Published in Biochemistry on January 08, 2002
Oxidation and haem loss kinetics of poly(ethylene glycol)-conjugated haemoglobin (MP4): dissociation between in vitro and in vivo oxidation rates. Biochem J (2006) 1.07
Modulation of reactivity and conformation within the T-quaternary state of human hemoglobin: the combined use of mutagenesis and sol-gel encapsulation. Biochemistry (2006) 0.98
Kinetics of NO and O2 binding to a maleimide poly(ethylene glycol)-conjugated human haemoglobin. Biochem J (2004) 0.97
The role of beta93 Cys in the inhibition of Hb S fiber formation. Biophys Chem (2007) 0.81
Site-selective glycosylation of hemoglobin with variable molecular weight oligosaccharides: potential alternative to PEGylation. J Am Chem Soc (2012) 0.75
Polyethylene Glycol Camouflaged Earthworm Hemoglobin. PLoS One (2017) 0.75
Antimicrobial and healing efficacy of sustained release nitric oxide nanoparticles against Staphylococcus aureus skin infection. J Invest Dermatol (2009) 2.16
Sustained release nitric oxide from long-lived circulating nanoparticles. Free Radic Biol Med (2010) 1.71
Susceptibility of Gram-positive and -negative bacteria to novel nitric oxide-releasing nanoparticle technology. Virulence (2011) 1.63
S-Nitrosohemoglobin is unstable in the reductive erythrocyte environment and lacks O2/NO-linked allosteric function. J Biol Chem (2002) 1.62
Sustained release nitric oxide releasing nanoparticles: characterization of a novel delivery platform based on nitrite containing hydrogel/glass composites. Nitric Oxide (2008) 1.50
Dissociation of local nitric oxide concentration and vasoconstriction in the presence of cell-free hemoglobin oxygen carriers. Blood (2006) 1.32
The use of nitric oxide releasing nanoparticles as a treatment against Acinetobacter baumannii in wound infections. Virulence (2010) 1.18
Nitric oxide releasing nanoparticles are therapeutic for Staphylococcus aureus abscesses in a murine model of infection. PLoS One (2009) 1.11
A hierarchy of functionally important relaxations within myoglobin based on solvent effects, mutations and kinetic model. Biochim Biophys Acta (2005) 1.08
Demonstration of antibiofilm and antifungal efficacy of chitosan against candidal biofilms, using an in vivo central venous catheter model. J Infect Dis (2010) 1.06
The position 68(E11) side chain in myoglobin regulates ligand capture, bond formation with heme iron, and internal movement into the xenon cavities. J Biol Chem (2005) 1.05
A pathway of structural changes produced by monastrol binding to Eg5. J Biol Chem (2006) 1.04
Oral ectomesenchymal chondromyxoid tumor: case report and literature review. Oral Surg Oral Med Oral Pathol Oral Radiol Endod (2009) 1.04
Nitric oxide-releasing nanoparticles accelerate wound healing by promoting fibroblast migration and collagen deposition. Am J Pathol (2012) 1.03
Reversal of hemoglobin-induced vasoconstriction with sustained release of nitric oxide. Am J Physiol Heart Circ Physiol (2010) 1.02
Spectroscopically and kinetically distinct conformational populations of sol-gel-encapsulated carbonmonoxy myoglobin. A comparison with hemoglobin. J Biol Chem (2002) 1.02
Conjugation of multiple copies of polyethylene glycol to hemoglobin facilitated through thiolation: influence on hemoglobin structure and function. Protein J (2005) 1.01
Nitrite reductase activity of sol-gel-encapsulated deoxyhemoglobin. Influence of quaternary and tertiary structure. J Biol Chem (2006) 1.01
Haptoglobin alters oxygenation and oxidation of hemoglobin and decreases propagation of peroxide-induced oxidative reactions. Free Radic Biol Med (2012) 0.99
