Published in Mol Cell Biol on April 01, 1997
The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6. Genes Dev (2002) 8.19
A new long form of Sox5 (L-Sox5), Sox6 and Sox9 are coexpressed in chondrogenesis and cooperatively activate the type II collagen gene. EMBO J (1998) 5.15
Interactions between Sox9 and beta-catenin control chondrocyte differentiation. Genes Dev (2004) 4.78
Osteo-chondroprogenitor cells are derived from Sox9 expressing precursors. Proc Natl Acad Sci U S A (2005) 4.25
Haploinsufficiency of Sox9 results in defective cartilage primordia and premature skeletal mineralization. Proc Natl Acad Sci U S A (2001) 4.13
SOX9 is an intestine crypt transcription factor, is regulated by the Wnt pathway, and represses the CDX2 and MUC2 genes. J Cell Biol (2004) 3.24
Control of cell fate and differentiation by Sry-related high-mobility-group box (Sox) transcription factors. Int J Biochem Cell Biol (2007) 2.78
Sox9 inhibits Wnt signaling by promoting beta-catenin phosphorylation in the nucleus. J Biol Chem (2008) 2.57
Direct interaction of SRY-related protein SOX9 and steroidogenic factor 1 regulates transcription of the human anti-Müllerian hormone gene. Mol Cell Biol (1998) 2.44
Dominance of SOX9 function over RUNX2 during skeletogenesis. Proc Natl Acad Sci U S A (2006) 2.23
BMP canonical Smad signaling through Smad1 and Smad5 is required for endochondral bone formation. Development (2009) 2.21
Beta-catenin signaling plays a disparate role in different phases of fracture repair: implications for therapy to improve bone healing. PLoS Med (2007) 2.14
Protein zero gene expression is regulated by the glial transcription factor Sox10. Mol Cell Biol (2000) 2.11
L-Sox5 and Sox6 drive expression of the aggrecan gene in cartilage by securing binding of Sox9 to a far-upstream enhancer. Mol Cell Biol (2008) 2.07
BMP receptor signaling is required for postnatal maintenance of articular cartilage. PLoS Biol (2004) 2.05
Isolation of adipose-derived stem cells and their induction to a chondrogenic phenotype. Nat Protoc (2010) 2.02
Constitutive activation of MEK1 in chondrocytes causes Stat1-independent achondroplasia-like dwarfism and rescues the Fgfr3-deficient mouse phenotype. Genes Dev (2004) 1.88
The potential of human allogeneic juvenile chondrocytes for restoration of articular cartilage. Am J Sports Med (2010) 1.83
Up-regulation of the chondrogenic Sox9 gene by fibroblast growth factors is mediated by the mitogen-activated protein kinase pathway. Proc Natl Acad Sci U S A (2000) 1.82
The chondrogenic transcription factor Sox9 is a target of signaling by the parathyroid hormone-related peptide in the growth plate of endochondral bones. Proc Natl Acad Sci U S A (2001) 1.81
Assembling neural crest regulatory circuits into a gene regulatory network. Annu Rev Cell Dev Biol (2010) 1.72
Directed differentiation of human embryonic stem cells toward chondrocytes. Nat Biotechnol (2010) 1.72
The three SoxC proteins--Sox4, Sox11 and Sox12--exhibit overlapping expression patterns and molecular properties. Nucleic Acids Res (2008) 1.70
Transcriptional coactivator PGC-1alpha regulates chondrogenesis via association with Sox9. Proc Natl Acad Sci U S A (2005) 1.64
Phosphorylation of SOX9 by cyclic AMP-dependent protein kinase A enhances SOX9's ability to transactivate a Col2a1 chondrocyte-specific enhancer. Mol Cell Biol (2000) 1.63
Mechanism of regulatory target selection by the SOX high-mobility-group domain proteins as revealed by comparison of SOX1/2/3 and SOX9. Mol Cell Biol (1999) 1.62
Oxidative stress inhibits insulin-like growth factor-I induction of chondrocyte proteoglycan synthesis through differential regulation of phosphatidylinositol 3-Kinase-Akt and MEK-ERK MAPK signaling pathways. J Biol Chem (2009) 1.60
SOX9 regulates multiple genes in chondrocytes, including genes encoding ECM proteins, ECM modification enzymes, receptors, and transporters. PLoS One (2014) 1.58
