Identification of a p53-dependent negative response element in the bcl-2 gene.

PubWeight™: 3.02‹?› | Rank: Top 1%

🔗 View Article (PMID 8205530)

Published in Cancer Res on June 15, 1994

Authors

T Miyashita1, M Harigai, M Hanada, J C Reed

Author Affiliations

1: La Jolla Cancer Research Foundation, Cancer Research Center, California 92037.

Articles citing this

(truncated to the top 100)

Myocyte apoptosis during acute myocardial infarction in the mouse localizes to hypoxic regions but occurs independently of p53. J Clin Invest (1997) 2.31

Induction of bcl-2 expression by phosphorylated CREB proteins during B-cell activation and rescue from apoptosis. Mol Cell Biol (1996) 2.17

Overexpression of the death-promoting gene bax-alpha which is downregulated in breast cancer restores sensitivity to different apoptotic stimuli and reduces tumor growth in SCID mice. J Clin Invest (1996) 2.00

Bax loss impairs Myc-induced apoptosis and circumvents the selection of p53 mutations during Myc-mediated lymphomagenesis. Mol Cell Biol (2001) 1.96

Deconvoluting the structural and drug-recognition complexity of the G-quadruplex-forming region upstream of the bcl-2 P1 promoter. J Am Chem Soc (2006) 1.93

17beta-estradiol inhibits apoptosis in MCF-7 cells, inducing bcl-2 expression via two estrogen-responsive elements present in the coding sequence. Mol Cell Biol (2000) 1.83

The AML1/ETO fusion protein activates transcription of BCL-2. Proc Natl Acad Sci U S A (1996) 1.78

Stretch-mediated release of angiotensin II induces myocyte apoptosis by activating p53 that enhances the local renin-angiotensin system and decreases the Bcl-2-to-Bax protein ratio in the cell. J Clin Invest (1998) 1.73

Nitric oxide-induced p53 accumulation and regulation of inducible nitric oxide synthase expression by wild-type p53. Proc Natl Acad Sci U S A (1996) 1.68

Curcumin significantly enhances dual PI3K/Akt and mTOR inhibitor NVP-BEZ235-induced apoptosis in human renal carcinoma Caki cells through down-regulation of p53-dependent Bcl-2 expression and inhibition of Mcl-1 protein stability. PLoS One (2014) 1.57

Human germinal center B cells express the apoptosis-inducing genes Fas, c-myc, P53, and Bax but not the survival gene bcl-2. J Exp Med (1996) 1.55

Oligomerization of BAK by p53 utilizes conserved residues of the p53 DNA binding domain. J Biol Chem (2008) 1.55

p53 acetylation is crucial for its transcription-independent proapoptotic functions. J Biol Chem (2009) 1.48

Cell cycle and apoptosis. Neoplasia (2001) 1.47

Dichotomy of AML1-ETO functions: growth arrest versus block of differentiation. Mol Cell Biol (2001) 1.46

Apoptosis and apoptosis related gene expression in normal conjunctiva and pterygium. Br J Ophthalmol (2000) 1.40

Potential role for p53 in the permissive life cycle of human cytomegalovirus. J Virol (2006) 1.40

The p53-Bcl-2 connection. Cell Death Differ (2006) 1.39

Loss of p53 function through PAX-mediated transcriptional repression. EMBO J (1995) 1.38

Inhibition of p53 transactivation function by the human T-cell lymphotropic virus type 1 Tax protein. J Virol (1998) 1.38

p53 directly transactivates Δ133p53α, regulating cell fate outcome in response to DNA damage. Cell Death Differ (2010) 1.36

Bcl-2 and p53 protein expression, apoptosis, and p53 mutation in human epithelial ovarian cancers. Am J Pathol (2000) 1.35

Prognostic value of bcl-2 expression in invasive breast cancer. Br J Cancer (1995) 1.30

Evidence of reciprocity of bcl-2 and p53 expression in human colorectal adenomas and carcinomas. Br J Cancer (1996) 1.28

