Antioxidants prevent health-promoting effects of physical exercise in humans.

PubWeight™: 5.19‹?› | Rank: Top 1%

🔗 View Article (PMC 2680430)

Published in Proc Natl Acad Sci U S A on May 11, 2009

Authors

Michael Ristow1, Kim Zarse, Andreas Oberbach, Nora Klöting, Marc Birringer, Michael Kiehntopf, Michael Stumvoll, C Ronald Kahn, Matthias Blüher

Author Affiliations

1: Department of Human Nutrition, Institute of Nutrition, University of Jena, Jena D-07743, Germany. mristow@mristow.org

Associated clinical trials:

Changes of Biomarkers in Response to Training and Antioxidant Treatment | NCT00638560

The Effects of Vitamin E and Vitamin C and Exercise | NCT01369043

Articles citing this

(truncated to the top 100)

ROS function in redox signaling and oxidative stress. Curr Biol (2014) 3.35

Targeted expression of catalase to mitochondria prevents age-associated reductions in mitochondrial function and insulin resistance. Cell Metab (2010) 3.07

Reactive oxygen species enhance insulin sensitivity. Cell Metab (2009) 2.77

The role of mitochondria in aging. J Clin Invest (2013) 2.71

Impaired insulin/IGF1 signaling extends life span by promoting mitochondrial L-proline catabolism to induce a transient ROS signal. Cell Metab (2012) 2.43

Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production. Proc Natl Acad Sci U S A (2011) 2.41

Antioxidants in Translational Medicine. Antioxid Redox Signal (2015) 2.32

Resveratrol blunts the positive effects of exercise training on cardiovascular health in aged men. J Physiol (2013) 2.10

Epigenetic silencing mediates mitochondria stress-induced longevity. Cell Metab (2013) 2.03

Normal adaptations to exercise despite protection against oxidative stress. Am J Physiol Endocrinol Metab (2011) 1.93

Vitamins C and E: beneficial effects from a mechanistic perspective. Free Radic Biol Med (2011) 1.93

Acute reversal of endothelial dysfunction in the elderly after antioxidant consumption. Hypertension (2012) 1.79

Cellular stress responses, the hormesis paradigm, and vitagenes: novel targets for therapeutic intervention in neurodegenerative disorders. Antioxid Redox Signal (2010) 1.77

Insulin signaling meets mitochondria in metabolism. Trends Endocrinol Metab (2010) 1.77

Regulation of exercise-induced fiber type transformation, mitochondrial biogenesis, and angiogenesis in skeletal muscle. J Appl Physiol (1985) (2010) 1.67

Reactive oxygen species are signalling molecules for skeletal muscle adaptation. Exp Physiol (2009) 1.67

Effects of oxidative stress on fatty acid- and one-carbon-metabolism in psychiatric and cardiovascular disease comorbidity. Acta Psychiatr Scand (2014) 1.65

Mitochondrial hormesis and diabetic complications. Diabetes (2015) 1.61

Exercise acts as a drug; the pharmacological benefits of exercise. Br J Pharmacol (2012) 1.61

Oxygen consumption and usage during physical exercise: the balance between oxidative stress and ROS-dependent adaptive signaling. Antioxid Redox Signal (2012) 1.60

Mitohormesis. Cell Metab (2014) 1.57

PGC-1alpha regulation by exercise training and its influences on muscle function and insulin sensitivity. Am J Physiol Endocrinol Metab (2010) 1.56

Leptin regulation of Hsp60 impacts hypothalamic insulin signaling. J Clin Invest (2013) 1.55

Short-term sprint interval training increases insulin sensitivity in healthy adults but does not affect the thermogenic response to beta-adrenergic stimulation. J Physiol (2010) 1.49

Reactive oxygen and nitrogen species as intracellular signals in skeletal muscle. J Physiol (2011) 1.45