Modulation of reactivity and conformation within the T-quaternary state of human hemoglobin: the combined use of mutagenesis and sol-gel encapsulation. Biochemistry (2006) 0.98
Anaerobic oxidations of myoglobin and hemoglobin by spectroelectrochemistry. Methods Enzymol (2002) 0.98
Structural bases for heme binding and diatomic ligand recognition in truncated hemoglobins. J Inorg Biochem (2005) 0.97
Survival time in severe hemorrhagic shock after perioperative hemodilution is longer with PEG-conjugated human serum albumin than with HES 130/0.4: a microvascular perspective. Crit Care (2008) 0.97
Reactions of Mycobacterium tuberculosis truncated hemoglobin O with ligands reveal a novel ligand-inclusive hydrogen bond network. Biochemistry (2003) 0.94
Conformational dependence of hemoglobin reactivity under high viscosity conditions: the role of solvent slaved dynamics. J Am Chem Soc (2007) 0.94
Reactivity of glass-embedded met hemoglobin derivatives toward external NO: implications for nitrite-mediated production of bioactive NO. J Am Chem Soc (2009) 0.94
The use of chitosan to damage Cryptococcus neoformans biofilms. Biomaterials (2009) 0.93
Spectroscopic and functional characterization of T state hemoglobin conformations encapsulated in silica gels. Biochemistry (2004) 0.93
Nitric oxide-releasing nanoparticles accelerate wound healing in NOD-SCID mice. Nanomedicine (2012) 0.92
Influence of the chemistry of conjugation of poly(ethylene glycol) to Hb on the oxygen-binding and solution properties of the PEG-Hb conjugate. Biochem J (2005) 0.92
Exogenous nitric oxide prevents cardiovascular collapse during hemorrhagic shock. Resuscitation (2011) 0.91
Ligand recombination and a hierarchy of solvent slaved dynamics: the origin of kinetic phases in hemeproteins. Gene (2007) 0.90
HBOC vasoactivity: interplay between nitric oxide scavenging and capacity to generate bioactive nitric oxide species. Antioxid Redox Signal (2013) 0.89
Trehalose glass-facilitated thermal reduction of metmyoglobin and methemoglobin. J Am Chem Soc (2002) 0.89
Sugar-derived glasses support thermal and photo-initiated electron transfer processes over macroscopic distances. J Biol Chem (2006) 0.89
Enhanced molecular volume of conservatively pegylated Hb: (SP-PEG5K)6-HbA is non-hypertensive. Artif Cells Blood Substit Immobil Biotechnol (2005) 0.89
Microvascular effects following treatment with polyethylene glycol-albumin in lipopolysaccharide-induced endotoxemia. Crit Care Med (2006) 0.89
NO reactions with sol-gel and solution phase samples of the ferric nitrite derivative of HbA. Nitric Oxide (2009) 0.89
Volume resuscitation from hemorrhagic shock with albumin and hexaPEGylated human serum albumin. Resuscitation (2008) 0.88
Functional and spectroscopic characterization of half-liganded iron-zinc hybrid hemoglobin: evidence for conformational plasticity within the T state. Biochemistry (2003) 0.87
Influence of intramolecular cross-links on the molecular, structural and functional properties of PEGylated haemoglobin. Biochem J (2007) 0.87
PEGylation of human serum albumin: reaction of PEG-phenyl-isothiocyanate with protein. Bioconjug Chem (2008) 0.87
The case of the missing NO-hemoglobin: spectral changes suggestive of heme redox reactions reflect changes in NO-heme geometry. Proc Natl Acad Sci U S A (2003) 0.87
Purification and molecular analysis of hemoglobin by high-performance liquid chromatography. Methods Mol Med (2003) 0.86
Geminate rebinding in trehalose-glass embedded myoglobins reveals residue-specific control of intramolecular trajectories. J Mol Biol (2002) 0.86
PEGylation of Val-1(alpha) destabilizes the tetrameric structure of hemoglobin. Biochemistry (2009) 0.86
