IFN-gamma-inducible protein-10 (CXCL10) is hepatoprotective during acute liver injury through the induction of CXCR2 on hepatocytes.

PubWeight™: 1.09‹?› | Rank: Top 10%

🔗 View Article (PMID 11739529)

Published in J Immunol on December 15, 2001

Authors

C L Bone-Larson1, C M Hogaboam, H Evanhoff, R M Strieter, S L Kunkel

Author Affiliations

1: Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109,USA.

Articles citing this

Mechanisms of acetaminophen-induced liver necrosis. Handb Exp Pharmacol (2010) 2.54

Critical role of c-jun (NH2) terminal kinase in paracetamol- induced acute liver failure. Gut (2006) 1.82

CXC receptor-2 knockout genotype increases X-linked inhibitor of apoptosis protein and protects mice from acetaminophen hepatotoxicity. Hepatology (2010) 1.71

Hepatocyte signaling through CXC chemokine receptor-2 is detrimental to liver recovery after ischemia/reperfusion in mice. Hepatology (2008) 1.36

CXCR3-dependent recruitment of antigen-specific T lymphocytes to the liver during murine cytomegalovirus infection. J Virol (2006) 1.27

The role of chemokines in acute liver injury. Front Physiol (2012) 1.09

CXC chemokine signaling in the liver: impact on repair and regeneration. Hepatology (2011) 1.07

Functional role of chemokines in liver disease models. Nat Rev Gastroenterol Hepatol (2010) 1.06

Analysis of serum inflammatory mediators identifies unique dynamic networks associated with death and spontaneous survival in pediatric acute liver failure. PLoS One (2013) 1.04

CXCL10 promotes liver fibrosis by prevention of NK cell mediated hepatic stellate cell inactivation. J Autoimmun (2010) 1.03

Mesenchymal stem cells promote liver regeneration and prolong survival in small-for-size liver grafts: involvement of C-Jun N-terminal kinase, cyclin D1, and NF-κB. PLoS One (2014) 0.90

Neutralization of CXCL10 accelerates liver regeneration in carbon tetrachloride-induced acute liver injury. Med Mol Morphol (2007) 0.89

Toll like receptor 3 plays a critical role in the progression and severity of acetaminophen-induced hepatotoxicity. PLoS One (2013) 0.86

IP-10 protects while MIP-2 promotes experimental anesthetic hapten - induced hepatitis. J Autoimmun (2009) 0.82

FK 409 ameliorates small-for-size liver graft injury by attenuation of portal hypertension and down-regulation of Egr-1 pathway. Ann Surg (2004) 0.81

Identification of a novel neurotrophic factor from primary retinal Müller cells using stable isotope labeling by amino acids in cell culture (SILAC). Mol Cell Proteomics (2014) 0.78

The role of interferon-γ inducible protein-10 in a mouse model of acute liver injury post induced pluripotent stem cells transplantation. PLoS One (2012) 0.78

Curative Effects of Thiacremonone against Acetaminophen-Induced Acute Hepatic Failure via Inhibition of Proinflammatory Cytokines Production and Infiltration of Cytotoxic Immune Cells and Kupffer Cells. Evid Based Complement Alternat Med (2013) 0.77

Regulatory mechanisms of injury and repair after hepatic ischemia/reperfusion. Scientifica (Cairo) (2012) 0.77

Data-Driven Modeling for Precision Medicine in Pediatric Acute Liver Failure. Mol Med (2016) 0.75

Articles by these authors

Neutrophil-activating peptide-1/interleukin 8, a novel cytokine that activates neutrophils. J Clin Invest (1989) 10.59

Interleukin-8 as a macrophage-derived mediator of angiogenesis. Science (1992) 7.92

Impaired monocyte migration and reduced type 1 (Th1) cytokine responses in C-C chemokine receptor 2 knockout mice. J Clin Invest (1997) 7.58

Abnormalities in monocyte recruitment and cytokine expression in monocyte chemoattractant protein 1-deficient mice. J Exp Med (1998) 6.52

Interleukin-8 and development of adult respiratory distress syndrome in at-risk patient groups. Lancet (1993) 6.39

Interleukin-8 gene expression by a pulmonary epithelial cell line. A model for cytokine networks in the lung. J Clin Invest (1990) 5.21

CD28 activation pathway regulates the production of multiple T-cell-derived lymphokines/cytokines. Proc Natl Acad Sci U S A (1989) 5.07

