse induced pluripotent stem cells. Nature (2010) 7.05
Pluripotency and cellular reprogramming: facts, hypotheses, unresolved issues. Cell (2010) 5.13
The promise of induced pluripotent stem cells in research and therapy. Nature (2012) 5.05
A maternal-zygotic effect gene, Zfp57, maintains both maternal and paternal imprints. Dev Cell (2008) 4.80
Association of in vitro fertilization with Beckwith-Wiedemann syndrome and epigenetic alterations of LIT1 and H19. Am J Hum Genet (2002) 3.93
Oct4 distribution and level in mouse clones: consequences for pluripotency. Genes Dev (2002) 3.52
Conservation of methylation reprogramming in mammalian development: aberrant reprogramming in cloned embryos. Proc Natl Acad Sci U S A (2001) 3.25
Reprogramming efficiency following somatic cell nuclear transfer is influenced by the differentiation and methylation state of the donor nucleus. Stem Cells (2006) 3.07
Naive pluripotency is associated with global DNA hypomethylation. Nat Struct Mol Biol (2013) 2.49
Disruption of the imprinted Grb10 gene leads to disproportionate overgrowth by an Igf2-independent mechanism. Proc Natl Acad Sci U S A (2003) 2.48
Deconstructing stem cell tumorigenicity: a roadmap to safe regenerative medicine. Stem Cells (2009) 2.48
In vitro fertilization may increase the risk of Beckwith-Wiedemann syndrome related to the abnormal imprinting of the KCN1OT gene. Am J Hum Genet (2003) 2.21
Embryonic stem cells and somatic cells differ in mutation frequency and type. Proc Natl Acad Sci U S A (2002) 2.17
A DNA methylation fingerprint of 1628 human samples. Genome Res (2011) 2.16
ES cells derived from cloned and fertilized blastocysts are transcriptionally and functionally indistinguishable. Proc Natl Acad Sci U S A (2006) 2.16
Abnormal gene expression in cloned mice derived from embryonic stem cell and cumulus cell nuclei. Proc Natl Acad Sci U S A (2002) 2.05
Zinc finger protein ZFP57 requires its co-factor to recruit DNA methyltransferases and maintains DNA methylation imprint in embryonic stem cells via its transcriptional repression domain. J Biol Chem (2011) 1.88
The dynamic DNA methylomes of double-stranded DNA viruses associated with human cancer. Genome Res (2009) 1.87
Placental overgrowth in mice lacking the imprinted gene Ipl. Proc Natl Acad Sci U S A (2002) 1.67
X-inactivation reveals epigenetic anomalies in most hESC but identifies sublines that initiate as expected. J Cell Physiol (2008) 1.59
Assessing self-renewal and differentiation in human embryonic stem cell lines. Stem Cells (2005) 1.58
A comparative analysis of DNA methylation across human embryonic stem cell lines. Genome Biol (2011) 1.52
Checkpoint-apoptosis uncoupling in human and mouse embryonic stem cells: a source of karyotpic instability. Blood (2007) 1.48
Analysis and accurate quantification of CpG methylation by MALDI mass spectrometry. Nucleic Acids Res (2003) 1.46
Gene-specific vulnerability to imprinting variability in human embryonic stem cell lines. Genome Res (2007) 1.41
The first half-century of nuclear transplantation. Proc Natl Acad Sci U S A (2003) 1.37
An epigenetic perspective on the free radical theory of development. Free Radic Biol Med (2007) 1.35
DNA methylation and healthy human aging. Aging Cell (2015) 1.27
Generation of haploid embryonic stem cells from Macaca fascicularis monkey parthenotes. Cell Res (2013) 1.24
Genomic imprinting in development, growth, behavior and stem cells. Development (2014) 1.23
Pax3-FKHR knock-in mice show developmental aberrations but do not develop tumors. Mol Cell Biol (2002) 1.20
Hematopoietic reconstitution with androgenetic and gynogenetic stem cells. Genes Dev (2007) 1.19
Dynamic instability of genomic methylation patterns in pluripotent stem cells. Epigenetics Chromatin (2010) 1.15
Histone H3 trimethylation at lysine 36 is associated with constitutive and facultative heterochromatin. Genome Res (2011) 1.13
From intestine to muscle: nuclear reprogramming through defective cloned embryos. Proc Natl Acad Sci U S A (2002) 1.11
The planarian flatworm: an in vivo model for stem cell biology and nervous system regeneration. Dis Model Mech (2010) 1.09
A comparison of genetically matched cell lines reveals the equivalence of human iPSCs and ESCs. Nat Biotechnol (2015) 1.09
Primordial germ cell specification from embryonic stem cells. PLoS One (2008) 1.09