Interactions between SOX factors and Wnt/beta-catenin signaling in development and disease. Dev Dyn (2010) 1.53
Deletion of long-range regulatory elements upstream of SOX9 causes campomelic dysplasia. Proc Natl Acad Sci U S A (1998) 1.51
Mutation analysis of LMX1B gene in nail-patella syndrome patients. Am J Hum Genet (1998) 1.49
Shh establishes an Nkx3.2/Sox9 autoregulatory loop that is maintained by BMP signals to induce somitic chondrogenesis. Genes Dev (2002) 1.48
SOX9 expression and its methylation status in gastric cancer. Virchows Arch (2012) 1.47
Campomelic dysplasia translocation breakpoints are scattered over 1 Mb proximal to SOX9: evidence for an extended control region. Am J Hum Genet (1999) 1.47
Generation of hyaline cartilaginous tissue from mouse adult dermal fibroblast culture by defined factors. J Clin Invest (2011) 1.45
Ewing sarcoma ewsa protein regulates chondrogenesis of Meckel's cartilage through modulation of Sox9 in zebrafish. PLoS One (2015) 1.44
Hypoxia mediated isolation and expansion enhances the chondrogenic capacity of bone marrow mesenchymal stromal cells. Stem Cell Res Ther (2012) 1.40
Retracted A zinc finger transcription factor, alphaA-crystallin binding protein 1, is a negative regulator of the chondrocyte-specific enhancer of the alpha1(II) collagen gene. Mol Cell Biol (2000) 1.40
Type II collagen expression is regulated by tissue-specific miR-675 in human articular chondrocytes. J Biol Chem (2010) 1.39
Transforming growth factors beta coordinate cartilage and tendon differentiation in the developing limb mesenchyme. J Biol Chem (2009) 1.35
P2X7 receptors on osteoblasts couple to production of lysophosphatidic acid: a signaling axis promoting osteogenesis. J Cell Biol (2008) 1.34
Unraveling the transcriptional regulatory machinery in chondrogenesis. J Bone Miner Metab (2011) 1.34
SOX9: a stem cell transcriptional regulator of secreted niche signaling factors. Genes Dev (2014) 1.34
Expression of the heparan sulfate proteoglycan, perlecan, during mouse embryogenesis and perlecan chondrogenic activity in vitro. J Cell Biol (1999) 1.33
Regulation of collagen type I in vascular smooth muscle cells by competition between Nkx2.5 and deltaEF1/ZEB1. Mol Cell Biol (2004) 1.32
SOX9 is a key player in ultraviolet B-induced melanocyte differentiation and pigmentation. Proc Natl Acad Sci U S A (2007) 1.32
Retracted A Krüppel-associated box-zinc finger protein, NT2, represses cell-type-specific promoter activity of the alpha 2(XI) collagen gene. Mol Cell Biol (2002) 1.32
Vertebrate skeletogenesis. Curr Top Dev Biol (2010) 1.30
Regulation of human chondrocyte function through direct inhibition of cartilage master regulator SOX9 by microRNA-145 (miRNA-145). J Biol Chem (2011) 1.29
Adjacent DNA sequences modulate Sox9 transcriptional activation at paired Sox sites in three chondrocyte-specific enhancer elements. Nucleic Acids Res (2003) 1.28
Idiopathic weight reduction in mice deficient in the high-mobility-group transcription factor Sox8. Mol Cell Biol (2001) 1.28
Wwp2 is essential for palatogenesis mediated by the interaction between Sox9 and mediator subunit 25. Nat Commun (2011) 1.27
The transcriptional activity of Sox9 in chondrocytes is regulated by RhoA signaling and actin polymerization. Mol Cell Biol (2009) 1.27
Constitutive activation of MKK6 in chondrocytes of transgenic mice inhibits proliferation and delays endochondral bone formation. Proc Natl Acad Sci U S A (2005) 1.26
Identification of SOX9 interaction sites in the genome of chondrocytes. PLoS One (2010) 1.26
Neural crest stem cell multipotency requires Foxd3 to maintain neural potential and repress mesenchymal fates. Development (2011) 1.25
Potential use of Sox9 gene therapy for intervertebral degenerative disc disease. Spine (Phila Pa 1976) (2003) 1.25
The new collagen gene COL27A1 contains SOX9-responsive enhancer elements. Matrix Biol (2005) 1.25
