MEKK1 plays a critical role in activating the transcription factor C/EBP-beta-dependent gene expression in response to IFN-gamma.

PubWeight™: 1.47‹?› | Rank: Top 5%

🔗 View Article (PMC 123000)

Published in Proc Natl Acad Sci U S A on June 04, 2002

Authors

Sanjit K Roy1, Junbo Hu, Qingjun Meng, Ying Xia, Paul S Shapiro, Sekhar P M Reddy, Leonidas C Platanias, Daniel J Lindner, Peter F Johnson, Catrin Pritchard, Gilles Pagés, Jacques Pouyssegur, Dhananjaya V Kalvakolanu

Author Affiliations

1: Department of Microbiology and Immunology, Molecular and Cellular Biology Program, Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD 21201, USA.

Articles citing this

Profiling the human protein-DNA interactome reveals ERK2 as a transcriptional repressor of interferon signaling. Cell (2009) 3.69

Nuclear receptor transrepression pathways that regulate inflammation in macrophages and T cells. Nat Rev Immunol (2010) 3.60

Sequential phosphorylation of CCAAT enhancer-binding protein beta by MAPK and glycogen synthase kinase 3beta is required for adipogenesis. Proc Natl Acad Sci U S A (2005) 2.51

Cooperative NCoR/SMRT interactions establish a corepressor-based strategy for integration of inflammatory and anti-inflammatory signaling pathways. Genes Dev (2009) 2.47

IL-17 receptor signaling inhibits C/EBPbeta by sequential phosphorylation of the regulatory 2 domain. Sci Signal (2009) 1.57

The cytosolic pattern recognition receptor NOD1 induces inflammatory interleukin-8 during Chlamydia trachomatis infection. Infect Immun (2008) 1.28

The tumor microenvironment strongly impacts master transcriptional regulators and gene expression class of glioblastoma. Am J Pathol (2012) 1.25

IFN-γ elicits macrophage autophagy via the p38 MAPK signaling pathway. J Immunol (2012) 1.24

Inducible gene deletion reveals different roles for B-Raf and Raf-1 in B-cell antigen receptor signalling. EMBO J (2002) 1.19

Critical role for transcription factor C/EBP-beta in regulating the expression of death-associated protein kinase 1. Mol Cell Biol (2008) 1.19

The interferon signaling network and transcription factor C/EBP-beta. Cell Mol Immunol (2007) 1.12

CCAAT/enhancer-binding protein beta and delta binding to CIITA promoters is associated with the inhibition of CIITA expression in response to Mycobacterium tuberculosis 19-kDa lipoprotein. J Immunol (2007) 1.03

Interferon receptor signaling in malignancy: a network of cellular pathways defining biological outcomes. Mol Cancer Res (2014) 0.99

The Med1 subunit of transcriptional mediator plays a central role in regulating CCAAT/enhancer-binding protein-beta-driven transcription in response to interferon-gamma. J Biol Chem (2008) 0.99

Essential role for Mnk kinases in type II interferon (IFNgamma) signaling and its suppressive effects on normal hematopoiesis. J Biol Chem (2010) 0.99

Interferon-gamma suppresses S100A4 transcription independently of apoptosis or cell cycle arrest. Br J Cancer (2003) 0.89

Activation of TORC1 transcriptional coactivator through MEKK1-induced phosphorylation. Mol Biol Cell (2008) 0.88

ERK signaling regulates tumor promoter induced c-Jun recruitment at the Fra-1 promoter. Biochem Biophys Res Commun (2008) 0.88

The transcription factor C/EBP-β mediates constitutive and LPS-inducible transcription of murine SerpinB2. PLoS One (2013) 0.86

Regulation of the death-associated protein kinase 1 expression and autophagy via ATF6 requires apoptosis signal-regulating kinase 1. Mol Cell Biol (2014) 0.83

Src mediates cytokine-stimulated gene expression in airway myocytes through ERK MAPK. Cell Commun Signal (2011) 0.80

