Published in Dev Cell on August 01, 2001
The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6. Genes Dev (2002) 8.19
Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies. Nat Genet (2009) 5.32
Interactions between Sox9 and beta-catenin control chondrocyte differentiation. Genes Dev (2004) 4.78
Genome-wide association study of PR interval. Nat Genet (2010) 3.73
The secreted glycoprotein lubricin protects cartilage surfaces and inhibits synovial cell overgrowth. J Clin Invest (2005) 3.56
Bmpr1a and Bmpr1b have overlapping functions and are essential for chondrogenesis in vivo. Proc Natl Acad Sci U S A (2005) 2.82
Control of cell fate and differentiation by Sry-related high-mobility-group box (Sox) transcription factors. Int J Biochem Cell Biol (2007) 2.78
Sox9 is required for determination of the chondrogenic cell lineage in the cranial neural crest. Proc Natl Acad Sci U S A (2003) 2.64
The Dlx5 and Dlx6 homeobox genes are essential for craniofacial, axial, and appendicular skeletal development. Genes Dev (2002) 2.48
SOX5 postmitotically regulates migration, postmigratory differentiation, and projections of subplate and deep-layer neocortical neurons. Proc Natl Acad Sci U S A (2008) 2.26
Copy number variation in intron 1 of SOX5 causes the Pea-comb phenotype in chickens. PLoS Genet (2009) 2.10
L-Sox5 and Sox6 drive expression of the aggrecan gene in cartilage by securing binding of Sox9 to a far-upstream enhancer. Mol Cell Biol (2008) 2.07
BMP receptor signaling is required for postnatal maintenance of articular cartilage. PLoS Biol (2004) 2.05
Runx2 induces osteoblast and chondrocyte differentiation and enhances their migration by coupling with PI3K-Akt signaling. J Cell Biol (2004) 1.99
Hif-1alpha regulates differentiation of limb bud mesenchyme and joint development. J Cell Biol (2007) 1.95
Development of the endochondral skeleton. Cold Spring Harb Perspect Biol (2013) 1.89
NF-kappaB signaling: multiple angles to target OA. Curr Drug Targets (2010) 1.89
Essential role of Sox9 in the pathway that controls formation of cardiac valves and septa. Proc Natl Acad Sci U S A (2004) 1.77
Advances in the understanding of haemoglobin switching. Br J Haematol (2010) 1.74
Assembling neural crest regulatory circuits into a gene regulatory network. Annu Rev Cell Dev Biol (2010) 1.72
The three SoxC proteins--Sox4, Sox11 and Sox12--exhibit overlapping expression patterns and molecular properties. Nucleic Acids Res (2008) 1.70
Transcriptome analysis of mammary epithelial subpopulations identifies novel determinants of lineage commitment and cell fate. BMC Genomics (2008) 1.70
The cell-intrinsic requirement of Sox6 for cortical interneuron development. Neuron (2009) 1.66
SOX6 controls dorsal progenitor identity and interneuron diversity during neocortical development. Nat Neurosci (2009) 1.58
Runx2 inhibits chondrocyte proliferation and hypertrophy through its expression in the perichondrium. Genes Dev (2006) 1.52
Shh establishes an Nkx3.2/Sox9 autoregulatory loop that is maintained by BMP signals to induce somitic chondrogenesis. Genes Dev (2002) 1.48
Generation of hyaline cartilaginous tissue from mouse adult dermal fibroblast culture by defined factors. J Clin Invest (2011) 1.45
Sox5 and Sox6 are needed to develop and maintain source, columnar, and hypertrophic chondrocytes in the cartilage growth plate. J Cell Biol (2004) 1.45
S100A1 and S100B, transcriptional targets of SOX trio, inhibit terminal differentiation of chondrocytes. EMBO Rep (2007) 1.36
Unraveling the transcriptional regulatory machinery in chondrogenesis. J Bone Miner Metab (2011) 1.34
Sox6 directly silences epsilon globin expression in definitive erythropoiesis. PLoS Genet (2006) 1.34
Vertebrate skeletogenesis. Curr Top Dev Biol (2010) 1.30
Hypoxia, HIFs and bone development. Bone (2010) 1.29
