Published in J Neurosci on October 13, 2004
The semaphorins. Genome Biol (2006) 2.73
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Human CHN1 mutations hyperactivate alpha2-chimaerin and cause Duane's retraction syndrome. Science (2008) 1.84
CRMP-2 is involved in kinesin-1-dependent transport of the Sra-1/WAVE1 complex and axon formation. Mol Cell Biol (2005) 1.64
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Human genetic disorders of axon guidance. Cold Spring Harb Perspect Biol (2010) 1.49
Semaphorin function in neural plasticity and disease. Curr Opin Neurobiol (2009) 1.48
The CRMP family of proteins and their role in Sema3A signaling. Adv Exp Med Biol (2007) 1.43
Distinct priming kinases contribute to differential regulation of collapsin response mediator proteins by glycogen synthase kinase-3 in vivo. J Biol Chem (2006) 1.33
Alpha2-chimaerin interacts with EphA4 and regulates EphA4-dependent growth cone collapse. Proc Natl Acad Sci U S A (2007) 1.32
Sema4D/plexin-B1 activates GSK-3beta through R-Ras GAP activity, inducing growth cone collapse. EMBO Rep (2006) 1.32
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Ferulic acid regulates the AKT/GSK-3β/CRMP-2 signaling pathway in a middle cerebral artery occlusion animal model. Lab Anim Res (2013) 1.00
α2-chimaerin controls neuronal migration and functioning of the cerebral cortex through CRMP-2. Nat Neurosci (2011) 1.00
Expansion of the CHN1 strabismus phenotype. Invest Ophthalmol Vis Sci (2011) 1.00
Dorsal root ganglion neurons react to semaphorin 3A application through a biphasic response that requires multiple myosin II isoforms. Mol Biol Cell (2008) 0.99
Semaphorin3A signaling mediated by Fyn-dependent tyrosine phosphorylation of collapsin response mediator protein 2 at tyrosine 32. J Biol Chem (2009) 0.96
Opening Pandora's jar: a primer on the putative roles of CRMP2 in a panoply of neurodegenerative, sensory and motor neuron, and central disorders. Future Neurol (2012) 0.95
There's more than one way to skin a chimaerin. Neuron (2007) 0.92
Relative resistance of Cdk5-phosphorylated CRMP2 to dephosphorylation. J Biol Chem (2008) 0.91
Collapsin response mediator proteins (CRMPs) are a new class of microtubule-associated protein (MAP) that selectively interacts with assembled microtubules via a taxol-sensitive binding interaction. J Biol Chem (2011) 0.90
GSK3 as a Sensor Determining Cell Fate in the Brain. Front Mol Neurosci (2012) 0.90
Axon guidance in the developing ocular motor system and Duane retraction syndrome depends on Semaphorin signaling via alpha2-chimaerin. Proc Natl Acad Sci U S A (2012) 0.89
T cell receptor-dependent tyrosine phosphorylation of beta2-chimaerin modulates its Rac-GAP function in T cells. J Biol Chem (2009) 0.88
Protein product of CLN6 gene responsible for variant late-onset infantile neuronal ceroid lipofuscinosis interacts with CRMP-2. J Neurosci Res (2009) 0.87
Chimaerin and Rac regulate cell number, adherens junctions, and ERK MAP kinase signaling in the Drosophila eye. Proc Natl Acad Sci U S A (2007) 0.85
Two novel CHN1 mutations in 2 families with Duane retraction syndrome. Arch Ophthalmol (2011) 0.85
CRMP4 and CRMP2 Interact to Coordinate Cytoskeleton Dynamics, Regulating Growth Cone Development and Axon Elongation. Neural Plast (2015) 0.85
Interaction of Mint2 with TrkA is involved in regulation of nerve growth factor-induced neurite outgrowth. J Biol Chem (2009) 0.83
A collapsin response mediator protein 2 isoform controls myosin II-mediated cell migration and matrix assembly by trapping ROCK II. Mol Cell Biol (2012) 0.82
PLXNA4 is associated with Alzheimer disease and modulates tau phosphorylation. Ann Neurol (2014) 0.81
Bioinformatic prediction and confirmation of beta-adducin as a novel substrate of glycogen synthase kinase 3. J Biol Chem (2011) 0.81
Differential regulation of collapsin response mediator protein 2 (CRMP2) phosphorylation by GSK3ß and CDK5 following traumatic brain injury. Front Cell Neurosci (2014) 0.81
α2-Chimaerin regulates a key axon guidance transition during development of the oculomotor projection. J Neurosci (2013) 0.80
Phosphorylation and mRNA splicing of collapsin response mediator protein-2 determine inhibition of rho-associated protein kinase (ROCK) II function in carcinoma cell migration and invasion. J Biol Chem (2013) 0.79