Distinct mechanisms for induction and tolerance regulate the immediate early genes encoding interleukin 1β and tumor necrosis factor α. PLoS One (2013) 0.78

Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults. PLoS Genet (2017) 0.78

Involvement of ERK and JNK pathways in IFN-γ-induced B7-DC expression on tumor cells. J Cancer Res Clin Oncol (2011) 0.78

High glucose-induced increased expression of endothelin-1 in human endothelial cells is mediated by activated CCAAT/enhancer-binding proteins. PLoS One (2013) 0.78

C/EBP transcription factors regulate NADPH oxidase in human aortic smooth muscle cells. J Cell Mol Med (2014) 0.78

Interferons, signal transduction pathways, and the central nervous system. J Interferon Cytokine Res (2014) 0.78

STAT-phosphorylation-independent induction of interferon regulatory factor-9 by interferon-beta. J Interferon Cytokine Res (2010) 0.77

LPS-Induced G-CSF Expression in Macrophages Is Mediated by ERK2, but Not ERK1. PLoS One (2015) 0.77

Genome-wide association analysis of chronic lymphocytic leukaemia, Hodgkin lymphoma and multiple myeloma identifies pleiotropic risk loci. Sci Rep (2017) 0.75

Polymorphisms in key bone modulator cytokines genes influence bisphosphonates therapy in postmenopausal women. Inflammopharmacology (2017) 0.75

Articles cited by this

How cells respond to interferons. Annu Rev Biochem (1998) 24.27

STATs and gene regulation. Science (1997) 16.55

Cellular responses to interferon-gamma. Annu Rev Immunol (1997) 13.23

Signal transduction through MAP kinase cascades. Adv Cancer Res (1998) 5.65

Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1. Nature (1995) 5.00

Targeted disruption of the NF-IL6 gene discloses its essential role in bacteria killing and tumor cytotoxicity by macrophages. Cell (1995) 4.34

Biological role of the CCAAT/enhancer-binding protein family of transcription factors. J Biol Chem (1998) 3.93

Defective thymocyte maturation in p44 MAP kinase (Erk 1) knockout mice. Science (1999) 3.85

Regulation of MHC class II expression by interferon-gamma mediated by the transactivator gene CIITA. Science (1994) 3.71

The role of C/EBP isoforms in the control of inflammatory and native immunity functions. J Biol Chem (1998) 3.64

Phosphorylation at threonine-235 by a ras-dependent mitogen-activated protein kinase cascade is essential for transcription factor NF-IL6. Proc Natl Acad Sci U S A (1993) 3.59

Regulation and properties of extracellular signal-regulated protein kinases 1 and 2 in vitro. J Biol Chem (1993) 3.57

Lymphoproliferative disorder and imbalanced T-helper response in C/EBP beta-deficient mice. EMBO J (1995) 3.48

Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain. Genes Dev (1999) 3.41

MAP kinase pathways. Prog Biophys Mol Biol (1999) 3.16

An essential role for C/EBPbeta in female reproduction. Genes Dev (1997) 2.96

Synergistic interaction between interferon-alpha and interferon-gamma through induced synthesis of one subunit of the transcription factor ISGF3. EMBO J (1990) 2.75

Biologic consequences of Stat1-independent IFN signaling. Proc Natl Acad Sci U S A (2001) 2.56

MEKK1 activates both IkappaB kinase alpha and IkappaB kinase beta. Proc Natl Acad Sci U S A (1998) 2.40

MEK kinase activity is not necessary for Raf-1 function. EMBO J (2001) 2.36

Embryonic lethality and fetal liver apoptosis in mice lacking the c-raf-1 gene. EMBO J (2001) 2.32

CCAAT/enhancer binding protein-beta is a mediator of keratinocyte survival and skin tumorigenesis involving oncogenic Ras signaling. Proc Natl Acad Sci U S A (2001) 2.15

