Published in J Biol Chem on January 28, 2002
Physiological role of ROCKs in the cardiovascular system. Am J Physiol Cell Physiol (2006) 2.61
Rho-kinase/ROCK: A key regulator of the cytoskeleton and cell polarity. Cytoskeleton (Hoboken) (2010) 2.59
RhoE binds to ROCK I and inhibits downstream signaling. Mol Cell Biol (2003) 2.46
PAK and other Rho-associated kinases--effectors with surprisingly diverse mechanisms of regulation. Biochem J (2005) 2.19
The Rho kinases I and II regulate different aspects of myosin II activity. J Cell Biol (2005) 2.16
Rho kinase (ROCK) inhibitors. J Cardiovasc Pharmacol (2007) 1.89
Rho kinase in the regulation of cell death and survival. Arch Immunol Ther Exp (Warsz) (2007) 1.60
Raf-1 regulates Rho signaling and cell migration. J Cell Biol (2005) 1.58
Apical Sarcomere-like Actomyosin Contracts Nonmuscle Drosophila Epithelial Cells. Dev Cell (2016) 1.40
ROCK and Rho: biochemistry and neuronal functions of Rho-associated protein kinases. Neuroscientist (2007) 1.38
ROCKs as therapeutic targets in cardiovascular diseases. Expert Rev Cardiovasc Ther (2005) 1.25
Interaction between ROCK II and nucleophosmin/B23 in the regulation of centrosome duplication. Mol Cell Biol (2006) 1.20
Rho-associated coiled-coil-forming kinases (ROCKs): potential targets for the treatment of atherosclerosis and vascular disease. Trends Pharmacol Sci (2011) 1.17
Role of rho kinase in the functional and dysfunctional tonic smooth muscles. Trends Pharmacol Sci (2011) 1.09
Deleted in liver cancer 1 (DLC1) negatively regulates Rho/ROCK/MLC pathway in hepatocellular carcinoma. PLoS One (2008) 1.08
Regulation of ROCK activity in cancer. J Histochem Cytochem (2012) 1.01
From autoinhibition to inhibition in trans: the Raf-1 regulatory domain inhibits Rok-alpha kinase activity. J Cell Biol (2009) 1.01
Rho-kinase in development and heart failure: insights from genetic models. Pediatr Cardiol (2011) 0.91
New insights into the structure-function relationships of Rho-associated kinase: a thermodynamic and hydrodynamic study of the dimer-to-monomer transition and its kinetic implications. Biochem J (2004) 0.89
A molecular ruler regulates cytoskeletal remodelling by the Rho kinases. Nat Commun (2015) 0.84
Myotonic dystrophy kinase-related Cdc42-binding kinases (MRCK), the ROCK-like effectors of Cdc42 and Rac1. Small GTPases (2015) 0.83
A collapsin response mediator protein 2 isoform controls myosin II-mediated cell migration and matrix assembly by trapping ROCK II. Mol Cell Biol (2012) 0.82
Impaired insulin-stimulated myosin phosphatase Rho-interacting protein signaling in diabetic Goto-Kakizaki vascular smooth muscle cells. Am J Physiol Cell Physiol (2012) 0.82
The interaction between Shroom3 and Rho-kinase is required for neural tube morphogenesis in mice. Biol Open (2014) 0.81
Myosin light chain kinases: division of work in cell migration. Cell Adh Migr (2009) 0.80
Ser1333 phosphorylation indicates ROCKI activation. J Biomed Sci (2013) 0.79
Signaling pathway of lysophosphatidic Acid-induced contraction in feline esophageal smooth muscle cells. Korean J Physiol Pharmacol (2013) 0.77
Structure of the Shroom-Rho Kinase Complex Reveals a Binding Interface with Monomeric Shroom That Regulates Cell Morphology and Stimulates Kinase Activity. J Biol Chem (2016) 0.76
A molecular mechanism of P-loop pliability of Rho-kinase investigated by molecular dynamic simulation. J Comput Aided Mol Des (2008) 0.75
Little ROCK is a ROCK1 pseudogene expressed in human smooth muscle cells. BMC Genet (2010) 0.75
Doxorubicin plus sorafenib vs doxorubicin alone in patients with advanced hepatocellular carcinoma: a randomized trial. JAMA (2010) 4.71
Gene expression analysis using oligonucleotide arrays produced by maskless photolithography. Genome Res (2002) 4.69
Nosology and classification of genetic skeletal disorders: 2010 revision. Am J Med Genet A (2011) 4.27
The GIT-associated kinase PAK targets to the centrosome and regulates Aurora-A. Mol Cell (2005) 2.11
Alpha2-chimaerin, cyclin-dependent Kinase 5/p35, and its target collapsin response mediator protein-2 are essential components in semaphorin 3A-induced growth-cone collapse. J Neurosci (2004) 1.66
Raf-1 regulates Rho signaling and cell migration. J Cell Biol (2005) 1.58
Endodermal ABA signaling promotes lateral root quiescence during salt stress in Arabidopsis seedlings. Plant Cell (2013) 1.46
A tripartite complex containing MRCK modulates lamellar actomyosin retrograde flow. Cell (2008) 1.42
Detection of the siphon internal carotid artery stenosis: transcranial Doppler versus digital subtraction angiography. J Neuroimaging (2009) 1.38
