Published in Development on January 01, 2010
Programmed cell death in animal development and disease. Cell (2011) 5.07
Clonogenic neoblasts are pluripotent adult stem cells that underlie planarian regeneration. Science (2011) 3.72
The p53 orchestra: Mdm2 and Mdmx set the tone. Trends Cell Biol (2010) 3.08
The cellular basis for animal regeneration. Dev Cell (2011) 2.14
Genetic regulators of a pluripotent adult stem cell system in planarians identified by RNAi and clonal analysis. Cell Stem Cell (2012) 2.03
Apoptosis, stem cells, and tissue regeneration. Sci Signal (2010) 1.95
Adult somatic stem cells in the human parasite Schistosoma mansoni. Nature (2013) 1.61
A Generic and Cell-Type-Specific Wound Response Precedes Regeneration in Planarians. Dev Cell (2015) 1.54
Stem cell systems and regeneration in planaria. Dev Genes Evol (2012) 1.51
A comparative transcriptomic analysis reveals conserved features of stem cell pluripotency in planarians and mammals. Stem Cells (2012) 1.48
The Mi-2-like Smed-CHD4 gene is required for stem cell differentiation in the planarian Schmidtea mediterranea. Development (2010) 1.40
Constitutive gene expression and the specification of tissue identity in adult planarian biology. Trends Genet (2011) 1.30
The role of apoptosis-induced proliferation for regeneration and cancer. Cold Spring Harb Perspect Biol (2012) 1.28
The history and enduring contributions of planarians to the study of animal regeneration. Wiley Interdiscip Rev Dev Biol (2012) 1.28
DNA damage in oocytes induces a switch of the quality control factor TAp63α from dimer to tetramer. Cell (2011) 1.25
Single-cell analysis reveals functionally distinct classes within the planarian stem cell compartment. Cell Stem Cell (2014) 1.19
A dual platform approach to transcript discovery for the planarian Schmidtea mediterranea to establish RNAseq for stem cell and regeneration biology. PLoS One (2010) 1.16
Selective amputation of the pharynx identifies a FoxA-dependent regeneration program in planaria. Elife (2014) 1.13
PRMT5 and the role of symmetrical dimethylarginine in chromatoid bodies of planarian stem cells. Development (2012) 1.13
Towards a bioinformatics of patterning: a computational approach to understanding regulative morphogenesis. Biol Open (2012) 1.12
SmedGD 2.0: The Schmidtea mediterranea genome database. Genesis (2015) 1.12
Specialized progenitors and regeneration. Development (2013) 1.10
The planarian flatworm: an in vivo model for stem cell biology and nervous system regeneration. Dis Model Mech (2010) 1.09
Functional genomic characterization of neoblast-like stem cells in larval Schistosoma mansoni. Elife (2013) 1.07
Smed454 dataset: unravelling the transcriptome of Schmidtea mediterranea. BMC Genomics (2010) 1.01
Regulation of p53 is critical for vertebrate limb regeneration. Proc Natl Acad Sci U S A (2013) 0.98
Amputation induces stem cell mobilization to sites of injury during planarian regeneration. Development (2012) 0.96
SMG-1 and mTORC1 act antagonistically to regulate response to injury and growth in planarians. PLoS Genet (2012) 0.95
A mex3 homolog is required for differentiation during planarian stem cell lineage development. Elife (2015) 0.95
Analysis of the oligomeric state and transactivation potential of TAp73α. Cell Death Differ (2013) 0.94
The p53 control of apoptosis and proliferation: lessons from Drosophila. Apoptosis (2014) 0.93
Stem cell progeny contribute to the schistosome host-parasite interface. Elife (2016) 0.91
Tumor suppressors: enhancers or suppressors of regeneration? Development (2013) 0.87
p53 activity is selectively licensed in the Drosophila stem cell compartment. Elife (2014) 0.87
Egr-5 is a post-mitotic regulator of planarian epidermal differentiation. Elife (2015) 0.87
Turning terminally differentiated skeletal muscle cells into regenerative progenitors. Nat Commun (2015) 0.86