Mitochondrial oxidative stress in aging and healthspan. Longev Healthspan (2014) 1.45

Mitochondrial antioxidative capacity regulates muscle glucose uptake in the conscious mouse: effect of exercise and diet. J Appl Physiol (1985) (2012) 1.43

Teaching the basics of redox biology to medical and graduate students: Oxidants, antioxidants and disease mechanisms. Redox Biol (2013) 1.42

Folate receptor-targeted antioxidant therapy ameliorates renal ischemia-reperfusion injury. J Am Soc Nephrol (2012) 1.41

Adiponectin, a key adipokine in obesity related liver diseases. World J Gastroenterol (2011) 1.41

Cardiac aging: from molecular mechanisms to significance in human health and disease. Antioxid Redox Signal (2012) 1.40

Increased reactive oxygen species production and lower abundance of complex I subunits and carnitine palmitoyltransferase 1B protein despite normal mitochondrial respiration in insulin-resistant human skeletal muscle. Diabetes (2010) 1.36

Recent progress toward hydrogen medicine: potential of molecular hydrogen for preventive and therapeutic applications. Curr Pharm Des (2011) 1.29

Type 2 diabetes mellitus and inflammation: Prospects for biomarkers of risk and nutritional intervention. Diabetes Metab Syndr Obes (2010) 1.28

Achieving the balance between ROS and antioxidants: when to use the synthetic antioxidants. Oxid Med Cell Longev (2013) 1.28

Lifespan extension by calorie restriction relies on the Sty1 MAP kinase stress pathway. EMBO J (2010) 1.27

Thermotolerance and heat acclimation may share a common mechanism in humans. Am J Physiol Regul Integr Comp Physiol (2011) 1.26

A systems biology perspective on Nrf2-mediated antioxidant response. Toxicol Appl Pharmacol (2009) 1.25

Redox homeostasis, oxidative stress and disuse muscle atrophy. J Physiol (2011) 1.25

Control of reactive oxygen species production in contracting skeletal muscle. Antioxid Redox Signal (2011) 1.24

Reactive oxygen species in skeletal muscle signaling. J Signal Transduct (2011) 1.23

Vitamin C and E supplementation hampers cellular adaptation to endurance training in humans: a double-blind, randomised, controlled trial. J Physiol (2014) 1.23

Good stress, bad stress--the delicate balance in the vasculature. Dtsch Arztebl Int (2009) 1.23

Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide. Nat Chem Biol (2013) 1.23

Mitochondrial ROS Signaling in Organismal Homeostasis. Cell (2015) 1.23

Age-related changes in skeletal muscle reactive oxygen species generation and adaptive responses to reactive oxygen species. J Physiol (2011) 1.22

Increased life span from overexpression of superoxide dismutase in Caenorhabditis elegans is not caused by decreased oxidative damage. Free Radic Biol Med (2011) 1.21

Irisin and exercise training in humans - results from a randomized controlled training trial. BMC Med (2013) 1.21

Neuronal ROS signaling rather than AMPK/sirtuin-mediated energy sensing links dietary restriction to lifespan extension. Mol Metab (2013) 1.18

Metabolic network topology reveals transcriptional regulatory signatures of type 2 diabetes. PLoS Comput Biol (2010) 1.18

Strategies to increase nitric oxide signalling in cardiovascular disease. Nat Rev Drug Discov (2015) 1.18

Low dose radiation adaptive protection to control neurodegenerative diseases. Dose Response (2013) 1.16

Combining short-term metformin treatment and one bout of exercise does not increase insulin action in insulin-resistant individuals. Am J Physiol Endocrinol Metab (2010) 1.16

Vitamins D, C, and E in the prevention of type 2 diabetes mellitus: modulation of inflammation and oxidative stress. Biologics (2011) 1.13

Muscle fatigue: from observations in humans to underlying mechanisms studied in intact single muscle fibres. Eur J Appl Physiol (2010) 1.13