Extension arm facilitated pegylation of alphaalpha-hemoglobin with modifications targeted exclusively to amino groups: functional and structural advantages of free Cys-93(beta) in the PEG-Hb adduct. Bioconjug Chem (2009) 0.85
Glass matrix-facilitated thermal reduction: a tool for probing reactions of met hemoglobin with nitrite and nitric oxide. J Phys Chem B (2010) 0.85
Binding and release of iron by gel-encapsulated human transferrin: evidence for a conformational search. Proc Natl Acad Sci U S A (2002) 0.84
The absence of proximal strain in the truncated hemoglobins from Mycobacterium tuberculosis. J Am Chem Soc (2004) 0.84
The hemoglobins of the sub-Antarctic fish Cottoperca gobio, a phyletically basal species--oxygen-binding equilibria, kinetics and molecular dynamics. FEBS J (2009) 0.84
Osmolyte-induced perturbations of hydrogen bonding between hydration layer waters: correlation with protein conformational changes. J Phys Chem B (2009) 0.84
PEG-albumin supraplasma expansion is due to increased vessel wall shear stress induced by blood viscosity shear thinning. Am J Physiol Heart Circ Physiol (2012) 0.84
Microvascular PO2 during extreme hemodilution with hemoglobin site specifically PEGylated at Cys-93(beta) in hamster window chamber. Am J Physiol Heart Circ Physiol (2004) 0.84
Domain-specific effector interactions within the central cavity of human adult hemoglobin in solution and in porous sol-gel matrices: evidence for long-range communication pathways. Biochemistry (2004) 0.84
Molecular level probing of preferential hydration and its modulation by osmolytes through the use of pyranine complexed to hemoglobin. J Biol Chem (2006) 0.83
Improved antimicrobial efficacy with nitric oxide releasing nanoparticle generated S-nitrosoglutathione. Nitric Oxide (2011) 0.83
Enhanced nitrite reductase activity associated with the haptoglobin complexed hemoglobin dimer: functional and antioxidative implications. Nitric Oxide (2012) 0.83
Semihemoglobins, high oxygen affinity dimeric forms of human hemoglobin respond efficiently to allosteric effectors without forming tetramers. J Biol Chem (2004) 0.83
Kinetic modulation in carbonmonoxy derivatives of truncated hemoglobins: the role of distal heme pocket residues and extended apolar tunnel. J Biol Chem (2003) 0.83
Structural and functional studies indicating altered redox properties of hemoglobin E: implications for production of bioactive nitric oxide. J Biol Chem (2011) 0.83
Molecular modeling studies of surface decoration of hemoglobin by maleimide PEG. Artif Cells Blood Substit Immobil Biotechnol (2006) 0.83
Autoxidation of the site-specifically PEGylated hemoglobins: role of the PEG chains and the sites of PEGylation in the autoxidation. Biochemistry (2008) 0.82
Nitric oxide nanoparticles: pre-clinical utility as a therapeutic for intramuscular abscesses. Virulence (2012) 0.82
Viscosity-dependent relaxation significantly modulates the kinetics of CO recombination in the truncated hemoglobin TrHbN from Mycobacterium tuberculosis. J Biol Chem (2004) 0.82
Generating S-nitrosothiols from hemoglobin: mechanisms, conformational dependence, and physiological relevance. J Biol Chem (2013) 0.82
Ligand binding to truncated hemoglobin N from Mycobacterium tuberculosis is strongly modulated by the interplay between the distal heme pocket residues and internal water. J Biol Chem (2008) 0.81
Probing the conformation of hemoglobin presbyterian in the R-state. J Protein Chem (2003) 0.81
A nanoparticle delivery vehicle for S-nitroso-N-acetyl cysteine: sustained vascular response. Nitric Oxide (2012) 0.81
Nitric oxide releasing nanoparticle synthesis and characterization. Methods Mol Biol (2011) 0.81