MEK kinase 1 is critically required for c-Jun N-terminal kinase activation by proinflammatory stimuli and growth factor-induced cell migration. Proc Natl Acad Sci U S A (2000) 2.12

Role of MEKK1 in cell survival and activation of JNK and ERK pathways defined by targeted gene disruption. Science (1998) 2.10

p38 MAP kinase is required for STAT1 serine phosphorylation and transcriptional activation induced by interferons. EMBO J (1999) 2.07

Stat1-independent regulation of gene expression in response to IFN-gamma. Proc Natl Acad Sci U S A (2001) 1.96

Activation of the p38 mitogen-activated protein kinase by type I interferons. J Biol Chem (1999) 1.94

Phosphorylation of rat serine 105 or mouse threonine 217 in C/EBP beta is required for hepatocyte proliferation induced by TGF alpha. Mol Cell (1999) 1.91

An IFN-gamma-inducible transcription factor, IFN consensus sequence binding protein (ICSBP), stimulates IL-12 p40 expression in macrophages. J Immunol (2000) 1.82

Stress-induced phosphorylation of STAT1 at Ser727 requires p38 mitogen-activated protein kinase whereas IFN-gamma uses a different signaling pathway. Proc Natl Acad Sci U S A (1999) 1.72

MEKK1 phosphorylates MEK1 and MEK2 but does not cause activation of mitogen-activated protein kinase. Proc Natl Acad Sci U S A (1995) 1.65

Collaboration of signal transducer and activator of transcription 1 (STAT1) and BRCA1 in differential regulation of IFN-gamma target genes. Proc Natl Acad Sci U S A (2000) 1.57

Protein kinase A and C site-specific phosphorylations of LAP (NF-IL6) modulate its binding affinity to DNA recognition elements. J Clin Invest (1994) 1.54

Interferon regulatory factor 1 is required for mouse Gbp gene activation by gamma interferon. Mol Cell Biol (1995) 1.51

ERK1 and ERK2 activate CCAAAT/enhancer-binding protein-beta-dependent gene transcription in response to interferon-gamma. J Biol Chem (2001) 1.44

Type I interferon induces inhibitory 16-kD CCAAT/ enhancer binding protein (C/EBP)beta, repressing the HIV-1 long terminal repeat in macrophages: pulmonary tuberculosis alters C/EBP expression, enhancing HIV-1 replication. J Exp Med (1998) 1.41

Molecular analysis of G1B and G3A IFN gamma mutants reveals that defects in CIITA or RFX result in defective class II MHC and Ii gene induction. Immunity (1994) 1.39

NF-IL6 and NF-kappa B in cytokine gene regulation. Adv Immunol (1997) 1.37

Gene induction by interferons: functional complementation between trans-acting factors induced by alpha interferon and gamma interferon. Mol Cell Biol (1990) 1.32

MEKK1 binds raf-1 and the ERK2 cascade components. J Biol Chem (2000) 1.25

Nuclear localization of mitogen-activated protein kinase kinase 1 (MKK1) is promoted by serum stimulation and G2-M progression. Requirement for phosphorylation at the activation lip and signaling downstream of MKK. J Biol Chem (1999) 1.22

Regulation of the activity of MEK kinase 1 (MEKK1) by autophosphorylation within the kinase activation domain. Biochem J (1997) 1.21

CCAAT/enhancer-binding protein-beta regulates interferon-induced transcription through a novel element. J Biol Chem (2000) 1.15

Interferon gamma-induced transcription of the murine ISGF3gamma (p48) gene is mediated by novel factors. Proc Natl Acad Sci U S A (1997) 1.08

Impaired generation of bone marrow B lymphocytes in mice deficient in C/EBPbeta. Blood (1997) 1.06

Virus interception of cytokine-regulated pathways. Trends Microbiol (1999) 1.05

Signaling pathways to the assembly of an interferon-beta enhanceosome. Chemical genetic studies with a small molecule. J Biol Chem (2000) 1.02

