Published in Mol Cell Biol on January 01, 2002
ATR: an essential regulator of genome integrity. Nat Rev Mol Cell Biol (2008) 11.86
DNA topoisomerase II and its growing repertoire of biological functions. Nat Rev Cancer (2009) 3.05
Rif1 prevents resection of DNA breaks and promotes immunoglobulin class switching. Science (2013) 3.02
A novel ring-like complex of Xenopus proteins essential for the initiation of DNA replication. Genes Dev (2003) 2.75
ATR signalling: more than meeting at the fork. Biochem J (2011) 2.37
Mouse HORMAD1 and HORMAD2, two conserved meiotic chromosomal proteins, are depleted from synapsed chromosome axes with the help of TRIP13 AAA-ATPase. PLoS Genet (2009) 2.15
Surveillance of different recombination defects in mouse spermatocytes yields distinct responses despite elimination at an identical developmental stage. Mol Cell Biol (2005) 2.13
Claspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activation. Mol Cell Biol (2006) 2.09
The Xenopus Xmus101 protein is required for the recruitment of Cdc45 to origins of DNA replication. J Cell Biol (2002) 2.00
Xenopus Cut5 is essential for a CDK-dependent process in the initiation of DNA replication. EMBO J (2003) 1.86
Regulation of E2F1 by BRCT domain-containing protein TopBP1. Mol Cell Biol (2003) 1.84
TopBP1 recruits Brg1/Brm to repress E2F1-induced apoptosis, a novel pRb-independent and E2F1-specific control for cell survival. Genes Dev (2004) 1.84
Mammalian Rif1 contributes to replication stress survival and homology-directed repair. J Cell Biol (2009) 1.66
BACH1/FANCJ acts with TopBP1 and participates early in DNA replication checkpoint control. Mol Cell (2010) 1.65
Yeast DNA replication protein Dpb11 activates the Mec1/ATR checkpoint kinase. J Biol Chem (2008) 1.61
Dpb11 activates the Mec1-Ddc2 complex. Proc Natl Acad Sci U S A (2008) 1.58
MDC1 directs chromosome-wide silencing of the sex chromosomes in male germ cells. Genes Dev (2011) 1.52
A vertebrate gene, ticrr, is an essential checkpoint and replication regulator. Genes Dev (2010) 1.47
TopBP1 functions with 53BP1 in the G1 DNA damage checkpoint. EMBO J (2010) 1.46
Regulation of TopBP1 oligomerization by Akt/PKB for cell survival. EMBO J (2006) 1.45
Regulation of chromatin architecture by the PWWP domain-containing DNA damage-responsive factor EXPAND1/MUM1. Mol Cell (2010) 1.40
MDC1 collaborates with TopBP1 in DNA replication checkpoint control. J Cell Biol (2011) 1.40
DNA damage tolerance: a double-edged sword guarding the genome. Transl Cancer Res (2013) 1.33
Human TopBP1 ensures genome integrity during normal S phase. Mol Cell Biol (2005) 1.31
How ATR turns on: TopBP1 goes on ATRIP with ATR. Genes Dev (2008) 1.30
A tale of two tails: activation of DNA damage checkpoint kinase Mec1/ATR by the 9-1-1 clamp and by Dpb11/TopBP1. DNA Repair (Amst) (2009) 1.29
PML colocalizes with and stabilizes the DNA damage response protein TopBP1. Mol Cell Biol (2003) 1.29
BRCT domains: easy as one, two, three. Cell Cycle (2011) 1.25
Viral transport of DNA damage that mimics a stalled replication fork. J Virol (2005) 1.24
Identification of candidate lung cancer susceptibility genes in mouse using oligonucleotide arrays. J Med Genet (2002) 1.23
TopBP1 and ATR colocalization at meiotic chromosomes: role of TopBP1/Cut5 in the meiotic recombination checkpoint. Mol Biol Cell (2004) 1.21
A genome-wide RNAi screen identifies core components of the G₂-M DNA damage checkpoint. Sci Signal (2011) 1.11
Nuclear RNA-seq of single neurons reveals molecular signatures of activation. Nat Commun (2016) 1.08