Selected drugs that inhibit DNA methylation can preferentially kill p53 deficient cells. Oncotarget (2014) 0.86
The CCR4-NOT complex mediates deadenylation and degradation of stem cell mRNAs and promotes planarian stem cell differentiation. PLoS Genet (2013) 0.84
Unusually Large Number of Mutations in Asexually Reproducing Clonal Planarian Dugesia japonica. PLoS One (2015) 0.83
Types or States? Cellular Dynamics and Regenerative Potential. Trends Cell Biol (2015) 0.82
HOX gene complement and expression in the planarian Schmidtea mediterranea. Evodevo (2016) 0.82
The Flatworm Macrostomum lignano Is a Powerful Model Organism for Ion Channel and Stem Cell Research. Stem Cells Int (2012) 0.81
p53 on the crossroad between regeneration and cancer. Cell Death Differ (2016) 0.80
Cellular hyperproliferation and cancer as evolutionary variables. Curr Biol (2012) 0.79
Egf Signaling Directs Neoblast Repopulation by Regulating Asymmetric Cell Division in Planarians. Dev Cell (2016) 0.78
Inhibitors of the p53-Mdm2 interaction increase programmed cell death and produce abnormal phenotypes in the placozoon Trichoplax adhaerens (F.E. Schulze). Dev Genes Evol (2014) 0.77
Go ahead, grow a head! A planarian's guide to anterior regeneration. Regeneration (Oxf) (2016) 0.76
Yorkie is required to restrict the injury responses in planarians. PLoS Genet (2017) 0.76
Alejandro Sánchez Alvarado: bootstrapping flatworms into the molecular age. J Cell Biol (2011) 0.75
Digital gene expression approach over multiple RNA-Seq data sets to detect neoblast transcriptional changes in Schmidtea mediterranea. BMC Genomics (2015) 0.75
Regional signals in the planarian body guide stem cell fate in the presence of genomic instability. Development (2016) 0.75
Stem cell proliferation patterns as an alternative for in vivo prediction and discrimination of carcinogenic compounds. Sci Rep (2017) 0.75
Alternative flow cytometry strategies to analyze stem cells and cell death in planarians. Regeneration (Oxf) (2016) 0.75
Integrins are required for tissue organization and restriction of neurogenesis in regenerating planarians. Development (2017) 0.75
A novel AKT inhibitor, AZD5363, inhibits phosphorylation of AKT downstream molecules, and activates phosphorylation of mTOR and SMG-1 dependent on the liver cancer cell type. Oncol Lett (2016) 0.75
Generation of cell type-specific monoclonal antibodies for the planarian and optimization of sample processing for immunolabeling. BMC Dev Biol (2014) 0.75
Ironing out how p53 regulates ferroptosis. Proc Natl Acad Sci U S A (2016) 0.75
Smed-dynA-1 is a planarian nervous system specific dynamin 1 homolog required for normal locomotion. Biol Open (2014) 0.75
Embryonic origin of adult stem cells required for tissue homeostasis and regeneration. Elife (2017) 0.75
Genome-Wide Analysis of Polyadenylation Events in Schmidtea mediterranea. G3 (Bethesda) (2016) 0.75
T-Coffee: A novel method for fast and accurate multiple sequence alignment. J Mol Biol (2000) 57.88
SMART, a simple modular architecture research tool: identification of signaling domains. Proc Natl Acad Sci U S A (1998) 36.83
InterProScan: protein domains identifier. Nucleic Acids Res (2005) 18.82
Mechanisms and functional implications of adult neurogenesis. Cell (2008) 14.50
p53: puzzle and paradigm. Genes Dev (1996) 13.16
The Biomolecular Interaction Network Database and related tools 2005 update. Nucleic Acids Res (2005) 12.94
Proliferation, cell cycle and apoptosis in cancer. Nature (2001) 9.57
Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer. Nat Genet (2001) 9.55
Regulating the p53 pathway: in vitro hypotheses, in vivo veritas. Nat Rev Cancer (2006) 8.83
p63 Is essential for the proliferative potential of stem cells in stratified epithelia. Cell (2007) 6.50
MAKER: an easy-to-use annotation pipeline designed for emerging model organism genomes. Genome Res (2007) 6.48
Fundamentals of planarian regeneration. Annu Rev Cell Dev Biol (2004) 4.60