Aiolos transcription factor controls cell death in T cells by regulating Bcl-2 expression and its cellular localization. EMBO J (1999) 1.26

AKT inhibition is associated with chemosensitisation in the pancreatic cancer cell line MIA-PaCa-2. Br J Cancer (2003) 1.22

DRAL is a p53-responsive gene whose four and a half LIM domain protein product induces apoptosis. J Cell Biol (2000) 1.21

p53 Involvement in the control of murine hair follicle regression. Am J Pathol (2001) 1.19

Apoptosis-related factors p53, Bcl2, and Bax in neuroendocrine lung tumors. Am J Pathol (1996) 1.19

NF-kappaB and p53 are the dominant apoptosis-inducing transcription factors elicited by the HIV-1 envelope. J Exp Med (2004) 1.13

Up-regulation of inducible nitric oxide synthase expression in cancer-prone p53 knockout mice. Proc Natl Acad Sci U S A (1998) 1.12

Expression of apoptosis-regulatory genes in lung tumour cell lines: relationship to p53 expression and relevance to acquired drug resistance. Br J Cancer (1996) 1.12

Intestinal mucositis: the role of the Bcl-2 family, p53 and caspases in chemotherapy-induced damage. Support Care Cancer (2006) 1.10

The retinoblastoma protein binds the promoter of the survival gene bcl-2 and regulates its transcription in epithelial cells through transcription factor AP-2. Mol Cell Biol (2002) 1.10

BCL-2 is a downstream target of ATF5 that mediates the prosurvival function of ATF5 in a cell type-dependent manner. J Biol Chem (2011) 1.09

Adenovirus E1A proteins inhibit activation of transcription by p53. Mol Cell Biol (1996) 1.09

Transcriptional repression by p53 involves molecular interactions distinct from those with the TATA box binding protein. Nucleic Acids Res (1996) 1.08

Honokiol induces apoptosis through p53-independent pathway in human colorectal cell line RKO. World J Gastroenterol (2004) 1.08

Expression of Bcl-2 in node-negative breast cancer is associated with various prognostic factors, but does not predict response to one course of perioperative chemotherapy. Br J Cancer (1996) 1.05

Cell proliferation and DNA breaks are involved in ultraviolet light-induced apoptosis in nucleotide excision repair-deficient Chinese hamster cells. Mol Biol Cell (2002) 1.03

Human immunodeficiency virus induces a dual regulation of Bcl-2, resulting in persistent infection of CD4(+) T- or monocytic cell lines. J Virol (1998) 1.02

Negative cross-talk between p53 and the glucocorticoid receptor and its role in neuroblastoma cells. EMBO J (2000) 1.01

Expression of apoptosis regulatory proteins of the Bcl-2 family and p53 in primary resected non-small-cell lung cancer. Br J Cancer (1999) 1.01

The intrinsic radioresistance of glioblastoma-derived cell lines is associated with a failure of p53 to induce p21(BAX) expression. Proc Natl Acad Sci U S A (1998) 1.00

Up-regulation of AT(1) and AT(2) receptors in postinfarcted hypertrophied myocytes and stretch-mediated apoptotic cell death. Am J Pathol (2000) 1.00

Expression and prognostic significance of Bcl-2 in ovarian tumours. Br J Cancer (1995) 0.98

GRAMD4 mimics p53 and mediates the apoptotic function of p73 at mitochondria. Cell Death Differ (2010) 0.97

Bax is downregulated in inflamed colonic mucosa of ulcerative colitis. Gut (2000) 0.97

Pi 1 binding sites are negative regulators of bcl-2 expression in pre-B cells. Mol Cell Biol (1995) 0.96

Loss of c/EBP-beta activity promotes the adaptive to apoptotic switch in hypoxic cortical neurons. Mol Cell Neurosci (2008) 0.96

Apoptosis and expression of Bax, Bcl-x, and Bcl-2 apoptotic regulatory proteins in colorectal carcinomas, and association with p53 genotype/phenotype. Mol Pathol (1998) 0.96

