Published in Mol Cell on May 15, 2009
The ATM protein kinase: regulating the cellular response to genotoxic stress, and more. Nat Rev Mol Cell Biol (2013) 5.33
53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress. Nat Cell Biol (2011) 4.57
More than just a focus: The chromatin response to DNA damage and its role in genome integrity maintenance. Nat Cell Biol (2011) 4.23
Origin of chromosomal translocations in lymphoid cancer. Cell (2010) 2.94
High-resolution profiling of gammaH2AX around DNA double strand breaks in the mammalian genome. EMBO J (2010) 2.89
Mechanisms of double-strand break repair in somatic mammalian cells. Biochem J (2009) 2.68
Analysis of protein dynamics at active, stalled, and collapsed replication forks. Genes Dev (2011) 2.47
Regulation of DNA end joining, resection, and immunoglobulin class switch recombination by 53BP1. Mol Cell (2011) 2.46
H2AX: functional roles and potential applications. Chromosoma (2009) 2.27
Chromatin remodeling at DNA double-strand breaks. Cell (2013) 2.18
H2AX prevents CtIP-mediated DNA end resection and aberrant repair in G1-phase lymphocytes. Nature (2010) 1.78
The role of mechanistic factors in promoting chromosomal translocations found in lymphoid and other cancers. Adv Immunol (2010) 1.77
DNA damage sensing by the ATM and ATR kinases. Cold Spring Harb Perspect Biol (2013) 1.72
The response to and repair of RAG-mediated DNA double-strand breaks. Annu Rev Immunol (2012) 1.64
Chromatin dynamics and the repair of DNA double strand breaks. Cell Cycle (2011) 1.63
MUS81 promotes common fragile site expression. Nat Cell Biol (2013) 1.40
Double strand break repair functions of histone H2AX. Mutat Res (2013) 1.31
Arabidopsis meiotic crossover hot spots overlap with H2A.Z nucleosomes at gene promoters. Nat Genet (2013) 1.29
Dephosphorylation of γ-H2AX by WIP1: an important homeostatic regulatory event in DNA repair and cell cycle control. Cell Cycle (2010) 1.27
Aberrantly resolved RAG-mediated DNA breaks in Atm-deficient lymphocytes target chromosomal breakpoints in cis. Proc Natl Acad Sci U S A (2009) 1.25
Histone H2AX stabilizes broken DNA strands to suppress chromosome breaks and translocations during V(D)J recombination. J Exp Med (2009) 1.24
Epigenetic modifications in double-strand break DNA damage signaling and repair. Clin Cancer Res (2010) 1.18
Cohesin protects genes against γH2AX Induced by DNA double-strand breaks. PLoS Genet (2012) 1.17
MDC1: The art of keeping things in focus. Chromosoma (2010) 1.15
Human SNF5/INI1, a component of the human SWI/SNF chromatin remodeling complex, promotes nucleotide excision repair by influencing ATM recruitment and downstream H2AX phosphorylation. Mol Cell Biol (2009) 1.10
H2AX post-translational modifications in the ionizing radiation response and homologous recombination. Cell Cycle (2010) 1.06
Ataxia telangiectasia mutated (Atm) and DNA-PKcs kinases have overlapping activities during chromosomal signal joint formation. Proc Natl Acad Sci U S A (2011) 1.05
Impact of histone H4 lysine 20 methylation on 53BP1 responses to chromosomal double strand breaks. PLoS One (2012) 1.01
Cell cycle-dependent induction of homologous recombination by a tightly regulated I-SceI fusion protein. PLoS One (2011) 0.99
NER initiation factors, DDB2 and XPC, regulate UV radiation response by recruiting ATR and ATM kinases to DNA damage sites. DNA Repair (Amst) (2013) 0.98
Chromatin modifications and DNA repair: beyond double-strand breaks. Front Genet (2014) 0.96
Unique and redundant functions of ATM and DNA-PKcs during V(D)J recombination. Cell Cycle (2011) 0.95
Functional overlaps between XLF and the ATM-dependent DNA double strand break response. DNA Repair (Amst) (2014) 0.94
Structural mechanism of the phosphorylation-dependent dimerization of the MDC1 forkhead-associated domain. Nucleic Acids Res (2012) 0.93
The ataxia telangiectasia mutated kinase controls Igκ allelic exclusion by inhibiting secondary Vκ-to-Jκ rearrangements. J Exp Med (2013) 0.93
Repair of chromosomal RAG-mediated DNA breaks by mutant RAG proteins lacking phosphatidylinositol 3-like kinase consensus phosphorylation sites. J Immunol (2011) 0.92