The emerging role of the mitochondrial-derived peptide humanin in stress resistance. J Mol Endocrinol (2013) 1.12

Mitochondrial longevity pathways. Biochim Biophys Acta (2011) 1.11

Metformin promotes lifespan through mitohormesis via the peroxiredoxin PRDX-2. Proc Natl Acad Sci U S A (2014) 1.10

Branched-chain amino acids, mitochondrial biogenesis, and healthspan: an evolutionary perspective. Aging (Albany NY) (2011) 1.09

Longevity in the red flour beetle Tribolium castaneum is enhanced by broccoli and depends on nrf-2, jnk-1 and foxo-1 homologous genes. Genes Nutr (2013) 1.08

NOX1, 2, 4, 5: counting out oxidative stress. Br J Pharmacol (2011) 1.08

Evolutionary aspects of human exercise--born to run purposefully. Ageing Res Rev (2012) 1.07

The neglected significance of "antioxidative stress". Oxid Med Cell Longev (2012) 1.06

Lower oxidative DNA damage despite greater ROS production in muscles from rats selectively bred for high running capacity. Am J Physiol Regul Integr Comp Physiol (2010) 1.05

Global Phosphoproteomic Analysis of Human Skeletal Muscle Reveals a Network of Exercise-Regulated Kinases and AMPK Substrates. Cell Metab (2015) 1.04

Mitochondria and PGC-1α in Aging and Age-Associated Diseases. J Aging Res (2011) 1.04

Antioxidant treatments do not improve force recovery after fatiguing stimulation of mouse skeletal muscle fibres. J Physiol (2014) 1.04

Mitochondrial hormesis links low-dose arsenite exposure to lifespan extension. Aging Cell (2013) 1.04

The role of oxidative stress in the pathogenesis of type 2 diabetes: from molecular mechanism to clinical implication. Am J Transl Res (2010) 1.03

Type 2 diabetes restricts multipotency of mesenchymal stem cells and impairs their capacity to augment postischemic neovascularization in db/db mice. J Am Heart Assoc (2012) 1.03

High selenium intake and increased diabetes risk: experimental evidence for interplay between selenium and carbohydrate metabolism. J Clin Biochem Nutr (2010) 1.03

Strategies for reducing or preventing the generation of oxidative stress. Oxid Med Cell Longev (2011) 1.03

Age associated low mitochondrial biogenesis may be explained by lack of response of PGC-1α to exercise training. Age (Dordr) (2011) 1.02

The Mitochondrial Basis of Aging. Mol Cell (2016) 1.02

Shifting the paradigm in radiation safety. Dose Response (2012) 1.02

Vitamin E and C supplementation reduces oxidative stress, improves antioxidant enzymes and positive muscle work in chronically loaded muscles of aged rats. Exp Gerontol (2010) 1.01

Vitamin C and E supplementation alters protein signalling after a strength training session, but not muscle growth during 10 weeks of training. J Physiol (2014) 1.01

Positive oxidative stress in aging and aging-related disease tolerance. Redox Biol (2014) 1.01

Higher energy expenditure in humans predicts natural mortality. J Clin Endocrinol Metab (2011) 1.01

Mitohormesis: Promoting Health and Lifespan by Increased Levels of Reactive Oxygen Species (ROS). Dose Response (2014) 1.00

Ryanodine receptor fragmentation and sarcoplasmic reticulum Ca2+ leak after one session of high-intensity interval exercise. Proc Natl Acad Sci U S A (2015) 1.00

Reduced coupling of oxidative phosphorylation in vivo precedes electron transport chain defects due to mild oxidative stress in mice. PLoS One (2011) 0.99

Oxidative Stress and Mitochondrial Dysfunction in Down's Syndrome: Relevance to Aging and Dementia. Curr Gerontol Geriatr Res (2012) 0.98