The regulation of valvular and vascular sclerosis by osteogenic morphogens. Circ Res (2011) 1.29
Genetics and function of neocortical GABAergic interneurons in neurodevelopmental disorders. Neural Plast (2011) 1.29
The E3 ubiquitin ligase Wwp2 regulates craniofacial development through mono-ubiquitylation of Goosecoid. Nat Cell Biol (2010) 1.29
Wwp2 is essential for palatogenesis mediated by the interaction between Sox9 and mediator subunit 25. Nat Commun (2011) 1.27
Powerful bivariate genome-wide association analyses suggest the SOX6 gene influencing both obesity and osteoporosis phenotypes in males. PLoS One (2009) 1.26
Constitutive activation of MKK6 in chondrocytes of transgenic mice inhibits proliferation and delays endochondral bone formation. Proc Natl Acad Sci U S A (2005) 1.26
Prolonged Sox4 expression in oligodendrocytes interferes with normal myelination in the central nervous system. Mol Cell Biol (2007) 1.24
Runx1 and Runx2 cooperate during sternal morphogenesis. Development (2010) 1.24
Transcriptional regulation of chondrogenesis by coactivator Tip60 via chromatin association with Sox9 and Sox5. Nucleic Acids Res (2008) 1.23
Requirement for RAR-mediated gene repression in skeletal progenitor differentiation. J Cell Biol (2002) 1.23
Molecular hallmarks of endogenous chromatin complexes containing master regulators of hematopoiesis. Mol Cell Biol (2008) 1.23
The SoxD transcription factors--Sox5, Sox6, and Sox13--are key cell fate modulators. Int J Biochem Cell Biol (2009) 1.21
A pathway to bone: signaling molecules and transcription factors involved in chondrocyte development and maturation. Development (2015) 1.19
Smad-dependent recruitment of a histone deacetylase/Sin3A complex modulates the bone morphogenetic protein-dependent transcriptional repressor activity of Nkx3.2. Mol Cell Biol (2003) 1.19
Morphogenetic and regulatory mechanisms during developmental chondrogenesis: new paradigms for cartilage tissue engineering. Tissue Eng Part B Rev (2009) 1.17
An in situ hybridization study of Runx2, Osterix, and Sox9 at the onset of condylar cartilage formation in fetal mouse mandible. J Anat (2006) 1.17
The transcription factor Sox5 modulates Sox10 function during melanocyte development. Nucleic Acids Res (2008) 1.16
Genetics of osteoporosis: accelerating pace in gene identification and validation. Hum Genet (2009) 1.14
Concerted regulation of myofiber-specific gene expression and muscle performance by the transcriptional repressor Sox6. Proc Natl Acad Sci U S A (2011) 1.13
A direct role of SRY and SOX proteins in pre-mRNA splicing. Proc Natl Acad Sci U S A (2002) 1.12
mTOR signaling contributes to chondrocyte differentiation. Dev Dyn (2008) 1.12
Sox6 regulation of cardiac myocyte development. Nucleic Acids Res (2003) 1.11
SoxE factors as multifunctional neural crest regulatory factors. Int J Biochem Cell Biol (2009) 1.09
Synovial joint morphogenesis requires the chondrogenic action of Sox5 and Sox6 in growth plate and articular cartilage. Dev Biol (2010) 1.08
TAK1 regulates cartilage and joint development via the MAPK and BMP signaling pathways. J Bone Miner Res (2010) 1.08
Molecular profiling of the developing mouse axial skeleton: a role for Tgfbr2 in the development of the intervertebral disc. BMC Dev Biol (2010) 1.07
Evidence for pleiotropic factors in genetics of the musculoskeletal system. Bone (2010) 1.06
BMP action in skeletogenesis involves attenuation of retinoid signaling. J Cell Biol (2006) 1.05
Focal adhesion kinase/Src suppresses early chondrogenesis: central role of CCN2. J Biol Chem (2008) 1.04
Sox15 is required for skeletal muscle regeneration. Mol Cell Biol (2004) 1.04
Distinct roles of Sox5, Sox6, and Sox9 in different stages of chondrogenic differentiation. J Bone Miner Metab (2005) 1.04
Sox5 and c-Maf cooperatively induce Th17 cell differentiation via RORγt induction as downstream targets of Stat3. J Exp Med (2014) 1.03