Wild-type p53-induced phosphatase 1 (Wip1) forestalls cellular premature senescence at physiological oxygen levels by regulating DNA damage response signaling during DNA replication. Cell Cycle (2014) 0.92
Non-redundant Functions of ATM and DNA-PKcs in Response to DNA Double-Strand Breaks. Cell Rep (2015) 0.90
Histone tails: Directing the chromatin response to DNA damage. FEBS Lett (2011) 0.90
Gammaherpesvirus gene expression and DNA synthesis are facilitated by viral protein kinase and histone variant H2AX. Virology (2011) 0.90
A small ubiquitin binding domain inhibits ubiquitin-dependent protein recruitment to DNA repair foci. Cell Cycle (2013) 0.88
Somatic inactivation of Tp53 in hematopoietic stem cells or thymocytes predisposes mice to thymic lymphomas with clonal translocations. Cell Cycle (2013) 0.88
Lymphocyte development: integration of DNA damage response signaling. Adv Immunol (2012) 0.87
ATM-Dependent Phosphorylation of All Three Members of the MRN Complex: From Sensor to Adaptor. Biomolecules (2015) 0.86
Beyond repair foci: DNA double-strand break repair in euchromatic and heterochromatic compartments analyzed by transmission electron microscopy. PLoS One (2012) 0.86
Trial Watch: Targeting ATM-CHK2 and ATR-CHK1 pathways for anticancer therapy. Mol Cell Oncol (2015) 0.86
Ataxia telangiectasia mutated (ATM) is dispensable for endonuclease I-SceI-induced homologous recombination in mouse embryonic stem cells. J Biol Chem (2013) 0.84
Sp1 facilitates DNA double-strand break repair through a nontranscriptional mechanism. Mol Cell Biol (2012) 0.83
DNA copy-number control through inhibition of replication fork progression. Cell Rep (2014) 0.83
Immobilizing topoisomerase I on a surface plasmon resonance biosensor chip to screen for inhibitors. J Biomed Sci (2010) 0.82
Quantification of gammaH2AX foci in response to ionising radiation. J Vis Exp (2010) 0.81
KAP-1 promotes resection of broken DNA ends not protected by γ-H2AX and 53BP1 in G₁-phase lymphocytes. Mol Cell Biol (2014) 0.80
Cellular context-dependent effects of H2ax and p53 deletion on the development of thymic lymphoma. Blood (2010) 0.80
Multifunctional role of ATM/Tel1 kinase in genome stability: from the DNA damage response to telomere maintenance. Biomed Res Int (2014) 0.80
Chipping away at gamma-H2AX foci. Cell Cycle (2009) 0.80
Redundant and nonredundant functions of ATM and H2AX in αβ T-lineage lymphocytes. J Immunol (2012) 0.80
Integrated signaling in developing lymphocytes: the role of DNA damage responses. Cell Cycle (2012) 0.77
Role of polycomb group proteins in the DNA damage response--a reassessment. PLoS One (2014) 0.77
Do chromatin changes around a nascent double strand DNA break spread spherically into linearly non-adjacent chromatin? Front Genet (2013) 0.77
ATR- and ATM-Mediated DNA Damage Response Is Dependent on Excision Repair Assembly during G1 but Not in S Phase of Cell Cycle. PLoS One (2016) 0.77
Restoration of ATM Expression in DNA-PKcs-Deficient Cells Inhibits Signal End Joining. J Immunol (2016) 0.76
Deciphering the DNA damage histone code. Cell Cycle (2010) 0.76
p53 and the PWWP domain containing effector proteins in chromatin damage repair. Cell Dev Biol (2013) 0.76
Epigenetic regulation of antigen receptor gene rearrangement. F1000 Biol Rep (2010) 0.76
Inhibiting DNA-PKcs in a non-homologous end-joining pathway in response to DNA double-strand breaks. Oncotarget (2017) 0.75
HCoDES reveals chromosomal DNA end structures with single-nucleotide resolution. Mol Cell (2014) 0.75
Immature Lymphocytes Inhibit Rag1 and Rag2 Transcription and V(D)J Recombination in Response to DNA Double-Strand Breaks. J Immunol (2017) 0.75
TLK1B mediated phosphorylation of Rad9 regulates its nuclear/cytoplasmic localization and cell cycle checkpoint. BMC Mol Biol (2016) 0.75
DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J Biol Chem (1998) 28.13
RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement. Cell (1992) 17.50
Megabase chromatin domains involved in DNA double-strand breaks in vivo. J Cell Biol (1999) 16.81