Posttranslational phosphorylation of mutant p53 protein in tumor development. Med Mol Morphol (2006) 0.96

Mitochondria and energetic depression in cell pathophysiology. Int J Mol Sci (2009) 0.95

Insulin-like growth factor-1 induces Mdm2 and down-regulates p53, attenuating the myocyte renin-angiotensin system and stretch-mediated apoptosis. Am J Pathol (1999) 0.95

Identification of Daxx interacting with p73, one of the p53 family, and its regulation of p53 activity by competitive interaction with PML. Nucleic Acids Res (2003) 0.95

Cystic medial degeneration of the aorta is associated with p53 accumulation, Bax upregulation, apoptotic cell death, and cell proliferation. Heart (1999) 0.94

Expression of the BCL-2 protein in normal and dysplastic bronchial epithelium and in lung carcinomas. Br J Cancer (1995) 0.94

Nuclear factor kappaB- and specificity protein 1-dependent p53-mediated bi-directional regulation of the human manganese superoxide dismutase gene. J Biol Chem (2010) 0.93

Differentiation-dependent p53 regulation of nucleotide excision repair in keratinocytes. Am J Pathol (1997) 0.93

Induction of apoptosis of human gastric carcinoma SGC-7901 cell line by 5, 7-dihydroxy-8-nitrochrysin in vitro. World J Gastroenterol (2007) 0.93

Mechanism of apoptotic cell death of human gastric carcinoma cells mediated by transforming growth factor beta. Biochem J (1997) 0.93

Multifunctional role of Bcl-2 in malignant transformation and tumorigenesis of Cr(VI)-transformed lung cells. PLoS One (2012) 0.92

Immunohistochemical analysis of Bcl-2 protein regulation in cutaneous melanoma. Am J Pathol (1995) 0.92

Identification of a novel Bcl-2 promoter region that counteracts in a p53-dependent manner the inhibitory P2 region. Gene (2007) 0.92

Differences in telomerase activity between colon and rectal cancer. Can J Surg (2014) 0.92

Bax-mediated cell death by the Gax homeoprotein requires mitogen activation but is independent of cell cycle activity. EMBO J (1998) 0.90

Wentilactone A as a novel potential antitumor agent induces apoptosis and G2/M arrest of human lung carcinoma cells, and is mediated by HRas-GTP accumulation to excessively activate the Ras/Raf/ERK/p53-p21 pathway. Cell Death Dis (2013) 0.90

Antiproliferative activity and apoptosis induction of crude extract and fractions of avicennia marina. Iran J Basic Med Sci (2013) 0.90

Blocking the transcription factor E2F/DP by dominant-negative mutants in a normal breast epithelial cell line efficiently inhibits apoptosis and induces tumor growth in SCID mice. J Exp Med (1996) 0.89

Methylation of RASSF1A gene promoter is regulated by p53 and DAXX. FASEB J (2012) 0.88

Down syndrome fibroblasts and mouse Prep1-overexpressing cells display increased sensitivity to genotoxic stress. Nucleic Acids Res (2010) 0.88

Bak compensated for Bax in p53-null cells to release cytochrome c for the initiation of mitochondrial signaling during Withanolide D-induced apoptosis. PLoS One (2012) 0.87

p53 and Ceramide as Collaborators in the Stress Response. Int J Mol Sci (2013) 0.87

Minocycline is cytoprotective in human trabecular meshwork cells and optic nerve head astrocytes by increasing expression of XIAP, survivin, and Bcl-2. Clin Ophthalmol (2010) 0.86

The role of zinc in the modulation of neuronal proliferation and apoptosis. Neurotox Res (2010) 0.86

Development and antitumor activity of a BCL-2 targeted single-stranded DNA oligonucleotide. Cancer Chemother Pharmacol (2014) 0.85

Watching the watcher: regulation of p53 by mitochondria. Future Oncol (2009) 0.85