Parthenogenetic dopamine neurons from primate embryonic stem cells restore function in experimental Parkinson's disease. Brain (2008) 1.06
Monoallelic expression and methylation of imprinted genes in human and mouse embryonic germ cell lineages. Proc Natl Acad Sci U S A (2002) 1.05
The genomically mosaic brain: aneuploidy and more in neural diversity and disease. Semin Cell Dev Biol (2013) 1.05
Limited demethylation leaves mosaic-type methylation states in cloned bovine pre-implantation embryos. EMBO J (2002) 1.05
The maternal to zygotic transition in mammals. Mol Aspects Med (2013) 1.05
Heterozygous embryonic stem cell lines derived from nonhuman primate parthenotes. Stem Cells (2008) 1.02
The dynamics of DNA methylation fidelity during mouse embryonic stem cell self-renewal and differentiation. Genome Res (2014) 1.00
A high-throughput DNA methylation analysis of a single cell. Nucleic Acids Res (2011) 1.00
Regenerant Arabidopsis lineages display a distinct genome-wide spectrum of mutations conferring variant phenotypes. Curr Biol (2011) 0.98
Epigenetic regulation of mesenchymal stem cells: a focus on osteogenic and adipogenic differentiation. Stem Cells Int (2011) 0.96
Hierarchical phenotypic and epigenetic variation in cloned swine. Biol Reprod (2003) 0.95
Germline competence of mouse ES and iPS cell lines: Chimera technologies and genetic background. World J Stem Cells (2009) 0.95
Cloning of non-human primates: the road "less traveled by". Int J Dev Biol (2010) 0.93
Cloning animals by somatic cell nuclear transfer--biological factors. Reprod Biol Endocrinol (2003) 0.93
Meat and milk compositions of bovine clones. Proc Natl Acad Sci U S A (2005) 0.93
Nuclear reprogramming in mammalian somatic cell nuclear cloning. Cytogenet Genome Res (2004) 0.92
Gonadotropin stimulation contributes to an increased incidence of epimutations in ICSI-derived mice. Hum Mol Genet (2012) 0.90
Transient in vitro epigenetic reprogramming of skin fibroblasts into multipotent cells. Biomaterials (2009) 0.90
In vitro culture and somatic cell nuclear transfer affect imprinting of SNRPN gene in pre- and post-implantation stages of development in cattle. BMC Dev Biol (2009) 0.89
Germline competency of parthenogenetic embryonic stem cells from immature oocytes of adult mouse ovary. Hum Mol Genet (2011) 0.89
Influence of in vitro manipulation on the stability of methylation patterns in the Snurf/Snrpn-imprinting region in mouse embryonic stem cells. Nucleic Acids Res (2004) 0.88
Hybrid embryonic stem cell-derived tetraploid mice show apparently normal morphological, physiological, and neurological characteristics. Mol Cell Biol (2003) 0.88
Comprehensive assessment of milk composition in transgenic cloned cattle. PLoS One (2012) 0.88
Regulatory issues for personalized pluripotent cells. Stem Cells (2008) 0.87
A mammal-specific exon of WT1 is not required for development or fertility. Mol Cell Biol (2002) 0.87
Differentiation of an embryonic stem cell to hemogenic endothelium by defined factors: essential role of bone morphogenetic protein 4. Development (2011) 0.87
MERVL/Zscan4 Network Activation Results in Transient Genome-wide DNA Demethylation of mESCs. Cell Rep (2016) 0.86
Centromere protein A dynamics in human pluripotent stem cell self-renewal, differentiation and DNA damage. Hum Mol Genet (2010) 0.86
Nuclear transfer in rodents. J Physiol (2004) 0.86
Familial molar tissues due to mutations in the inflammatory gene, NALP7, have normal postzygotic DNA methylation. Hum Genet (2006) 0.86
Myogenic Differentiation of Mouse Embryonic Stem Cells That Lack a Functional Pax7 Gene. Stem Cells Dev (2016) 0.86
Generating pluripotent stem cells: differential epigenetic changes during cellular reprogramming. FEBS Lett (2012) 0.86
Imprinted gene expression, transplantation medicine, and the "other" human embryonic stem cell. Proc Natl Acad Sci U S A (2002) 0.85
Correlation of developmental differences of nuclear transfer embryos cells to the methylation profiles of nuclear transfer donor cells in Swine. Epigenetics (2007) 0.85
Epigenetic memory in the context of nuclear reprogramming and cancer. Brief Funct Genomics (2013) 0.84
Functional neuronal cells generated by human parthenogenetic stem cells. PLoS One (2012) 0.83
Reshaping the transcriptional frontier: epigenetics and somatic cell nuclear transfer. Mol Reprod Dev (2013) 0.82