IFN consensus sequence binding protein potentiates STAT1-dependent activation of IFNgamma-responsive promoters in macrophages. Proc Natl Acad Sci U S A (2000) 1.00

Feedback regulation of Raf-1 and mitogen-activated protein kinase (MAP) kinase kinases 1 and 2 by MAP kinase phosphatase-1 (MKP-1). J Biol Chem (1998) 0.99

Activation of Raf-1 by interferon gamma and oncostatin M requires expression of the Stat1 transcription factor. J Biol Chem (1998) 0.97

Interferon gamma activation of Raf-1 is Jak1-dependent and p21ras-independent. J Biol Chem (1998) 0.96

Beta and gamma interferons act synergistically to produce an antiviral state in cells resistant to both interferons individually. J Virol (1989) 0.94

Analysis of the defect in IFN-gamma induction of MHC class II genes in G1B cells: identification of a novel and functionally critical leucine-rich motif (62-LYLYLQL-68) in the regulatory factor X 5 transcription factor. J Immunol (1999) 0.86

CCAAT/enhancer-binding protein beta mediates interferon-gamma-induced p48 (ISGF3-gamma ) gene transcription in human monocytic cells. J Biol Chem (2001) 0.81

Articles by these authors

Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08

Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF. Cell (2010) 17.48

Tumor cell metabolism: cancer's Achilles' heel. Cancer Cell (2008) 11.18

Role of NRF2 in protection against hyperoxic lung injury in mice. Am J Respir Cell Mol Biol (2002) 5.57

Oncogenic Braf induces melanocyte senescence and melanoma in mice. Cancer Cell (2009) 4.76

TGF-beta1-induced migration of bone mesenchymal stem cells couples bone resorption with formation. Nat Med (2009) 4.58

Prolyl hydroxylase-1 negatively regulates IkappaB kinase-beta, giving insight into hypoxia-induced NFkappaB activity. Proc Natl Acad Sci U S A (2006) 4.08

Jun turnover is controlled through JNK-dependent phosphorylation of the E3 ligase Itch. Science (2004) 3.66

A complex secretory program orchestrated by the inflammasome controls paracrine senescence. Nat Cell Biol (2013) 2.98

Potential risks of bone marrow cell transplantation into infarcted hearts. Blood (2007) 2.97

MAPK3/1 (ERK1/2) in ovarian granulosa cells are essential for female fertility. Science (2009) 2.86

Bone marrow-derived fibroblast precursors mediate ischemic cardiomyopathy in mice. Proc Natl Acad Sci U S A (2006) 2.85

Targeting the ERK signaling pathway in cancer therapy. Ann Med (2006) 2.64

The transcription factor NRF2 protects against pulmonary fibrosis. FASEB J (2004) 2.43

Hypoxia-enhanced wound-healing function of adipose-derived stem cells: increase in stem cell proliferation and up-regulation of VEGF and bFGF. Wound Repair Regen (2009) 2.33

Engraftment of engineered ES cell-derived cardiomyocytes but not BM cells restores contractile function to the infarcted myocardium. J Exp Med (2006) 2.23

CCAAT/enhancer binding protein-beta is a mediator of keratinocyte survival and skin tumorigenesis involving oncogenic Ras signaling. Proc Natl Acad Sci U S A (2001) 2.15

Critical role of monocyte chemoattractant protein-1/CC chemokine ligand 2 in the pathogenesis of ischemic cardiomyopathy. Circulation (2007) 2.14

CCAAT/enhancer-binding protein δ is a critical mediator of lipopolysaccharide-induced acute lung injury. Am J Pathol (2012) 2.12

Host-dependent tumorigenesis of embryonic stem cell transplantation in experimental stroke. J Cereb Blood Flow Metab (2003) 2.01

Mitochondrial reactive oxygen species activation of p38 mitogen-activated protein kinase is required for hypoxia signaling. Mol Cell Biol (2005) 1.97