Genome-wide mapping of Sox6 binding sites in skeletal muscle reveals both direct and indirect regulation of muscle terminal differentiation by Sox6. BMC Dev Biol (2011) 1.03
MiR-194 regulates chondrogenic differentiation of human adipose-derived stem cells by targeting Sox5. PLoS One (2012) 1.02
Site-1 protease is essential for endochondral bone formation in mice. J Cell Biol (2007) 1.02
Sequence evaluation of FGF and FGFR gene conserved non-coding elements in non-syndromic cleft lip and palate cases. Am J Med Genet A (2007) 1.02
Highly conserved proximal promoter element harbouring paired Sox9-binding sites contributes to the tissue- and developmental stage-specific activity of the matrilin-1 gene. Biochem J (2005) 1.02
Spatial and temporal regulation of gene expression in the mammalian growth plate. Bone (2010) 1.01
An in situ hybridization study of Runx2, Osterix, and Sox9 in the anlagen of mouse mandibular condylar cartilage in the early stages of embryogenesis. J Anat (2008) 1.00
Human circulating fibrocytes have the capacity to differentiate osteoblasts and chondrocytes. Int J Biochem Cell Biol (2009) 1.00
Sox9 family members negatively regulate maturation and calcification of chondrocytes through up-regulation of parathyroid hormone-related protein. Mol Biol Cell (2009) 1.00
L-Sox5 and Sox6 proteins enhance chondrogenic miR-140 microRNA expression by strengthening dimeric Sox9 activity. J Biol Chem (2012) 0.99
The transcription factors SOX9 and SOX5/SOX6 cooperate genome-wide through super-enhancers to drive chondrogenesis. Nucleic Acids Res (2015) 0.99
Genomewide linkage and peakwide association analyses of carotid plaque in Caribbean Hispanics. Stroke (2010) 0.98
Normal proliferation and differentiation of Hoxc-8 transgenic chondrocytes in vitro. BMC Dev Biol (2003) 0.98
New insights into osteogenic and chondrogenic differentiation of human bone marrow mesenchymal stem cells and their potential clinical applications for bone regeneration in pediatric orthopaedics. Stem Cells Int (2013) 0.98
Inactivation of Patched1 in the mouse limb has novel inhibitory effects on the chondrogenic program. J Biol Chem (2010) 0.98
Nfat1 regulates adult articular chondrocyte function through its age-dependent expression mediated by epigenetic histone methylation. J Bone Miner Res (2011) 0.97
Quantitative trait loci, genes, and polymorphisms that regulate bone mineral density in mouse. Genomics (2009) 0.96
Genome-wide map of quantified epigenetic changes during in vitro chondrogenic differentiation of primary human mesenchymal stem cells. BMC Genomics (2013) 0.96
MiR-499 regulates cell proliferation and apoptosis during late-stage cardiac differentiation via Sox6 and cyclin D1. PLoS One (2013) 0.95
Chondrocyte-specific regulatory activity of Runx2 is essential for survival and skeletal development. Cells Tissues Organs (2011) 0.95
Sox6, jack of all trades: a versatile regulatory protein in vertebrate development. Dev Dyn (2011) 0.94
Grape-seed proanthocyanidin extract as suppressors of bone destruction in inflammatory autoimmune arthritis. PLoS One (2012) 0.94
Runx2 regulates endochondral ossification through control of chondrocyte proliferation and differentiation. J Bone Miner Res (2014) 0.93
Genetic variants in the SOX6 gene are associated with bone mineral density in both Caucasian and Chinese populations. Osteoporos Int (2011) 0.93
Ribosome biogenesis in skeletal development and the pathogenesis of skeletal disorders. Biochim Biophys Acta (2013) 0.93
Haploinsufficiency of SOX5 at 12p12.1 is associated with developmental delays with prominent language delay, behavior problems, and mild dysmorphic features. Hum Mutat (2012) 0.93
Evolutionarily conserved, growth plate zone-specific regulation of the matrilin-1 promoter: L-Sox5/Sox6 and Nfi factors bound near TATA finely tune activation by Sox9. Mol Cell Biol (2010) 0.93