Dynamic expression patterns of imprinted genes in human embryonic stem cells following prolonged passaging and differentiation. J Assist Reprod Genet (2010) 0.81
Altered gene expression profiles in the brain, kidney, and lung of deceased neonatal cloned pigs. Cell Reprogram (2010) 0.81
Altered gene expression profiles in the brain, kidney, and lung of one-month-old cloned pigs. Cell Reprogram (2011) 0.80
Generation of mice derived from induced pluripotent stem cells. J Vis Exp (2012) 0.80
Age-associated telomere shortening in mouse oocytes. Reprod Biol Endocrinol (2013) 0.80
Imprinted genes and satellite loci are differentially methylated in bovine somatic cell nuclear transfer clones. Cell Reprogram (2013) 0.80
A potential use of embryonic stem cell medium for the in vitro culture of preimplantation embryos. J Assist Reprod Genet (2011) 0.80
Nuclear transfer: progress and quandaries. Reprod Biol Endocrinol (2003) 0.79
Assessment of difference in gene expression profile between embryos of different derivations. Cell Reprogram (2014) 0.79
Transcriptomic Features of Bovine Blastocysts Derived by Somatic Cell Nuclear Transfer. G3 (Bethesda) (2015) 0.79
Expression of innate immune response genes in liver and three types of adipose tissue in cloned pigs. Cell Reprogram (2012) 0.79
Current progress with primate embryonic stem cells. Curr Stem Cell Res Ther (2006) 0.79
Chromosome instability in mouse embryonic stem cells. Sci Rep (2014) 0.79
Germ cell formation from embryonic stem cells and the use of somatic cell nuclei in oocytes. Ann N Y Acad Sci (2011) 0.78
Early in vitro differentiation of mouse definitive endoderm is not correlated with progressive maturation of nuclear DNA methylation patterns. PLoS One (2011) 0.78
Genomic imprinting is variably lost during reprogramming of mouse iPS cells. Stem Cell Res (2013) 0.78
Landscape of monoallelic DNA accessibility in mouse embryonic stem cells and neural progenitor cells. Nat Genet (2017) 0.78
Regulation of Pluripotency-related Genes and Differentiation in Mouse Embryonic Stem Cells by Direct Delivery of Cell-penetrating Peptide-conjugated CARM1 Recombinant Protein. Balsaenggwa Saengsig (2013) 0.77
Genomic imprinting effects on complex traits in domesticated animal species. Front Genet (2015) 0.77
Histone modification of embryonic stem cells produced by somatic cell nuclear transfer and fertilized blastocysts. Cell J (2013) 0.77
Post-death cloning of endangered Jeju black cattle (Korean native cattle): fertility and serum chemistry in a cloned bull and cow and their offspring. J Reprod Dev (2013) 0.77
Mammalian-specific genomic functions: Newly acquired traits generated by genomic imprinting and LTR retrotransposon-derived genes in mammals. Proc Jpn Acad Ser B Phys Biol Sci (2015) 0.77
An epigenetic aberration increased in intergenic regions of cloned mice. Mamm Genome (2008) 0.77
A background to nuclear transfer and its applications in agriculture and human therapeutic medicine. J Anat (2002) 0.77
Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell (1992) 27.80
Epigenetic memory in induced pluripotent stem cells. Nature (2010) 14.31
Role for DNA methylation in genomic imprinting. Nature (1993) 12.65
Simplified mammalian DNA isolation procedure. Nucleic Acids Res (1991) 12.56
A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival. Immunity (2001) 9.45
Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice. Nat Genet (2001) 8.64
Beta 2-microglobulin deficient mice lack CD4-8+ cytolytic T cells. Nature (1990) 8.57
Full-term development of mice from enucleated oocytes injected with cumulus cell nuclei. Nature (1998) 8.42
Non-CpG methylation is prevalent in embryonic stem cells and may be mediated by DNA methyltransferase 3a. Proc Natl Acad Sci U S A (2000) 8.12
De novo DNA cytosine methyltransferase activities in mouse embryonic stem cells. Development (1996) 7.98
Mutations in T-cell antigen receptor genes alpha and beta block thymocyte development at different stages. Nature (1992) 7.66
MyoD or Myf-5 is required for the formation of skeletal muscle. Cell (1993) 7.14
WT-1 is required for early kidney development. Cell (1993) 7.05
Loss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulation. Nat Genet (2001) 6.92