Natural antioxidants and hypertension: promise and challenges. Cardiovasc Ther (2010) 0.98

α-Lipoic acid antioxidant treatment limits glaucoma-related retinal ganglion cell death and dysfunction. PLoS One (2013) 0.97

Concentration-dependent dual effects of hydrogen peroxide on insulin signal transduction in H4IIEC hepatocytes. PLoS One (2011) 0.97

Vascular endothelial ageing, heartbeat after heartbeat. Cardiovasc Res (2009) 0.97

FFA-induced hepatic insulin resistance in vivo is mediated by PKCδ, NADPH oxidase, and oxidative stress. Am J Physiol Endocrinol Metab (2014) 0.97

Vitamin E therapy results in a reduction in HDL function in individuals with diabetes and the haptoglobin 2-1 genotype. Atherosclerosis (2011) 0.97

Does vitamin C and E supplementation impair the favorable adaptations of regular exercise? Oxid Med Cell Longev (2012) 0.97

Forever young: SIRT3 a shield against mitochondrial meltdown, aging, and neurodegeneration. Front Aging Neurosci (2013) 0.97

Sestrin2 inhibits uncoupling protein 1 expression through suppressing reactive oxygen species. Proc Natl Acad Sci U S A (2014) 0.95

Signaling and Damaging Functions of Free Radicals in Aging-Free Radical Theory, Hormesis, and TOR. Aging Dis (2010) 0.95

Reduction of delayed onset muscle soreness by a novel curcumin delivery system (Meriva®): a randomised, placebo-controlled trial. J Int Soc Sports Nutr (2014) 0.95

Ectopic catalase expression in mitochondria by adeno-associated virus enhances exercise performance in mice. PLoS One (2009) 0.95

Autophagy is not required to sustain exercise and PRKAA1/AMPK activity but is important to prevent mitochondrial damage during physical activity. Autophagy (2014) 0.95

Two tales of antioxidant enzymes on β cells and diabetes. Antioxid Redox Signal (2010) 0.95

Non-thermal plasma activates human keratinocytes by stimulation of antioxidant and phase II pathways. J Biol Chem (2015) 0.95

N-acetylcysteine reduces markers of differentiation in 3T3-L1 adipocytes. Int J Mol Sci (2011) 0.94

A framework for prescription in exercise-oncology research. J Cachexia Sarcopenia Muscle (2015) 0.94

Articles cited by this

Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med (2002) 101.79

PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat Genet (2003) 53.59

Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol (1979) 27.52

Global and societal implications of the diabetes epidemic. Nature (2001) 25.18

Effects of diet and exercise in preventing NIDDM in people with impaired glucose tolerance. The Da Qing IGT and Diabetes Study. Diabetes Care (1997) 23.95

Aging: a theory based on free radical and radiation chemistry. J Gerontol (1956) 20.39

Health benefits of physical activity: the evidence. CMAJ (2006) 19.45

Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1. Proc Natl Acad Sci U S A (2003) 17.10

Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis. JAMA (2007) 11.87

Type 2 diabetes: principles of pathogenesis and therapy. Lancet (2005) 10.71

Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators. Cell (2006) 10.18

Reactive oxygen species have a causal role in multiple forms of insulin resistance. Nature (2006) 10.07

Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress. Cell Metab (2007) 7.07

Exercise-induced oxidative stress: cellular mechanisms and impact on muscle force production. Physiol Rev (2008) 5.74

Banting Lecture. Insulin action, diabetogenes, and the cause of type II diabetes. Diabetes (1994) 4.30

Adiponectin and protection against type 2 diabetes mellitus. Lancet (2003) 3.79

Oral administration of vitamin C decreases muscle mitochondrial biogenesis and hampers training-induced adaptations in endurance performance. Am J Clin Nutr (2008) 3.01

Altered glycolytic and oxidative capacities of skeletal muscle contribute to insulin resistance in NIDDM. J Appl Physiol (1985) (1997) 2.57