Inhibition of the TGF-beta receptor I kinase promotes hematopoiesis in MDS. Blood (2008) 1.95

Expression of endogenous oncogenic V600EB-raf induces proliferation and developmental defects in mice and transformation of primary fibroblasts. Cancer Res (2005) 1.93

BCL-3 and NF-kappaB p50 attenuate lipopolysaccharide-induced inflammatory responses in macrophages. J Biol Chem (2004) 1.92

Thyrotrophin receptor signaling dependence of Braf-induced thyroid tumor initiation in mice. Proc Natl Acad Sci U S A (2011) 1.82

Role of the Akt pathway in mRNA translation of interferon-stimulated genes. Proc Natl Acad Sci U S A (2008) 1.81

Cocaine-induced intracellular signaling and gene expression are oppositely regulated by the dopamine D1 and D3 receptors. J Neurosci (2004) 1.80

The cell death regulator GRIM-19 is an inhibitor of signal transducer and activator of transcription 3. Proc Natl Acad Sci U S A (2003) 1.80

Identification of an mRNP complex regulating tumorigenesis at the translational elongation step. Mol Cell (2011) 1.80

An essential role for a MEK-C/EBP pathway during growth factor-regulated cortical neurogenesis. Neuron (2002) 1.79

Structural basis for DNA recognition by the basic region leucine zipper transcription factor CCAAT/enhancer-binding protein alpha. J Biol Chem (2003) 1.79

The oxygen sensor factor-inhibiting hypoxia-inducible factor-1 controls expression of distinct genes through the bifunctional transcriptional character of hypoxia-inducible factor-1alpha. Cancer Res (2006) 1.75

Critical roles for mTORC2- and rapamycin-insensitive mTORC1-complexes in growth and survival of BCR-ABL-expressing leukemic cells. Proc Natl Acad Sci U S A (2010) 1.75

NADPH oxidase and ERK signaling regulates hyperoxia-induced Nrf2-ARE transcriptional response in pulmonary epithelial cells. J Biol Chem (2004) 1.73

Linkage analysis of susceptibility to hyperoxia. Nrf2 is a candidate gene. Am J Respir Cell Mol Biol (2002) 1.73

A role for MEK kinase 1 in TGF-beta/activin-induced epithelium movement and embryonic eyelid closure. EMBO J (2003) 1.72

Protein kinase C-delta (PKC-delta ) is activated by type I interferons and mediates phosphorylation of Stat1 on serine 727. J Biol Chem (2002) 1.72

Mesogastrium: a fifth route of metastasis in gastric cancer? Med Hypotheses (2013) 1.72

Activation of the p38 mitogen-activated protein kinase mediates the suppressive effects of type I interferons and transforming growth factor-beta on normal hematopoiesis. J Biol Chem (2001) 1.71

CCR5 signaling suppresses inflammation and reduces adverse remodeling of the infarcted heart, mediating recruitment of regulatory T cells. Am J Pathol (2010) 1.69

Ah receptor signals cross-talk with multiple developmental pathways. Biochem Pharmacol (2004) 1.69

Autophagic degradation of the BCR-ABL oncoprotein and generation of antileukemic responses by arsenic trioxide. Blood (2012) 1.66

AMPK as a therapeutic target in renal cell carcinoma. Cancer Biol Ther (2010) 1.66

pH control mechanisms of tumor survival and growth. J Cell Physiol (2011) 1.62

Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction by modulating glutamate receptor recycling in Down's syndrome. Nat Med (2013) 1.61

Stop and go: anti-proliferative and mitogenic functions of the transcription factor C/EBPbeta. Cell Cycle (2006) 1.58

IL-17 receptor signaling inhibits C/EBPbeta by sequential phosphorylation of the regulatory 2 domain. Sci Signal (2009) 1.57

Interferons: mechanisms of action and clinical applications. Curr Opin Oncol (2003) 1.56