Specific binding of lacosamide to collapsin response mediator protein 2 (CRMP2) and direct impairment of its canonical function: implications for the therapeutic potential of lacosamide. Mol Neurobiol (2014) 0.79
The functionalized amino acid (S)-Lacosamide subverts CRMP2-mediated tubulin polymerization to prevent constitutive and activity-dependent increase in neurite outgrowth. Front Cell Neurosci (2014) 0.78
Phosphorylation of a splice variant of collapsin response mediator protein 2 in the nucleus of tumour cells links cyclin dependent kinase-5 to oncogenesis. BMC Cancer (2015) 0.77
Mutant α2-chimaerin signals via bidirectional ephrin pathways in Duane retraction syndrome. J Clin Invest (2017) 0.76
Repulsive axon guidance by Draxin is mediated by protein Kinase B (Akt), glycogen synthase kinase-3β (GSK-3β) and microtubule-associated protein 1B. PLoS One (2015) 0.76
Divergent functions through alternative splicing: the Drosophila CRMP gene in pyrimidine metabolism, brain, and behavior. Genetics (2012) 0.76
A Tale of the Good and Bad: Remodeling of the Microtubule Network in the Brain by Cdk5. Mol Neurobiol (2016) 0.76
DRP5 is involved in cancer cell growth and predicts poor prognosis in human osteosarcoma. Cancer Med (2017) 0.75
Biological functions of CDK5 and potential CDK5 targeted clinical treatments. Oncotarget (2017) 0.75
Binocular pattern deprivation interferes with the expression of proteins involved in primary visual cortex maturation in the cat. Mol Brain (2015) 0.75
Identification of α-chimaerin as a candidate gene for critical period neuronal plasticity in cat and mouse visual cortex. BMC Neurosci (2011) 0.75
Doxorubicin plus sorafenib vs doxorubicin alone in patients with advanced hepatocellular carcinoma: a randomized trial. JAMA (2010) 4.71
Gene expression analysis using oligonucleotide arrays produced by maskless photolithography. Genome Res (2002) 4.69
Nosology and classification of genetic skeletal disorders: 2010 revision. Am J Med Genet A (2011) 4.27
Identification of a neuronal Cdk5 activator-binding protein as Cdk5 inhibitor. J Biol Chem (2002) 2.43
CDK5RAP2 is a pericentriolar protein that functions in centrosomal attachment of the gamma-tubulin ring complex. Mol Biol Cell (2007) 2.13
The GIT-associated kinase PAK targets to the centrosome and regulates Aurora-A. Mol Cell (2005) 2.11
Circulating endothelial progenitor cells in preterm infants with bronchopulmonary dysplasia. Am J Respir Crit Care Med (2009) 1.92
CDK5RAP2 stimulates microtubule nucleation by the gamma-tubulin ring complex. J Cell Biol (2010) 1.80
Raf-1 regulates Rho signaling and cell migration. J Cell Biol (2005) 1.58
A tripartite complex containing MRCK modulates lamellar actomyosin retrograde flow. Cell (2008) 1.42
Detection of the siphon internal carotid artery stenosis: transcranial Doppler versus digital subtraction angiography. J Neuroimaging (2009) 1.38
Alpha2-chimaerin interacts with EphA4 and regulates EphA4-dependent growth cone collapse. Proc Natl Acad Sci U S A (2007) 1.32
A combined proteomics and metabolomics profiling of gastric cardia cancer reveals characteristic dysregulations in glucose metabolism. Mol Cell Proteomics (2010) 1.30
The p21-activated kinase PAK is negatively regulated by POPX1 and POPX2, a pair of serine/threonine phosphatases of the PP2C family. Curr Biol (2002) 1.30
PAK is regulated by PI3K, PIX, CDC42, and PP2Calpha and mediates focal adhesion turnover in the hyperosmotic stress-induced p38 pathway. J Biol Chem (2008) 1.24
Conserved motif of CDK5RAP2 mediates its localization to centrosomes and the Golgi complex. J Biol Chem (2010) 1.24
Characterization of RhoA-binding kinase ROKalpha implication of the pleckstrin homology domain in ROKalpha function using region-specific antibodies. J Biol Chem (2002) 1.22
Phosphorylation and reorganization of vimentin by p21-activated kinase (PAK). Genes Cells (2002) 1.22
Transcriptional activation of the Rhodobacter sphaeroides cytochrome c(2) gene P2 promoter by the response regulator PrrA. J Bacteriol (2002) 1.19
Wound-healing protocols for diabetic foot and pressure ulcers. Surg Technol Int (2003) 1.17
Specific inhibition of cyclin-dependent kinases and cell proliferation by harmine. Biochem Biophys Res Commun (2004) 1.17
Interaction of CDK5RAP2 with EB1 to track growing microtubule tips and to regulate microtubule dynamics. Mol Biol Cell (2009) 1.16
Whole-genome screening identifies proteins localized to distinct nuclear bodies. J Cell Biol (2013) 1.15