Pro-growth role of the JMJD2C histone demethylase in HCT-116 colon cancer cells and identification of curcuminoids as JMJD2 inhibitors. Am J Transl Res (2014) 0.84

Spontaneous apoptosis in ovarian carcinomas: a positive association with p53 gene mutation is dependent on growth fraction. Br J Cancer (2000) 0.84

A p38MAPK-p53 cascade regulates mesodermal differentiation and neurogenesis of embryonic stem cells. Cell Death Dis (2013) 0.84

Loss of BCL-2 in the progression of oral cancer is not attributable to mutations. J Clin Pathol (2005) 0.83

Inhibition of p53 function prevents renin-angiotensin system activation and stretch-mediated myocyte apoptosis. Am J Pathol (2000) 0.83

Dolastatin-10 in metastatic melanoma: a phase II and pharmokinetic trial of the California Cancer Consortium. Invest New Drugs (2001) 0.83

The Tumor Suppressor BCL7B Functions in the Wnt Signaling Pathway. PLoS Genet (2015) 0.83

Bcl-2 expression related to altered p53 protein and its impact on the progression of human pancreatic carcinoma. Br J Cancer (1999) 0.82

Etoposide induces cell death via mitochondrial-dependent actions of p53. Cancer Cell Int (2015) 0.80

Protective Effects of Valproic Acid, a Histone Deacetylase Inhibitor, against Hyperoxic Lung Injury in a Neonatal Rat Model. PLoS One (2015) 0.80

The molecular pathology of p53 in primitive neuroectodermal tumours of the central nervous system. Br J Cancer (2002) 0.79

Autonomous proliferation and bcl-2 expression involving haematopoietic cells in patients with myelodysplastic syndrome. Br J Cancer (1998) 0.79

DNA binding specificity of proteins derived from alternatively spliced mouse p53 mRNAs. Nucleic Acids Res (1997) 0.79

Overexpression of bax associated with mutations in the loop-sheet-helix motif of p53. Am J Pathol (1999) 0.79

A novel SATB1 binding site in the BCL2 promoter region possesses transcriptional regulatory function. J Biomed Res (2010) 0.78

P53 tumour-suppressor gene mutations are mainly localised on exon 7 in human primary and metastatic prostate cancer. Br J Cancer (1996) 0.78

Cell proliferation, cell loss and expression of bcl-2 and p53 in human pulmonary neoplasms. Br J Cancer (1997) 0.78

Suppression of tumorigenic and metastatic potentials of human melanoma cell lines by mutated (143 Val-Ala) p53. Br J Cancer (1998) 0.78

Prostate tumours from an Asian population: examination of bax, bcl-2, p53 and ras and identification of bax as a prognostic marker. Br J Cancer (2000) 0.77

Expression of bcl-2 in bladder neoplasms is a cell lineage associated and p53-independent event. Mol Pathol (1997) 0.77

Molecular mechanisms of anti-tumor properties of P276-00 in head and neck squamous cell carcinoma. J Transl Med (2013) 0.77

Differential response to zinc-induced apoptosis in benign prostate hyperplasia and prostate cancer cells. J Nutr Biochem (2009) 0.77

The role of apoptosis in intestinal disease. J Gastroenterol (1997) 0.77

Articles by these authors

(truncated to the top 100)

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature (2002) 28.79

Mitochondria and apoptosis. Science (1998) 23.41

Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors. Science (1998) 21.13

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell (1995) 14.90

Regulation of cell death protease caspase-9 by phosphorylation. Science (1998) 11.26

IAP family proteins--suppressors of apoptosis. Genes Dev (1999) 9.96

Mitochondrial control of cell death. Nat Med (2000) 9.17

X-linked IAP is a direct inhibitor of cell-death proteases. Nature (1997) 8.26

Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype. Science (1997) 7.31

Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo. Oncogene (1994) 7.24

Bax directly induces release of cytochrome c from isolated mitochondria. Proc Natl Acad Sci U S A (1998) 6.69

Apoptosis in the failing human heart. N Engl J Med (1997) 6.35

Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner. J Cell Biol (1999) 6.24