Transcriptional activity of CCAAT/enhancer-binding proteins is controlled by a conserved inhibitory domain that is a target for sumoylation. J Biol Chem (2002) 1.54

Activation of the p38 Map kinase pathway is essential for the antileukemic effects of dasatinib. Leuk Lymphoma (2009) 1.53

Distinct cell cycle timing requirements for extracellular signal-regulated kinase and phosphoinositide 3-kinase signaling pathways in somatic cell mitosis. Mol Cell Biol (2002) 1.52

Jak family of kinases in cancer. Cancer Metastasis Rev (2003) 1.52

C/EBPbeta is a critical mediator of steroid hormone-regulated cell proliferation and differentiation in the uterine epithelium and stroma. Proc Natl Acad Sci U S A (2006) 1.50

Differential regulation of membrane type 1-matrix metalloproteinase activity by ERK 1/2- and p38 MAPK-modulated tissue inhibitor of metalloproteinases 2 expression controls transforming growth factor-beta1-induced pericellular collagenolysis. J Biol Chem (2004) 1.49

Inhibition of overactivated p38 MAPK can restore hematopoiesis in myelodysplastic syndrome progenitors. Blood (2006) 1.48

Fc receptor engagement mediates differentiation of cardiac fibroblast precursor cells. Proc Natl Acad Sci U S A (2008) 1.48

Regulation of insulin gene transcription by ERK1 and ERK2 in pancreatic beta cells. J Biol Chem (2003) 1.46

c-Jun N-terminal kinases (JNK) antagonize cardiac growth through cross-talk with calcineurin-NFAT signaling. EMBO J (2003) 1.42

Cutting edge: activation of the p38 mitogen-activated protein kinase signaling pathway mediates cytokine-induced hemopoietic suppression in aplastic anemia. J Immunol (2002) 1.41

Regulatory effects of mammalian target of rapamycin-activated pathways in type I and II interferon signaling. J Biol Chem (2006) 1.41

cAMP-dependent protein kinase and Ca2+ influx through L-type voltage-gated calcium channels mediate Raf-independent activation of extracellular regulated kinase in response to glucagon-like peptide-1 in pancreatic beta-cells. J Biol Chem (2002) 1.41

Down-regulation of signal transducer and activator of transcription 3 expression using vector-based small interfering RNAs suppresses growth of human prostate tumor in vivo. Clin Cancer Res (2005) 1.40

Genistein inhibits p38 map kinase activation, matrix metalloproteinase type 2, and cell invasion in human prostate epithelial cells. Cancer Res (2005) 1.40

Hypoxia-inducible factor 1 transactivates the human leptin gene promoter. J Biol Chem (2002) 1.37

The aryl hydrocarbon receptor functions as a tumor suppressor of liver carcinogenesis. Cancer Res (2009) 1.37

Differential control of the CCAAT/enhancer-binding protein beta (C/EBPbeta) products liver-enriched transcriptional activating protein (LAP) and liver-enriched transcriptional inhibitory protein (LIP) and the regulation of gene expression during the response to endoplasmic reticulum stress. J Biol Chem (2008) 1.37

Activation of the p70 S6 kinase and phosphorylation of the 4E-BP1 repressor of mRNA translation by type I interferons. J Biol Chem (2003) 1.36

Decreased brain damage and curtailed inflammation in transcription factor CCAAT/enhancer binding protein beta knockout mice following transient focal cerebral ischemia. J Neurochem (2006) 1.35

Destabilization of vascular endothelial growth factor mRNA by the zinc-finger protein TIS11b. Oncogene (2004) 1.34

The angiopoietin-2 gene of endothelial cells is up-regulated in hypoxia by a HIF binding site located in its first intron and by the central factors GATA-2 and Ets-1. J Cell Physiol (2008) 1.34