Exercise training, without weight loss, increases insulin sensitivity and postheparin plasma lipase activity in previously sedentary adults. Diabetes Care (2003) 2.49

Redox paradox: insulin action is facilitated by insulin-stimulated reactive oxygen species with multiple potential signaling targets. Diabetes (2005) 2.31

Development of insulin resistance and obesity in mice overexpressing cellular glutathione peroxidase. Proc Natl Acad Sci U S A (2004) 2.27

Vitamin E and risk of type 2 diabetes in the women's health study randomized controlled trial. Diabetes (2006) 2.17

Prolonged oxidative stress impairs insulin-induced GLUT4 translocation in 3T3-L1 adipocytes. Diabetes (1998) 2.11

Intake of fruit, vegetables, and antioxidants and risk of type 2 diabetes: systematic review and meta-analysis. J Hypertens (2007) 1.85

Effect of a 4 week physical training program on plasma concentrations of inflammatory markers in patients with abnormal glucose tolerance. Eur J Endocrinol (2006) 1.76

Antioxidant supplementation does not affect fasting plasma glucose in the Supplementation with Antioxidant Vitamins and Minerals (SU.VI.MAX) study in France: association with dietary intake and plasma concentrations. Am J Clin Nutr (2006) 1.57

Effects of physical activity on insulin action and glucose tolerance in obesity. Med Sci Sports Exerc (1999) 1.38

Long-term beta-carotene supplementation and risk of type 2 diabetes mellitus: a randomized controlled trial. JAMA (1999) 1.37

Superoxide dismutase and catalase in skeletal muscle: adaptive response to exercise. J Gerontol (1985) 1.30

Sublethal mitochondrial stress with an attendant stoichiometric augmentation of reactive oxygen species may precipitate many of the beneficial alterations in cellular physiology produced by caloric restriction, intermittent fasting, exercise and dietary phytonutrients: "Mitohormesis" for health and vitality. Med Hypotheses (2005) 1.29

Invited review: Exercise training-induced changes in insulin signaling in skeletal muscle. J Appl Physiol (1985) (2002) 1.28

The effect of vitamin E on blood pressure in individuals with type 2 diabetes: a randomized, double-blind, placebo-controlled trial. J Hypertens (2007) 1.24

Longevity of exercising male rats: effect of an antioxidant supplemented diet. Mech Ageing Dev (1998) 1.05

Effect of exercise training on whole-body insulin sensitivity and responsiveness. J Appl Physiol Respir Environ Exerc Physiol (1984) 0.97

Improved glucose metabolism in mice lacking alpha-tocopherol transfer protein. Eur J Nutr (2007) 0.91

Articles by these authors

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08

Identification and importance of brown adipose tissue in adult humans. N Engl J Med (2009) 20.57

Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01

Intensive insulin therapy and pentastarch resuscitation in severe sepsis. N Engl J Med (2008) 19.93

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89

Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1. Proc Natl Acad Sci U S A (2003) 17.10

Weight loss with a low-carbohydrate, Mediterranean, or low-fat diet. N Engl J Med (2008) 12.41

Critical nodes in signalling pathways: insights into insulin action. Nat Rev Mol Cell Biol (2006) 10.67

Retinol-binding protein 4 and insulin resistance in lean, obese, and diabetic subjects. N Engl J Med (2006) 9.53

Developmental origin of fat: tracking obesity to its source. Cell (2007) 8.80

Extended longevity in mice lacking the insulin receptor in adipose tissue. Science (2003) 8.53

Suppression of aging in mice by the hormone Klotho. Science (2005) 8.11

Hepatic insulin resistance is sufficient to produce dyslipidemia and susceptibility to atherosclerosis. Cell Metab (2008) 7.97

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet (2010) 7.94

Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress. Cell Metab (2007) 7.07