Transcriptional regulation of an axonemal central apparatus gene, sperm-associated antigen 6, by a SRY-related high mobility group transcription factor, S-SOX5. J Biol Chem (2010) 0.92
Upregulation of Runx2 and Osterix during in vitro chondrogenesis of human adipose-derived stromal cells. Biochem Biophys Res Commun (2008) 0.92
Myostatin (GDF-8) inhibits chondrogenesis and chondrocyte proliferation in vitro by suppressing Sox-9 expression. Growth Factors (2011) 0.92
Constitutive E2F1 overexpression delays endochondral bone formation by inhibiting chondrocyte differentiation. Mol Cell Biol (2003) 0.91
Transcriptional control of mesenchymal stem cell differentiation. Transfus Med Hemother (2008) 0.90
Sox6 is necessary for efficient erythropoiesis in adult mice under physiological and anemia-induced stress conditions. PLoS One (2010) 0.90
Sry-box (Sox) transcription factors in gastrointestinal physiology and disease. Am J Physiol Gastrointest Liver Physiol (2011) 0.89
Arid5a cooperates with Sox9 to stimulate chondrocyte-specific transcription. Mol Biol Cell (2011) 0.88
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res (1997) 665.31
A computer program for aligning a cDNA sequence with a genomic DNA sequence. Genome Res (1998) 22.69
Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy. N Engl J Med (2001) 22.32
PipMaker--a web server for aligning two genomic DNA sequences. Genome Res (2000) 17.46
Evidence for two functional gal promoters in intact Escherichia coli cells. J Biol Chem (1981) 17.42
Cyclic AMP receptor protein: role in transcription activation. Science (1984) 8.37
The status of online Mendelian inheritance in man (OMIM) medio 1994. Nucleic Acids Res (1994) 8.00
Sox9 is required for cartilage formation. Nat Genet (1999) 7.89
Comparison of DNA sequences with protein sequences. Genomics (1997) 7.76
Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein. Nature (1997) 7.10
Therapeutic benefit of intravenous administration of bone marrow stromal cells after cerebral ischemia in rats. Stroke (2001) 6.61
SOX9 is a potent activator of the chondrocyte-specific enhancer of the pro alpha1(II) collagen gene. Mol Cell Biol (1997) 5.72
Identification of a functional promoter in the long terminal repeat of Rous sarcoma virus. Cell (1980) 5.51
Dual control for transcription of the galactose operon by cyclic AMP and its receptor protein at two interspersed promoters. Cell (1977) 5.29
Some recent advances in the chemistry and biology of transforming growth factor-beta. J Cell Biol (1987) 5.25
Introns increase transcriptional efficiency in transgenic mice. Proc Natl Acad Sci U S A (1988) 5.18
A new long form of Sox5 (L-Sox5), Sox6 and Sox9 are coexpressed in chondrogenesis and cooperatively activate the type II collagen gene. EMBO J (1998) 5.15
Biochemical and functional analysis of mice deficient in expression of the CD45-associated phosphoprotein LPAP. Eur J Immunol (1999) 5.02
Structure of the promoter for chicken alpha 2 type I collagen gene. Proc Natl Acad Sci U S A (1981) 4.89
Requirement for Wnt3 in vertebrate axis formation. Nat Genet (1999) 4.68
Roles of PLC-beta2 and -beta3 and PI3Kgamma in chemoattractant-mediated signal transduction. Science (2000) 4.61
A single erythroid-specific DNase I super-hypersensitive site activates high levels of human beta-globin gene expression in transgenic mice. Genes Dev (1989) 4.60
High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C--dependent activation of NAD(P)H oxidase in cultured vascular cells. Diabetes (2000) 4.55
Inhibition of ICE family proteases by baculovirus antiapoptotic protein p35. Science (1995) 4.41
twist is required in head mesenchyme for cranial neural tube morphogenesis. Genes Dev (1995) 4.38
Bmpr encodes a type I bone morphogenetic protein receptor that is essential for gastrulation during mouse embryogenesis. Genes Dev (1995) 4.23