Cartilage, SOX9 and Notch signals in chondrogenesis. J Anat (2006) 1.25
Transcriptional regulation of chondrogenesis by coactivator Tip60 via chromatin association with Sox9 and Sox5. Nucleic Acids Res (2008) 1.23
Requirement for RAR-mediated gene repression in skeletal progenitor differentiation. J Cell Biol (2002) 1.23
Sox9 directly promotes Bapx1 gene expression to repress Runx2 in chondrocytes. Exp Cell Res (2009) 1.21
Repression of chondrogenesis through binding of notch signaling proteins HES-1 and HEY-1 to N-box domains in the COL2A1 enhancer site. Arthritis Rheum (2008) 1.20
Smad-dependent recruitment of a histone deacetylase/Sin3A complex modulates the bone morphogenetic protein-dependent transcriptional repressor activity of Nkx3.2. Mol Cell Biol (2003) 1.19
A pathway to bone: signaling molecules and transcription factors involved in chondrocyte development and maturation. Development (2015) 1.19
Global comparative transcriptome analysis of cartilage formation in vivo. BMC Dev Biol (2009) 1.18
An in situ hybridization study of Runx2, Osterix, and Sox9 at the onset of condylar cartilage formation in fetal mouse mandible. J Anat (2006) 1.17
Lamprey type II collagen and Sox9 reveal an ancient origin of the vertebrate collagenous skeleton. Proc Natl Acad Sci U S A (2006) 1.17
SOX9 governs differentiation stage-specific gene expression in growth plate chondrocytes via direct concomitant transactivation and repression. PLoS Genet (2011) 1.16
Brachyury, SOX-9, and podoplanin, new markers in the skull base chordoma vs chondrosarcoma differential: a tissue microarray-based comparative analysis. Mod Pathol (2008) 1.16
Monolayer cell expansion conditions affect the chondrogenic potential of adipose-derived stem cells. Biotechnol Bioeng (2008) 1.14
Inhibitory role of Notch1 in calcific aortic valve disease. PLoS One (2011) 1.13
SOX9 transduction of a human chondrocytic cell line identifies novel genes regulated in primary human chondrocytes and in osteoarthritis. Arthritis Res Ther (2007) 1.13
Dominant TRPV4 mutations in nonlethal and lethal metatropic dysplasia. Am J Med Genet A (2010) 1.12
Induction of the neural crest state: control of stem cell attributes by gene regulatory, post-transcriptional and epigenetic interactions. Dev Biol (2012) 1.11
Expression profiling of Dexamethasone-treated primary chondrocytes identifies targets of glucocorticoid signalling in endochondral bone development. BMC Genomics (2007) 1.10
Signal transduction and transcriptional regulation during mesenchymal cell differentiation. J Bone Miner Metab (2008) 1.10
Uncoupling of chondrocyte differentiation and perichondrial mineralization underlies the skeletal dysplasia in tricho-rhino-phalangeal syndrome. Hum Mol Genet (2008) 1.08
TGF-beta mediated Dlx5 signaling plays a crucial role in osteo-chondroprogenitor cell lineage determination during mandible development. Dev Biol (2008) 1.07
Crosstalk between AHR and Wnt signaling through R-Spondin1 impairs tissue regeneration in zebrafish. FASEB J (2008) 1.07
Regulation of the human SOX9 promoter by Sp1 and CREB. Exp Cell Res (2007) 1.07
Bioreactors to influence stem cell fate: augmentation of mesenchymal stem cell signaling pathways via dynamic culture systems. Biochim Biophys Acta (2012) 1.07
Isolation and characterization of neural crest-derived stem cells from dental pulp of neonatal mice. PLoS One (2011) 1.07
Chordoma and chondrosarcoma gene profile: implications for immunotherapy. Cancer Immunol Immunother (2008) 1.05
Fine mapping of chromosome 17 translocation breakpoints > or = 900 Kb upstream of SOX9 in acampomelic campomelic dysplasia and a mild, familial skeletal dysplasia. Am J Hum Genet (2005) 1.05
Distinct roles of Sox5, Sox6, and Sox9 in different stages of chondrogenic differentiation. J Bone Miner Metab (2005) 1.04