Mammalian BTBD12 (SLX4) protects against genomic instability during mammalian spermatogenesis. PLoS Genet (2011) 1.07
TopBP1 regulates human papillomavirus type 16 E2 interaction with chromatin. J Virol (2007) 1.06
Molecular basis of BACH1/FANCJ recognition by TopBP1 in DNA replication checkpoint control. J Biol Chem (2010) 1.06
TopBP1 controls BLM protein level to maintain genome stability. Mol Cell (2013) 1.04
The E3 ubiquitin ligase EDD is an adverse prognostic factor for serous epithelial ovarian cancer and modulates cisplatin resistance in vitro. Br J Cancer (2008) 1.02
TopBP1 localises to centrosomes in mitosis and to chromosome cores in meiosis. Chromosoma (2004) 0.98
Integrator3, a partner of single-stranded DNA-binding protein 1, participates in the DNA damage response. J Biol Chem (2009) 0.96
TopBP1 deficiency causes an early embryonic lethality and induces cellular senescence in primary cells. J Biol Chem (2010) 0.95
Neurogenesis requires TopBP1 to prevent catastrophic replicative DNA damage in early progenitors. Nat Neurosci (2012) 0.91
Four pillars of the S-phase checkpoint. Genes Dev (2013) 0.89
TopBP1 contains a transcriptional activation domain suppressed by two adjacent BRCT domains. Biochem J (2006) 0.89
An essential function for the ATR-activation-domain (AAD) of TopBP1 in mouse development and cellular senescence. PLoS Genet (2013) 0.88
Identification and cloning of two putative subunits of DNA polymerase epsilon in fission yeast. Nucleic Acids Res (2004) 0.84
Regulation of the DNA damage response on male meiotic sex chromosomes. Nat Commun (2013) 0.83
Importin β-dependent nuclear import of TopBP1 in ATR-Chk1 checkpoint in Xenopus egg extracts. Cell Signal (2014) 0.82
Structural insights into recognition of MDC1 by TopBP1 in DNA replication checkpoint control. Structure (2013) 0.82
Poly(ADP-Ribose) Mediates the BRCA2-Dependent Early DNA Damage Response. Cell Rep (2015) 0.81
DNA Damage and Pulmonary Hypertension. Int J Mol Sci (2016) 0.81
Levels of the E2 interacting protein TopBP1 modulate papillomavirus maintenance stage replication. Virology (2015) 0.81
Analysis of the Cullin binding sites of the E4orf6 proteins of human adenovirus E3 ubiquitin ligases. J Virol (2014) 0.79
The 53BP1-EXPAND1 connection in chromatin structure regulation. Nucleus (2010) 0.79
TOPBP1(Dpb11) plays a conserved role in homologous recombination DNA repair through the coordinated recruitment of 53BP1(Rad9). J Cell Biol (2017) 0.78
Cell cycle-dependent inhibition of 53BP1 signaling by BRCA1. Cell Discov (2015) 0.77
TopBP1 deficiency impairs V(D)J recombination during lymphocyte development. EMBO J (2014) 0.76
Modeling the study of DNA damage responses in mice. Methods Mol Biol (2015) 0.75
The DNA damage response: putting checkpoints in perspective. Nature (2000) 19.07
Megabase chromatin domains involved in DNA double-strand breaks in vivo. J Cell Biol (1999) 16.81
A superfamily of conserved domains in DNA damage-responsive cell cycle checkpoint proteins. FASEB J (1997) 15.10
A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage. Curr Biol (2000) 13.46
From BRCA1 to RAP1: a widespread BRCT module closely associated with DNA repair. FEBS Lett (1997) 12.43
Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. Science (1998) 11.90
BRCA1 protein products ... Functional motifs... Nat Genet (1996) 11.50
Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint. Genes Dev (2000) 11.49
Enhanced phosphorylation of p53 by ATM in response to DNA damage. Science (1998) 10.89
Linkage of ATM to cell cycle regulation by the Chk2 protein kinase. Science (1998) 8.74