Investigation of the subcellular distribution of the bcl-2 oncoprotein: residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes. Cancer Res (1993) 5.83

IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs. Cancer Res (1998) 5.41

IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases. EMBO J (1998) 5.28

Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis. Science (1998) 4.84

Conversion of lytic to persistent alphavirus infection by the bcl-2 cellular oncogene. Nature (1993) 4.81

Alterations in T4 (CD4) protein and mRNA synthesis in cells infected with HIV. Science (1986) 4.79

The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases. EMBO J (1997) 4.66

Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses. Mol Cell (2001) 4.62

Cytochrome c release and apoptosis induced by mitochondrial targeting of nuclear orphan receptor TR3. Science (2000) 4.57

Cloning and functional analysis of BAG-1: a novel Bcl-2-binding protein with anti-cell death activity. Cell (1995) 4.53

Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD. Science (1999) 4.43

Cell-free apoptosis in Xenopus egg extracts: inhibition by Bcl-2 and requirement for an organelle fraction enriched in mitochondria. Cell (1994) 4.32

Expression of apoptosis-regulating proteins in chronic lymphocytic leukemia: correlations with In vitro and In vivo chemoresponses. Blood (1998) 4.07

Bcl-2 targets the protein kinase Raf-1 to mitochondria. Cell (1996) 4.04

Bcl-2 blocks apoptosis in cells lacking mitochondrial DNA. Nature (1993) 4.00

Anchorage dependence, integrins, and apoptosis. Cell (1994) 3.96

Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases. EMBO J (1999) 3.51

Channel formation by antiapoptotic protein Bcl-2. Proc Natl Acad Sci U S A (1997) 3.45

Bcl-2 family proteins and cancer. Oncogene (2008) 3.42

Apoptotic and necrotic myocyte cell deaths are independent contributing variables of infarct size in rats. Lab Invest (1996) 3.42

Interactions among members of the Bcl-2 protein family analyzed with a yeast two-hybrid system. Proc Natl Acad Sci U S A (1994) 3.26

Caspase-9 can be activated without proteolytic processing. J Biol Chem (1999) 3.20

Changes in intramitochondrial and cytosolic pH: early events that modulate caspase activation during apoptosis. Nat Cell Biol (2000) 3.20

Sequential expression of protooncogenes during lectin-stimulated mitogenesis of normal human lymphocytes. Proc Natl Acad Sci U S A (1986) 3.19

Bax inhibitor-1, a mammalian apoptosis suppressor identified by functional screening in yeast. Mol Cell (1998) 3.09

FAP-1: a protein tyrosine phosphatase that associates with Fas. Science (1995) 3.06

An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators. J Biol Chem (1999) 2.97

Immunohistochemical analysis of bcl-2, bax, bcl-X, and mcl-1 expression in prostate cancers. Am J Pathol (1996) 2.97

Oocyte apoptosis is suppressed by disruption of the acid sphingomyelinase gene or by sphingosine-1-phosphate therapy. Nat Med (2000) 2.96

Bcl-2 oncoprotein blocks chemotherapy-induced apoptosis in a human leukemia cell line. Blood (1993) 2.96

Pro-caspase-3 is a major physiologic target of caspase-8. J Biol Chem (1998) 2.93

BAG-1 modulates the chaperone activity of Hsp70/Hsc70. EMBO J (1997) 2.91

The alpha 5 beta 1 integrin supports survival of cells on fibronectin and up-regulates Bcl-2 expression. Proc Natl Acad Sci U S A (1995) 2.90

Expression and prognostic significance of IAP-family genes in human cancers and myeloid leukemias. Clin Cancer Res (2000) 2.86

Comparison of chemical inhibitors of antiapoptotic Bcl-2-family proteins. Cell Death Differ (2006) 2.85

The central executioner of apoptosis: multiple connections between protease activation and mitochondria in Fas/APO-1/CD95- and ceramide-induced apoptosis. J Exp Med (1997) 2.83