Anxa2 plays a critical role in enhanced invasiveness of the multidrug resistant human breast cancer cells. J Proteome Res (2009) 1.15
CaMKII phosphorylates collapsin response mediator protein 2 and modulates axonal damage during glutamate excitotoxicity. J Neurochem (2009) 1.14
GIT1 activates p21-activated kinase through a mechanism independent of p21 binding. Mol Cell Biol (2004) 1.13
IQGAP1 promotes neurite outgrowth in a phosphorylation-dependent manner. J Biol Chem (2005) 1.13
Down-regulation of active ACK1 is mediated by association with the E3 ubiquitin ligase Nedd4-2. J Biol Chem (2009) 1.13
Treatment for hepatocellular carcinoma with portal vein tumor thrombosis: the emerging role for radioembolization using yttrium-90. Oncology (2013) 1.12
Leptin contributes to the adaptive responses of mice to high-fat diet intake through suppressing the lipogenic pathway. PLoS One (2009) 1.10
Mypt1-mediated spatial positioning of Bmp2-producing cells is essential for liver organogenesis. Development (2008) 1.10
DAAM1 is a formin required for centrosome re-orientation during cell migration. PLoS One (2010) 1.09
Identification of nuclear import mechanisms for the neuronal Cdk5 activator. J Biol Chem (2006) 1.08
Actin-binding and cell proliferation activities of angiomotin family members are regulated by Hippo pathway-mediated phosphorylation. J Biol Chem (2013) 1.08
Rho-mediated assembly of stress fibers is differentially regulated in corneal fibroblasts and myofibroblasts. Exp Cell Res (2004) 1.07
SNX9 as an adaptor for linking synaptojanin-1 to the Cdc42 effector ACK1. FEBS Lett (2005) 1.05
Paxillin nuclear-cytoplasmic localization is regulated by phosphorylation of the LD4 motif: evidence that nuclear paxillin promotes cell proliferation. Biochem J (2009) 1.05
Microtubule association of the neuronal p35 activator of Cdk5. J Biol Chem (2007) 1.03
ArhGAP15, a novel human RacGAP protein with GTPase binding property. FEBS Lett (2003) 1.03
The protein SET binds the neuronal Cdk5 activator p35nck5a and modulates Cdk5/p35nck5a activity. J Biol Chem (2001) 1.02
The p21-activated kinase is required for neuronal migration in the cerebral cortex. Cereb Cortex (2008) 1.02
Recurrent dominant mutations affecting two adjacent residues in the motor domain of the monomeric kinesin KIF22 result in skeletal dysplasia and joint laxity. Am J Hum Genet (2011) 1.02
From autoinhibition to inhibition in trans: the Raf-1 regulatory domain inhibits Rok-alpha kinase activity. J Cell Biol (2009) 1.01
Geographic and sex difference in the distribution of intracranial atherosclerosis in China. Stroke (2013) 0.99
Proteasome inhibition by lactacystin in primary neuronal cells induces both potentially neuroprotective and pro-apoptotic transcriptional responses: a microarray analysis. J Neurochem (2005) 0.99
A functional requirement for PAK1 binding to the KH(2) domain of the fragile X protein-related FXR1. Mol Cell (2010) 0.99
The pharmacokinetics, CNS pharmacodynamics and adverse event profile of brivaracetam after single increasing oral doses in healthy males. Br J Clin Pharmacol (2007) 0.98
Vimentin intermediate filament reorganization by Cdc42: involvement of PAK and p70 S6 kinase. Eur J Cell Biol (2002) 0.97
Constitutional deletion of chromosome 20q in two patients affected with albright hereditary osteodystrophy. Am J Med Genet (2002) 0.97
Bioavailability of encapsulated resveratrol into nanoemulsion-based delivery systems. Food Chem (2013) 0.96
Regulation of IRSp53-dependent filopodial dynamics by antagonism between 14-3-3 binding and SH3-mediated localization. Mol Cell Biol (2009) 0.94
Phosphorylation of myosin phosphatase targeting subunit 3 (MYPT3) and regulation of protein phosphatase 1 by protein kinase A. J Biol Chem (2006) 0.94
Signal intensity ratio as a novel measure of hemodynamic significance for intracranial atherosclerosis. Int J Stroke (2013) 0.94
Regulation and function of protein kinases and phosphatases. Enzyme Res (2011) 0.94
GATA2 as a potential metastasis-driving gene in prostate cancer. Oncotarget (2014) 0.94
Excited Delirium Syndrome (ExDS): defining based on a review of the literature. J Emerg Med (2011) 0.93
Phenotypic characterization of overexpression or deletion of the Escherichia coli crcA, cspE and crcB genes. Microbiology (2003) 0.93