Association of BRCA1 with Rad51 in mitotic and meiotic cells. Cell (1997) 8.28
Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25. Science (1997) 8.24
Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine. Cancer Res (1999) 7.82
ATR disruption leads to chromosomal fragmentation and early embryonic lethality. Genes Dev (2000) 7.28
p53 binding protein 1 (53BP1) is an early participant in the cellular response to DNA double-strand breaks. J Cell Biol (2000) 7.26
Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks. Science (1999) 6.93
The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis. Nature (2001) 6.73
The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response. Cell (1998) 6.58
A role for ATR in the DNA damage-induced phosphorylation of p53. Genes Dev (1999) 6.34
Substrate specificities and identification of putative substrates of ATM kinase family members. J Biol Chem (1999) 6.14
Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53. Genes Dev (2000) 5.90
The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites. Genes Dev (2000) 5.72
ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway. Nature (2000) 5.55
Rapid destruction of human Cdc25A in response to DNA damage. Science (2000) 4.74
Rad53 FHA domain associated with phosphorylated Rad9 in the DNA damage checkpoint. Science (1998) 4.59
Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice. Genes Dev (2000) 4.38
Fission yeast cut5+, required for S phase onset and M phase restraint, is identical to the radiation-damage repair gene rad4+. Cell (1993) 4.20
hMre11 and hRad50 nuclear foci are induced during the normal cellular response to DNA double-strand breaks. Mol Cell Biol (1997) 4.11
Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products. Nature (2000) 3.96
Tumor suppressor p53 binding protein 1 (53BP1) is involved in DNA damage-signaling pathways. J Cell Biol (2001) 3.92
Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress. Genes Dev (2000) 3.86
DNA damage-dependent nuclear dynamics of the Mre11 complex. Mol Cell Biol (2001) 3.78
ATM associates with and phosphorylates p53: mapping the region of interaction. Nat Genet (1998) 3.66
hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response. Nature (2000) 3.65
Dpb11, which interacts with DNA polymerase II(epsilon) in Saccharomyces cerevisiae, has a dual role in S-phase progression and at a cell cycle checkpoint. Proc Natl Acad Sci U S A (1995) 3.59
ATM-dependent phosphorylation of nibrin in response to radiation exposure. Nat Genet (2000) 3.49
The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01. J Biol Chem (2000) 3.49
ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response. Nature (2000) 3.48
Association of BRCA1 with the hRad50-hMre11-p95 complex and the DNA damage response. Science (1999) 3.47
Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice. Curr Biol (2000) 3.34
Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway. Oncogene (1999) 3.23
Phosphorylation and rapid relocalization of 53BP1 to nuclear foci upon DNA damage. Mol Cell Biol (2001) 3.22
Damage and replication checkpoint control in fission yeast is ensured by interactions of Crb2, a protein with BRCT motif, with Cut5 and Chk1. Genes Dev (1997) 3.12
The budding yeast Rad9 checkpoint protein is subjected to Mec1/Tel1-dependent hyperphosphorylation and interacts with Rad53 after DNA damage. EMBO J (1998) 3.09
A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase. Curr Biol (1999) 2.73
BRCT domain-containing protein TopBP1 functions in DNA replication and damage response. J Biol Chem (2001) 2.60