Identification of genes needed for regeneration, stem cell function, and tissue homeostasis by systematic gene perturbation in planaria. Dev Cell (2005) 4.35
Targeted mutagenesis by homologous recombination in D. melanogaster. Genes Dev (2002) 4.21
Understanding the function-structure and function-mutation relationships of p53 tumor suppressor protein by high-resolution missense mutation analysis. Proc Natl Acad Sci U S A (2003) 4.06
p63 protects the female germ line during meiotic arrest. Nature (2006) 3.98
Drosophila p53 binds a damage response element at the reaper locus. Cell (2000) 3.92
SMEDWI-2 is a PIWI-like protein that regulates planarian stem cells. Science (2005) 3.83
On the shoulders of giants: p63, p73 and the rise of p53. Trends Genet (2002) 3.57
p53/p63/p73 isoforms: an orchestra of isoforms to harmonise cell differentiation and response to stress. Cell Death Differ (2006) 3.49
Drosophila p53 is a structural and functional homolog of the tumor suppressor p53. Cell (2000) 3.41
p53 suppresses the self-renewal of adult neural stem cells. Development (2006) 3.35
Beta-catenin defines head versus tail identity during planarian regeneration and homeostasis. Science (2007) 3.26
Caenorhabditis elegans p53: role in apoptosis, meiosis, and stress resistance. Science (2001) 3.16
Not your father's planarian: a classic model enters the era of functional genomics. Nat Rev Genet (2002) 3.06
SmedGD: the Schmidtea mediterranea genome database. Nucleic Acids Res (2007) 3.02
p63 and p73: roles in development and tumor formation. Mol Cancer Res (2004) 2.96
Bromodeoxyuridine specifically labels the regenerative stem cells of planarians. Dev Biol (2000) 2.94
Molecular analysis of stem cells and their descendants during cell turnover and regeneration in the planarian Schmidtea mediterranea. Cell Stem Cell (2008) 2.73
The Schmidtea mediterranea database as a molecular resource for studying platyhelminthes, stem cells and regeneration. Development (2002) 2.71
Compensatory proliferation in Drosophila imaginal discs requires Dronc-dependent p53 activity. Curr Biol (2006) 2.51
Ingestion of bacterially expressed double-stranded RNA inhibits gene expression in planarians. Proc Natl Acad Sci U S A (2003) 2.44
Formaldehyde-based whole-mount in situ hybridization method for planarians. Dev Dyn (2009) 2.42
p53: guardian of the genome and policeman of the oncogenes. Cell Cycle (2007) 2.23
p63 and p73 in human cancer: defining the network. Oncogene (2007) 2.13
A Bruno-like gene is required for stem cell maintenance in planarians. Dev Cell (2006) 2.08
Loss of p53 induces changes in the behavior of subventricular zone cells: implication for the genesis of glial tumors. J Neurosci (2006) 2.00
Are interactions with p63 and p73 involved in mutant p53 gain of oncogenic function? Oncogene (2007) 1.97
Isolation of planarian X-ray-sensitive stem cells by fluorescence-activated cell sorting. Dev Growth Differ (2006) 1.94
Use of human tissue to assess the oncogenic activity of melanoma-associated mutations. Nat Genet (2005) 1.90
The oncogenic roles of p53 mutants in mouse models. Curr Opin Genet Dev (2007) 1.59
Of flies and men; p53, a tumour suppressor. FEBS Lett (2004) 1.53
p73 is required for survival and maintenance of CNS neurons. J Neurosci (2002) 1.53
Complicating the complexity of p53. Carcinogenesis (2005) 1.34
Structural evolution of C-terminal domains in the p53 family. EMBO J (2007) 1.32
Lessons from p53 in non-mammalian models. Cell Death Differ (2006) 1.18
Early diversification and complex evolutionary history of the p53 tumor suppressor gene family. Dev Genes Evol (2007) 1.13
Regeneration, stem cells, and the evolution of tumor suppression. Cold Spring Harb Symp Quant Biol (2009) 1.01
Phosphorylation by DNAPK inhibits the DNA-binding function of p53/T antigen complex in vitro. Anticancer Res (1999) 0.78
MAKER: an easy-to-use annotation pipeline designed for emerging model organism genomes. Genome Res (2007) 6.48