Outgrowth of neurites from NIE-115 neuroblastoma cells is prevented on repulsive substrates through the action of PAK. Mol Cell Biol (2005) 0.92
Collapsin response mediator proteins (CRMPs) are a new class of microtubule-associated protein (MAP) that selectively interacts with assembled microtubules via a taxol-sensitive binding interaction. J Biol Chem (2011) 0.90
Long-term prognosis of Chinese patients with a lacunar infarct associated with small vessel disease: a five-year longitudinal study. Int J Stroke (2009) 0.90
The Drosophila homologue of Arf-GAP GIT1, dGIT, is required for proper muscle morphogenesis and guidance during embryogenesis. Dev Biol (2008) 0.90
ACK family tyrosine kinase activity is a component of Dcdc42 signaling during dorsal closure in Drosophila melanogaster. Mol Cell Biol (2002) 0.90
Interobserver reproducibility of signal intensity ratio on magnetic resonance angiography for hemodynamic impact of intracranial atherosclerosis. J Stroke Cerebrovasc Dis (2013) 0.90
Pulsed electric field-assisted vinification of aglianico and piedirosso grapes. J Agric Food Chem (2010) 0.90
Capacity-related interfacility patient transports: patients affected, wait times involved and associated morbidity. CJEM (2006) 0.90
p80 ROKalpha binding protein is a novel splice variant of CRMP-1 which associates with CRMP-2 and modulates RhoA-induced neuronal morphology. FEBS Lett (2002) 0.90
Regulation of s6 kinase 1 activation by phosphorylation at ser-411. J Biol Chem (2007) 0.89
Magnetic resonance angiography signal intensity as a marker of hemodynamic impairment in intracranial arterial stenosis. PLoS One (2013) 0.89
Epigenetic stability, adaptability, and reversibility in human embryonic stem cells. Proc Natl Acad Sci U S A (2012) 0.89
Design of nanoemulsion-based delivery systems of natural antimicrobials: effect of the emulsifier. J Biotechnol (2011) 0.89
Evaluation of age-related white matter changes using transcranial Doppler ultrasonography. J Neuroimaging (2011) 0.88
Functional interactions between phosphatase POPX2 and mDia modulate RhoA pathways. J Cell Sci (2008) 0.88
Calmodulin binding and Cdk5 phosphorylation of p35 regulate its effect on microtubules. J Biol Chem (2008) 0.88
Protein-protein interactions in Cdk5 regulation and function. Neurosignals (2003) 0.88
Cyclin-dependent kinases in neural development and degeneration. J Alzheimers Dis (2003) 0.88
Direct regulation of microtubule dynamics by protein kinase CK2. J Biol Chem (2003) 0.88
Chronic exposure to U18666A induces apoptosis in cultured murine cortical neurons. Biochem Biophys Res Commun (2004) 0.87
Frequent decreased expression of candidate tumor suppressor gene, DEC1, and its anchorage-independent growth properties and impact on global gene expression in esophageal carcinoma. Int J Cancer (2008) 0.87
Drac1 and Crumbs participate in amnioserosa morphogenesis during dorsal closure in Drosophila. J Cell Sci (2002) 0.87
The neuronal p35 activator of Cdk5 is a novel F-actin binding and bundling protein. Cell Mol Life Sci (2010) 0.86
Preliminary findings of the effects of autonomic dysfunction on functional outcome after acute ischemic stroke. Clin Neurol Neurosurg (2011) 0.86
Chelerythrine perturbs lamellar actomyosin filaments by selective inhibition of myotonic dystrophy kinase-related Cdc42-binding kinase. FEBS Lett (2011) 0.86
Characteristics of patients with abnormal glucose challenge test and normal oral glucose tolerance test results: comparison with normal and gestational diabetic patients. Am J Obstet Gynecol (2006) 0.85
dPak is required for integrity of the leading edge cytoskeleton during Drosophila dorsal closure but does not signal through the JNK cascade. Dev Biol (2004) 0.85
Selection of aptamers for signal transduction proteins by capillary electrophoresis. Electrophoresis (2010) 0.84
Comparison of 3 algorithms for Basal insulin in transitioning from intravenous to subcutaneous insulin in stable patients after cardiothoracic surgery. Endocr Pract (2011) 0.84
C1, see them all. Trends Biochem Sci (2005) 0.84
Neurabin-I is phosphorylated by Cdk5: implications for neuronal morphogenesis and cortical migration. Mol Biol Cell (2007) 0.84
Alpha1,3-galactosyltransferase knockout does not alter the properties of porcine extracellular matrix bioscaffolds. Acta Biomater (2011) 0.84
Early B-cell factors 2 and 3 (EBF2/3) regulate early migration of Cajal-Retzius cells from the cortical hem. Dev Biol (2012) 0.84