Radiation damage in the TEM and SEM. Micron (2004) 4.15
Haploinsufficiency of Sox9 results in defective cartilage primordia and premature skeletal mineralization. Proc Natl Acad Sci U S A (2001) 4.13
Cell lineage ablation in transgenic mice by cell-specific expression of a toxin gene. Cell (1987) 4.02
Vectors that facilitate the expression and purification of foreign peptides in Escherichia coli by fusion to maltose-binding protein. Gene (1988) 3.92
Effect of long-term estrogen deprivation on apoptotic responses of breast cancer cells to 17beta-estradiol. J Natl Cancer Inst (2001) 3.88
Requirement for Lim1 in head-organizer function. Nature (1995) 3.86
Interaction site of Escherichia coli cyclic AMP receptor protein on DNA of galactose operon promoters. Proc Natl Acad Sci U S A (1979) 3.83
The pathogenesis and diagnosis of foot-and-mouth disease. J Comp Pathol (2003) 3.83
Levels of translatable mRNAs for cell surface protein, collagen precursors, and two membrane proteins are altered in Rous sarcoma virus-transformed chick embryo fibroblasts. Proc Natl Acad Sci U S A (1977) 3.80
Comparative sequence analysis of a gene-rich cluster at human chromosome 12p13 and its syntenic region in mouse chromosome 6. Genome Res (1998) 3.80
Cryopyrin and pyrin activate caspase-1, but not NF-kappaB, via ASC oligomerization. Cell Death Differ (2006) 3.77
Col2a1-directed expression of Cre recombinase in differentiating chondrocytes in transgenic mice. Genesis (2000) 3.74
A nuclear factor 1 binding site mediates the transcriptional activation of a type I collagen promoter by transforming growth factor-beta. Cell (1988) 3.72
Identification of a new catenin: the tyrosine kinase substrate p120cas associates with E-cadherin complexes. Mol Cell Biol (1994) 3.66
The collagen gene: evidence for its evolutinary assembly by amplification of a DNA segment containing an exon of 54 bp. Cell (1980) 3.66
Dachshund and eyes absent proteins form a complex and function synergistically to induce ectopic eye development in Drosophila. Cell (1997) 3.58
Identification of an angiogenic mitogen selective for endocrine gland endothelium. Nature (2001) 3.42
Parallel expression of Sox9 and Col2a1 in cells undergoing chondrogenesis. Dev Dyn (1997) 3.35
A gene for a novel zinc-finger protein expressed in differentiated epithelial cells and transiently in certain mesenchymal cells. J Biol Chem (1996) 3.30
Psychosocial research is essential to understanding and treating AIDS. Am Psychol (1984) 3.27
Dual time point 18F-FDG PET imaging for differentiating malignant from inflammatory processes. J Nucl Med (2001) 3.24
Interaction of human immunodeficiency virus type 1 and human herpesvirus type 8 infections on the incidence of Kaposi's sarcoma. J Infect Dis (2000) 3.20
Separate cis-acting DNA elements of the mouse pro-alpha 1(I) collagen promoter direct expression of reporter genes to different type I collagen-producing cells in transgenic mice. J Cell Biol (1995) 3.16
Source-zone characterization of a chlorinated-solvent contaminated Superfund site in Tucson, AZ. J Contam Hydrol (2006) 3.10
A novel positive feedback loop mediated by the docking protein Gab1 and phosphatidylinositol 3-kinase in epidermal growth factor receptor signaling. Mol Cell Biol (2000) 3.04
The family of collagen genes. Annu Rev Biochem (1990) 2.98
The actinomycete Thermobispora bispora contains two distinct types of transcriptionally active 16S rRNA genes. J Bacteriol (1997) 2.96
New tumor markers: CA125 and beyond. Int J Gynecol Cancer (2005) 2.92
Requirement of endogenous stem cell factor and granulocyte-colony-stimulating factor for IL-17-mediated granulopoiesis. J Immunol (2000) 2.81
Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R. J Biol Chem (2000) 2.73
Distinct types of rRNA operons exist in the genome of the actinomycete Thermomonospora chromogena and evidence for horizontal transfer of an entire rRNA operon. J Bacteriol (1999) 2.72