Proapoptotic protein Bax heterodimerizes with Bcl-2 and homodimerizes with Bax via a novel domain (BH3) distinct from BH1 and BH2. J Biol Chem (1996) 2.79

BNIP3 heterodimerizes with Bcl-2/Bcl-X(L) and induces cell death independent of a Bcl-2 homology 3 (BH3) domain at both mitochondrial and nonmitochondrial sites. J Biol Chem (2000) 2.68

A single BIR domain of XIAP sufficient for inhibiting caspases. J Biol Chem (1998) 2.64

Immunohistochemical analysis of in vivo patterns of Bcl-X expression. Cancer Res (1994) 2.63

Interleukin-2 receptor common gamma-chain signaling cytokines regulate activated T cell apoptosis in response to growth factor withdrawal: selective induction of anti-apoptotic (bcl-2, bcl-xL) but not pro-apoptotic (bax, bcl-xS) gene expression. Eur J Immunol (1996) 2.63

Lysosomal protease pathways to apoptosis. Cleavage of bid, not pro-caspases, is the most likely route. J Biol Chem (2000) 2.62

The HIV-1 viral protein R induces apoptosis via a direct effect on the mitochondrial permeability transition pore. J Exp Med (2000) 2.62

Molecular chaperone targeting and regulation by BAG family proteins. Nat Cell Biol (2001) 2.61

Unequal death in T helper cell (Th)1 and Th2 effectors: Th1, but not Th2, effectors undergo rapid Fas/FasL-mediated apoptosis. J Exp Med (1997) 2.59

Immunohistochemical determination of in vivo distribution of Bax, a dominant inhibitor of Bcl-2. Am J Pathol (1994) 2.57

The permeability transition pore complex: a target for apoptosis regulation by caspases and bcl-2-related proteins. J Exp Med (1998) 2.51

Integrin activation by R-ras. Cell (1996) 2.50

Immediate early up-regulation of bax expression by p53 but not TGF beta 1: a paradigm for distinct apoptotic pathways. Oncogene (1994) 2.49

An informatics approach identifying markers of chemosensitivity in human cancer cell lines. Cancer Res (2000) 2.47

bcl-2 gene hypomethylation and high-level expression in B-cell chronic lymphocytic leukemia. Blood (1993) 2.45

p21-activated kinase 1 phosphorylates the death agonist bad and protects cells from apoptosis. Mol Cell Biol (2000) 2.42

Characterization of the 13q14 tumor suppressor locus in CLL: identification of ALT1, an alternative splice variant of the LEU2 gene. Cancer Res (2001) 2.41

Regulation of bcl-2 proto-oncogene expression during normal human lymphocyte proliferation. Science (1987) 2.36

Structure-function analysis of Bcl-2 protein. Identification of conserved domains important for homodimerization with Bcl-2 and heterodimerization with Bax. J Biol Chem (1995) 2.35

Apoptosis in the terminal endbud of the murine mammary gland: a mechanism of ductal morphogenesis. Development (1996) 2.35

Apoptosis induced by withdrawal of interleukin-3 (IL-3) from an IL-3-dependent hematopoietic cell line is associated with repartitioning of intracellular calcium and is blocked by enforced Bcl-2 oncoprotein production. J Biol Chem (1993) 2.32

Elevated expression of the apoptotic regulator Mcl-1 at the time of leukemic relapse. Blood (1998) 2.31

Reduced expression of proapoptotic gene BAX is associated with poor response rates to combination chemotherapy and shorter survival in women with metastatic breast adenocarcinoma. Cancer Res (1995) 2.31

Structure-function comparisons of the proapoptotic protein Bax in yeast and mammalian cells. Mol Cell Biol (1996) 2.24

Bcl-2 interacting protein, BAG-1, binds to and activates the kinase Raf-1. Proc Natl Acad Sci U S A (1996) 2.21

The AKT kinase is activated in multiple myeloma tumor cells. Blood (2001) 2.20

Age-associated cardiac dysfunction in Drosophila melanogaster. Circ Res (2001) 2.20