A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage. Curr Biol (2000) 13.46
Genomic instability in mice lacking histone H2AX. Science (2002) 10.23
Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM. Cancer Res (2004) 9.70
Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer. Nat Genet (2001) 9.55
A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival. Immunity (2001) 9.45
RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins. Cell (2007) 9.25
ATM phosphorylates histone H2AX in response to DNA double-strand breaks. J Biol Chem (2001) 8.78
RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly. Cell (2007) 8.71
Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks. Nat Cell Biol (2003) 8.55
MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks. Cell (2005) 8.39
MDC1 is a mediator of the mammalian DNA damage checkpoint. Nature (2003) 6.81
ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation. Cancer Res (2004) 6.38
Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination. Cell (2002) 6.34
The mechanism and regulation of chromosomal V(D)J recombination. Cell (2002) 6.28
MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals. Mol Cell (2006) 6.09
DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1. Nat Cell Biol (2002) 5.85
A role for Saccharomyces cerevisiae histone H2A in DNA repair. Nature (2001) 5.28
Histone H2AX: a dosage-dependent suppressor of oncogenic translocations and tumors. Cell (2003) 5.26
Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX. Proc Natl Acad Sci U S A (2002) 5.07
Acetylation by Tip60 is required for selective histone variant exchange at DNA lesions. Science (2004) 4.97
H2AX haploinsufficiency modifies genomic stability and tumor susceptibility. Cell (2003) 4.94
Gamma-H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin. Nucleic Acids Res (2008) 4.79
DNA damage response pathway uses histone modification to assemble a double-strand break-specific cohesin domain. Mol Cell (2004) 4.54
gammaH2AX and MDC1: anchoring the DNA-damage-response machinery to broken chromosomes. DNA Repair (Amst) (2006) 4.36
Distribution and dynamics of chromatin modification induced by a defined DNA double-strand break. Curr Biol (2004) 4.35
Monoclonal mice generated by nuclear transfer from mature B and T donor cells. Nature (2002) 4.16
Response to RAG-mediated VDJ cleavage by NBS1 and gamma-H2AX. Science (2000) 3.95
Role of genomic instability and p53 in AID-induced c-myc-Igh translocations. Nature (2006) 3.90
H2AX prevents DNA breaks from progressing to chromosome breaks and translocations. Mol Cell (2006) 3.53
ATM stabilizes DNA double-strand-break complexes during V(D)J recombination. Nature (2006) 3.35
gamma-H2AX dephosphorylation by protein phosphatase 2A facilitates DNA double-strand break repair. Mol Cell (2005) 3.24
DNA damage-dependent acetylation and ubiquitination of H2AX enhances chromatin dynamics. Mol Cell Biol (2007) 3.03
Leaky Scid phenotype associated with defective V(D)J coding end processing in Artemis-deficient mice. Mol Cell (2002) 2.49
Control of sister chromatid recombination by histone H2AX. Mol Cell (2004) 2.43
Nuclear retention of ATM at sites of DNA double strand breaks. J Biol Chem (2001) 2.43
V(D)J recombination activates a p53-dependent DNA damage checkpoint in scid lymphocyte precursors. Genes Dev (1996) 2.29
A PP4-phosphatase complex dephosphorylates gamma-H2AX generated during DNA replication. Mol Cell (2008) 2.28
A small molecule Abl kinase inhibitor induces differentiation of Abelson virus-transformed pre-B cell lines. Nat Immunol (2002) 2.07
FACT-mediated exchange of histone variant H2AX regulated by phosphorylation of H2AX and ADP-ribosylation of Spt16. Mol Cell (2008) 1.99
DNA double-strand breaks activate a multi-functional genetic program in developing lymphocytes. Nature (2008) 1.88
Aberrant V(D)J recombination is not required for rapid development of H2ax/p53-deficient thymic lymphomas with clonal translocations. Blood (2007) 1.61
A novel histone exchange factor, protein phosphatase 2Cgamma, mediates the exchange and dephosphorylation of H2A-H2B. J Cell Biol (2006) 1.34