Fibroblast growth factor-2 primes human mesenchymal stem cells for enhanced chondrogenesis. PLoS One (2011) 1.03
Role of canonical Wnt signaling/ß-catenin via Dermo1 in cranial dermal cell development. Development (2010) 1.03
Combined 3D and hypoxic culture improves cartilage-specific gene expression in human chondrocytes. Acta Orthop (2011) 1.03
A far-upstream (-70 kb) enhancer mediates Sox9 auto-regulation in somatic tissues during development and adult regeneration. Nucleic Acids Res (2013) 1.03
Rho kinase-dependent activation of SOX9 in chondrocytes. Arthritis Rheum (2010) 1.02
Cloning and characterisation of the Sry-related transcription factor gene Sox8. Nucleic Acids Res (2000) 1.01
Computational identification and functional validation of regulatory motifs in cartilage-expressed genes. Genome Res (2007) 1.01
An in situ hybridization study of Runx2, Osterix, and Sox9 in the anlagen of mouse mandibular condylar cartilage in the early stages of embryogenesis. J Anat (2008) 1.00
Shh signaling from the nucleus pulposus is required for the postnatal growth and differentiation of the mouse intervertebral disc. PLoS One (2012) 1.00
Sox9 family members negatively regulate maturation and calcification of chondrocytes through up-regulation of parathyroid hormone-related protein. Mol Biol Cell (2009) 1.00
L-Sox5 and Sox6 proteins enhance chondrogenic miR-140 microRNA expression by strengthening dimeric Sox9 activity. J Biol Chem (2012) 0.99
Mesodermal fate decisions of a stem cell: the Wnt switch. Cell Mol Life Sci (2008) 0.99
The versatile functions of Sox9 in development, stem cells, and human diseases. Genes Dis (2014) 0.98
Expression of a single transfected cDNA converts fibroblasts to myoblasts. Cell (1987) 22.17
Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor. Cell (1994) 17.58
Transcriptional activation: a complex puzzle with few easy pieces. Cell (1994) 8.63
Differential transcriptional activation by Oct-1 and Oct-2: interdependent activation domains induce Oct-2 phosphorylation. Cell (1990) 8.11
Male development of chromosomally female mice transgenic for Sry. Nature (1991) 7.73
Autosomal sex reversal and campomelic dysplasia are caused by mutations in and around the SRY-related gene SOX9. Cell (1994) 7.39
Campomelic dysplasia and autosomal sex reversal caused by mutations in an SRY-related gene. Nature (1994) 7.30
Empirical estimation of protein-induced DNA bending angles: applications to lambda site-specific recombination complexes. Nucleic Acids Res (1988) 7.05
Calcium phosphate-mediated gene transfer: a highly efficient transfection system for stably transforming cells with plasmid DNA. Biotechniques (1990) 6.90
ADD1/SREBP1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolism. Genes Dev (1996) 6.54
Cooperative activation of muscle gene expression by MEF2 and myogenic bHLH proteins. Cell (1995) 6.24
Expression of a large family of POU-domain regulatory genes in mammalian brain development. Nature (1989) 5.68
HMG domain proteins: architectural elements in the assembly of nucleoprotein structures. Trends Genet (1994) 5.43
Developmental-specific activity of the FGF-4 enhancer requires the synergistic action of Sox2 and Oct-3. Genes Dev (1995) 5.42
The HMG domain of lymphoid enhancer factor 1 bends DNA and facilitates assembly of functional nucleoprotein structures. Cell (1992) 5.24
Bending of DNA by gene-regulatory proteins: construction and use of a DNA bending vector. Gene (1989) 4.41
Assembly and function of a TCR alpha enhancer complex is dependent on LEF-1-induced DNA bending and multiple protein-protein interactions. Genes Dev (1995) 4.34
The Sry-related gene Sox9 is expressed during chondrogenesis in mouse embryos. Nat Genet (1995) 3.45
DNA binding activity of recombinant SRY from normal males and XY females. Science (1992) 3.32
SRY, like HMG1, recognizes sharp angles in DNA. EMBO J (1992) 3.29