Inactivation of MyoD in mice leads to up-regulation of the myogenic HLH gene Myf-5 and results in apparently normal muscle development. Cell (1992) 5.98
Hybrid vigor, fetal overgrowth, and viability of mice derived by nuclear cloning and tetraploid embryo complementation. Proc Natl Acad Sci U S A (2001) 5.76
Xist-deficient mice are defective in dosage compensation but not spermatogenesis. Genes Dev (1997) 4.90
Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor. Cell (1995) 4.73
Vascular tumors in livers with targeted inactivation of the von Hippel-Lindau tumor suppressor. Proc Natl Acad Sci U S A (2001) 4.60
Clearance of influenza virus respiratory infection in mice lacking class I major histocompatibility complex-restricted CD8+ T cells. J Exp Med (1991) 4.49
Germ-line transmission of a disrupted beta 2-microglobulin gene produced by homologous recombination in embryonic stem cells. Nature (1989) 4.46
Chromosomal position and activation of retroviral genomes inserted into the germ line of mice. Cell (1981) 4.42
De novo methylation and expression of retroviral genomes during mouse embryogenesis. Nature (1982) 4.42
Replicating SV40 molecules containing closed circular template DNA strands. Nat New Biol (1971) 4.36
Conditional deletion of brain-derived neurotrophic factor in the postnatal brain leads to obesity and hyperactivity. Mol Endocrinol (2001) 4.34
Chromosomal position or virus mutation permits retrovirus expression in embryonal carcinoma cells. Cell (1986) 4.32
A shift from reversible to irreversible X inactivation is triggered during ES cell differentiation. Mol Cell (2000) 4.26
Alpha 3 beta 1 integrin has a crucial role in kidney and lung organogenesis. Development (1996) 4.20
Suppression of intestinal neoplasia by DNA hypomethylation. Cell (1995) 4.16
Embryonic lethal mutation in mice induced by retrovirus insertion into the alpha 1(I) collagen gene. Nature (1983) 4.14
Germ line integration and Mendelian transmission of the exogenous Moloney leukemia virus. Proc Natl Acad Sci U S A (1976) 4.07
MHC class I deficiency: susceptibility to natural killer (NK) cells and impaired NK activity. Science (1991) 3.93
Targeted mutation of the gene encoding the low affinity NGF receptor p75 leads to deficits in the peripheral sensory nervous system. Cell (1992) 3.91
Nuclear cloning and epigenetic reprogramming of the genome. Science (2001) 3.79
De novo methylation, expression, and infectivity of retroviral genomes introduced into embryonal carcinoma cells. Proc Natl Acad Sci U S A (1982) 3.77
ES cells do not activate p53-dependent stress responses and undergo p53-independent apoptosis in response to DNA damage. Curr Biol (1998) 3.77
DNA methylation and gene expression: endogenous retroviral genome becomes infectious after molecular cloning. Proc Natl Acad Sci U S A (1981) 3.70
Targeted inactivation of the muscle regulatory gene Myf-5 results in abnormal rib development and perinatal death. Cell (1992) 3.65
Mice lacking brain-derived neurotrophic factor develop with sensory deficits. Nature (1994) 3.64
DNA hypomethylation leads to elevated mutation rates. Nature (1998) 3.60
Intracytoplasmic sperm injection in the mouse. Biol Reprod (1995) 3.53
DNA methylation in Drosophila melanogaster. Nature (2000) 3.46
Retrovirus integration and chromatin structure: Moloney murine leukemia proviral integration sites map near DNase I-hypersensitive sites. J Virol (1987) 3.45
Retrovirus genomes methylated by mammalian but not bacterial methylase are non-infectious. Nature (1983) 3.43
Rejection of class I MHC-deficient haemopoietic cells by irradiated MHC-matched mice. Nature (1991) 3.36
Delayed clearance of Sendai virus in mice lacking class I MHC-restricted CD8+ T cells. J Immunol (1992) 3.31
Germ-line passage is required for establishment of methylation and expression patterns of imprinted but not of nonimprinted genes. Genes Dev (1996) 3.29
Transcription factor AP-2 essential for cranial closure and craniofacial development. Nature (1996) 3.27
Retroviral expression in embryonic stem cells and hematopoietic stem cells. Mol Cell Biol (2000) 3.20
Synergism of Xist RNA, DNA methylation, and histone hypoacetylation in maintaining X chromosome inactivation. J Cell Biol (2001) 2.94
Toxicity of 5-aza-2'-deoxycytidine to mammalian cells is mediated primarily by covalent trapping of DNA methyltransferase rather than DNA demethylation. Proc Natl Acad Sci U S A (1994) 2.92