MEK/ERK signaling pathway regulates the expression of Bcl-2, Bcl-X(L), and Mcl-1 and promotes survival of human pancreatic cancer cells. J Cell Biochem (2000) 2.19

Immunohistochemical analysis of in vivo patterns of expression of CPP32 (Caspase-3), a cell death protease. Cancer Res (1997) 2.16

bcl-2 gene transfer increases relative resistance of S49.1 and WEHI7.2 lymphoid cells to cell death and DNA fragmentation induced by glucocorticoids and multiple chemotherapeutic drugs. Cancer Res (1992) 2.15

BCL-2 family proteins: regulators of cell death involved in the pathogenesis of cancer and resistance to therapy. J Cell Biochem (1996) 2.14

Toso, a cell surface, specific regulator of Fas-induced apoptosis in T cells. Immunity (1998) 2.11

Protein kinase inhibitors flavopiridol and 7-hydroxy-staurosporine down-regulate antiapoptosis proteins in B-cell chronic lymphocytic leukemia. Blood (2000) 2.11

Structure-function analysis of the Bcl-2 oncoprotein. Addition of a heterologous transmembrane domain to portions of the Bcl-2 beta protein restores function as a regulator of cell survival. J Biol Chem (1993) 2.07

Control of mitochondrial membrane permeabilization by adenine nucleotide translocator interacting with HIV-1 viral protein rR and Bcl-2. J Exp Med (2001) 2.07

A hallmark of active class switch recombination: transcripts directed by I promoters on looped-out circular DNAs. Proc Natl Acad Sci U S A (2001) 2.03

Postmarketing surveillance of the safety profile of infliximab in 5000 Japanese patients with rheumatoid arthritis. Ann Rheum Dis (2007) 2.01

p53-inducible human homologue of Drosophila seven in absentia (Siah) inhibits cell growth: suppression by BAG-1. EMBO J (1998) 1.99

Human Daxx regulates Fas-induced apoptosis from nuclear PML oncogenic domains (PODs). EMBO J (1999) 1.99

BAG-1: a novel biomarker predicting long-term survival in early-stage breast cancer. J Clin Oncol (2001) 1.97

A novel member of the TRAF family of putative signal transducing proteins binds to the cytosolic domain of CD40. FEBS Lett (1995) 1.97

Immunohistochemical analysis of Mcl-1 protein in human tissues. Differential regulation of Mcl-1 and Bcl-2 protein production suggests a unique role for Mcl-1 in control of programmed cell death in vivo. Am J Pathol (1995) 1.97

Elevated expression of Bcl-X and reduced Bak in primary colorectal adenocarcinomas. Cancer Res (1996) 1.97

Programmed myocyte cell death affects the viable myocardium after infarction in rats. Exp Cell Res (1996) 1.95

Metastatic melanoma in the thorax: report of 130 patients. AJR Am J Roentgenol (1981) 1.95

The Mitochondrial F0F1-ATPase proton pump is required for function of the proapoptotic protein Bax in yeast and mammalian cells. Mol Cell (1998) 1.94

Dexamethasone inhibition of interleukin 1 beta production by human monocytes. Posttranscriptional mechanisms. J Clin Invest (1988) 1.93

Estrogen promotes chemotherapeutic drug resistance by a mechanism involving Bcl-2 proto-oncogene expression in human breast cancer cells. Cancer Res (1995) 1.93

Release of caspase-9 from mitochondria during neuronal apoptosis and cerebral ischemia. Proc Natl Acad Sci U S A (1999) 1.93

A survey of the anti-apoptotic Bcl-2 subfamily expression in cancer types provides a platform to predict the efficacy of Bcl-2 antagonists in cancer therapy. Cell Death Dis (2010) 1.87

Effects of p56lck deficiency on the growth and cytolytic effector function of an interleukin-2-dependent cytotoxic T-cell line. Mol Cell Biol (1992) 1.87