Characterization of the 13q14 tumor suppressor locus in CLL: identification of ALT1, an alternative splice variant of the LEU2 gene.

PubWeight™: 2.41‹?› | Rank: Top 2%

🔗 View Article (PMID 11559527)

Published in Cancer Res on September 15, 2001

Authors

F Bullrich1, H Fujii, G Calin, H Mabuchi, M Negrini, Y Pekarsky, L Rassenti, H Alder, J C Reed, M J Keating, T J Kipps, C M Croce

Author Affiliations

1: Department of Microbiology and Immunology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.

Articles citing this

Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A (2002) 32.26

Causes and consequences of microRNA dysregulation in cancer. Nat Rev Genet (2009) 16.58

New microRNAs from mouse and human. RNA (2003) 10.35

Downregulation of death-associated protein kinase 1 (DAPK1) in chronic lymphocytic leukemia. Cell (2007) 3.58

Abnormal microRNA-16 locus with synteny to human 13q14 linked to CLL in NZB mice. Blood (2007) 3.11

Chromosomal rearrangements and microRNAs: a new cancer link with clinical implications. J Clin Invest (2007) 1.72

Regulation of innate immune signalling pathways by the tripartite motif (TRIM) family proteins. EMBO Mol Med (2011) 1.42

MicroRNAs in Human Diseases: From Cancer to Cardiovascular Disease. Immune Netw (2011) 1.29

Molecular basis of CLL. Semin Cancer Biol (2010) 1.26

TSGene 2.0: an updated literature-based knowledgebase for tumor suppressor genes. Nucleic Acids Res (2015) 1.14

The Role of MicroRNAs in Regulatory T Cells and in the Immune Response. Immune Netw (2011) 1.13

Role of miR-15/16 in CLL. Cell Death Differ (2014) 1.12

Epigenetic upregulation of lncRNAs at 13q14.3 in leukemia is linked to the In Cis downregulation of a gene cluster that targets NF-kB. PLoS Genet (2013) 1.08

MicroRNA in the adaptive immune system, in sickness and in health. J Clin Immunol (2010) 1.07

The roles of microRNAs in tumorigenesis and angiogenesis. Int J Physiol Pathophysiol Pharmacol (2010) 1.03

Array-based karyotyping for prognostic assessment in chronic lymphocytic leukemia: performance comparison of Affymetrix 10K2.0, 250K Nsp, and SNP6.0 arrays. J Mol Diagn (2010) 1.02

The next thing in prognostic molecular markers: microRNA signatures of cancer. Gut (2010) 0.99

Investigating the targets of MIR-15a and MIR-16-1 in patients with chronic lymphocytic leukemia (CLL). PLoS One (2009) 0.96

Murine models of chronic lymphocytic leukaemia: role of microRNA-16 in the New Zealand Black mouse model. Br J Haematol (2007) 0.92

MicroRNAs (miRNAs) as biomarker(s) for prognosis and diagnosis of gastrointestinal (GI) cancers. Curr Pharm Des (2014) 0.90

MicroRNAs in mouse models of lymphoid malignancies. J Nucleic Acids Investig (2010) 0.90

Systemic in vivo lentiviral delivery of miR-15a/16 reduces malignancy in the NZB de novo mouse model of chronic lymphocytic leukemia. Genes Immun (2011) 0.89

Genomic vulnerability to LINE-1 hypomethylation is a potential determinant of the clinicogenetic features of multiple myeloma. Genome Med (2012) 0.88

The New Zealand black mouse as a model for the development and progression of chronic lymphocytic leukemia. Cytometry B Clin Cytom (2010) 0.82

miR deregulation in CLL. Adv Exp Med Biol (2013) 0.79

Translocation t(2;11) in CLL cells results in CXCR4/MAML2 fusion oncogene. Blood (2014) 0.78

miRNA-mediated deregulation in leukemia. Front Genet (2012) 0.78

ARLTS1 polymorphisms and basal cell carcinoma of the skin. Hered Cancer Clin Pract (2007) 0.77

Inflamma-miRs in Aging and Breast Cancer: Are They Reliable Players? Front Med (Lausanne) (2015) 0.76

Cellular and viral microRNAs in sepsis: mechanisms of action and clinical applications. Cell Death Differ (2016) 0.75

A Single-Array-Based Method for Detecting Copy Number Variants Using Affymetrix High Density SNP Arrays and its Application to Breast Cancer. Cancer Inform (2015) 0.75

Articles by these authors

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature (2002) 28.79

Mitochondria and apoptosis. Science (1998) 23.41

The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers. Cell (1996) 15.19

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell (1995) 14.90

National Cancer Institute-sponsored Working Group guidelines for chronic lymphocytic leukemia: revised guidelines for diagnosis and treatment. Blood (1996) 13.35

Regulation of cell death protease caspase-9 by phosphorylation. Science (1998) 11.26

Human c-myc onc gene is located on the region of chromosome 8 that is translocated in Burkitt lymphoma cells. Proc Natl Acad Sci U S A (1982) 11.15