New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure. Nature (2008) 6.82

Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. Nat Genet (2010) 6.66

Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior. Nat Genet (2010) 6.49

SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation. Nature (2010) 6.48

New loci associated with kidney function and chronic kidney disease. Nat Genet (2010) 5.58

T-lymphocyte infiltration in visceral adipose tissue: a primary event in adipose tissue inflammation and the development of obesity-mediated insulin resistance. Arterioscler Thromb Vasc Biol (2008) 5.44

Beneficial effects of subcutaneous fat transplantation on metabolism. Cell Metab (2008) 5.07

Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intolerance. Dev Cell (2002) 5.01

Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARgamma by Cdk5. Nature (2010) 5.01

Evidence for a role of developmental genes in the origin of obesity and body fat distribution. Proc Natl Acad Sci U S A (2006) 4.81

Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nat Genet (2012) 4.73

From mice to men: insights into the insulin resistance syndromes. Annu Rev Physiol (2006) 4.58

A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. Nat Genet (2012) 4.37

Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways. Cell (2002) 4.35

Cellular bioenergetics as a target for obesity therapy. Nat Rev Drug Discov (2010) 4.23

Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways. Diabetes (2010) 4.07

Targeted deletion of AIF decreases mitochondrial oxidative phosphorylation and protects from obesity and diabetes. Cell (2007) 3.82

A guide to analysis of mouse energy metabolism. Nat Methods (2011) 3.82

Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms. Mol Cell Biol (2004) 3.79

Effects of Initiating Moderate Alcohol Intake on Cardiometabolic Risk in Adults With Type 2 Diabetes: A 2-Year Randomized, Controlled Trial. Ann Intern Med (2015) 3.78

Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose production. Cell Metab (2007) 3.69

Hepatic insulin resistance directly promotes formation of cholesterol gallstones. Nat Med (2008) 3.66

Loss of ARNT/HIF1beta mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes. Cell (2005) 3.52

Insulin-sensitive obesity. Am J Physiol Endocrinol Metab (2010) 3.46

Ectopic brown adipose tissue in muscle provides a mechanism for differences in risk of metabolic syndrome in mice. Proc Natl Acad Sci U S A (2007) 3.40

A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism. Nature (2012) 3.35

Role of hepatic STAT3 in brain-insulin action on hepatic glucose production. Cell Metab (2006) 3.34

SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome. Mol Cell (2011) 3.33

Endocrine regulation of ageing. Nat Rev Mol Cell Biol (2007) 3.28

Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nat Genet (2013) 3.25

Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet (2012) 3.21

Insulin receptor functionally enhances multistage tumor progression and conveys intrinsic resistance to IGF-1R targeted therapy. Proc Natl Acad Sci U S A (2010) 3.16

New gene functions in megakaryopoiesis and platelet formation. Nature (2011) 3.14

Effect of empirical treatment with moxifloxacin and meropenem vs meropenem on sepsis-related organ dysfunction in patients with severe sepsis: a randomized trial. JAMA (2012) 3.13

Retracted Positive and negative roles of p85 alpha and p85 beta regulatory subunits of phosphoinositide 3-kinase in insulin signaling. J Biol Chem (2003) 3.06

Insulin signaling to the glomerular podocyte is critical for normal kidney function. Cell Metab (2010) 3.05

Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Nat Genet (2012) 3.04

How increased oxidative stress promotes longevity and metabolic health: The concept of mitochondrial hormesis (mitohormesis). Exp Gerontol (2010) 2.99

Muscle-specific PPARgamma-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones. J Clin Invest (2003) 2.87

Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1. Nat Med (2012) 2.86

Divergent regulation of hepatic glucose and lipid metabolism by phosphoinositide 3-kinase via Akt and PKClambda/zeta. Cell Metab (2006) 2.82

Macrophage infiltration into omental versus subcutaneous fat across different populations: effect of regional adiposity and the comorbidities of obesity. J Clin Endocrinol Metab (2007) 2.81