Sox9 expression during gonadal development implies a conserved role for the gene in testis differentiation in mammals and birds. Nat Genet (1996) 3.11
A male-specific role for SOX9 in vertebrate sex determination. Development (1996) 2.98
Sox-4, an Sry-like HMG box protein, is a transcriptional activator in lymphocytes. EMBO J (1993) 2.85
An SRY-related gene expressed during spermatogenesis in the mouse encodes a sequence-specific DNA-binding protein. EMBO J (1992) 2.56
High mobility group protein 2 functionally interacts with the POU domains of octamer transcription factors. EMBO J (1995) 2.48
Ancestry and diversity of the HMG box superfamily. Nucleic Acids Res (1993) 2.47
Definition of a consensus DNA binding site for SRY. Nucleic Acids Res (1994) 2.34
Sequence-specific interaction of the HMG box proteins TCF-1 and SRY occurs within the minor groove of a Watson-Crick double helix. EMBO J (1992) 2.32
A clinical and genetic study of campomelic dysplasia. J Med Genet (1995) 2.20
Chondrocyte differentiation. Int Rev Cytol (1995) 2.15
Expression of the mouse alpha 1(II) collagen gene is not restricted to cartilage during development. Development (1991) 2.14
Characterization of primary cultures of chondrocytes from type II collagen/beta-galactosidase transgenic mice. Matrix Biol (1994) 2.12
Seven new members of the Sox gene family expressed during mouse development. Nucleic Acids Res (1993) 2.03
A 182 bp fragment of the mouse pro alpha 1(II) collagen gene is sufficient to direct chondrocyte expression in transgenic mice. J Cell Sci (1995) 1.90
Use of a new rat chondrosarcoma cell line to delineate a 119-base pair chondrocyte-specific enhancer element and to define active promoter segments in the mouse pro-alpha 1(II) collagen gene. J Biol Chem (1995) 1.85
SRY and sex determination in mammals. Annu Rev Genet (1993) 1.82
Sex reversal by loss of the C-terminal transactivation domain of human SOX9. Nat Genet (1996) 1.76
Tissue-specific expression of the mouse alpha 2(I) collagen promoter. Studies in transgenic mice and in tissue culture cells. J Biol Chem (1992) 1.69
The HMG-1 box protein family: classification and functional relationships. Nucleic Acids Res (1995) 1.67
Mutations in SOX9, the gene responsible for Campomelic dysplasia and autosomal sex reversal. Am J Hum Genet (1995) 1.67
Functional interaction between the POU domain protein Tst-1/Oct-6 and the high-mobility-group protein HMG-I/Y. Mol Cell Biol (1995) 1.65
An 18-base-pair sequence in the mouse proalpha1(II) collagen gene is sufficient for expression in cartilage and binds nuclear proteins that are selectively expressed in chondrocytes. Mol Cell Biol (1996) 1.64
Interaction between a novel F9-specific factor and octamer-binding proteins is required for cell-type-restricted activity of the fibroblast growth factor 4 enhancer. Mol Cell Biol (1994) 1.61
The Sry-related HMG box-containing gene Sox6 is expressed in the adult testis and developing nervous system of the mouse. Nucleic Acids Res (1995) 1.61
DNA binding and bending properties of the post-meiotically expressed Sry-related protein Sox-5. Nucleic Acids Res (1994) 1.54
Identification of a minimum enhancer sequence for the type II collagen gene reveals several core sequence motifs in common with the link protein gene. J Biol Chem (1996) 1.52
Translocation breakpoints in three patients with campomelic dysplasia and autosomal sex reversal map more than 130 kb from SOX9. Hum Genet (1996) 1.43
Studies on transcription activation by the multimeric CCAAT-binding factor CBF. J Biol Chem (1995) 1.41
Type X collagen gene expression in mouse chondrocytes immortalized by a temperature-sensitive simian virus 40 large tumor antigen. J Cell Biol (1995) 1.32
Expression of simian virus 40 large T (tumor) oncogene in mouse chondrocytes induces cell proliferation without loss of the differentiated phenotype. Proc Natl Acad Sci U S A (1993) 1.12