Role of the CCAAT-binding protein CBF/NF-Y in transcription. Trends Biochem Sci (1998) 2.71
Kinesin family in murine central nervous system. J Cell Biol (1992) 2.70
Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function. Oncogene (2007) 2.68
Mouse gastrulation: the formation of a mammalian body plan. Mech Dev (1997) 2.68
beta-Trcp couples beta-catenin phosphorylation-degradation and regulates Xenopus axis formation. Proc Natl Acad Sci U S A (1999) 2.66
Genetic relationship of populations in China. Proc Natl Acad Sci U S A (1998) 2.65
Transcriptional mechanisms of chondrocyte differentiation. Matrix Biol (2000) 2.61
Nucleotide sequence of the operator-promoter region of the galactose operon of Escherichia coli. Proc Natl Acad Sci U S A (1977) 2.57
Probing the non-covalent structure of proteins by amide hydrogen exchange and mass spectrometry. J Mass Spectrom (1997) 2.54
Wnt-1 signaling inhibits apoptosis by activating beta-catenin/T cell factor-mediated transcription. J Cell Biol (2001) 2.52
Characterization of HIV replication complexes early after cell-to-cell infection. AIDS Res Hum Retroviruses (1993) 2.52
Clinical manifestations and diagnosis of acute pyrethroid poisoning. Arch Toxicol (1989) 2.50
CA 125: the past and the future. Int J Biol Markers (1999) 2.50
Regulatory mechanisms in the pathways of cartilage and bone formation. Curr Opin Cell Biol (2001) 2.49
Comprehensive assessment and standardization of solid phase multiplex-bead arrays for the detection of antibodies to HLA. Am J Transplant (2013) 2.45
Genetically haploid spermatids are phenotypically diploid. Nature (1989) 2.45
Xa21D encodes a receptor-like molecule with a leucine-rich repeat domain that determines race-specific recognition and is subject to adaptive evolution. Plant Cell (1998) 2.43
Interactions of human NKG2D with its ligands MICA, MICB, and homologs of the mouse RAE-1 protein family. Immunogenetics (2001) 2.43
Sulforaphane, a naturally occurring isothiocyanate, induces cell cycle arrest and apoptosis in HT29 human colon cancer cells. Cancer Res (2000) 2.42
The 40-kDa subunit of DNA fragmentation factor induces DNA fragmentation and chromatin condensation during apoptosis. Proc Natl Acad Sci U S A (1998) 2.38
Superfibronectin is a functionally distinct form of fibronectin. Nature (1994) 2.38
Unusual methylation pattern of the alpha 2 (l) collagen gene. Cell (1982) 2.36
Spermatid-specific expression of protamine 1 in transgenic mice. Proc Natl Acad Sci U S A (1987) 2.36
Unusual location and function of the operator in the Escherichia coli galactose operon. Nature (1979) 2.35
Functional recovery in parkinsonian monkeys treated with GDNF. Nature (1996) 2.35
Overexpression of insulin-like growth factor-1 in the heart is coupled with myocyte proliferation in transgenic mice. Proc Natl Acad Sci U S A (1996) 2.34
Mutations in the Escherichia coli operon that define two promoters and the binding site of the cyclic AMP receptor protein. J Mol Biol (1982) 2.30
Copy number variations of chromosome 16p13.1 region associated with schizophrenia. Mol Psychiatry (2009) 2.29
Rapid and efficient cell-to-cell transmission of human immunodeficiency virus infection from monocyte-derived macrophages to peripheral blood lymphocytes. Virology (1999) 2.27
Neurobehavioural testing in workers occupationally exposed to lead: systematic review and meta-analysis of publications. Occup Environ Med (2002) 2.27
High-level erythroid expression of human alpha-globin genes in transgenic mice. Proc Natl Acad Sci U S A (1989) 2.26
Structural and mechanistic studies on 2-oxoglutarate-dependent oxygenases and related enzymes. Curr Opin Struct Biol (1999) 2.25
Syndecans serve as attachment receptors for human immunodeficiency virus type 1 on macrophages. J Virol (2001) 2.24