Statins in tumor suppression. Cancer Lett (2008) 1.34

N-terminally PEGylated human interferon-beta-1a with improved pharmacokinetic properties and in vivo efficacy in a melanoma angiogenesis model. Bioconjug Chem (2006) 1.33

Phosphorylation of forkhead transcription factors by erythropoietin and stem cell factor prevents acetylation and their interaction with coactivator p300 in erythroid progenitor cells. Oncogene (2002) 1.32

A feedback transcriptional mechanism controls the level of the arginine/lysine transporter cat-1 during amino acid starvation. Biochem J (2007) 1.32

Cell fate determination factor Dachshund reprograms breast cancer stem cell function. J Biol Chem (2010) 1.31

Role of the p38 mitogen-activated protein kinase pathway in the generation of arsenic trioxide-dependent cellular responses. Cancer Res (2006) 1.31

PEA-15 binding to ERK1/2 MAPKs is required for its modulation of integrin activation. J Biol Chem (2003) 1.30

Dual mTORC2/mTORC1 targeting results in potent suppressive effects on acute myeloid leukemia (AML) progenitors. Clin Cancer Res (2011) 1.29

The interferon consensus sequence-binding protein activates transcription of the gene encoding neurofibromin 1. J Biol Chem (2004) 1.29

Butylhydroquinone protects cells genetically deficient in glutathione biosynthesis from arsenite-induced apoptosis without significantly changing their prooxidant status. Toxicol Sci (2005) 1.29

Induction of the CXC chemokine interferon-gamma-inducible protein 10 regulates the reparative response following myocardial infarction. Circ Res (2009) 1.28

Curcumin suppresses constitutive activation of nuclear factor-kappa B and requires functional Bax to induce apoptosis in Burkitt's lymphoma cell lines. Mol Cancer Ther (2008) 1.28

FRA-1 proto-oncogene induces lung epithelial cell invasion and anchorage-independent growth in vitro, but is insufficient to promote tumor growth in vivo. Cancer Res (2007) 1.27

Oxygen-sensitive {delta}-opioid receptor-regulated survival and death signals: novel insights into neuronal preconditioning and protection. J Biol Chem (2005) 1.26

AZD1208, a potent and selective pan-Pim kinase inhibitor, demonstrates efficacy in preclinical models of acute myeloid leukemia. Blood (2013) 1.26

Targeting mTOR for the treatment of AML. New agents and new directions. Oncotarget (2011) 1.26

Activation of protein kinase C delta by IFN-gamma. J Immunol (2003) 1.25

Interferon-gamma engages the p70 S6 kinase to regulate phosphorylation of the 40S S6 ribosomal protein. Exp Cell Res (2004) 1.25

Electroacupuncture increased cerebral blood flow and reduced ischemic brain injury: dependence on stimulation intensity and frequency. J Appl Physiol (1985) (2011) 1.23

The p38 mitogen-activated protein kinase pathway in interferon signal transduction. J Interferon Cytokine Res (2005) 1.23

Role of p38alpha Map kinase in Type I interferon signaling. J Biol Chem (2003) 1.23

Synergism between rhinovirus infection and oxidant pollutant exposure enhances airway epithelial cell cytokine production. Environ Health Perspect (2002) 1.23

Role of the aryl hydrocarbon receptor in cell cycle regulation. Chem Biol Interact (2002) 1.23

Dual regulatory roles of phosphatidylinositol 3-kinase in IFN signaling. J Immunol (2008) 1.22

Interferon-dependent engagement of eukaryotic initiation factor 4B via S6 kinase (S6K)- and ribosomal protein S6K-mediated signals. Mol Cell Biol (2009) 1.21

Pharmacological inhibitors of the ERK signaling pathway: application as anticancer drugs. Prog Cell Cycle Res (2003) 1.21

Cellular cardiomyoplasty improves survival after myocardial injury. Circulation (2002) 1.21

The aryl hydrocarbon receptor binds to E2F1 and inhibits E2F1-induced apoptosis. Mol Biol Cell (2008) 1.21