Trans-activation and DNA-binding properties of the transcription factor, Sox-18. Nucleic Acids Res (1995) 1.00
The high mobility group transcription factor, SOX4, transactivates the human CD2 enhancer. J Biol Chem (1995) 0.93
The genome of black cottonwood, Populus trichocarpa (Torr. & Gray). Science (2006) 21.03
Evidence for two functional gal promoters in intact Escherichia coli cells. J Biol Chem (1981) 17.42
A gene map of the human genome. Science (1996) 14.32
Requirement of interleukin 17 receptor signaling for lung CXC chemokine and granulocyte colony-stimulating factor expression, neutrophil recruitment, and host defense. J Exp Med (2001) 12.38
The Arabidopsis Information Resource (TAIR): a comprehensive database and web-based information retrieval, analysis, and visualization system for a model plant. Nucleic Acids Res (2001) 11.93
A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif. Nature (1990) 10.97
A novel phenotypic drug susceptibility assay for human immunodeficiency virus type 1. Antimicrob Agents Chemother (2000) 8.54
Cyclic AMP receptor protein: role in transcription activation. Science (1984) 8.37
Sox9 is required for cartilage formation. Nat Genet (1999) 7.89
Campomelic dysplasia and autosomal sex reversal caused by mutations in an SRY-related gene. Nature (1994) 7.30
The Genome Sequence DataBase: towards an integrated functional genomics resource. Nucleic Acids Res (1999) 6.20
Identification of a functional promoter in the long terminal repeat of Rous sarcoma virus. Cell (1980) 5.51
Dual control for transcription of the galactose operon by cyclic AMP and its receptor protein at two interspersed promoters. Cell (1977) 5.29
Some recent advances in the chemistry and biology of transforming growth factor-beta. J Cell Biol (1987) 5.25
A new long form of Sox5 (L-Sox5), Sox6 and Sox9 are coexpressed in chondrogenesis and cooperatively activate the type II collagen gene. EMBO J (1998) 5.15
Structure of the promoter for chicken alpha 2 type I collagen gene. Proc Natl Acad Sci U S A (1981) 4.89
A radiation hybrid map of the human genome. Hum Mol Genet (1996) 4.75
Haploinsufficiency of Sox9 results in defective cartilage primordia and premature skeletal mineralization. Proc Natl Acad Sci U S A (2001) 4.13
The transcription factors L-Sox5 and Sox6 are essential for cartilage formation. Dev Cell (2001) 4.11
Leptin enters the brain by a saturable system independent of insulin. Peptides (1996) 3.97
A dual thrombin receptor system for platelet activation. Nature (1998) 3.96
Cystic fibrosis: steady steps lead to the gene. Nature (1989) 3.90
Interaction site of Escherichia coli cyclic AMP receptor protein on DNA of galactose operon promoters. Proc Natl Acad Sci U S A (1979) 3.83
Levels of translatable mRNAs for cell surface protein, collagen precursors, and two membrane proteins are altered in Rous sarcoma virus-transformed chick embryo fibroblasts. Proc Natl Acad Sci U S A (1977) 3.80
A nuclear factor 1 binding site mediates the transcriptional activation of a type I collagen promoter by transforming growth factor-beta. Cell (1988) 3.72
The collagen gene: evidence for its evolutinary assembly by amplification of a DNA segment containing an exon of 54 bp. Cell (1980) 3.66
Y-Chromosome evidence for a northward migration of modern humans into Eastern Asia during the last Ice Age. Am J Hum Genet (1999) 3.60
Sequence variation of the human Y chromosome. Nature (1995) 3.59
IL-17 stimulates granulopoiesis in mice: use of an alternate, novel gene therapy-derived method for in vivo evaluation of cytokines. J Immunol (1998) 3.37
DNA binding activity of recombinant SRY from normal males and XY females. Science (1992) 3.32
A gene for a novel zinc-finger protein expressed in differentiated epithelial cells and transiently in certain mesenchymal cells. J Biol Chem (1996) 3.30
SRY, like HMG1, recognizes sharp angles in DNA. EMBO J (1992) 3.29