IAP family proteins--suppressors of apoptosis. Genes Dev (1999) 9.96

Mitochondrial control of cell death. Nat Med (2000) 9.17

Cloning of the chromosome breakpoint of neoplastic B cells with the t(14;18) chromosome translocation. Science (1984) 8.80

X-linked IAP is a direct inhibitor of cell-death proteases. Nature (1997) 8.26

Involvement of the bcl-2 gene in human follicular lymphoma. Science (1985) 8.19

Extensive modulation of a set of microRNAs in primary glioblastoma. Biochem Biophys Res Commun (2005) 7.50

Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype. Science (1997) 7.31

Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo. Oncogene (1994) 7.24

Bax directly induces release of cytochrome c from isolated mitochondria. Proc Natl Acad Sci U S A (1998) 6.69

The t(14;18) chromosome translocations involved in B-cell neoplasms result from mistakes in VDJ joining. Science (1985) 6.63

Apoptosis in the failing human heart. N Engl J Med (1997) 6.35

Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner. J Cell Biol (1999) 6.24

Molecular cloning of a new transforming gene from a chemically transformed human cell line. Nature (1984) 5.85

Investigation of the subcellular distribution of the bcl-2 oncoprotein: residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes. Cancer Res (1993) 5.83

Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma. Proc Natl Acad Sci U S A (1986) 5.54

IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs. Cancer Res (1998) 5.41

The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene. Cell (1992) 5.39

IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases. EMBO J (1998) 5.28

Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis. Science (1998) 4.84

Nucleotide sequence of cloned cDNA of human c-myc oncogene. Nature (1983) 4.83

Relation of gene expression phenotype to immunoglobulin mutation genotype in B cell chronic lymphocytic leukemia. J Exp Med (2001) 4.83

Conversion of lytic to persistent alphavirus infection by the bcl-2 cellular oncogene. Nature (1993) 4.81

Alterations in T4 (CD4) protein and mRNA synthesis in cells infected with HIV. Science (1986) 4.79

The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases. EMBO J (1997) 4.66

Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses. Mol Cell (2001) 4.62

Cytochrome c release and apoptosis induced by mitochondrial targeting of nuclear orphan receptor TR3. Science (2000) 4.57

Cloning and functional analysis of BAG-1: a novel Bcl-2-binding protein with anti-cell death activity. Cell (1995) 4.53

Chromosomal location of the genes for human immunoglobulin heavy chains. Proc Natl Acad Sci U S A (1979) 4.52

Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD. Science (1999) 4.43

Cell-free apoptosis in Xenopus egg extracts: inhibition by Bcl-2 and requirement for an organelle fraction enriched in mitochondria. Cell (1994) 4.32

Production of antibodies against influenza virus by somatic cell hybrids between mouse myeloma and primed spleen cells. Proc Natl Acad Sci U S A (1977) 4.30

Blood-derived nurse-like cells protect chronic lymphocytic leukemia B cells from spontaneous apoptosis through stromal cell-derived factor-1. Blood (2000) 4.18

MiR-221 controls CDKN1C/p57 and CDKN1B/p27 expression in human hepatocellular carcinoma. Oncogene (2008) 4.11

MicroRNA deregulation in human thyroid papillary carcinomas. Endocr Relat Cancer (2006) 4.11

Expression of apoptosis-regulating proteins in chronic lymphocytic leukemia: correlations with In vitro and In vivo chemoresponses. Blood (1998) 4.07

Bcl-2 targets the protein kinase Raf-1 to mitochondria. Cell (1996) 4.04

Bcl-2 blocks apoptosis in cells lacking mitochondrial DNA. Nature (1993) 4.00

Anchorage dependence, integrins, and apoptosis. Cell (1994) 3.96

Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors. J Clin Invest (1998) 3.96

miR-15a and miR-16-1 in cancer: discovery, function and future perspectives. Cell Death Differ (2009) 3.94

Transcriptionally active c-myc oncogene is contained within NIARD, a DNA sequence associated with chromosome translocations in B-cell neoplasia. Proc Natl Acad Sci U S A (1983) 3.90

Translocation and rearrangements of the c-myc oncogene locus in human undifferentiated B-cell lymphomas. Science (1983) 3.82

Left-right asymmetric expression of the TGF beta-family member lefty in mouse embryos. Nature (1996) 3.79

Translocation of an immunoglobulin kappa locus to a region 3' of an unrearranged c-myc oncogene enhances c-myc transcription. Proc Natl Acad Sci U S A (1983) 3.75

Cloning and structure of a yeast gene encoding a general transcription initiation factor TFIID that binds to the TATA box. Nature (1989) 3.74

Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells. Proc Natl Acad Sci U S A (2000) 3.69

Molecular cloning of the chromosomal breakpoint of B-cell lymphomas and leukemias with the t(11;14) chromosome translocation. Science (1984) 3.64

Transcriptional activation of an unrearranged and untranslocated c-myc oncogene by translocation of a C lambda locus in Burkitt. Proc Natl Acad Sci U S A (1983) 3.53

Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases. EMBO J (1999) 3.51

Results of treatment with hyper-CVAD, a dose-intensive regimen, in adult acute lymphocytic leukemia. J Clin Oncol (2000) 3.50

Transcriptional activation of the translocated c-myc oncogene in burkitt lymphoma. Proc Natl Acad Sci U S A (1983) 3.46

Channel formation by antiapoptotic protein Bcl-2. Proc Natl Acad Sci U S A (1997) 3.45

Superoxide dismutase as a target for the selective killing of cancer cells. Nature (2000) 3.44

Assignment of the genes for human lambda immunoglobulin chains to chromosome 22. Nature (1981) 3.43

Differential expression of the normal and of the translocated human c-myc oncogenes in B cells. Proc Natl Acad Sci U S A (1983) 3.43

Bcl-2 family proteins and cancer. Oncogene (2008) 3.42

Apoptotic and necrotic myocyte cell deaths are independent contributing variables of infarct size in rats. Lab Invest (1996) 3.42

Differential expression of the translocated and the untranslocated c-myc oncogene in Burkitt lymphoma. Science (1983) 3.40

Rituximab dose-escalation trial in chronic lymphocytic leukemia. J Clin Oncol (2001) 3.38

Translocation of immunoglobulin VH genes in Burkitt lymphoma. Proc Natl Acad Sci U S A (1982) 3.30

Specific microRNAs are downregulated in human thyroid anaplastic carcinomas. Oncogene (2007) 3.29

Caspase-9 can be activated without proteolytic processing. J Biol Chem (1999) 3.20

Changes in intramitochondrial and cytosolic pH: early events that modulate caspase activation during apoptosis. Nat Cell Biol (2000) 3.20

Report of the National Cancer Institute-sponsored workshop on definitions of diagnosis and response in acute myeloid leukemia. J Clin Oncol (1990) 3.19

Sequential expression of protooncogenes during lectin-stimulated mitogenesis of normal human lymphocytes. Proc Natl Acad Sci U S A (1986) 3.19

Inactivation of Bcl-2 by phosphorylation. Proc Natl Acad Sci U S A (1995) 3.13

Chronic lymphocytic leukemia B cells express functional CXCR4 chemokine receptors that mediate spontaneous migration beneath bone marrow stromal cells. Blood (1999) 3.10

Bax inhibitor-1, a mammalian apoptosis suppressor identified by functional screening in yeast. Mol Cell (1998) 3.09

FAP-1: a protein tyrosine phosphatase that associates with Fas. Science (1995) 3.06

Activated T cells induce expression of B7/BB1 on normal or leukemic B cells through a CD40-dependent signal. J Exp Med (1993) 3.04

Identification of a p53-dependent negative response element in the bcl-2 gene. Cancer Res (1994) 3.02

microRNA-29 can regulate expression of the long non-coding RNA gene MEG3 in hepatocellular cancer. Oncogene (2011) 3.02

Increased high-density lipoprotein levels caused by a common cholesteryl-ester transfer protein gene mutation. N Engl J Med (1990) 3.02

Characterization of the mammalian YAP (Yes-associated protein) gene and its role in defining a novel protein module, the WW domain. J Biol Chem (1995) 3.01

An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators. J Biol Chem (1999) 2.97

Methylation patterns of the E-cadherin 5' CpG island are unstable and reflect the dynamic, heterogeneous loss of E-cadherin expression during metastatic progression. J Biol Chem (2000) 2.97

Immunohistochemical analysis of bcl-2, bax, bcl-X, and mcl-1 expression in prostate cancers. Am J Pathol (1996) 2.97

Oocyte apoptosis is suppressed by disruption of the acid sphingomyelinase gene or by sphingosine-1-phosphate therapy. Nat Med (2000) 2.96

International standardized approach for flow cytometric residual disease monitoring in chronic lymphocytic leukaemia. Leukemia (2007) 2.96

Bcl-2 oncoprotein blocks chemotherapy-induced apoptosis in a human leukemia cell line. Blood (1993) 2.96

Pro-caspase-3 is a major physiologic target of caspase-8. J Biol Chem (1998) 2.93

Clustering of breakpoints on chromosome 11 in human B-cell neoplasms with the t(11;14) chromosome translocation. Nature (1985) 2.91

BAG-1 modulates the chaperone activity of Hsp70/Hsc70. EMBO J (1997) 2.91

The alpha 5 beta 1 integrin supports survival of cells on fibronectin and up-regulates Bcl-2 expression. Proc Natl Acad Sci U S A (1995) 2.90

Expression and prognostic significance of IAP-family genes in human cancers and myeloid leukemias. Clin Cancer Res (2000) 2.86

Comparison of chemical inhibitors of antiapoptotic Bcl-2-family proteins. Cell Death Differ (2006) 2.85

The central executioner of apoptosis: multiple connections between protease activation and mitochondria in Fas/APO-1/CD95- and ceramide-induced apoptosis. J Exp Med (1997) 2.83