Alpha2-chimaerin interacts with EphA4 and regulates EphA4-dependent growth cone collapse. Proc Natl Acad Sci U S A (2007) 1.32
The p21-activated kinase PAK is negatively regulated by POPX1 and POPX2, a pair of serine/threonine phosphatases of the PP2C family. Curr Biol (2002) 1.30
PAK is regulated by PI3K, PIX, CDC42, and PP2Calpha and mediates focal adhesion turnover in the hyperosmotic stress-induced p38 pathway. J Biol Chem (2008) 1.24
Phosphorylation and reorganization of vimentin by p21-activated kinase (PAK). Genes Cells (2002) 1.22
Transcriptional activation of the Rhodobacter sphaeroides cytochrome c(2) gene P2 promoter by the response regulator PrrA. J Bacteriol (2002) 1.19
CaMKII phosphorylates collapsin response mediator protein 2 and modulates axonal damage during glutamate excitotoxicity. J Neurochem (2009) 1.14
GIT1 activates p21-activated kinase through a mechanism independent of p21 binding. Mol Cell Biol (2004) 1.13
IQGAP1 promotes neurite outgrowth in a phosphorylation-dependent manner. J Biol Chem (2005) 1.13
Down-regulation of active ACK1 is mediated by association with the E3 ubiquitin ligase Nedd4-2. J Biol Chem (2009) 1.13
Treatment for hepatocellular carcinoma with portal vein tumor thrombosis: the emerging role for radioembolization using yttrium-90. Oncology (2013) 1.12
Mypt1-mediated spatial positioning of Bmp2-producing cells is essential for liver organogenesis. Development (2008) 1.10
DAAM1 is a formin required for centrosome re-orientation during cell migration. PLoS One (2010) 1.09
Actin-binding and cell proliferation activities of angiomotin family members are regulated by Hippo pathway-mediated phosphorylation. J Biol Chem (2013) 1.08
Rho-mediated assembly of stress fibers is differentially regulated in corneal fibroblasts and myofibroblasts. Exp Cell Res (2004) 1.07
SNX9 as an adaptor for linking synaptojanin-1 to the Cdc42 effector ACK1. FEBS Lett (2005) 1.05
Paxillin nuclear-cytoplasmic localization is regulated by phosphorylation of the LD4 motif: evidence that nuclear paxillin promotes cell proliferation. Biochem J (2009) 1.05
ArhGAP15, a novel human RacGAP protein with GTPase binding property. FEBS Lett (2003) 1.03
Recurrent dominant mutations affecting two adjacent residues in the motor domain of the monomeric kinesin KIF22 result in skeletal dysplasia and joint laxity. Am J Hum Genet (2011) 1.02
From autoinhibition to inhibition in trans: the Raf-1 regulatory domain inhibits Rok-alpha kinase activity. J Cell Biol (2009) 1.01
Geographic and sex difference in the distribution of intracranial atherosclerosis in China. Stroke (2013) 0.99
A functional requirement for PAK1 binding to the KH(2) domain of the fragile X protein-related FXR1. Mol Cell (2010) 0.99
Vimentin intermediate filament reorganization by Cdc42: involvement of PAK and p70 S6 kinase. Eur J Cell Biol (2002) 0.97
Constitutional deletion of chromosome 20q in two patients affected with albright hereditary osteodystrophy. Am J Med Genet (2002) 0.97
Phosphorylation of myosin phosphatase targeting subunit 3 (MYPT3) and regulation of protein phosphatase 1 by protein kinase A. J Biol Chem (2006) 0.94
Signal intensity ratio as a novel measure of hemodynamic significance for intracranial atherosclerosis. Int J Stroke (2013) 0.94
Regulation of IRSp53-dependent filopodial dynamics by antagonism between 14-3-3 binding and SH3-mediated localization. Mol Cell Biol (2009) 0.94
Excited Delirium Syndrome (ExDS): defining based on a review of the literature. J Emerg Med (2011) 0.93
Phenotypic characterization of overexpression or deletion of the Escherichia coli crcA, cspE and crcB genes. Microbiology (2003) 0.93
Outgrowth of neurites from NIE-115 neuroblastoma cells is prevented on repulsive substrates through the action of PAK. Mol Cell Biol (2005) 0.92
Collapsin response mediator proteins (CRMPs) are a new class of microtubule-associated protein (MAP) that selectively interacts with assembled microtubules via a taxol-sensitive binding interaction. J Biol Chem (2011) 0.90
Long-term prognosis of Chinese patients with a lacunar infarct associated with small vessel disease: a five-year longitudinal study. Int J Stroke (2009) 0.90
The Drosophila homologue of Arf-GAP GIT1, dGIT, is required for proper muscle morphogenesis and guidance during embryogenesis. Dev Biol (2008) 0.90
Interobserver reproducibility of signal intensity ratio on magnetic resonance angiography for hemodynamic impact of intracranial atherosclerosis. J Stroke Cerebrovasc Dis (2013) 0.90