MEC1-dependent phosphorylation of Rad9p in response to DNA damage. Mol Cell (1998) 2.55
RAD9 and DNA polymerase epsilon form parallel sensory branches for transducing the DNA damage checkpoint signal in Saccharomyces cerevisiae. Genes Dev (1996) 2.53
A human Cds1-related kinase that functions downstream of ATM protein in the cellular response to DNA damage. Proc Natl Acad Sci U S A (1999) 2.51
Caffeine inhibits the checkpoint kinase ATM. Curr Biol (1999) 2.47
Fission yeast cut5 links nuclear chromatin and M phase regulator in the replication checkpoint control. EMBO J (1994) 2.45
Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response. Nature (2000) 2.44
RAD9 and RAD24 define two additive, interacting branches of the DNA damage checkpoint pathway in budding yeast normally required for Rad53 modification and activation. EMBO J (1998) 2.32
The radiosensitizing agent 7-hydroxystaurosporine (UCN-01) inhibits the DNA damage checkpoint kinase hChk1. Cancer Res (2000) 2.20
Stimulation of p53-mediated transcriptional activation by the p53-binding proteins, 53BP1 and 53BP2. J Biol Chem (1998) 2.07
BRCA1 is a 220-kDa nuclear phosphoprotein that is expressed and phosphorylated in a cell cycle-dependent manner. Cancer Res (1996) 2.04
DRC1, DNA replication and checkpoint protein 1, functions with DPB11 to control DNA replication and the S-phase checkpoint in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1999) 2.00
Role for ATM in DNA damage-induced phosphorylation of BRCA1. Cancer Res (2000) 1.76
Cell cycle checkpoints and their inactivation in human cancer. Cell Prolif (2000) 1.76
Negative cell cycle regulation and DNA damage-inducible phosphorylation of the BRCT protein 53BP1. J Biol Chem (2000) 1.72
Inactivation of mouse Hus1 results in genomic instability and impaired responses to genotoxic stress. Genes Dev (2000) 1.70
Cloning and characterization of the rad4 gene of Schizosaccharomyces pombe; a gene showing short regions of sequence similarity to the human XRCC1 gene. Nucleic Acids Res (1991) 1.66
A DNA-topoisomerase-II-binding protein with eight repeating regions similar to DNA-repair enzymes and to a cell-cycle regulator. Eur J Biochem (1997) 1.65
Ataxia telangiectasia mutated (ATM) kinase and ATM and Rad3 related kinase mediate phosphorylation of Brca1 at distinct and overlapping sites. In vivo assessment using phospho-specific antibodies. J Biol Chem (2001) 1.60
The Drosophila mus101 gene, which links DNA repair, replication and condensation of heterochromatin in mitosis, encodes a protein with seven BRCA1 C-terminus domains. Genetics (2000) 1.58
Conserved BRCT regions of TopBP1 and of the tumor suppressor BRCA1 bind strand breaks and termini of DNA. Oncogene (1999) 1.45
The ataxia-telangiectasia related protein ATR mediates DNA-dependent phosphorylation of p53. Oncogene (1999) 1.41
Characterisation of the Schizosaccharomyces pombe rad4/cut5 mutant phenotypes: dissection of DNA replication and G2 checkpoint control function. Mol Gen Genet (1997) 1.33
Ataxia telangiectasia-related protein is involved in the phosphorylation of BRCA1 following deoxyribonucleic acid damage. Cancer Res (2000) 1.26
Checkpoints: it takes more than time to heal some wounds. Curr Biol (2001) 1.16
Cut5 is a component of the UV-responsive DNA damage checkpoint in fission yeast. Mol Gen Genet (1998) 1.15
Coupling of DNA replication and mitosis by fission yeast rad4/cut5. J Cell Sci Suppl (1994) 1.10
Independence of R/M/N focus formation and the presence of intact BRCA1. Science (2000) 1.02
RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly. Cell (2007) 8.71
Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair. Cell (2006) 8.12
The BRCT domain is a phospho-protein binding domain. Science (2003) 7.42
MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals. Mol Cell (2006) 6.09
Ubiquitin-binding protein RAP80 mediates BRCA1-dependent DNA damage response. Science (2007) 5.88
DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1. Nat Cell Biol (2002) 5.85
DNA damage-induced cell cycle checkpoint control requires CtIP, a phosphorylation-dependent binding partner of BRCA1 C-terminal domains. Mol Cell Biol (2004) 4.78
DBC1 is a negative regulator of SIRT1. Nature (2008) 4.66
DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells. Mol Cell Biol (2008) 4.56
Genomic instability in laminopathy-based premature aging. Nat Med (2005) 4.54
p53 Binding protein 53BP1 is required for DNA damage responses and tumor suppression in mice. Mol Cell Biol (2003) 4.36
Role of genomic instability and p53 in AID-induced c-myc-Igh translocations. Nature (2006) 3.90
BRCA1 and its toolbox for the maintenance of genome integrity. Nat Rev Mol Cell Biol (2009) 3.79
53BP1 is required for class switch recombination. J Cell Biol (2004) 3.57
H2AX prevents DNA breaks from progressing to chromosome breaks and translocations. Mol Cell (2006) 3.53
BRCA1 ubiquitinates its phosphorylation-dependent binding partner CtIP. Genes Dev (2006) 3.44
CDK2-dependent phosphorylation of FOXO1 as an apoptotic response to DNA damage. Science (2006) 3.41
Accumulation of checkpoint protein 53BP1 at DNA breaks involves its binding to phosphorylated histone H2AX. J Biol Chem (2003) 3.34
Sirtuin 1 modulates cellular responses to hypoxia by deacetylating hypoxia-inducible factor 1alpha. Mol Cell (2010) 3.33
MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways. Nature (2003) 3.00
PALB2 is an integral component of the BRCA complex required for homologous recombination repair. Proc Natl Acad Sci U S A (2009) 2.98
Distinct roles of chromatin-associated proteins MDC1 and 53BP1 in mammalian double-strand break repair. Mol Cell (2007) 2.88
FAN1 acts with FANCI-FANCD2 to promote DNA interstrand cross-link repair. Science (2010) 2.80
UV-induced ataxia-telangiectasia-mutated and Rad3-related (ATR) activation requires replication stress. J Biol Chem (2004) 2.72
Plk1-dependent phosphorylation of FoxM1 regulates a transcriptional programme required for mitotic progression. Nat Cell Biol (2008) 2.68
RAD18 transmits DNA damage signalling to elicit homologous recombination repair. Nat Cell Biol (2009) 2.67
19F magnetic resonance imaging for stem/progenitor cell tracking with multiple unique perfluorocarbon nanobeacons. FASEB J (2007) 2.63
CCDC98 is a BRCA1-BRCT domain-binding protein involved in the DNA damage response. Nat Struct Mol Biol (2007) 2.55
Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains. J Biol Chem (2003) 2.50
MERIT40 facilitates BRCA1 localization and DNA damage repair. Genes Dev (2009) 2.49
A selective requirement for 53BP1 in the biological response to genomic instability induced by Brca1 deficiency. Mol Cell (2009) 2.41
The annealing helicase HARP protects stalled replication forks. Genes Dev (2009) 2.19
Human claspin is required for replication checkpoint control. J Biol Chem (2003) 2.02
Mediator of DNA damage checkpoint protein 1 regulates BRCA1 localization and phosphorylation in DNA damage checkpoint control. J Biol Chem (2003) 2.00
WWP2 is an E3 ubiquitin ligase for PTEN. Nat Cell Biol (2011) 2.00
Enhanced intra-switch region recombination during immunoglobulin class switch recombination in 53BP1-/- B cells. Eur J Immunol (2007) 1.98