The emerging genetic architecture of type 2 diabetes. Cell Metab (2008) 2.77

FTO genotype is associated with phenotypic variability of body mass index. Nature (2012) 2.77

Seventy-five genetic loci influencing the human red blood cell. Nature (2012) 2.77

Effects of diet and genetic background on sterol regulatory element-binding protein-1c, stearoyl-CoA desaturase 1, and the development of the metabolic syndrome. Diabetes (2005) 2.72

Lead poisoning due to adulterated marijuana in leipzig. Dtsch Arztebl Int (2008) 2.72

Plasma adiponectin concentrations predict insulin sensitivity of both glucose and lipid metabolism. Diabetes (2003) 2.71

CUBN is a gene locus for albuminuria. J Am Soc Nephrol (2011) 2.70

Serum retinol-binding protein is more highly expressed in visceral than in subcutaneous adipose tissue and is a marker of intra-abdominal fat mass. Cell Metab (2007) 2.69

Prediction of preadipocyte differentiation by gene expression reveals role of insulin receptor substrates and necdin. Nat Cell Biol (2005) 2.68

Platform-independent and label-free quantitation of proteomic data using MS1 extracted ion chromatograms in skyline: application to protein acetylation and phosphorylation. Mol Cell Proteomics (2012) 2.66

Reduced expression of the murine p85alpha subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes. J Clin Invest (2002) 2.65

PDX-1 haploinsufficiency limits the compensatory islet hyperplasia that occurs in response to insulin resistance. J Clin Invest (2004) 2.56

Genetic determinants of energy expenditure and insulin resistance in diet-induced obesity in mice. Diabetes (2004) 2.54

Central role of suppressors of cytokine signaling proteins in hepatic steatosis, insulin resistance, and the metabolic syndrome in the mouse. Proc Natl Acad Sci U S A (2004) 2.54

Role for neuronal insulin resistance in neurodegenerative diseases. Proc Natl Acad Sci U S A (2004) 2.54

Insulin signaling coordinately regulates cardiac size, metabolism, and contractile protein isoform expression. J Clin Invest (2002) 2.53

Increased insulin sensitivity in mice lacking p85beta subunit of phosphoinositide 3-kinase. Proc Natl Acad Sci U S A (2001) 2.49

Phlorizin: a review. Diabetes Metab Res Rev (2005) 2.48

Chymotrypsin C (CTRC) variants that diminish activity or secretion are associated with chronic pancreatitis. Nat Genet (2007) 2.48

Detailed physiologic characterization reveals diverse mechanisms for novel genetic Loci regulating glucose and insulin metabolism in humans. Diabetes (2010) 2.44

Impaired insulin/IGF1 signaling extends life span by promoting mitochondrial L-proline catabolism to induce a transient ROS signal. Cell Metab (2012) 2.43

Molecular balance between the regulatory and catalytic subunits of phosphoinositide 3-kinase regulates cell signaling and survival. Mol Cell Biol (2002) 2.42

SIRT2 regulates adipocyte differentiation through FoxO1 acetylation/deacetylation. Cell Metab (2007) 2.42

Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production. Proc Natl Acad Sci U S A (2011) 2.41

Dysregulation of the peripheral and adipose tissue endocannabinoid system in human abdominal obesity. Diabetes (2006) 2.40

Plasma visfatin concentrations and fat depot-specific mRNA expression in humans. Diabetes (2005) 2.34

Analysis of gene expression in pathophysiological states: balancing false discovery and false negative rates. Proc Natl Acad Sci U S A (2006) 2.32

Tumstatin, an endothelial cell-specific inhibitor of protein synthesis. Science (2002) 2.28

Association of nicotinamide-N-methyltransferase mRNA expression in human adipose tissue and the plasma concentration of its product, 1-methylnicotinamide, with insulin resistance. Diabetologia (2015) 2.25