Neurite outgrowth of PC12 cells is suppressed by wortmannin, a specific inhibitor of phosphatidylinositol 3-kinase.

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Published in J Biol Chem on July 22, 1994

Authors

K Kimura1, S Hattori, Y Kabuyama, Y Shizawa, J Takayanagi, S Nakamura, S Toki, Y Matsuda, K Onodera, Y Fukui

Author Affiliations

1: Department of Applied Biological Chemistry, University of Tokyo, Japan.

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Complete nucleotide sequence of the gene for human interleukin 1 alpha. Nucleic Acids Res (1986) 1.95

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