Endothelial cell gene expression of a neutrophil chemotactic factor by TNF-alpha, LPS, and IL-1 beta. Science (1989) 4.99

The functional role of the ELR motif in CXC chemokine-mediated angiogenesis. J Biol Chem (1995) 4.77

Reduction of the extent of ischemic myocardial injury by neutrophil depletion in the dog. Circulation (1983) 4.01

Regulation of transendothelial neutrophil migration by endogenous interleukin-8. Science (1991) 3.96

Enhanced production of monocyte chemoattractant protein-1 in rheumatoid arthritis. J Clin Invest (1992) 3.72

Cellular and molecular regulation of tumor necrosis factor-alpha production by pentoxifylline. Biochem Biophys Res Commun (1988) 3.63

Interleukin-8 (IL-8): the major neutrophil chemotactic factor in the lung. Exp Lung Res (1991) 3.49

Role of tumor necrosis factor-alpha in the pathophysiologic alterations after hepatic ischemia/reperfusion injury in the rat. J Clin Invest (1990) 3.39

The CXC chemokine receptor 2, CXCR2, is the putative receptor for ELR+ CXC chemokine-induced angiogenic activity. J Immunol (2000) 3.26

Expression of specific chemokines and chemokine receptors in the central nervous system of multiple sclerosis patients. J Clin Invest (1999) 3.21

CXC chemokines in angiogenesis. J Leukoc Biol (2000) 3.17

The link between fungi and severe asthma: a summary of the evidence. Eur Respir J (2006) 3.16

Tumor necrosis factor stimulates interleukin-1 and prostaglandin E2 production in resting macrophages. Biochem Biophys Res Commun (1986) 2.96

Hyaluronan (HA) fragments induce chemokine gene expression in alveolar macrophages. The role of HA size and CD44. J Clin Invest (1996) 2.86

Inflammatory cytokines in patients with persistence of the acute respiratory distress syndrome. Am J Respir Crit Care Med (1996) 2.81

Purification and chemical characterization of the heat-labile enterotoxin produced by enterotoxigenic Escherichia coli. Infect Immun (1979) 2.80

Neutralization of macrophage inflammatory protein-2 attenuates neutrophil recruitment and bacterial clearance in murine Klebsiella pneumonia. J Infect Dis (1996) 2.72

CXC chemokine receptor CXCR2 is essential for protective innate host response in murine Pseudomonas aeruginosa pneumonia. Infect Immun (2000) 2.66

Cultured lung fibroblasts isolated from patients with idiopathic pulmonary fibrosis have a diminished capacity to synthesize prostaglandin E2 and to express cyclooxygenase-2. J Clin Invest (1995) 2.59

Lung cytokine production in bleomycin-induced pulmonary fibrosis. Exp Lung Res (1992) 2.57

CXC chemokine receptor-2 ligands are necessary components of neutrophil-mediated host defense in invasive pulmonary aspergillosis. J Immunol (1999) 2.56

Alveolar macrophages are required for protective pulmonary defenses in murine Klebsiella pneumonia: elimination of alveolar macrophages increases neutrophil recruitment but decreases bacterial clearance and survival. Infect Immun (1997) 2.54

An important role for the chemokine macrophage inflammatory protein-1 alpha in the pathogenesis of the T cell-mediated autoimmune disease, experimental autoimmune encephalomyelitis. J Immunol (1995) 2.52

Neutralization of IL-10 increases survival in a murine model of Klebsiella pneumonia. J Immunol (1995) 2.51

Structure and neutrophil-activating properties of a novel inflammatory peptide (ENA-78) with homology to interleukin 8. J Exp Med (1991) 2.46

Monokine-induced neutrophil chemotactic factor gene expression in human fibroblasts. J Biol Chem (1989) 2.43

Balance of inflammatory cytokines related to severity and mortality of murine sepsis. Infect Immun (1996) 2.43

Epithelial-neutrophil activating peptide (ENA-78) is an important angiogenic factor in non-small cell lung cancer. J Clin Invest (1998) 2.42

The CXC chemokines, IL-8 and IP-10, regulate angiogenic activity in idiopathic pulmonary fibrosis. J Immunol (1997) 2.41

IL-4 inhibits the expression of IL-8 from stimulated human monocytes. J Immunol (1990) 2.41

Critical role for the chemokine MCP-1/CCR2 in the pathogenesis of bronchiolitis obliterans syndrome. J Clin Invest (2001) 2.39