Chfr is required for tumor suppression and Aurora A regulation. Nat Genet (2005) 1.97
Deleted in breast cancer-1 regulates SIRT1 activity and contributes to high-fat diet-induced liver steatosis in mice. J Clin Invest (2010) 1.97
Angiomotin-like proteins associate with and negatively regulate YAP1. J Biol Chem (2010) 1.95
Direct interaction between SET8 and proliferating cell nuclear antigen couples H4-K20 methylation with DNA replication. J Biol Chem (2008) 1.93
RIF1 counteracts BRCA1-mediated end resection during DNA repair. J Biol Chem (2013) 1.86
Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest. J Cell Biol (2004) 1.82
Structural basis of BACH1 phosphopeptide recognition by BRCA1 tandem BRCT domains. Structure (2004) 1.82
The LIM domain protein LMO4 interacts with the cofactor CtIP and the tumor suppressor BRCA1 and inhibits BRCA1 activity. J Biol Chem (2001) 1.82
The DNA damage response pathways: at the crossroad of protein modifications. Cell Res (2008) 1.80
Protein kinase DYRK2 is a scaffold that facilitates assembly of an E3 ligase. Nat Cell Biol (2009) 1.79
Image-based models of cardiac structure in health and disease. Wiley Interdiscip Rev Syst Biol Med (2010) 1.67
Human immunodeficiency virus type 1 Vpr-mediated G2 arrest requires Rad17 and Hus1 and induces nuclear BRCA1 and gamma-H2AX focus formation. Mol Cell Biol (2004) 1.66
BACH1/FANCJ acts with TopBP1 and participates early in DNA replication checkpoint control. Mol Cell (2010) 1.65
The E3 ligase RNF8 regulates KU80 removal and NHEJ repair. Nat Struct Mol Biol (2012) 1.64
The tandem BRCT domains of Ect2 are required for both negative and positive regulation of Ect2 in cytokinesis. J Biol Chem (2004) 1.64
MDC1 regulates intra-S-phase checkpoint by targeting NBS1 to DNA double-strand breaks. Proc Natl Acad Sci U S A (2008) 1.63
SOSS complexes participate in the maintenance of genomic stability. Mol Cell (2009) 1.63
Gemcitabine-induced activation of checkpoint signaling pathways that affect tumor cell survival. Mol Pharmacol (2005) 1.61
BRCA1 participates in DNA decatenation. Nat Struct Mol Biol (2005) 1.59
Focus on histone variant H2AX: to be or not to be. FEBS Lett (2010) 1.56
53BP1 cooperates with p53 and functions as a haploinsufficient tumor suppressor in mice. Mol Cell Biol (2005) 1.56
Enhancement of RAD51 recombinase activity by the tumor suppressor PALB2. Nat Struct Mol Biol (2010) 1.55
MCPH1 functions in an H2AX-dependent but MDC1-independent pathway in response to DNA damage. J Biol Chem (2007) 1.55
MDC1 directs chromosome-wide silencing of the sex chromosomes in male germ cells. Genes Dev (2011) 1.52
Microcephalin/MCPH1 associates with the Condensin II complex to function in homologous recombination repair. J Biol Chem (2008) 1.52
PALB2 regulates recombinational repair through chromatin association and oligomerization. J Biol Chem (2009) 1.50
Histone ubiquitination associates with BRCA1-dependent DNA damage response. Mol Cell Biol (2008) 1.50
Assembly of checkpoint and repair machineries at DNA damage sites. Trends Biochem Sci (2009) 1.49
The mitotic checkpoint in cancer and aging: what have mice taught us? Curr Opin Cell Biol (2005) 1.47
The tandem BRCT domain of 53BP1 is not required for its repair function. J Biol Chem (2006) 1.45
Regulation of chromatin architecture by the PWWP domain-containing DNA damage-responsive factor EXPAND1/MUM1. Mol Cell (2010) 1.40
MDC1 collaborates with TopBP1 in DNA replication checkpoint control. J Cell Biol (2011) 1.40