H2AX chromatin structures and their response to DNA damage revealed by 4Pi microscopy. Proc Natl Acad Sci U S A (2006) 1.27
A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells. Nature (2008) 10.84
Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map. Nature (2007) 9.25
Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells. Science (2002) 8.34
H2AX prevents DNA breaks from progressing to chromosome breaks and translocations. Mol Cell (2006) 3.53
53BP1 facilitates long-range DNA end-joining during V(D)J recombination. Nature (2008) 3.47
Recurrent hemizygous deletions in cancers may optimize proliferative potential. Science (2012) 3.41
ATM stabilizes DNA double-strand-break complexes during V(D)J recombination. Nature (2006) 3.35
Activating Notch1 mutations in mouse models of T-ALL. Blood (2005) 3.08
Signaling kinase AMPK activates stress-promoted transcription via histone H2B phosphorylation. Science (2010) 3.05
Mastermind critically regulates Notch-mediated lymphoid cell fate decisions. Blood (2004) 2.90
ATM prevents the persistence and propagation of chromosome breaks in lymphocytes. Cell (2007) 2.78
The SIOD disorder protein SMARCAL1 is an RPA-interacting protein involved in replication fork restart. Genes Dev (2009) 2.44
Control of sister chromatid recombination by histone H2AX. Mol Cell (2004) 2.43
Deletion of a conserved Il4 silencer impairs T helper type 1-mediated immunity. Nat Immunol (2004) 2.38
Mechanism and control of V(D)J recombination versus class switch recombination: similarities and differences. Adv Immunol (2005) 2.19
53BP1 mediates productive and mutagenic DNA repair through distinct phosphoprotein interactions. Cell (2013) 2.05
RAG-1 and ATM coordinate monoallelic recombination and nuclear positioning of immunoglobulin loci. Nat Immunol (2009) 1.98
Notch signaling is a potent inducer of growth arrest and apoptosis in a wide range of B-cell malignancies. Blood (2005) 1.96
Control of the development of CD8αα+ intestinal intraepithelial lymphocytes by TGF-β. Nat Immunol (2011) 1.94
DNA double-strand breaks activate a multi-functional genetic program in developing lymphocytes. Nature (2008) 1.88
Damage-induced phosphorylation of Sld3 is important to block late origin firing. Nature (2010) 1.86
Elucidation of IgH intronic enhancer functions via germ-line deletion. Proc Natl Acad Sci U S A (2005) 1.85
Novel roles for A-type lamins in telomere biology and the DNA damage response pathway. EMBO J (2009) 1.83
The cell-cycle regulator c-Myc is essential for the formation and maintenance of germinal centers. Nat Immunol (2012) 1.82
Notch subunit heterodimerization and prevention of ligand-independent proteolytic activation depend, respectively, on a novel domain and the LNR repeats. Mol Cell Biol (2004) 1.78
H2AX prevents CtIP-mediated DNA end resection and aberrant repair in G1-phase lymphocytes. Nature (2010) 1.78
Chimeric IgH-TCRalpha/delta translocations in T lymphocytes mediated by RAG. Cell Cycle (2009) 1.75
A 3' enhancer in the IL-4 gene regulates cytokine production by Th2 cells and mast cells. Immunity (2002) 1.74
Gamma-herpesvirus kinase actively initiates a DNA damage response by inducing phosphorylation of H2AX to foster viral replication. Cell Host Microbe (2007) 1.71
Nuclear accumulation of cyclin D1 during S phase inhibits Cul4-dependent Cdt1 proteolysis and triggers p53-dependent DNA rereplication. Genes Dev (2007) 1.65
The response to and repair of RAG-mediated DNA double-strand breaks. Annu Rev Immunol (2012) 1.64
ATR and H2AX cooperate in maintaining genome stability under replication stress. J Biol Chem (2008) 1.55
T-cell glucocorticoid receptor is required to suppress COX-2-mediated lethal immune activation. Nat Med (2003) 1.55
Antigen receptor allelic exclusion: an update and reappraisal. J Immunol (2010) 1.54
Intrathymic proliferation wave essential for Valpha14+ natural killer T cell development depends on c-Myc. Proc Natl Acad Sci U S A (2009) 1.50
A genome-wide camptothecin sensitivity screen identifies a mammalian MMS22L-NFKBIL2 complex required for genomic stability. Mol Cell (2010) 1.50