Packing density of the PEG-shell in PEG-albumins: PEGylation induced viscosity and COP are inverse correlate of packing density. Artif Cells Blood Substit Immobil Biotechnol (2011) 0.80
Proximal ligand motions in H93G myoglobin. Eur J Biochem (2002) 0.80
Intersubunit interactions associated with Tyr42 alpha stabilize the quaternary-T tetramer but are not major quaternary constraints in deoxyhemoglobin. Biochemistry (2005) 0.80
Hexa-thiocarbamoyl phenyl PEG5K Hb: vasoactivity and structure: influence of rigidity of the conjugation linkage on the PEGylation induced plasma expander-like solution properties of PEG-Hb adducts. Protein J (2009) 0.79
Multiple active site conformers in the carbon monoxide complexes of trematode hemoglobins. J Biol Chem (2006) 0.79
Distal heme pocket conformers of carbonmonoxy derivatives of Ascaris hemoglobin: evidence of conformational trapping in porous sol-gel matrices. J Biol Chem (2003) 0.79
Functional and biochemical properties of the hemoglobins of the burrowing brittle star Hemipholis elongata say (Echinodermata, Ophiuroidea). Biol Bull (2003) 0.78
Surface decoration of red blood cells with maleimidophenyl-polyethylene glycol facilitated by thiolation with iminothiolane: an approach to mask A, B, and D antigens to generate universal red blood cells. Transfusion (2005) 0.78
Solubility measurement of the sickle polymer. Methods Mol Med (2003) 0.78
PEGylation of αα-Hb using succinimidyl propionic acid PEG 5K: Conjugation chemistry and PEG shell structure dictate respectively the oxygen affinity and resuscitation fluid like properties of PEG αα-Hbs. Artif Cells Nanomed Biotechnol (2014) 0.78
Non-conservative surface decoration of hemoglobin: influence of neutralization of positive charges at PEGylation sites on molecular and functional properties of PEGylated hemoglobin. Biochim Biophys Acta (2008) 0.77
Charge density-dependent modifications of hydration shell waters by Hofmeister ions. J Am Chem Soc (2009) 0.77
Conformational changes in hemoglobin S (betaE6V) imposed by mutation of the beta Glu7-beta Lys132 salt bridge and detected by UV resonance Raman spectroscopy. J Biol Chem (2002) 0.77
Oxygen binding to partially nitrosylated hemoglobin. Biochim Biophys Acta (2013) 0.77
Analysis of functionalization of methoxy-PEG as maleimide-PEG. Anal Biochem (2007) 0.77
Distinct domain responses of R-state human hemoglobins A, C, and S to anions. Blood Cells Mol Dis (2002) 0.77
Induced plasma expander-like properties as a function of PEG-chains on extension arm facilitated PEGylation of albumin: "mushroom to brush-like" conformational transition of the PEG-albumin conjugate. Artif Cells Blood Substit Immobil Biotechnol (2009) 0.77
Role of extension arm in PEG-Hb conjugates on the stability of the tetramer: non-conservative EAF maleimide thio-PEG mediated PEGylation. Artif Cells Blood Substit Immobil Biotechnol (2008) 0.77
Genetic diversity of coastal bottlenose dolphins revealed by structurally and functionally diverse hemoglobins. Gene (2007) 0.77
Combining the influence of two low O2 affinity-inducing chemical modifications of the central cavity of hemoglobin. Biochemistry (2007) 0.77
Proteins in motion: resonance Raman spectroscopy as a probe of functional intermediates. Methods Mol Biol (2005) 0.77
Nitrosoglutathione generating nitric oxide nanoparticles as an improved strategy for combating Pseudomonas aeruginosa-infected wounds. J Drugs Dermatol (2012) 0.77
Rationale for early versus late intervention with arthroscopy for treatment of inflammatory/degenerative temporomandibular joint disorders. J Oral Maxillofac Surg (2010) 0.76
A 96-well electrochemical method for the screening of enzymatic activities. Anal Chem (2013) 0.76