Fundamentals of planarian regeneration. Annu Rev Cell Dev Biol (2004) 4.60
Identification of genes needed for regeneration, stem cell function, and tissue homeostasis by systematic gene perturbation in planaria. Dev Cell (2005) 4.35
SMEDWI-2 is a PIWI-like protein that regulates planarian stem cells. Science (2005) 3.83
Beta-catenin defines head versus tail identity during planarian regeneration and homeostasis. Science (2007) 3.26
Not your father's planarian: a classic model enters the era of functional genomics. Nat Rev Genet (2002) 3.06
SmedGD: the Schmidtea mediterranea genome database. Nucleic Acids Res (2007) 3.02
Molecular analysis of stem cells and their descendants during cell turnover and regeneration in the planarian Schmidtea mediterranea. Cell Stem Cell (2008) 2.73
Ingestion of bacterially expressed double-stranded RNA inhibits gene expression in planarians. Proc Natl Acad Sci U S A (2003) 2.44
Formaldehyde-based whole-mount in situ hybridization method for planarians. Dev Dyn (2009) 2.42
Planarian Hh signaling regulates regeneration polarity and links Hh pathway evolution to cilia. Science (2009) 2.25
Slicing across kingdoms: regeneration in plants and animals. Cell (2008) 2.18
Cell turnover and adult tissue homeostasis: from humans to planarians. Annu Rev Genet (2007) 2.10
Cell death and tissue remodeling in planarian regeneration. Dev Biol (2009) 1.87
FGFR-related gene nou-darake restricts brain tissues to the head region of planarians. Nature (2002) 1.80
De novo assembly and validation of planaria transcriptome by massive parallel sequencing and shotgun proteomics. Genome Res (2011) 1.70
Expression of secreted Wnt pathway components reveals unexpected complexity of the planarian amputation response. Dev Biol (2010) 1.68
BMP signaling regulates the dorsal planarian midline and is needed for asymmetric regeneration. Development (2007) 1.66
High-resolution profiling and discovery of planarian small RNAs. Proc Natl Acad Sci U S A (2009) 1.53
Allometric scaling and proportion regulation in the freshwater planarian Schmidtea mediterranea. Dev Dyn (2003) 1.49
Centrosome loss in the evolution of planarians. Science (2012) 1.29
Morphological and functional recovery of the planarian photosensing system during head regeneration. Zoolog Sci (2004) 1.28
The history and enduring contributions of planarians to the study of animal regeneration. Wiley Interdiscip Rev Dev Biol (2012) 1.28
The maintenance and regeneration of the planarian excretory system are regulated by EGFR signaling. Development (2011) 1.27
Mitochondrial pathway of apoptosis is ancestral in metazoans. Proc Natl Acad Sci U S A (2012) 1.21
Identification of immunological reagents for use in the study of freshwater planarians by means of whole-mount immunofluorescence and confocal microscopy. Genesis (2002) 1.18
Selective amputation of the pharynx identifies a FoxA-dependent regeneration program in planaria. Elife (2014) 1.13
Amputation induces stem cell mobilization to sites of injury during planarian regeneration. Development (2012) 0.96
Planarian PTEN homologs regulate stem cells and regeneration through TOR signaling. Dis Model Mech (2008) 0.93
Flow cytometry methods for the study of cell-cycle parameters of planarian stem cells. Dev Dyn (2009) 0.87
TORC1 is required to balance cell proliferation and cell death in planarians. Dev Biol (2012) 0.87
Gene nomenclature guidelines for the planarian Schmidtea mediterranea. Dev Dyn (2008) 0.82
Molecular cloning and characterization of SL3: a stem cell-specific SL RNA from the planarian Schmidtea mediterranea. Gene (2013) 0.80
Planarian immobilization, partial irradiation, and tissue transplantation. J Vis Exp (2012) 0.79
Developmental biology: A cellular view of regeneration. Nature (2009) 0.78
Alejandro Sánchez Alvarado: bootstrapping flatworms into the molecular age. J Cell Biol (2011) 0.75