Cutting edge: IFN-inducible ELR- CXC chemokines display defensin-like antimicrobial activity. J Immunol (2001) 2.38

Prostaglandins as endogenous mediators of interleukin 1 production. J Immunol (1986) 2.37

The role of monocyte chemotactic protein-1 (MCP-1) in the recruitment of monocytes and CD4+ T cells during a pulmonary Cryptococcus neoformans infection. J Immunol (1995) 2.37

IL-10 is a major mediator of sepsis-induced impairment in lung antibacterial host defense. J Immunol (1999) 2.25

Neutrophil chemotactic factor (IL-8) gene expression by cytokine-treated retinal pigment epithelial cells. Am J Pathol (1990) 2.25

Cellular localization of interleukin-8 and its inducer, tumor necrosis factor-alpha in psoriasis. Am J Pathol (1991) 2.24

Cytokine-induced neutrophil-derived interleukin-8. Am J Pathol (1992) 2.24

Role of TNF-alpha in pulmonary host defense in murine invasive aspergillosis. J Immunol (1999) 2.23

Inhibition of interleukin-8 reduces tumorigenesis of human non-small cell lung cancer in SCID mice. J Clin Invest (1996) 2.20

Role of monocyte chemoattractant protein-1 (MCP-1) in Th1 (mycobacterial) and Th2 (schistosomal) antigen-induced granuloma formation: relationship to local inflammation, Th cell expression, and IL-12 production. J Immunol (1996) 2.20

Involvement of endothelial PECAM-1/CD31 in angiogenesis. Am J Pathol (1997) 2.17

Induction of gamma interferon production in human alveolar macrophages by Mycobacterium tuberculosis. Infect Immun (1997) 2.16

Macrophage inflammatory protein-1 alpha. A novel chemotactic cytokine for macrophages in rheumatoid arthritis. J Clin Invest (1994) 2.15

Interferon-gamma-inducible protein 10 (IP-10) is an angiostatic factor that inhibits human non-small cell lung cancer (NSCLC) tumorigenesis and spontaneous metastases. J Exp Med (1996) 2.14

Afferent phase production of TNF-alpha is required for the development of protective T cell immunity to Cryptococcus neoformans. J Immunol (1996) 2.12

MCP-1 protects mice in lethal endotoxemia. J Clin Invest (1997) 2.12

MIP-1alpha as a critical macrophage chemoattractant in murine wound repair. J Clin Invest (1998) 2.09

Interleukin-8. A corneal factor that induces neovascularization. Am J Pathol (1992) 2.08

Aberrant in vivo T helper type 2 cell response and impaired eosinophil recruitment in CC chemokine receptor 8 knockout mice. J Exp Med (2001) 2.07

Acute in vivo effects of human recombinant tumor necrosis factor. Lab Invest (1987) 2.06

Alveolar macrophage-derived cytokines induce monocyte chemoattractant protein-1 expression from human pulmonary type II-like epithelial cells. J Biol Chem (1991) 2.06

Inhibition of interleukin 8 attenuates angiogenesis in bronchogenic carcinoma. J Exp Med (1994) 2.05

A central role for CD4(+) T cells and RANTES in virus-induced central nervous system inflammation and demyelination. J Virol (2000) 2.04

Neutralization of IL-10 increases lethality in endotoxemia. Cooperative effects of macrophage inflammatory protein-2 and tumor necrosis factor. J Immunol (1995) 2.02

Monocyte chemotactic protein gene expression by cytokine-treated human fibroblasts and endothelial cells. Biochem Biophys Res Commun (1989) 2.01

Mast cells control neutrophil recruitment during T cell-mediated delayed-type hypersensitivity reactions through tumor necrosis factor and macrophage inflammatory protein 2. J Exp Med (2000) 2.00

Human alveolar macrophage gene expression of interleukin-8 by tumor necrosis factor-alpha, lipopolysaccharide, and interleukin-1 beta. Am J Respir Cell Mol Biol (1990) 1.98

Macrophage inflammatory protein-1 alpha mediates lung leukocyte recruitment, lung capillary leak, and early mortality in murine endotoxemia. J Immunol (1995) 1.98

Regulation of macrophage tumor necrosis factor production by prostaglandin E2. Biochem Biophys Res Commun (1986) 1.95

Cytokines and the liver. J Hepatol (1997) 1.92