MRN complex function in the repair of chromosomal Rag-mediated DNA double-strand breaks. J Exp Med (2009) 1.50
Deletion of the RAG2 C terminus leads to impaired lymphoid development in mice. Proc Natl Acad Sci U S A (2003) 1.49
Histone H2AX is integral to hypoxia-driven neovascularization. Nat Med (2009) 1.48
Dynamic regulation of c-Myc proto-oncogene expression during lymphocyte development revealed by a GFP-c-Myc knock-in mouse. Eur J Immunol (2008) 1.48
Complementary functions of ATM and H2AX in development and suppression of genomic instability. Proc Natl Acad Sci U S A (2008) 1.42
Thymocyte apoptosis induced by T cell activation is mediated by glucocorticoids in vivo. J Immunol (2002) 1.39
Proteasome activator PA200 is required for normal spermatogenesis. Mol Cell Biol (2006) 1.38
Genotoxic stress-induced cyclin D1 phosphorylation and proteolysis are required for genomic stability. Mol Cell Biol (2008) 1.37
Congenital bone marrow failure in DNA-PKcs mutant mice associated with deficiencies in DNA repair. J Cell Biol (2011) 1.36
ATM-deficient thymic lymphoma is associated with aberrant tcrd rearrangement and gene amplification. J Exp Med (2010) 1.36
Allelic exclusion at the TCRbeta locus. Curr Opin Immunol (2002) 1.30
Defects in coding joint formation in vivo in developing ATM-deficient B and T lymphocytes. J Exp Med (2007) 1.29
Regulation of hematopoietic stem cell differentiation by a single ubiquitin ligase-substrate complex. Nat Immunol (2010) 1.28
miR-211 is a prosurvival microRNA that regulates chop expression in a PERK-dependent manner. Mol Cell (2012) 1.27
53BP1 and p53 synergize to suppress genomic instability and lymphomagenesis. Proc Natl Acad Sci U S A (2006) 1.27
Regulation of cell differentiation by the DNA damage response. Trends Cell Biol (2011) 1.25
Aberrantly resolved RAG-mediated DNA breaks in Atm-deficient lymphocytes target chromosomal breakpoints in cis. Proc Natl Acad Sci U S A (2009) 1.25
Histone H2AX stabilizes broken DNA strands to suppress chromosome breaks and translocations during V(D)J recombination. J Exp Med (2009) 1.24
Loss of ATM kinase activity leads to embryonic lethality in mice. J Cell Biol (2012) 1.23
Impaired V(D)J recombination and lymphocyte development in core RAG1-expressing mice. J Exp Med (2003) 1.18
Autoreactive marginal zone B cells are spontaneously activated but lymph node B cells require T cell help. J Exp Med (2006) 1.17
Distinct roles for PTEN in prevention of T cell lymphoma and autoimmunity in mice. J Clin Invest (2010) 1.17
Selective requirement of p38alpha MAPK in cytokine-dependent, but not antigen receptor-dependent, Th1 responses. J Immunol (2006) 1.16
Intra- and inter-allelic ordering of T cell receptor beta chain gene assembly. Eur J Immunol (2005) 1.11
Regulation of T cell receptor beta allelic exclusion at a level beyond accessibility. Nat Immunol (2005) 1.06
Ataxia telangiectasia mutated (Atm) and DNA-PKcs kinases have overlapping activities during chromosomal signal joint formation. Proc Natl Acad Sci U S A (2011) 1.05
Extrachromosomal recombination substrates recapitulate beyond 12/23 restricted VDJ recombination in nonlymphoid cells. Immunity (2003) 1.05
Revision of T cell receptor {alpha} chain genes is required for normal T lymphocyte development. Proc Natl Acad Sci U S A (2005) 1.04
Mice heterozygous for germ-line mutations in methylthioadenosine phosphorylase (MTAP) die prematurely of T-cell lymphoma. Cancer Res (2009) 1.04
MAPK p38 alpha is dispensable for lymphocyte development and proliferation. J Immunol (2005) 1.03
Collateral damage from antigen receptor gene diversification. Cell (2008) 1.03
Taking it off: regulation of H3 K56 acetylation by Hst3 and Hst4. Cell Cycle (2006) 1.03
β-Catenin induces T-cell transformation by promoting genomic instability. Proc Natl Acad Sci U S A (2013) 1.03
Cd8 enhancer E8I and Runx factors regulate CD8α expression in activated CD8+ T cells. Proc Natl Acad Sci U S A (2011) 1.01
Dramatically increased rearrangement and peripheral representation of Vbeta14 driven by the 3'Dbeta1 recombination signal sequence. Immunity (2003) 1.01