Genetic evidence equating SRY and the testis-determining factor. Nature (1990) 3.22
A method for constructing radiation hybrid maps of whole genomes. Nat Genet (1994) 3.19
Separate cis-acting DNA elements of the mouse pro-alpha 1(I) collagen promoter direct expression of reporter genes to different type I collagen-producing cells in transgenic mice. J Cell Biol (1995) 3.16
Role of thrombin signalling in platelets in haemostasis and thrombosis. Nature (2001) 3.15
Report of the Committee on the Genetic Constitution of the X and Y Chromosomes. Cytogenet Cell Genet (1985) 3.07
A monoclonal antibody to the human epidermal growth factor receptor. J Cell Biochem (1982) 3.04
A comparison of the properties of Sox-3 with Sry and two related genes, Sox-1 and Sox-2. Development (1996) 3.02
DNA microarrays in drug discovery and development. Nat Genet (1999) 3.02
Tissue factor- and factor X-dependent activation of protease-activated receptor 2 by factor VIIa. Proc Natl Acad Sci U S A (2000) 3.01
A genome screen in multiple sclerosis reveals susceptibility loci on chromosome 6p21 and 17q22. Nat Genet (1996) 3.00
The family of collagen genes. Annu Rev Biochem (1990) 2.98
Crystal structure of delta9 stearoyl-acyl carrier protein desaturase from castor seed and its relationship to other di-iron proteins. EMBO J (1996) 2.84
Requirement of endogenous stem cell factor and granulocyte-colony-stimulating factor for IL-17-mediated granulopoiesis. J Immunol (2000) 2.81
Dentinogenesis imperfecta 1 with or without progressive hearing loss is associated with distinct mutations in DSPP. Nat Genet (2001) 2.75
Role of the CCAAT-binding protein CBF/NF-Y in transcription. Trends Biochem Sci (1998) 2.71
Genetic relationship of populations in China. Proc Natl Acad Sci U S A (1998) 2.65
Transcriptional mechanisms of chondrocyte differentiation. Matrix Biol (2000) 2.61
Nucleotide sequence of the operator-promoter region of the galactose operon of Escherichia coli. Proc Natl Acad Sci U S A (1977) 2.57
A role for thrombin receptor signaling in endothelial cells during embryonic development. Science (2001) 2.55
A radiation hybrid map of the rat genome containing 5,255 markers. Nat Genet (1999) 2.54
Rapid sequence evolution of the mammalian sex-determining gene SRY. Nature (1993) 2.52
The DNA-binding specificity of SOX9 and other SOX proteins. Nucleic Acids Res (1999) 2.50
Cellular localization of membrane-type serine protease 1 and identification of protease-activated receptor-2 and single-chain urokinase-type plasminogen activator as substrates. J Biol Chem (2000) 2.50
Isolation and characterization of an alphoid centromeric repeat family from the human Y chromosome. J Mol Biol (1985) 2.39
Unusual methylation pattern of the alpha 2 (l) collagen gene. Cell (1982) 2.36
Unusual location and function of the operator in the Escherichia coli galactose operon. Nature (1979) 2.35
Definition of a consensus DNA binding site for SRY. Nucleic Acids Res (1994) 2.34
TGFbeta-mediated upregulation of hepatic miR-181b promotes hepatocarcinogenesis by targeting TIMP3. Oncogene (2009) 2.33
Inactivation of the protein phosphatase 2A regulatory subunit A results in morphological and transcriptional defects in Saccharomyces cerevisiae. Mol Cell Biol (1992) 2.33
Mutations in the Escherichia coli operon that define two promoters and the binding site of the cyclic AMP receptor protein. J Mol Biol (1982) 2.30
The beta2-microglobulin gene is on chromosome 15 and not in the HL-A region. Nature (1975) 2.29
Chondrocyte-specific enhancer elements in the Col11a2 gene resemble the Col2a1 tissue-specific enhancer. J Biol Chem (1998) 2.21
Isolation and characterization of overlapping genomic clones covering the chicken alpha 2 (type I) collagen gene. Proc Natl Acad Sci U S A (1980) 2.18
Recombinant rat CBF-C, the third subunit of CBF/NFY, allows formation of a protein-DNA complex with CBF-A and CBF-B and with yeast HAP2 and HAP3. Proc Natl Acad Sci U S A (1995) 2.17