Accumulation of Pax2 transactivation domain interaction protein (PTIP) at sites of DNA breaks via RNF8-dependent pathway is required for cell survival after DNA damage. J Biol Chem (2009) 1.39
MRE11-RAD50-NBS1 complex dictates DNA repair independent of H2AX. J Biol Chem (2009) 1.39
Distinct versus overlapping functions of MDC1 and 53BP1 in DNA damage response and tumorigenesis. J Cell Biol (2008) 1.38
Improved molecular imaging contrast agent for detection of human thrombus. Magn Reson Med (2003) 1.37
The HARP-like domain-containing protein AH2/ZRANB3 binds to PCNA and participates in cellular response to replication stress. Mol Cell (2012) 1.37
Harmonic phase MR tagging for direct quantification of Lagrangian strain in rat hearts after myocardial infarction. Magn Reson Med (2004) 1.35
Activation of the ATR pathway by human immunodeficiency virus type 1 Vpr involves its direct binding to chromatin in vivo. J Virol (2005) 1.34
DNA damage tolerance: a double-edged sword guarding the genome. Transl Cancer Res (2013) 1.33
Class switching and meiotic defects in mice lacking the E3 ubiquitin ligase RNF8. J Exp Med (2010) 1.33
MDC1 regulates DNA-PK autophosphorylation in response to DNA damage. J Biol Chem (2004) 1.32
Topoisomerase IIalpha controls the decatenation checkpoint. Nat Cell Biol (2008) 1.32
BRCA1 is a negative modulator of the PRC2 complex. EMBO J (2013) 1.31
Fanconi anemia complementation group D2 (FANCD2) functions independently of BRCA2- and RAD51-associated homologous recombination in response to DNA damage. J Biol Chem (2005) 1.31
Human TopBP1 ensures genome integrity during normal S phase. Mol Cell Biol (2005) 1.31
SIRT1 regulates autoacetylation and histone acetyltransferase activity of TIP60. J Biol Chem (2010) 1.30
Resolution of established cardiac hypertrophy and fibrosis and prevention of systolic dysfunction in a transgenic rabbit model of human cardiomyopathy through thiol-sensitive mechanisms. Circulation (2009) 1.30
Polo-like kinase 1 is essential for early embryonic development and tumor suppression. Mol Cell Biol (2008) 1.29
MR tagging demonstrates quantitative differences in regional ventricular wall motion in mice, rats, and men. Am J Physiol Heart Circ Physiol (2006) 1.28
MRG15 is a novel PALB2-interacting factor involved in homologous recombination. J Biol Chem (2009) 1.26
Targeted PARACEST nanoparticle contrast agent for the detection of fibrin. Magn Reson Med (2006) 1.25
Fanconi anemia (FA) binding protein FAAP20 stabilizes FA complementation group A (FANCA) and participates in interstrand cross-link repair. Proc Natl Acad Sci U S A (2012) 1.25
PTPN14 is required for the density-dependent control of YAP1. Genes Dev (2012) 1.23
Noncanonical E2 variant-independent function of UBC13 in promoting checkpoint protein assembly. Mol Cell Biol (2008) 1.23
The Lys63-specific deubiquitinating enzyme BRCC36 is regulated by two scaffold proteins localizing in different subcellular compartments. J Biol Chem (2010) 1.22
The SOSS1 single-stranded DNA binding complex promotes DNA end resection in concert with Exo1. EMBO J (2012) 1.19
The E3 ubiquitin ligase Rnf8 stabilizes Tpp1 to promote telomere end protection. Nat Struct Mol Biol (2011) 1.18
Aurora A is essential for early embryonic development and tumor suppression. J Biol Chem (2008) 1.17
Repeated phosphopeptide motifs in human Claspin are phosphorylated by Chk1 and mediate Claspin function. J Biol Chem (2006) 1.17
Both DNA topoisomerase II-binding protein 1 and BRCA1 regulate the G2-M cell cycle checkpoint. Cancer Res (2003) 1.17
Proliferating cell nuclear antigen (PCNA)-binding protein C1orf124 is a regulator of translesion synthesis. J Biol Chem (2012) 1.16