Capacity-related interfacility patient transports: patients affected, wait times involved and associated morbidity. CJEM (2006) 0.90
p80 ROKalpha binding protein is a novel splice variant of CRMP-1 which associates with CRMP-2 and modulates RhoA-induced neuronal morphology. FEBS Lett (2002) 0.90
ACK family tyrosine kinase activity is a component of Dcdc42 signaling during dorsal closure in Drosophila melanogaster. Mol Cell Biol (2002) 0.90
Magnetic resonance angiography signal intensity as a marker of hemodynamic impairment in intracranial arterial stenosis. PLoS One (2013) 0.89
Epigenetic stability, adaptability, and reversibility in human embryonic stem cells. Proc Natl Acad Sci U S A (2012) 0.89
Functional interactions between phosphatase POPX2 and mDia modulate RhoA pathways. J Cell Sci (2008) 0.88
Evaluation of age-related white matter changes using transcranial Doppler ultrasonography. J Neuroimaging (2011) 0.88
Drac1 and Crumbs participate in amnioserosa morphogenesis during dorsal closure in Drosophila. J Cell Sci (2002) 0.87
Preliminary findings of the effects of autonomic dysfunction on functional outcome after acute ischemic stroke. Clin Neurol Neurosurg (2011) 0.86
Chelerythrine perturbs lamellar actomyosin filaments by selective inhibition of myotonic dystrophy kinase-related Cdc42-binding kinase. FEBS Lett (2011) 0.86
Characteristics of patients with abnormal glucose challenge test and normal oral glucose tolerance test results: comparison with normal and gestational diabetic patients. Am J Obstet Gynecol (2006) 0.85
dPak is required for integrity of the leading edge cytoskeleton during Drosophila dorsal closure but does not signal through the JNK cascade. Dev Biol (2004) 0.85
Alpha1,3-galactosyltransferase knockout does not alter the properties of porcine extracellular matrix bioscaffolds. Acta Biomater (2011) 0.84
C1, see them all. Trends Biochem Sci (2005) 0.84
Comparison of 3 algorithms for Basal insulin in transitioning from intravenous to subcutaneous insulin in stable patients after cardiothoracic surgery. Endocr Pract (2011) 0.84
Selection of aptamers for signal transduction proteins by capillary electrophoresis. Electrophoresis (2010) 0.84
Cdc42 antagonizes inductive action of cAMP on cell shape, via effects of the myotonic dystrophy kinase-related Cdc42-binding kinase (MRCK) on myosin light chain phosphorylation. Eur J Cell Biol (2002) 0.83
Co-proxamol and suicide: Availability of co-proxamol has been successfully reduced in Doncaster. BMJ (2003) 0.83
Kantaputra mesomelic dysplasia: a second reported family. Am J Med Genet A (2004) 0.82
A randomized, controlled dose-ranging study of risedronate in children with moderate and severe osteogenesis imperfecta. J Bone Miner Res (2010) 0.82
Expression of the human myotonic dystrophy kinase-related Cdc42-binding kinase gamma is regulated by promoter DNA methylation and Sp1 binding. J Biol Chem (2004) 0.81
Myosin light chain kinases: division of work in cell migration. Cell Adh Migr (2009) 0.80
Central osteosclerosis with trichothiodystrophy. Pediatr Radiol (2004) 0.79
Production of CGMP-Grade Lentiviral Vectors. Bioprocess Int (2012) 0.79
Further delineation of spondylometaphyseal dysplasia with cone-rod dystrophy. Am J Med Genet A (2008) 0.79
"Bath salts" intoxication: a new recreational drug that presents with a familiar toxidrome. CJEM (2014) 0.78
Clinical phenotype associated with homozygosity for a HOXD13 7-residue polyalanine tract expansion. Eur J Med Genet (2006) 0.78
Primary colorectal tumors fail to express the proapoptotic mediator PTAG and its reexpression augments drug-induced apoptosis. Genes Chromosomes Cancer (2007) 0.77
Calpains promote neutrophil recruitment and bacterial clearance in an acute bacterial peritonitis model. Eur J Immunol (2013) 0.77
Cerebral Microbleeds and Cognitive Function in Ischemic Stroke or Transient Ischemic Attack Patients. Dement Geriatr Cogn Disord (2015) 0.77
Molecular aptamer beacon for myotonic dystrophy kinase-related Cdc42-binding kinase alpha. Talanta (2010) 0.76
Rivastigmine in Chinese patients with subcortical vascular dementia. Neuropsychiatr Dis Treat (2007) 0.76
Comparison of carotid atherosclerotic plaque characteristics between patients with first-time and recurrent acute ischaemic stroke using B-mode ultrasound. Neurol Res (2015) 0.75
POPX adds to cell motility. Cell Cycle (2010) 0.75
Coexistence of Helicobacter pylori spiral and coccoid forms in experimental mice. World J Gastroenterol (1998) 0.75
Long-term safety and efficacy of a universal nursing-run intravenous insulin guideline. Jt Comm J Qual Patient Saf (2014) 0.75