Beta-adrenergic blockade accelerates conversion of postoperative supraventricular tachyarrhythmias. Anesthesiology (1998) 2.17
Microsurgical replantation of the avulsed scalp: report of 20 cases. Plast Reconstr Surg (1996) 2.17
Selective activation of transcription by a novel CCAAT binding factor. Science (1988) 2.12
Phylogenetic analysis of nucleoproteins suggests that human influenza A viruses emerged from a 19th-century avian ancestor. Mol Biol Evol (1990) 2.07
Use of recombinant plasmids to characterize collagen RNAs in normal and transformed chick embryo fibroblasts. J Biol Chem (1979) 2.07
Identification of a cell-specific transcriptional enhancer in the first intron of the mouse alpha 2 (type I) collagen gene. Proc Natl Acad Sci U S A (1987) 2.07
Signal, noise power spectrum, and detective quantum efficiency of indirect-detection flat-panel imagers for diagnostic radiology. Med Phys (1998) 2.06
Cellular distrubtion, purification, and molecular nature of human Ia antigens. Scand J Immunol (1977) 2.04
Empirical and theoretical investigation of the noise performance of indirect detection, active matrix flat-panel imagers (AMFPIs) for diagnostic radiology. Med Phys (1997) 2.04
Chromosomal localisation of the human homologues to the oncogenes erbA and B. EMBO J (1984) 2.02
Correlation between splicing sites within an intron and their sequence complementarity with U1 RNA. Cell (1980) 2.02
Transforming growth factor beta: biochemistry and roles in embryogenesis, tissue repair and remodeling, and carcinogenesis. Recent Prog Horm Res (1988) 1.99
Transcriptional activation encoded by the v-fos gene. Proc Natl Acad Sci U S A (1986) 1.99
Chromosomal localization of human cellular homologues of two viral oncogenes. Nature (1982) 1.96
L-Sox5, Sox6 and Sox9 control essential steps of the chondrocyte differentiation pathway. Osteoarthritis Cartilage (2001) 1.96
Femoral vein ligation increases bone mass in the hindlimb suspended rat. Bone (1999) 1.95
A pseudoautosomal gene in man. Science (1986) 1.94
A CCAAT DNA binding factor consisting of two different components that are both required for DNA binding. J Biol Chem (1988) 1.93
The 19S regulatory complex of the proteasome functions independently of proteolysis in nucleotide excision repair. Mol Cell (1999) 1.92
A 182 bp fragment of the mouse pro alpha 1(II) collagen gene is sufficient to direct chondrocyte expression in transgenic mice. J Cell Sci (1995) 1.90
Human T cell leukemia viruses use a receptor determined by human chromosome 17. Science (1988) 1.87
Potent inhibition of the master chondrogenic factor Sox9 gene by interleukin-1 and tumor necrosis factor-alpha. J Biol Chem (2000) 1.86
The gene, MIC4, which controls expression of the antigen defined by monoclonal antibody F10.44.2, is on human chromosome 11. Eur J Immunol (1982) 1.86
Immunoglobulin heavy chain genes in humans are located on chromosome. Ann Hum Genet (1981) 1.85
Regulation of a collagen gene promoter by the product of viral mos oncogene. Nature (1985) 1.85
Use of a new rat chondrosarcoma cell line to delineate a 119-base pair chondrocyte-specific enhancer element and to define active promoter segments in the mouse pro-alpha 1(II) collagen gene. J Biol Chem (1995) 1.85
Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver. Proc Natl Acad Sci U S A (2001) 1.84
Up-regulation of the chondrogenic Sox9 gene by fibroblast growth factors is mediated by the mitogen-activated protein kinase pathway. Proc Natl Acad Sci U S A (2000) 1.82
A sequence conserved in both the chicken and mouse alpha 2(I) collagen promoter contains sites sensitive to S1 nuclease. J Biol Chem (1984) 1.81
Sex-reversing mutations affect the architecture of SRY-DNA complexes. EMBO J (1994) 1.80
Effects of transformation on fibronectin gene expression using cloned fibronectin cDNA. J Biol Chem (1981) 1.79