DNA methylation and cancer. Hum Mol Genet (1994) 2.84
A generic intron increases gene expression in transgenic mice. Mol Cell Biol (1991) 2.75
DNA hypomethylation perturbs the function and survival of CNS neurons in postnatal animals. J Neurosci (2001) 2.75
Infectivity and methylation of retroviral genomes is correlated with expression in the animal. Cell (1981) 2.73
Functional analysis of activins during mammalian development. Nature (1995) 2.71
Lack of neurotrophin-3 leads to deficiencies in the peripheral nervous system and loss of limb proprioceptive afferents. Cell (1994) 2.65
Infection of preimplantation mouse embryos and of newborn mice with leukemia virus: tissue distribution of viral DNA and RNA and leukemogenesis in the adult animal. Proc Natl Acad Sci U S A (1975) 2.64
The role of DNA methylation in cancer genetic and epigenetics. Annu Rev Genet (1996) 2.63
Conditional deletion of Xist disrupts histone macroH2A localization but not maintenance of X inactivation. Nat Genet (1999) 2.62
Long-range cis effects of ectopic X-inactivation centres on a mouse autosome. Nature (1997) 2.62
X chromosome inactivation is mediated by Xist RNA stabilization. Cell (1997) 2.60
X-Chromosome inactivation in cloned mouse embryos. Science (2000) 2.59
Defective neural tube morphogenesis and altered apoptosis in the absence of both JNK1 and JNK2. Mech Dev (1999) 2.56
A 450 kb transgene displays properties of the mammalian X-inactivation center. Cell (1996) 2.52
DNA hypomethylation can activate Xist expression and silence X-linked genes. Genes Dev (1996) 2.51
Perinatal lethal osteogenesis imperfecta in transgenic mice bearing an engineered mutant pro-alpha 1(I) collagen gene. Nature (1988) 2.49
alpha3beta1 Integrin is required for normal development of the epidermal basement membrane. J Cell Biol (1997) 2.46
Type III collagen is crucial for collagen I fibrillogenesis and for normal cardiovascular development. Proc Natl Acad Sci U S A (1997) 2.37
Is calcium ionophore a universal activator for unfertilised eggs? Nature (1974) 2.36
Generation of mice from wild-type and targeted ES cells by nuclear cloning. Nat Genet (2000) 2.36
The recombination activating gene-1 (RAG-1) transcript is present in the murine central nervous system. Cell (1991) 2.33
Germline integration of moloney murine leukemia virus at the Mov13 locus leads to recessive lethal mutation and early embryonic death. Cell (1983) 2.33
Insertion of retrovirus into the first intron of alpha 1(I) collagen gene to embryonic lethal mutation in mice. Proc Natl Acad Sci U S A (1984) 2.30
A targeted mutation at the known collagenase cleavage site in mouse type I collagen impairs tissue remodeling. J Cell Biol (1995) 2.30
Mammalian transgenesis by intracytoplasmic sperm injection. Science (1999) 2.28
Complementary roles of BDNF and NT-3 in vestibular and auditory development. Neuron (1995) 2.27
Retroviruses as probes for mammalian development: allocation of cells to the somatic and germ cell lineages. Cell (1986) 2.26
Retrovirus-induced de novo methylation of flanking host sequences correlates with gene inactivity. Nature (1985) 2.26
Simian virus 40 DNA sequences in DNA of healthy adult mice derived from preimplantation blastocysts injected with viral DNA. Proc Natl Acad Sci U S A (1974) 2.26
Activation and transposition of endogenous retroviral elements in hypomethylation induced tumors in mice. Oncogene (2007) 2.22
Mice lacking major histocompatibility complex class I and class II molecules. Proc Natl Acad Sci U S A (1993) 2.18
Integration of Moloney leukaemia virus into the germ line of mice: correlation between site of integration and virus activation. Nature (1980) 2.18
Beta 2-microglobulin-deficient NOD mice do not develop insulitis or diabetes. Diabetes (1994) 2.16
Mouse cloning with nucleus donor cells of different age and type. Mol Reprod Dev (2001) 2.16
Association of the Bloom syndrome protein with topoisomerase IIIalpha in somatic and meiotic cells. Cancer Res (2000) 2.13
RNA and the epigenetic regulation of X chromosome inactivation. Cell (1998) 2.10
Loss of methylation activates Xist in somatic but not in embryonic cells. Genes Dev (1995) 2.08
Retroviruses and embryogenesis: microinjection of Moloney leukemia virus into midgestation mouse embryos. Cell (1980) 2.05